scholarly journals The Role of Cytochrome P450s in Insect Toxicology and Resistance

2021 ◽  
Vol 67 (1) ◽  
Author(s):  
Ralf Nauen ◽  
Chris Bass ◽  
René Feyereisen ◽  
John Vontas
Keyword(s):  
Cytochrome P450 ◽  
Insecticide Resistance ◽  
Insect Pests ◽  
Cytochrome P450s ◽  
Cytochrome P450 Monooxygenases ◽  
Annual Review ◽  
Publication Date ◽  
Beneficial Insects ◽  
P450 Monooxygenases

Insect cytochrome P450 monooxygenases (P450s) perform a variety of important physiological functions, but it is their role in the detoxification of xenobiotics, such as natural and synthetic insecticides, that is the topic of this review. Recent advances in insect genomics and postgenomic functional approaches have provided an unprecedented opportunity to understand the evolution of insect P450s and their role in insect toxicology. These approaches have also been harnessed to provide new insights into the genomic alterations that lead to insecticide resistance, the mechanisms by which P450s are regulated, and the functional determinants of P450-mediated insecticide resistance. In parallel, an emerging body of work on the role of P450s in defining the sensitivity of beneficial insects to insecticides has been developed. The knowledge gained from these studies has applications for the management of P450-mediated resistance in insect pests and can be leveraged to safeguard the health of important beneficial insects. Expected final online publication date for the Annual Review of Entomology, Volume 67 is January 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

DETOXICATIVE ENZYME ACTIVITIES IN FIVE SPECIES OF FIELD-COLLECTED MELANOPLINE GRASSHOPPERS (ORTHOPTERA: ACRIDIDAE)

1996 ◽  
Vol 128 (2) ◽  
pp. 353-354 ◽  
Author(s):  
Murray B. Isman ◽  
Ruying Feng ◽  
Dan L. Johnson
Keyword(s):  
Cytochrome P450 ◽  
Insecticide Resistance ◽  
Host Plant ◽  
Enzyme Activities ◽  
Cytochrome P450 Monooxygenases ◽  
Insect Host ◽  
Suitable Host ◽  
P450 Monooxygenases ◽  
Enzyme Systems ◽  
General Esterases

Detoxicative enzyme systems, such as the cytochrome P450 monooxygenases, gluthione S-transferases, and general esterases, have been widely studied in holometabolous insects (e.g. Lepidoptera, Diptera, and Coleoptera). These, and other enzyme systems, play important roles in insecticide resistance, but are also important in insect–host plant relationships, because host range can partially depend on the ability of an insect to cope with putatively toxic allelochemicals in an otherwise suitable host plant (e.g. Lindroth 1989). In some cases, differences in the relative activities of these enzymes between closely related insect taxa can have significant biological consequences (Siegfried and Mullin 1989).

Cytochrome P450 Monooxygenases and Interactions of Psychotropic Drugs: A Five-Year Update

1995 ◽  
Vol 25 (3) ◽  
pp. 277-290 ◽  
Author(s):  
Winston W. Shen
Keyword(s):  
Cytochrome P450 ◽  
Psychotropic Drugs ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Gene Clusters ◽  
Serum Levels ◽  
Cytochrome P450s ◽  
Cytochrome P450 Monooxygenases ◽  
P450 Monooxygenases ◽  
Human Cytochrome ◽  
Enzymatic Induction

Objective: This article is a five-year update on a previous review article ( International Journal of Psychiatry in Medicine, 21:47–56, 1991) on cytochrome P450 monooxygenases and interactions of psychotropic drugs. Method: In the literature review, the recent committee work on nomenclature of the P450 superfamily are highlighted. Then, the author reviewed gene clusters of three human cytochrome P450s— CYP1A2, CYP2D6, and CYP3A4 with the focus on the changes of serum levels of the coadministered psychotropic drugs in the context of enzymatic induction and inhibition of these three hepatic enzymes. Results: As indicated in one table, the author stratified probes, inducers, inhibitors, chemical reactions, and substrates under these three gene clusters. As shown in another simple table, the author compared the hepatic enzymatic inhibitions of four selective serotonin reuptake inhibitors and pointed out the inhibition potentials of fluvoxamine at CYP1A2, fluoxetine and paroxetine at CYP2D6, and fluoxetine and fluvoxamine at CYP3A4 if these two SSRIs have higher serum concentrations. Conclusion: The author suggests that with these systematic approaches, this rapidly adding knowledge can help psychiatrists better understand psychotropic drug interactions and maximize the benefits of patients' psychopharmacotherapy.

scholarly journals Cytochrome P450 monooxygenases and insecticide resistance in insects

1998 ◽  
Vol 353 (1376) ◽  
pp. 1701-1705 ◽  
Author(s):  
J. Bergé ◽  
R. Feyereisen ◽  
M. Amichot
Keyword(s):  
Cytochrome P450 ◽  
Insecticide Resistance ◽  
3D Structure ◽  
Resistance Mechanisms ◽  
Cytochrome P450 Monooxygenases ◽  
Wild Type ◽  
P450 Gene ◽  
P450 Monooxygenases ◽  
Loss Of Resistance ◽  
Cytochrome P450 Genes

Cytochrome P450 monooxygenases are involved in many cases of resistance of insects to insecticides. Resistance has long been associated with an increase in monooxygenase activities and with an increase in cytochrome P450 content. However, this increase does not always account for all of the resistance. In Drosophila melanogaster , we have shown that the overproduction of cytochrome P450 can be lost by the fly without a corresponding complete loss of resistance. These results prompted the sequencing of a cytochrome P450 candidate for resistance in resistant and susceptible flies. Several mutations leading to amino–acid substitutions have been detected in the P450 gene CYP6A2 of a resistant strain. The location of these mutations in a model of the 3D structure of the CYP6A2 protein suggested that some of them may be important for enzyme activity of this molecule. This has been verified by heterologous expression of wild–type and mutated cDNA in Escherichia coli . When other resistance mechanisms are considered, relatively few genetic mutations are involved in insecticide resistance, and this has led to an optimistic view of the management of resistance. Our observations compel us to survey in more detail the genetic diversity of cytochrome P450 genes and alleles involved in resistance.

scholarly journals The central role of mosquito cytochrome P450 CYP6Zs in insecticide detoxification revealed by functional expression and structural modelling

2013 ◽  
Vol 455 (1) ◽  
pp. 75-85 ◽  
Author(s):  
Alexia Chandor-Proust ◽  
Jaclyn Bibby ◽  
Myriam Régent-Kloeckner ◽  
Jessica Roux ◽  
Emilie Guittard-Crilat ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
In Silico ◽  
Functional Expression ◽  
Cytochrome P450 Monooxygenases ◽  
Structural Modelling ◽  
P450 Monooxygenases ◽  
In Silico Modelling

The key role of mosquito cytochrome P450 monooxygenases from the CYP6Z subfamily in the resistance of mosquitoes to insecticides was revealed. By using functional expression and in silico modelling, the capacity of CYP6Zs to degrade insecticide metabolites produced by esterase-mediated hydrolysis was demonstrated.

The role of cytochrome P450 monooxygenases in microbial fatty acid metabolism

FEBS Journal ◽  
2010 ◽  
Vol 278 (2) ◽  
pp. 206-221 ◽  
Author(s):  
Inge N. A. Van Bogaert ◽  
Sara Groeneboer ◽  
Karen Saerens ◽  
Wim Soetaert
Keyword(s):  
Cytochrome P450 ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Cytochrome P450 Monooxygenases ◽  
P450 Monooxygenases ◽  
Microbial Fatty Acid
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