A Fitting Method of Dose-Effect Data of Traditional Chinese Medicine Fusing Softmax Regression and an Improved PSO Algorithm

2020 ◽  
Author(s):  
Mingfeng Zhu ◽  
Yan He ◽  
Jianqiang Du ◽  
Bin Nie ◽  
Qing Ye ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Pso Algorithm ◽  
Dose Effect ◽  
Effect Data ◽  
Softmax Regression ◽  
Fitting Method ◽  
Improved Pso

Clinical Strategy for Optimal Traditional Chinese Medicine (TCM) Herbal Dose Selection in Disease Therapeutics: Expert Consensus on Classic TCM Herbal Formula Dose Conversion

2015 ◽  
Vol 43 (08) ◽  
pp. 1515-1524 ◽  
Author(s):  
Lin-Hua Zha ◽  
Li-Sha He ◽  
Feng-Mei Lian ◽  
Zhong Zhen ◽  
Hang-Yu Ji ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Measurement System ◽  
Expert Consensus ◽  
Dose Effect ◽  
Herbal Formula ◽  
Dose Selection ◽  
Effect Relationship ◽  
Weight Measurement ◽  
Relationship Of

The clinical therapeutics of traditional Chinese medicine (TCM) constitutes a complicated process which involves theory, diagnosis, and formula prescription with specific herbal dosage. Zhang Zhong-Jing’s classic work, Treatise on Febrile and Miscellaneous Diseases, has been influencing TCM practice for almost 2000 years. However, during this extended period of time in Chinese history, the Chinese weight measurement system experienced noticeable changes. This change in the weight measurement system inevitably, and perhaps even negatively, affected TCM herbal dosage determination and treatment outcome. Thus, in modern society, a full understanding of the accuracy of herbal dose selection has a critical importance in the TCM daily practice of delivering the best treatment to the patients suffering from different illnesses. In the 973 Project of the Chinese National Basic Research Program, expert consensus on classic TCM formula dose conversion has been reached based on extensive literature review and discussion on the dose–effect relationship of classic TCM formulas. One “liang” (两) in classic TCM formulas is equivalent to 13.8[Formula: see text]g. However, based on many TCM basic and clinical studies of variable herbal formula prescriptions and herbal drug preparations, the rule of one liang equals 13.8[Formula: see text]g should be adjusted according to different disease conditions. Recommended by the committee on TCM formula dose–effect relationship of the China Association of Chinese Medicine and the World Federation of Chinese Medicine Societies, the following expert consensus has been reached: (i) One liang converts to 6–9[Formula: see text]g for the severely and critically ill patients. (ii) One liang converts to 3–6[Formula: see text]g for the patients suffering from chronic diseases. (iii) One liang converts to 1–3[Formula: see text]g in preventive medicine. The above conversions should be used as a future TCM practice guideline. Using this recommended guideline should enhance the effectiveness of daily TCM practice.

scholarly journals Study on the Dose-effect Relationship of Moxa Burning Fumigation in Air Disinfection in Traditional Chinese Medicine Clinics

2020 ◽  
Vol 1 (3) ◽  
Author(s):  
Shunhua Teng ◽  
Guoyong Ma ◽  
Guozhong Lyu
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Indoor Air ◽  
Dose Effect ◽  
Effect Relationship ◽  
Significant Difference ◽  
Moxa Stick ◽  
Bacterial Content ◽  
Air Disinfection ◽  
Relationship Of

Objective — It’s to study the dose-effect relationship of moxa produced by Gansu Baicao Group in the air disinfection in traditional Chinese medicine clinics. Method — Use moxa sticks burning fumigation to disinfect indoor air in the clinics of traditional Chinese medicine experts; use the natural sedimentation method to detect the bacterial content in the air; compare the sterilization effects of 0.5, 1 and 1.5 moxa sticks 0 h, 1 h and 2 h after air disinfection. Results — In the 54m3 TCM clinic, there was no significant difference in the sterilization rate of air bacteria 0h, 1h, and 2h after using 1 moxa stick and 1.5 moxa sticks respectively for fumigation and disinfection (P>0.05). There was a significant difference in the sterilization rate of air bacteria between 1 moxa stick group and 0.5 moxa stick group 0 h after air disinfection (P < 0. 05). There was a significant difference in the sterilization rate of air bacteria between 0 hour and 1 hour after burning fumigation for air disinfection in 0.5 moxa group (P < 0. 05). Conclusion — The best dose of moxa burning fumigation for air disinfection in 54m3 Chinese medicine clinic is 0.5 stick; the best time for air disinfection is 1h after disinfection.

The Approach for Dose-Effect Relationship of TCM Research Based the Overall Effect of Metabonomics

2014 ◽  
Vol 590 ◽  
pp. 833-836
Author(s):  
Qi Yun Zhang ◽  
Jia Li ◽  
Bing Tao Li ◽  
Jian Jiang Fu ◽  
Ri Yue Yu ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Water Extract ◽  
Dose Effect ◽  
Time Saving ◽  
Effect Relationship ◽  
Bioinformatics Software ◽  
Relationship Of ◽  
Tof Ms

In this paper, PCA combined with Mass Profiler Professional (MPP) bioinformatics software were used to build the dose-effect relationship of traditional Chinese medicine which based on the overall effect of metabonomics. The dataset from Da Cheng Qi Decoction (DCQD) water extract administrated rats plasma collected by UHPLC-Q-TOF-MS and used to demonstrate this method. The approach was confirmed to be an effective and time-saving tool for describing the dose-effect relationship of traditional Chinese medicine.

A New Approach to Investigate the Pharmacokinetics of Traditional Chinese Medicine YL2000

2004 ◽  
Vol 32 (06) ◽  
pp. 921-929 ◽  
Author(s):  
Yu Nan Zhao ◽  
Yi Ding ◽  
Ru Feng Wang ◽  
Dong Ming Xing ◽  
Jie Cheng ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Time Effect ◽  
Concentration Data ◽  
New Approach ◽  
Effect Data ◽  
Effect Curve ◽  
Concentration Curves ◽  
Made In

Much progress has been made in the pharmacology of Traditional Chinese Medicine (TCM). However, the question on how to investigate pharmacokinetics of TCM extract remains. In this study, we selected a new TCM extract YL2000 developed in our laboratory as the research object and investigated both the pharmacokinetics of baicalin and berberine in YL2000 and the pharmacodynamics of YL2000 in febrile rats. The correlation analysis between the time-concentration curves of baicalin and berberine and the time-effect curve of YL2000 was conducted in plasma by statistical methods. The results showed that the time-effect data of anti-pyretic effect of YL2000 had a negative correlation (r=-0.8312, P<0.1) with the time-concentration data of baicalin in plasma, but had no correlation (r=0.01368, P>0.5) with berberine. These data suggested that baicalin could be selected as a marker of anti-pyretic effect, and that YL2000 could be used to treat fevers according to the disposition of baicalin in vivo. In this study, we also proposed that one or more active elements in TCM extracts could be selected to represent the pharmacokinetics of TCM extracts in vivo, combined with the pharmacodynamics of TCM extract.

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