scholarly journals ANALYSIS OF RS-FMRI IMAGES CLARIFIES BRAIN ALTERATIONS IN TYPE 2 DIABETES MELLITUS PATIENTS WITH COGNITIVE IMPAIRMENT

2021 ◽  
pp. 2140015
Author(s):  
DONGXUE QIN ◽  
HAOTIAN QIAN ◽  
SHOULIANG QI ◽  
YUEYANG TENG ◽  
JIANLIN WU
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cognitive Impairment ◽  
Inferior Frontal Gyrus ◽  
Middle Frontal Gyrus ◽  
Cingulate Gyrus ◽  
Posterior Cingulate ◽  
Posterior Cingulate Gyrus

Type 2 Diabetes Mellitus (T2DM) increases the risk of cognitive impairment (CI); however, the underlying pathophysiological mechanisms are still not well understood. We propose to clarify the altered spontaneous brain activity and functional connectivity implicated in CI of T2DM by analyzing resting state functional MRI (rs-fMRI) data. Totally 22 T2DM patients with cognitive impairment (T2DM-CI) and 31 T2DM patients with normal cognition (T2DM-NC) are included in this study. The whole brain amplitude of low frequency fluctuation (ALFF) value, regional homogeneity (ReHo) value and functional connectivity (FC) analysis using posterior cingulate cortex (PCC) as a seed region are investigated through comparison between groups of T2DM-CI and T2DM-NC. It is found that, compared with T2DM-NC, T2DM-CI demonstrates the decreased ALFF in the regions of precuneus, posterior cingulate gyrus, middle occipital gyrus and left superior/middle frontal gyrus, but the increased ALFF in the left middle frontal gyrus and left superior temporal gyrus. In T2DM-CI, ReHo decreases in bilateral posterior cingulate gyrus, right precuneus, right inferior frontal gyrus, but increases in the middle frontal gyrus and right superior occipital gyrus. Higher FC between PCC and bilateral inferior parietal lobule and right middle/inferior frontal gyrus, lower FC between PCC and bilateral precuneus and right superior frontal gyrus are observed in T2DM-CI group. Compared with T2DM-NC, patients with T2DM-CI have presented altered ALFF, ReHo and FC in and between important brain regions. The observed alterations are thought to be implicated with cognitive impairment of T2DM as the potential imaging pathophysiological basis.

scholarly journals Alterations of Brain Structural Network Connectivity in Type 2 Diabetes Mellitus Patients With Mild Cognitive Impairment

2021 ◽  
Vol 12 ◽  
Author(s):  
Chang Li ◽  
Jingna Zhang ◽  
Mingguo Qiu ◽  
Kaijun Liu ◽  
Yang Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Inferior Frontal Gyrus ◽  
Global Network ◽  
Structural Network

Patients with type 2 diabetes mellitus (T2DM) are highly susceptible to developing dementia, especially for those with mild cognitive impairment (MCI), but its underlying cause is still unclear. This study aims to investigate the early detection of white matter structural network changes in T2DM patients with MCI and assess the relationship between cognitive impairment and structural network alterations in T2DM patients. In this study, we performed a battery of neuropsychological tests and diffusion tensor MRI in 30 T2MD-MCI patients, 30 T2DM patients with normal cognition (T2DM-NC) and 30 age-, sex-, and education-matched healthy control (HC) individuals. Cognitive performance exhibited obvious differences among the three groups. The structural network was significantly disrupted in both global and regional levels in T2DM patients. The T2DM-MCI group showed more severe impairment of global network efficiency, and lower nodal efficiency and fewer connections within multiple regions like the limbic system, basal ganglia, and several cortical structures. Moreover, a subnetwork impaired in T2DM-MCI patients was characterized by cortical-limbic fibers, and commissural fibers and pathways within the frontal, temporal, and occipital lobes. These altered global and nodal parameters were significantly correlated with cognitive function in T2DM-MCI patients. In particular, executive dysfunction and working memory impairment in T2DM-MCI patients correlated with nodal efficiency in the right opercular part and triangular part of the inferior frontal gyrus, which indicated that white matter disruption in these regions may act as potential biomarkers for T2DM-associated MCI detection. Our investigation provides a novel insight into the neuropathological effects of white matter network disruption on cognition impairments induced by T2DM.

scholarly journals Risk factors for developing dementia in type 2 diabetes mellitus patients with mild cognitive impairment

2019 ◽  
Vol Volume 15 ◽  
pp. 167-175 ◽  
Author(s):  
Oana Albai ◽  
Mirela Frandes ◽  
Romulus Timar ◽  
Deiana Roman ◽  
Bogdan Timar
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment

Cognitive impairment epidemiology in elderly with type 2 diabetes mellitus

2021 ◽  
Vol 10 (2) ◽  
pp. 154-156
Author(s):  
A.V. Balashova ◽  
◽  
M.D. Nikolaev ◽  
V.V. Fadeev ◽  
I.V. Glinkina ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cognitive Impairment

scholarly journals Cognitive impairment and its association with glycemic control in type 2 diabetes mellitus patients

2019 ◽  
Vol 23 (3) ◽  
pp. 353 ◽  
Author(s):  
ChankramathS Arun ◽  
CoredathVenugopal Lalithambika ◽  
LakshmiAmmal Saraswathy ◽  
Renjitha Bhaskaran
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cognitive Impairment ◽  
Glycemic Control

scholarly journals Walking Speed is the Sole Determinant of Mild Cognitive Impairment in Japanese Patients with type 2 Diabetes Mellitus

2020 ◽  
Author(s):  
Noritaka Machii ◽  
Akihiro Kudo ◽  
Haruka Saito ◽  
Hayato Tanabe ◽  
Mariko Iwasaki ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Walking Speed ◽  
Japanese Patients ◽  
Duration Of Diabetes ◽  
Skeletal Mass

Diabetes is a risk factor for mild cognitive impairment (MCI) and dementia. However, how the clinical characteristics of type 2 diabetic patients with MCI are linked to sarcopenia and/or its criterion remain to be elucidated. Japanese patients with type 2 diabetes mellitus were categorized into the MCI group for MoCA-J (the Japanese version of the Montreal cognitive assessment) score <26, and into the non-MCI group for MoCA-J ≥26. Sarcopenia was defined by a low skeletal mass index along with low muscle strength (handgrip strength) or low physical performance (walking speed <1.0 m/s). Univariate and multivariate-adjusted odds ratio models were used to determine the independent contributors for MoCA-J <26. Among 438 participants, 221 (50.5%) and 217 (49.5%) comprised the non-MCI and MCI groups, respectively. In the MCI group, age (61 ± 12 vs. 71 ± 10 years, p < 0.01) and duration of diabetes (14 ± 9 vs. 17 ± 9 years, p < 0.01) were higher than those in the non-MCI group. Patients in the MCI group exhibited lower hand grip strength, walking speed, and skeletal mass index, but higher prevalence of sarcopenia. Only walking speed (rather than muscle loss or muscle weakness) was found to be an independent determinant of MCI after adjusting for multiple factors, such as age, gender, BMI, duration of diabetes, hypertension, dyslipidemia, smoking, drinking, eGFR, HbA1c, and history of coronary heart diseases and stroke. In subgroup analysis, a group consisting of male patients aged ≥65 years, with BMI <25, showed a significant OR for walking speed. This is the first study to show that slow walking speed is a sole determinant for the presence of MCI in patients with type 2 diabetes. It was suggested that walking speed is an important factor in the prediction and prevention of MCI development in patients with diabetes mellitus.

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