Taste Receptors in the Gastrointestinal Tract. V. Acid sensing in the gastrointestinal tract
2007 ◽
Vol 292
(3)
◽
pp. G699-G705
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Keyword(s):
Luminal acidity is a physiological challenge in the foregut, and acidosis can occur throughout the gastrointestinal tract as a result of inflammation or ischemia. These conditions are surveyed by an elaborate network of acid-governed mechanisms to maintain homeostasis. Deviations from physiological values of extracellular pH are monitored by multiple acid sensors expressed by epithelial cells and sensory neurons. Acid-sensing ion channels are activated by moderate acidification, whereas transient receptor potential ion channels of the vanilloid subtype are gated by severe acidosis. Some ionotropic purinoceptor ion channels and two-pore domain background K+ channels are also sensitive to alterations of extracellular pH.
2020 ◽
Vol 21
(17)
◽
pp. 6221
◽
2019 ◽
Vol 374
(1785)
◽
pp. 20190291
◽
2016 ◽
Vol 207
◽
pp. 32-37
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