Effect of dietary fish oil on myocardial phospholipids and myocardial ischemic damage

The effect of dietary fish oil on myocardial phospholipids and ischemic damage to the heart was studied in the rat. Four weeks of feeding 5% (i.e., 12 energy percent) menhaden oil (MO) produced both profound changes in the fatty acyl composition of phospholipids in myocardial membranes and a significant reduction in the loss of creatine kinase following coronary artery ligation compared with feeding 5% (i.e., 12 energy percent) corn oil (CO). The MO diet did not change the content of either phospholipids or cholesterol in the heart. However, dietary MO resulted in significant elevations in the percent of fatty acids in the total phospholipids that were saturated, the n-3/n-6 ratio and the double-bond index. The changes in total phospholipids were not uniform for all phospholipid classes. Although the n-3/n-6 ratio was increased in each of the individual phospholipids examined, the predominant n-3 fatty acid incorporated (i.e., 20:5, 22:5, 22:6) differed among the major phospholipid classes. Also, the percent saturation was elevated in phosphatidylcholine with no change in double-bond index, whereas both the percent saturation and double-bond index were elevated in phosphatidylethanolamine. Thus dietary MO resulted in selective alterations in individual myocardial phospholipids. These membrane changes may be involved in the observed reduction of ischemic damage in the heart.

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Effects of dietary fish oil and corn oil on gonadosomatic and hepatosomatic index, gonadal histology, 17β‐oestradiol level and fatty acids profile of mahseer ( Tor tambroides ) broodstock in captivity

Aquaculture Nutrition ◽

10.1111/anu.13282 ◽

2021 ◽

Author(s):

Muhammad Yazed Abduh ◽

Ivan Chong Chu Koh ◽

Ambok Bolong Abol‐Munafi ◽

Nor Hakim Norazmi‐Lokman ◽

Noordiyana Mat Noordin

Keyword(s):

Fatty Acids ◽

Fish Oil ◽

Corn Oil ◽

Hepatosomatic Index ◽

Oestradiol Level ◽

Fatty Acids Profile ◽

Gonadal Histology ◽

In Captivity ◽

Dietary Fish

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Double Bond Index

Analytical Chemistry ◽

10.1021/ac60019a002 ◽

1948 ◽

Vol 20 (7) ◽

pp. 598-606 ◽

Cited By ~ 9

Author(s):

M. R. Lipkin ◽

Albert. Sankin ◽

C. C. Martin

Keyword(s):

Double Bond ◽

Bond Index ◽

Double Bond Index

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Ozone dosage effect on C6 cell growth, in vitro and in vivo tests: double bond index for characterization

Analytical Methods ◽

10.1039/c4ay00104d ◽

2014 ◽

Vol 6 (13) ◽

pp. 4567-4575 ◽

Cited By ~ 2

Author(s):

Arizbeth Pérez ◽

Clara L. Santos Cuevas ◽

Isaac Chairez ◽

Tatyana Poznyak ◽

David Ordaz-Rosado ◽

...

Keyword(s):

Double Bond ◽

Cell Growth ◽

Medical Therapy ◽

Saline Solution ◽

Bond Index ◽

Double Bond Index ◽

In Vivo Tests ◽

C6 Tumor

Ozone dissolved in a saline solution applied as a medical therapy promoted an 85% decrement in C6 tumor activity.

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Effects of dietary fish oil on cardiac responsiveness to adrenoceptor stimulation

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.1988.254.3.h494 ◽

1988 ◽

Vol 254 (3) ◽

pp. H494-H499 ◽

Cited By ~ 2

Author(s):

D. K. Reibel ◽

M. A. Holahan ◽

C. E. Hock

Keyword(s):

Fish Oil ◽

Corn Oil ◽

Left Ventricular Pressure ◽

Left Ventricular ◽

Beta Adrenoceptor ◽

Cardiac Inotropy ◽

Rat Hearts ◽

Dietary Fish ◽

Pressure Development ◽

Standard Laboratory Diet

The effect of dietary fish oil on cardiac function and responsiveness to alpha- and beta-adrenergic receptor agonists was examined in isolated perfused rat hearts. Rats were fed either a standard laboratory diet (SD) or diets containing 5% corn oil (CO) or 5% menhaden oil (MO) for 4 wk. When perfused as working preparations at varying preloads and afterloads, the peak aortic pressures, aortic outputs, and coronary flows were comparable in hearts of rats fed the three experimental diets. Inotropic responsiveness to phenylephrine was examined by infusing graded doses of the drug into the heart while monitoring changes in the rate of left ventricular pressure development (+dP/dt). Prior to phenylephrine administration +dP/dt was not different among the three groups of hearts. However, at each dose of phenylephrine employed, delta +dP/dt was approximately 50% less in hearts of rats fed MO when compared with either SD or CO. Thus cardiac inotropic responsiveness to this alpha-agonist was reduced by dietary fish oil. In contrast, cardiac inotropic responsiveness to isoproterenol was not altered with MO feeding. The data demonstrate that dietary fish oil results in alterations in alpha- but not beta-adrenoceptor mediated changes in cardiac inotropy.

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Effect of dietary fish oil and corn oil on lipid metabolism and apolipoprotein gene expression by rat liver

European Journal of Biochemistry ◽

10.1111/j.1432-1033.1991.tb15842.x ◽

1991 ◽

Vol 196 (2) ◽

pp. 499-507 ◽

Cited By ~ 48

Author(s):

Agnes RIBEIRO ◽

Marise MANGENEY ◽

Philippe CARDOT ◽

Claude LORIETTE ◽

Yves RAYSSIGUIER ◽

...

Keyword(s):

Gene Expression ◽

Lipid Metabolism ◽

Fish Oil ◽

Rat Liver ◽

Corn Oil ◽

Dietary Fish

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Effects of Dietary Fish Oil and Corn Oil on Protein Kinase C Distribution in the Colon

Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury ◽

10.1007/978-1-4615-3874-5_33 ◽

1991 ◽

pp. 219-222

Author(s):

R. Nelson ◽

O. Holian

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Fish Oil ◽

Corn Oil ◽

Kinase C ◽

C Distribution ◽

Dietary Fish

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Effect of dietary fish oil on lung lipid profile and hypoxic pulmonary hypertension

Journal of Applied Physiology ◽

10.1152/jappl.1989.66.4.1662 ◽

1989 ◽

Vol 66 (4) ◽

pp. 1662-1673 ◽

Cited By ~ 19

Author(s):

S. L. Archer ◽

G. J. Johnson ◽

R. L. Gebhard ◽

W. L. Castleman ◽

A. S. Levine ◽

...

Keyword(s):

Pulmonary Hypertension ◽

Fish Oil ◽

Chronic Hypoxia ◽

Corn Oil ◽

Pulmonary Arteries ◽

Hypoxic Pulmonary Hypertension ◽

Dietary Fish ◽

Lung Lipid ◽

Pulmonary Arterial ◽

Fish Oil Diet

The effects of dietary polyunsaturated fats on chronic hypoxic pulmonary hypertension were assessed in rats fed fish oil, corn oil, or a lower fat, “high-carbohydrate” diet (regular) beginning 1 mo before the start of hypoxia (0.4 atm, n = 30 for each). Mean pulmonary arterial pressures were lower in the chronically hypoxic rats fed fish oil (19.7 +/- 1.8 mm Hg) than in the rats fed corn oil (25.3 +/- 1.6 mm Hg) or regular diets (27.5 +/- 1.5 mm Hg, P less than 0.05). The fish oil diet increased lung eicosapentaenoic acid 50-fold and depleted lung arachidonic acid 60% (P less than 0.0001 for each). Lung thromboxane B2 and 6-ketoprostaglandin F1 alpha levels were lower, and platelet aggregation, in response to collagen, was reduced in rats fed fish oil. Chronically hypoxic rats fed fish oil had lower mortality rates than the other hypoxic rats. They also had lower blood viscosity, as well as less right ventricular hypertrophy and less peripheral extension of vascular smooth muscle to intra-acinar pulmonary arteries (P less than 0.05 for each). The mechanism by which dietary fish oil decreases pulmonary hypertension and vascular remodeling during chronic hypoxia remains uncertain. The finding that a fish oil diet can reduce the hemodynamic and morphological sequelae of chronic hypoxia may have therapeutic significance.

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Decreased R:FR Ratio in Incident White Light Affects the Composition of Barley Leaf Lipidome and Freezing Tolerance in a Temperature-Dependent Manner

International Journal of Molecular Sciences ◽

10.3390/ijms21207557 ◽

2020 ◽

Vol 21 (20) ◽

pp. 7557

Author(s):

Terézia Kovács ◽

Mohamed Ahres ◽

Tamás Pálmai ◽

László Kovács ◽

Matsuo Uemura ◽

...

Keyword(s):

Double Bond ◽

White Light ◽

Red Light ◽

Frost Tolerance ◽

Light Illumination ◽

Dependent Manner ◽

Bond Index ◽

Double Bond Index ◽

Barley Leaves ◽

Barley Leaf

In cereals, C-repeat binding factor genes have been defined as key components of the light quality-dependent regulation of frost tolerance by integrating phytochrome-mediated light and temperature signals. This study elucidates the differences in the lipid composition of barley leaves illuminated with white light or white light supplemented with far-red light at 5 or 15 °C. According to LC-MS analysis, far-red light supplementation increased the amount of monogalactosyldiacylglycerol species 36:6, 36:5, and 36:4 after 1 day at 5 °C, and 10 days at 15 °C resulted in a perturbed content of 38:6 species. Changes were observed in the levels of phosphatidylethanolamine, and phosphatidylserine under white light supplemented with far-red light illumination at 15 °C, whereas robust changes were observed in the amount of several phosphatidylserine species at 5 °C. At 15 °C, the amount of some phosphatidylglycerol species increased as a result of white light supplemented with far-red light illumination after 1 day. The ceramide (42:2)-3 content increased regardless of the temperature. The double-bond index of phosphatidylglycerol, phosphatidylserine, phosphatidylcholine ceramide together with total double-bond index changed when the plant was grown at 15 °C as a function of white light supplemented with far-red light. white light supplemented with far-red light increased the monogalactosyldiacylglycerol/diacylglycerol ratio as well. The gene expression changes are well correlated with the alterations in the lipidome.

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