:
The content and the application of pharmaceutical dosage forms must meet several basic
requirements to ensure and maintain efficiency, safety and quality. A large number of active
substances have limited ability to direct administration. Excipients are generally used to overcome the
limitation of direct administration of these active substances. However, the function, behavior and
composition of the excipients need to be well known in the design, development and production of
pharmaceutical dosage forms. In this review, excipients used to assist in any pharmaceutical dosage
form production processes of drugs, to preserve, promote or increase stability, bioavailability and
patient compliance, to assist in product identification / separation, or to enhance overall safety and
effectiveness of the drug delivery system during storage or use are explained. Moreover, the use of
these excipients in drug delivery systems are identified. Excipient toxicity, which is an issue discussed
in the light of current studies, also discussed in this review.