Utility of PET/CT to Evaluate Retroperitoneal Lymph Node Metastasis                    in High-Risk Endometrial Cancer: Results of ACRIN 6671/GOG 0233                    Trial

Background: to elucidate the predictors of progression-free survival (PFS) and overall survival (OS) in high-risk endometrial cancer patients. Methods: the medical records of all consecutivewomen with high-risk endometrial cancer were reviewed. Results: among 92 high-risk endometrial cancer patients, 30 women experienced recurrence, and 21 women died. The 5-year PFS and OS probabilities were 65.3% and 75.9%, respectively. Multivariable Cox regression revealed that body mass index (hazard ratio (HR) = 1.11), paraaortic lymph node metastasis (HR = 11.11), lymphovascular space invasion (HR = 5.61), and sandwich chemoradiotherapy (HR = 0.15) were independently predictors of PFS. Body mass index (HR = 1.31), paraaortic lymph node metastasis (HR = 32.74), non-endometrioid cell type (HR = 11.31), and sandwich chemoradiotherapy (HR = 0.07) were independently predictors of OS. Among 51 women who underwent sandwich (n = 35) or concurrent (n = 16) chemoradiotherapy, the use of sandwich chemoradiotherapy were associated with better PFS (adjusted HR = 0.26, 95% CI = 0.08–0.87, p = 0.03) and OS (adjusted HR = 0.11, 95% CI = 0.02–0.71, p = 0.02) compared with concurrent chemoradiotherapy. Conclusion: compared with concurrent chemoradiotherapy, sandwich chemoradiotherapy was associated with better PFS and OS in high-risk endometrial cancer patients. In addition, high body mass index, paraaortic lymph node metastasis, and non-endometrioid cell type were also predictors of poor OS in high-risk endometrial cancer patients.

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PREDICTIBILITY OF RETROPÉRITONEAL LYMPH NODE METASTASIS IN ENDOMETRIAL CANCER

International Journal of Gynecological Cancer ◽

10.1136/ijgc-00009577-200303001-00091 ◽

2003 ◽

Vol 13 (Suppl 1) ◽

pp. 27.2-27

Author(s):

C. Taskiran ◽

K. Yuce ◽

A. Ayhan

Keyword(s):

Endometrial Cancer ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Retroperitoneal Lymph Node ◽

Node Metastasis

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DNA ploidy in curettage specimens identifies high-risk patients and lymph node metastasis in endometrial cancer

British Journal of Cancer ◽

10.1038/bjc.2015.123 ◽

2015 ◽

Vol 112 (10) ◽

pp. 1656-1664 ◽

Cited By ~ 15

Author(s):

T S Njølstad ◽

◽

J Trovik ◽

T S Hveem ◽

M L Kjæreng ◽

...

Keyword(s):

Endometrial Cancer ◽

Lymph Node ◽

High Risk ◽

Lymph Node Metastasis ◽

Dna Ploidy ◽

High Risk Patients ◽

Node Metastasis ◽

Risk Patients

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Comparison of integrated PET/MRI with PET/CT in evaluation of endometrial cancer: a retrospective analysis of 81 cases

PeerJ ◽

10.7717/peerj.7081 ◽

2019 ◽

Vol 7 ◽

pp. e7081 ◽

Cited By ~ 4

Author(s):

Li-hua Bian ◽

Min Wang ◽

Jing Gong ◽

Hong-hong Liu ◽

Nan Wang ◽

...

Keyword(s):

Endometrial Cancer ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Regional Lymph Node ◽

Myometrial Invasion ◽

Regional Lymph Node Metastasis ◽

Primary Tumors ◽

Node Metastasis ◽

Pet Ct ◽

Invasion Detection

Background The objective of this study was to compare the diagnostic value of integrated PET/MRI with PET/CT for assessment of regional lymph node metastasis and deep myometrial invasion detection of endometrial cancer. Methods Eighty-one patients with biopsy-proven endometrial cancer underwent preoperative PET/CT (n = 37) and integrated PET/MRI (n = 44) for initial staging. The diagnostic performance of PET/CT and integrated PET/MRI for assessing the extent of the primary tumor and metastasis to the regional lymph nodes was evaluated by two experienced readers. Histopathological and follow-up imaging results were used as the gold standard. McNemar’s test was employed for statistical analysis. Results Integrated PET/MRI and PET/CT both detected 100% of the primary tumors. Integrated PET/MRI proved significantly more sensitivity and specificity than PET/CT in regional lymph node metastasis detection (P = 0.015 and P < 0.001, respectively). The overall accuracy of myometrial invasion detection for PET/CT and Integrated PET/MRI was 45.9% and 81.8%, respectively. Integrated PET/MRI proved significantly more accurate than PET/CT (P < 0.001). Conclusion Integrated PET/MRI, which complements the individual advantages of MRI and PET, is a valuable technique for the assessment of the lymph node metastasis and myometrial invasion in patients with endometrial cancer.

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