Radiation Therapy in the Management of Cancers of the Oral Cavity and OropharynxRadiation Therapy in the Management of Cancers of the Oral Cavity and Oropharynx. By FletcherGilbert H., M.D., Radiotherapist, and MacCombWilliam S., M.D., Surgeon, Chief of Head and Neck Service. With the collaboration of BallantyneAlando J., M.D., Associate Surgeon, Head and Neck Service.Physics Section: The Calculation of Dose in Interstitial Implantations. By ShalekRobert J., Ph.D., Associate Physicist, and StovallMarilyn, B.A., Senior Dosimetrist. From the University of Texas M. D. Anderson Hospital and Tumor Institute, Houston, Texas. Publication No. 447, American Lecture Series. A monograph of 396 pages, with numerous figures and tables. Published by Charles C Thomas, Springfield, Ill., 1962. Price $16.50.

Radiology ◽  
1963 ◽  
Vol 81 (1) ◽  
pp. 146-146
Keyword(s):  
Radiation Therapy ◽  
Oral Cavity ◽  
Head And Neck ◽  
University Of Texas ◽  
Lecture Series ◽  
The University

Value of Radiation Therapy in Addition to Surgery for Cancer of the Head and Neck

1986 ◽  
Vol 94 (5) ◽  
pp. 601-604 ◽  
Author(s):  
Ahmad Sadeghi ◽  
John McLaren ◽  
William L. Grist ◽  
Luu Tran ◽  
Hans Kuisk
Keyword(s):  
Radiation Therapy ◽  
Oral Cavity ◽  
Head And Neck ◽  
Primary Site ◽  
Surgical Margins ◽  
Controlled Study ◽  
Tumor Control ◽  
Postoperative Radiation Therapy ◽  
Treatment Groups ◽  
Nodal Control

This historically controlled study evaluates radiation therapy in 119 patients—With squamous cell carcinomas of the head and neck—who underwent surgery alone (SA) or surgery plus radiation (S + R). The primary tumor control and nodal control, in patients with negative surgical margins who had surgery alone (SA), were 63% in the oral cavity, 60% in the oropharynx, and 67% in the hypopharynx. The same rates for S + R group and negative surgical margins were 100%, 73%, and 100%. Combining the patients with negative and positive surgical margins, control of the tumor and nodal control were the same in the oral cavity for both treatment groups (41% for SA and 44% for S + R) and increased with the addition of radiation in the oropharynx (30% for SA to 65% for S + R) and hypopharynx (33% for SA to 86% for S + R), in spite of higher percentages of T3 and T4 tumor and positive lymph nodes in the S + R group. The lower control rate in patients who had surgery alone could be due (in part) to inadequate surgery at the primary site (42% local excision) and lack of neck dissection (35% for SA vs. 77% for S + R). Postoperative radiation therapy to the primary site and neck is shown to effectively reduce local recurrence in patients with oral cavity and oropharynx cancer, regardless of surgical margins.

scholarly journals An Updated Review on Head and Neck Cancer Treatment with Radiation Therapy

Cancers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 4912
Author(s):  
Garrett Anderson ◽  
Maryam Ebadi ◽  
Kim Vo ◽  
Jennifer Novak ◽  
Ameish Govindarajan ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Head And Neck Cancer ◽  
Side Effects ◽  
Oral Cavity ◽  
Head And Neck ◽  
Multidisciplinary Approach ◽  
Critical Role ◽  
Optimal Management ◽  
Sinus Cavity

The complexity of head and neck cancers (HNC) mandates a multidisciplinary approach and radiation therapy (RT) plays a critical role in the optimal management of patients with HNC, either as frontline or adjuvant treatment postoperatively. The advent of both definitive and post-operative RT has significantly improved the outcomes of patients with HNC. Herein, we discuss the role of postoperative RT in different subtypes of HNC, its side effects, and the importance of surveillance. The treatment regions discussed in this paper are the oral cavity, nasopharynx, paranasal sinus cavity, oropharynx, larynx and hypopharynx. Multiple studies that demonstrate the importance of definitive and/or postoperative RT, which led to an improved outlook of survival for HNC patients will be discussed.

Metastatic Breast Carcinoma Presenting as Cavernous Sinus Syndrome

1996 ◽  
Vol 105 (8) ◽  
pp. 666-668 ◽  
Author(s):  
Matthew W. Ryan ◽  
Christopher H. Rassekh ◽  
Gregory Chaljub
Keyword(s):  
Breast Carcinoma ◽  
Head And Neck ◽  
Cavernous Sinus ◽  
Metastatic Breast ◽  
Neck Surgery ◽  
Texas Medical ◽  
Metastatic Breast Carcinoma ◽  
Cavernous Sinus Syndrome ◽  
University Of Texas ◽  
The University

From the Departments of Otolaiyngology-Head and Neck Surgery (Ryan, Rassekh) and Radiology (Chaljub), The University of Texas Medical Branch, Galveston, Texas.

Value of Radiation Therapy in Addition to Surgery for Cancer of the Head and Neck

1986 ◽  
Vol 94 (6) ◽  
pp. 601-604 ◽  
Author(s):  
Ahmad Sadeghi ◽  
John Mclaren ◽  
William L. Grist ◽  
Luu Tran ◽  
Hans Kuisk
Keyword(s):  
Radiation Therapy ◽  
Oral Cavity ◽  
Head And Neck ◽  
Primary Site ◽  
Surgical Margins ◽  
Controlled Study ◽  
Tumor Control ◽  
Postoperative Radiation Therapy ◽  
Treatment Groups ◽  
Nodal Control

This historically controlled study evaluates radiation therapy in 119 patients—with squamous cell carcinomas of the head and neck—who underwent surgery alone (SA) or surgery plus radiation (S + R). The primary tumor control and nodal control, in patients with negative surgical margins who had surgery alone (SA), were 63% in the oral cavity, 60% in the oropharynx, and 67% in the hypopharynx. The same rates for S + R group and negative surgical margins were 100%, 73%, and 100%. Combining the patients with negative and positive surgical margins, control of the tumor and noddl control were the same in the oral cavity for both treatment groups (41% for SA and 44% for S + R) and increased with the addition of radiation in the oropharynx (30% for SA to 65% for S + R) and hypopharynx (33% for SA to 86% for S + R), in spite of higher percentages of T3 and T4 tumor and positive lymph nodes in the S + R group. The lower control rote in patients who had surgery alone could be due (in part) to inadequate surgery at the primary site (42% local excision) and lack of neck dissection (35% for SA vs. 77% for S + R). Postoperative radiation therapy to the primary site and neck is shown to effectively reduce local recurrence in patients with oral cavity and oropharynx cancer, regardless of surgical margins.

scholarly journals Mucosal Melanomas of the Head and Neck: The Role of Postoperative Radiation Therapy

ISRN Oncology ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Kunal Saigal ◽  
Donald T. Weed ◽  
Isildinha M. Reis ◽  
Arnold M. Markoe ◽  
Aaron H. Wolfson ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Head And Neck ◽  
Neck Region ◽  
Distant Metastases ◽  
Postoperative Radiation ◽  
Postoperative Radiation Therapy ◽  
Head And Neck Region ◽  
Definitive Surgery ◽  
The University

Objectives. Mucosal melanomas are rarer than their cutaneous counterparts and are associated with a poorer prognosis. We report the clinical outcomes of patients with mucosal melanomas of the head and neck region generally treated with definitive surgery followed by postoperative radiation therapy (RT). Methods. We reviewed the records of 17 patients treated at the University of Miami in 1990–2007. Patients generally received conventionally fractionated RT regimens to the postoperative bed. Elective nodal RT was not routinely delivered. Eight patients received adjuvant chemotherapy or immunotherapy. Results. Median followup was 35.2 months (range 5–225). As the first site of failure: 3 patients recurred locally, 2 regionally and 2 distantly. All 3 patients who recurred locally had not received RT. Of the 5 locoregional recurrences, 4 were salvaged successfully with multimodality therapy with no evidence of disease at last followup. Overall survival was 64.7% at 2 years and 51.5% at 5 years. Conclusions. Patients with mucosal melanoma of the head and neck are best treated with surgery to achieve negative margins, followed by postoperative RT to optimize local control. Elective nodal irradiation may not be indicated in all cases, as regional failures were not predominant. Distant metastases were fewer when compared to historical data, potentially due to advancements in adjuvant therapies as well as aggressive multi-modality salvage at time of failure.

scholarly journals Building a Comprehensive Cancer Education Program to Increase Clinical Capacity in Mozambique

2017 ◽  
Vol 3 (2_suppl) ◽  
pp. 22s-23s
Author(s):  
Melissa S. Lopez ◽  
Ellen S. Baker ◽  
Cesaltina Lorenzoni ◽  
Elvira Xavier Luis ◽  
Flora Mabota ◽  
...  
Keyword(s):  
Cancer Prevention ◽  
Head And Neck ◽  
Education Program ◽  
Head And Neck Cancers ◽  
Cancer Center ◽  
University Of Texas ◽  
Treatment Services ◽  
Hands On ◽  
Md Anderson ◽  
The University

Abstract 8 Background: Worldwide, 14.1 million new cancer cases and 8.2 million cancer-related deaths occur annually. Of global cancer deaths, 65% occur in low- and middle-income countries, where there are not enough medical specialists to provide prevention, screening, and treatment services. For example, there are 245 physicians per 100,000 people in the United States and four physicians per 100,000 people in Mozambique. We undertook this work to investigate how to increase clinical capacity and improve cancer prevention and treatment services to ultimately reduce cancer mortality in Mozambique. Methods: Our education program has three complementary components: Strong partnerships with four academic institutions in Brazil, the Ministry of Health of Mozambique, Maputo Central Hospital, and Mavalane Hospital (Maputo) to develop educational programs and collaborative research; use of technology to implement resource-specific and culturally appropriate telementoring programs; and in-country, hands-on training. Collaboration with Brazilian institutions facilitates communication and provides clinical expertise and program expansion opportunities. The telementoring component uses the Project ECHO model, a program that was developed at the University of New Mexico to engage providers in a horizontal manner through regular case-based discussions. Hands-on training complements the telementoring program and increases the level of expertise. Results: Since January 2015, 120 training hours have been provided through ECHO videoconferences to an average of 11 participants on breast, cervical, and head and neck cancers. Two in-country workshops have provided an average of 1,200 training hours to approximately 100 providers in diagnosis, secondary prevention, and surgical management of breast, cervical, and head and neck cancers, as well as training for medical oncology, oncology nursing, palliative care, and radiation physics. Conclusion: Collaborations with Pink Ribbon Red Ribbon, US academic institutions, and industry partners are being developed to strengthen these programs. Funding: The Cancer Prevention Research Institute of Texas Grant No. PP150012; The University of Texas MD Anderson Cancer Center R. Lee Clark Fellowship award, generously supported by the Jeanne F. Shelby Scholarship Fund; The University of Texas MD Anderson Sister Institution Network Fund (SINF) award; The University of Texas MD Anderson Cancer Center HPV-related cancers Moon Shot program; and The University of Texas MD Anderson Cancer Center Cancer Prevention and Control Platform. AUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST Melissa S. Lopez No relationship to disclose Ellen S. Baker Stock or Other Ownership: Merck Cesaltina Lorenzoni No relationship to disclose Elvira Xavier Luis No relationship to disclose Flora Mabota No relationship to disclose Pedro Rafael Machava No relationship to disclose Jose Humberto Tavares No relationship to disclose Donato Callegaro Filho No relationship to disclose Thiago Chulam Travel, Accommodations, Expenses: AC Camargo Cancer Center Kathleen M. Schmeler Research Funding: Becton Dickinson Patents, Royalties, Other Intellectual Property: UpToDate

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