Multifocal Glioblastoma

2020 ◽  
Author(s):  
Nader Zakhari, MD, FRCPC
Author(s):  
Issam Sa’adeh ◽  
Mohamed Jamal Saadh

Abstract Background Glioblastoma multiform is the most common and aggressive type of primary malignant tumor that affects the central nervous system in adults. It clinically presents with seizures, headache, and/or progressive focal neurological deficits. Radiologically, glioblastoma multiform appears as a single distinguishable, large heterogeneous lesion affecting the cerebrum with characteristic central necrosis, marginal enhancement, and surrounding vasogenic edema. This article describes a patient that exhibited an atypical clinical presentation of multifocal glioblastoma multiform with misleading early radiological features that simulated herpetic encephalitis. Results A 66-year-old female that presented with left-sided hemiparesis and left partial motor seizures underwent multi-slice computed tomography (MSCT) and magnetic resonance imaging (MRI) scans. A cerebrospinal fluid (CSF) polymerase chain reaction (PCR) test was also performed to screen for herpes simplex virus 1 (HSV-1). Conclusions The early stages of glioblastoma may manifest as symptoms typical to encephalitis, which can delay diagnosis and treatment. Therefore, early diagnosis and identification of atypical glioblastoma multiform presentations, as reported in this article, are essential.


2018 ◽  
Vol Volume 10 ◽  
pp. 4229-4235 ◽  
Author(s):  
Mustafa Syed ◽  
Jakob Liermann ◽  
Vivek Verma ◽  
Denise Bernhardt ◽  
Nina Bougatf ◽  
...  

2007 ◽  
Vol 69 (3) ◽  
pp. 820-824 ◽  
Author(s):  
Timothy N. Showalter ◽  
Jocelyn Andrel ◽  
David W. Andrews ◽  
Walter J. Curran ◽  
Constantine Daskalakis ◽  
...  

2021 ◽  
Vol 2 (1) ◽  
pp. 39-41
Author(s):  
Simonenko A.Yu.

48 birth histories of patients in the Perinatal center of the V. D. Seredavin SOKB with various diseases of the nervous system were analyzed. 27 patients had planned delivery by caesarean section, due to the combination of relative indications from the fetus and a burdened obstetric history, and 21 – delivery through the natural birth canal. Delivery via the natural birth canal was performed in women with epilepsy-in 28% of patients with neurocirculatory dystonia: - in 16%, with encephalopathy-in 12%, with a herniated disc: - in 12%, with a history of traumatic brain injury-in 12%, with dorsopathy-in 12%, with multiple sclerosis-in 8%, with lumboishalgia-in 4%, with multifocal glioblastoma – 4%. 48% of newborns in women after delivery through the natural birth canal were completely healthy, only 11% had signs of cerebral ischemia, and 19% had slightly pronounced hypoxic and hypotrophic changes. Joint observation of such women during pregnancy by an obstetrician-gynecologist and a neurologist with rational pre-test training allowed to avoid operative delivery.


2020 ◽  
Vol 148 (1) ◽  
pp. 155-164 ◽  
Author(s):  
Long Di ◽  
Rainya N. Heath ◽  
Ashish H. Shah ◽  
Alexander D. Sanjurjo ◽  
Daniel G. Eichberg ◽  
...  

2013 ◽  
Vol 2 (2) ◽  
pp. 185-195 ◽  
Author(s):  
Emil Lou ◽  
Katherine B. Peters ◽  
Ashley L. Sumrall ◽  
Annick Desjardins ◽  
David A. Reardon ◽  
...  

2017 ◽  
Vol 19 (4) ◽  
pp. 546-557 ◽  
Author(s):  
Khalil Abou-El-Ardat ◽  
Michael Seifert ◽  
Kerstin Becker ◽  
Sophie Eisenreich ◽  
Matthias Lehmann ◽  
...  

2014 ◽  
Vol 20 (2) ◽  
pp. 502-505
Author(s):  
Ilian Koev ◽  
Emil Slavov ◽  
Hristo Zhelyazkov ◽  
Dmitrii Staikov ◽  
Krasimira Halacheva ◽  
...  

2021 ◽  
Author(s):  
Thomas Campion ◽  
Sara Stoneham ◽  
Ayisha Al-Busaidi ◽  
Atul Kumar ◽  
Zane Jaunmuktane ◽  
...  

We highlight an unusual case of multifocal glioblastoma in an adolescent patient, manifesting as four discrete brain lesions, each distinct in appearance. Familiarity with the diverse imaging features of glioblastoma can reduce misdiagnosis and avoid treatment delays.


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