Selective induction of manganous superoxide dismutase in human monocytes
1985 ◽
Vol 249
(5)
◽
pp. C393-C397
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Keyword(s):
Radioimmunoassays for both human copper-zinc and manganous superoxide dismutases (Cu-Zn SOD and Mn SOD, respectively) have been developed, validated, and utilized to measure the concentrations of these enzymes in cultured monocytes. Monocyte Mn SOD increased 4.7-fold over basal during 3 days of culture, an increase that was markedly enhanced by stimulation with bacterial lipopolysaccharide (LPS). Cu-Zn SOD showed a transient decrease over the culture period but was unaffected by LPS. Stimulation with muramyl dipeptide had minimal effect on Mn SOD and no effect on Cu-Zn SOD during culture, even at a concentration capable of activating the monocytes, as defined by zymosan-induced superoxide production.
1990 ◽
Vol 265
(19)
◽
pp. 10872-10875
1983 ◽
Vol 258
(7)
◽
pp. 4339-4344
1992 ◽
Vol 122
(suppl_3)
◽
pp. 636-640
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2011 ◽
Vol 20
(1)
◽
pp. 75-78
1979 ◽
Vol 44
(4)
◽
pp. 201-217
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1989 ◽
Vol 105
(1-2)
◽
pp. 41-46
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