Synthesis and photophysical properties of silicon(IV) tetrapyrazinoporphyrazines axially substituted with ethylene glycol chains as potential photosensitizer

2015 ◽  
Vol 19 (08) ◽  
pp. 967-972 ◽  
Author(s):  
Cheol Jun Song ◽  
Jong Min Park ◽  
Wang Yao ◽  
Chang Young Jung ◽  
Jae Yun Jaung
Keyword(s):  
Photodynamic Therapy ◽  
Ethylene Glycol ◽  
Water Solubility ◽  
Photophysical Properties ◽  
Poly Ethylene Glycol ◽  
Design And Synthesis ◽  
Metabolic Conversion ◽  
Poly Ethylene

Photodynamic therapy involves administration of a tumor-localizing photosensitizer, which may require metabolic conversion, followed by activation of the photosensitizer with light of a specific wavelength. In this paper, we report the design and synthesis of silicon(IV) tetrapyrazinoporphyrazines derived from 5,9,9-trimethyl-5,6,7,8-tetrahydro-5,8-methanoquinoxaline-2,3-dicarbonitrile. The HO –( CH 2 CH 2 O )n– CH 3 groups were introduced at axial positions to give a specific functionality. In particular, poly(ethylene glycol) groups were expected to increase water solubility without changing the λmax.

Tracing the transport of organic colloids in porous media using tailored poly(ethylene glycol)

2021 ◽  
Author(s):  
Thomas Ritschel ◽  
Katharina Lehmann ◽  
Michaela Brunzel ◽  
Jürgen Vitz ◽  
Ivo Nischang ◽  
...  
Keyword(s):  
Porous Media ◽  
Ethylene Glycol ◽  
Water Solubility ◽  
Size Range ◽  
Large Fraction ◽  
Colloid Interface ◽  
Poly Ethylene Glycol ◽  
Polymer Backbone ◽  
Colloidal Transport ◽  
Poly Ethylene

<p>A large fraction of organic matter in natural aqueous soil solutions is given by molecules in sizes above one nanometer, which classifies them as colloids according to the IUPAC definition. Such colloids feature discernable mobility in soils and their transport is decisive for the cycling of carbon as well as the migration of nutrients or contaminants. Yet, their size-dependent hydrodynamics and functional diversity result in transport phenomena that are specific to colloids and, thus, largely differ from those observed for smaller substances. Still, tracers that appropriately represent small organic colloids are not available and the investigation of their transport in laboratory column experiments, in dependence of size and chemistry, remains difficult. To overcome this limitation, we tested if well-defined synthetic polymers in the colloidal size range are suitable as non-conventional tracers of colloidal transport. As polymer backbone, we selected poly(ethylene glycol) (PEG) due to its high water-solubility and established pathway of synthesis that permits tailoring of functional moieties to the fullest extent. An easy and sensitive detection in the aqueous phase became possible by using a fluorophore as starting group. After full characterization, we studied PEG adsorption to quartz, illite, goethite, and their mixtures in batch and column transport experiments. In numerical simulations, we successfully reconstructed and predicted PEG transport based on its physicochemical as well as hydrodynamic properties and, thus, show that PEG transport can be comprehensively and quantitatively studied. Considering also its low adverse effect on the environment, functional PEG therefore presents as promising candidate to be used as organic tracer, designable in the size range of natural organic (macro-)molecules (Ritschel et al., 2021).</p><p>References</p><p>Ritschel, T., Lehmann, K., Brunzel, M., Vitz, J., Nischang, I., Schubert, U., Totsche, K. U. (2021) <strong>Well-defined poly(ethylene glycol) polymers as non-conventional reactive tracers of colloidal transport in porous media</strong>.<em> J. Colloid Interface Sci.</em> 548, 592-601, doi: 10.1016/j.jcis.2020.09.056.</p>

Development of chlorin e6-conjugated poly(ethylene glycol)-poly(d,l-lactide) nanoparticles for photodynamic therapy

Nanomedicine ◽  
2019 ◽  
Vol 14 (7) ◽  
pp. 819-834 ◽  
Author(s):  
Preeti Kumari ◽  
Sri Vishnu Kiran Rompicharla ◽  
Himanshu Bhatt ◽  
Balaram Ghosh ◽  
Swati Biswas
Keyword(s):  
Photodynamic Therapy ◽  
Ethylene Glycol ◽  
Chlorin E6 ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Chlorin e6 Conjugated Methoxy-Poly(Ethylene Glycol)-Poly(D,L-Lactide) Glutathione Sensitive Micelles for Photodynamic Therapy

2020 ◽  
Vol 37 (2) ◽  
Author(s):  
Preeti Kumari ◽  
Milan Paul ◽  
Himanshu Bhatt ◽  
Sri Vishnu Kiran Rompicharla ◽  
Debolina Sarkar ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Ethylene Glycol ◽  
Chlorin E6 ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Star-shaped poly(l-lactide)-b-poly(ethylene glycol) with porphyrin core: synthesis, self-assembly, drug-release behavior and singlet oxygen research

2014 ◽  
Vol 38 (8) ◽  
pp. 3569-3578 ◽  
Author(s):  
Xiao-Hui Dai ◽  
Zhi-Ming Wang ◽  
Lu-You Gao ◽  
Jian-Ming Pan ◽  
Xiao-Hong Wang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Block Copolymer ◽  
Drug Release ◽  
Ethylene Glycol ◽  
Self Assembly ◽  
Release Behavior ◽  
Poly Ethylene Glycol ◽  
Drug Release Behavior ◽  
Porphyrin Core ◽  
Poly Ethylene

pH-induced block copolymer SPPLA-b-PEG with porphyrin core for photodynamic therapy.

Targeted poly(ethylene glycol) nanoparticles for photodynamic therapy

2020 ◽  
Vol 606 ◽  
pp. 125394 ◽  
Author(s):  
Xiao Fu ◽  
Haifeng Sun ◽  
Guiqiang Zhang ◽  
Kaijie Zhao ◽  
Yuan Tian ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Dual pH-responsive 5-aminolevulinic acid pseudopolyrotaxane prodrug micelles for enhanced photodynamic therapy

2016 ◽  
Vol 52 (20) ◽  
pp. 3966-3969 ◽  
Author(s):  
Hongxin Tong ◽  
Yin Wang ◽  
Huan Li ◽  
Qiao Jin ◽  
Jian Ji
Keyword(s):  
Photodynamic Therapy ◽  
Ethylene Glycol ◽  
Aminolevulinic Acid ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Novel 5-aminolevulinic acid (ALA) pseudopolyrotaxane prodrug micelles with dual pH-responsive properties were prepared by the host–guest interaction of α-cyclodextrin (α-CD) and poly(ethylene glycol) (PEG).

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