Vasopressin in blood and third ventricle CSF of dogs in chronic experiments

1983 ◽  
Vol 245 (4) ◽  
pp. R541-R548 ◽  
Author(s):  
C. Simon-Oppermann ◽  
D. Gray ◽  
E. Szczepanska-Sadowska ◽  
E. Simon
Keyword(s):  
Cerebrospinal Fluid ◽  
Arginine Vasopressin ◽  
Anterior Part ◽  
Third Ventricle ◽  
Conscious State ◽  
Conscious Dogs ◽  
Inhalation Anesthesia ◽  
Blood Samples ◽  
The Third ◽  
Device Implantation

A device for chronic implantation was developed that allowed sampling of cerebrospinal fluid (CSF) from the anterior part of the third cerebral ventricle (A3V) of dogs in repeated experiments for up to 4 mo. Osmolalities, electrolyte concentrations, and concentrations of arginine vasopressin (AVP) measured with a radioimmunoassay were determined in repeated experiments on the chronically prepared animals under conditions of normal hydration, both in the conscious state and during inhalation anesthesia. In conscious dogs, AVP concentrations in plasma and CSF were 3.3 +/- 0.4 and 21.8 +/- 2.5 pg X ml-1, respectively. During anesthesia without surgical interference, the AVP concentrations in plasma and CSF were increased twofold above the levels obtained in conscious dogs. During the time of observation (180 min) all measured parameters remained constant. The AVP concentrations in plasma and CSF samples collected during the surgical procedure of device implantation were about 10-fold higher than in the samples collected during the conscious state. Thus, in each experimental condition, AVP concentration in the CSF collected from the A3V was consistently higher than that in the simultaneously collected blood samples.

Effects of chronic icv infusion of vasopressin on sleep-waking cycle of rats

1989 ◽  
Vol 256 (3) ◽  
pp. R674-R684 ◽  
Author(s):  
E. Arnauld ◽  
V. Bibene ◽  
J. Meynard ◽  
F. Rodriguez ◽  
J. D. Vincent
Keyword(s):  
Cerebrospinal Fluid ◽  
Arginine Vasopressin ◽  
Third Ventricle ◽  
Relative Proportion ◽  
The Third ◽  
Visual Scoring ◽  
Artificial Cerebrospinal Fluid ◽  
Constant Rate ◽  
Structural Analogues ◽  
Polygraphic Recordings

The effect of arginine vasopressin (AVP) on the duration and the relative proportion of sleeping and wakeful periods has been investigated. Vigilance states were determined by visual scoring of polygraphic recordings from unrestrained rats. Animals were implanted with a cannula into the third ventricle through which AVP or related drugs, dissolved in artificial cerebrospinal fluid, were infused at a constant rate by an osmotic pump. Polygraphic data were collected 24 h/day from day 4 to day 9. Recordings were continued for 3 additional days during AVP recovery. AVP infusions significantly increased the amount of time spent in waking compared with control or recovery periods (12%). This effect was mimicked by an AVP agonist (2-phenylalanine, 8-ornithine oxytocin). Oxytocin, a peptide structurally close to AVP, induced a mild change in waking time. The infusion of an AVP antagonist, 1-desaminopenicillamine-2-(O-methyl)tyrosine-arginine vasopressin (dPTyr(Me)AVP), or of anti-AVP antibodies significantly decreased duration of waking. The infusion of antioxytocin antibodies did not modify the duration of waking. The effects of structural analogues of AVP relatively specific for each type of peripheral AVP receptor indicated the participation of a V1-like AVP receptor in the action of AVP on waking time. During infusion of anti-AVP antibodies and dPTyr(Me)AVP and during the first days of recovery from AVP infusion, the ultradian rhythmic distribution of sleep and wakefulness was still present, but the amplitude of the circadian rhythm was reduced.

Independent osmoregulatory control of central and systemic angiotensin II concentrations in dogs

1986 ◽  
Vol 250 (5) ◽  
pp. R918-R925 ◽  
Author(s):  
C. Simon-Oppermann ◽  
D. A. Gray ◽  
E. Simon
Keyword(s):  
Cerebrospinal Fluid ◽  
Angiotensin Ii ◽  
Anterior Part ◽  
Conscious Dogs ◽  
Cerebral Ventricle ◽  
Ang Ii ◽  
Salt Loading ◽  
The Third ◽  
Rich Food ◽  
Conscious Animals

In 14 dogs angiotensin (ANG II)-like immunoreactivity was analyzed in simultaneously collected samples of cerebrospinal fluid (CSF) from the anterior part of the third cerebral ventricle and of plasma. Plasma and CSF ANG II were not different in euhydrated conscious dogs (29.3 +/- 2.7 and 30.8 +/- 2.8 pg X ml-1, means +/- SE). During anesthesia CSF ANG II was not significantly altered, but plasma ANG II was more than doubled in comparison with conscious animals. In conscious dogs 24 h of dehydration with sodium-rich food significantly increased ANG II concentration in the plasma (to 59.8 +/- 16.5 pg X ml-1) and CSF (to 71.8 +/- 20.1 pg X ml-1). Subsequent rehydration by drinking caused no consistent changes in plasma ANG II within 90 min but reduced CSF ANG II significantly. Salt loading by infusion of 5% saline in seven conscious dogs produced a small but consistent decrease in plasma ANG II by 20%, on average, whereas CSF ANG II rose in five animals. The directions of changes in concentration of central ANG II compared with plasma ANG II suggest that central endogenous ANG II may function as a central osmoregulatory mediator independent from systemic ANG II.

Vasopressin in blood and third ventricle CSF during dehydration, thirst, and hemorrhage

1983 ◽  
Vol 245 (4) ◽  
pp. R549-R555 ◽  
Author(s):  
E. Szczepanska-Sadowska ◽  
D. Gray ◽  
C. Simon-Oppermann
Keyword(s):  
Cerebrospinal Fluid ◽  
Fluid Balance ◽  
Water Deprivation ◽  
Anterior Part ◽  
Third Ventricle ◽  
Venous Blood ◽  
Plasma Samples ◽  
The Third ◽  
Implanted Device ◽  
Modest Reduction

Samples of cerebrospinal fluid (CSF) were collected from the anterior part of the third cerebral ventricle of mongrel dogs with a chronically implanted device. Repeated experiments with simultaneous sampling of CSF and venous blood in 60- to 90-min intervals were performed in conscious dogs after 24-h water deprivation and during subsequent rehydration by drinking, during thirst stimulation by intravenous infusion of 5% saline, and during blood removal (12 ml X kg body wt-1). The CSF and plasma samples were analyzed for osmolality and arginine vasopressin (AVP) with a radioimmunoassay. Compared with normally hydrated dogs, 24-h water deprivation caused plasma AVP to rise significantly from 2.5 to 7.7 pg X ml-1 and CSF AVP from 24.2 to 31.3 pg X ml-1. Subsequent drinking significantly reduced plasma and CSF AVP. Thirst stimulation by hypertonic infusions was associated with rises of plasma and CSF AVP. Modest reduction of blood volume also increased both plasma and CSF AVP. Plasma AVP in each of the described physiological disturbances of salt or fluid balance was positively correlated with CSF AVP.

Cerebrospinal fluid rhinorrhea and acquired anterior basal encephalocoele in a patient with colloid cyst of the third ventricle

2010 ◽  
Vol 58 (1) ◽  
pp. 156 ◽  
Author(s):  
Chandrasekharan Kesavadas ◽  
TirurRaman Kapilamoorthy ◽  
Gireesh Menon ◽  
KythasandraShivakumar Deepak
Keyword(s):  
Cerebrospinal Fluid ◽  
Third Ventricle ◽  
Colloid Cyst ◽  
Cerebrospinal Fluid Rhinorrhea ◽  
The Third

Hypothalamic Hamartoma in a Dog

1977 ◽  
Vol 14 (2) ◽  
pp. 138-145 ◽  
Author(s):  
R. W. Cook
Keyword(s):  
Cerebrospinal Fluid ◽  
Third Ventricle ◽  
Fluid Pressure ◽  
Hypothalamic Hamartoma ◽  
Tuber Cinereum ◽  
Mammillary Bodies ◽  
Spongiform Change ◽  
The Third ◽  
The Brain ◽  
Rostral Part

A 10-month-old female, Wire-haired Pointing Griffon dog had a hamartoma of the hypothalamus. Episodes of sudden flaccid collapse had increased in frequency and duration for 7 months. Cerebrospinal fluid pressure was normal. A flat, pedunculated mass, 2.5×3.0×0.9 cm, covered the brain stem between the pituitary gland and pons. Its 1.2-cm-diameter connection to the hypothalamus obliterated the mammillary bodies and extended to the tuber cinereum, distorting the hypothalamus and displacing the third ventricle which also divided the rostral part of the mass. The tissue of the hamartoma resembled gray matter with bullous cytoplasmic vacuolation of many neurons, spongiform change, gemistocytosis and microscopic foci of calcification.

Neuroepithelial (colloid) cyst of the third ventricle in identical twins

1986 ◽  
Vol 65 (3) ◽  
pp. 401-403 ◽  
Author(s):  
Abdel Wahab M. Ibrahim ◽  
Hisham Farag ◽  
Mohammed Naguib ◽  
Ezzeldin Ibrahim
Keyword(s):  
Cerebrospinal Fluid ◽  
Obstructive Hydrocephalus ◽  
Third Ventricle ◽  
Colloid Cyst ◽  
Content Type ◽  
The Third ◽  
Colloid Cysts ◽  
Fluid Pathway ◽  
Ocular Signs ◽  
Fine Print

✓ Colloid cysts of the third ventricle are described in middle-aged twin brothers. One of them presented with recurrent attacks of headache. In this patient the cyst had reached a size large enough to obstruct the cerebrospinal fluid pathway, resulting in hydrocephalus. The twin brother, although asymptomatic, was suspected of the anomaly and investigated because of the similarity of his ocular signs. The diagnosis was confirmed by computerized tomography in both the patient and his brother. The latter proved to have a smaller colloid cyst situated anteriorly in the third ventricle with no obstructive hydrocephalus. The patient was successfully operated on, while the brother is still under observation. Both brothers have had bilateral cataracts, retinal detachments, and left lateral rectus palsies. The familial occurrence of colloid cysts and their association with these ocular findings have apparently not been described before.

Migrating Lateral Ventricle Choroid Plexus Cyst into the Fourth Ventricle Causing Acute Hydrocephalus

2021 ◽  
Author(s):  
Lacey M. Carter ◽  
Benjamin Cornwell ◽  
Naina L. Gross
Keyword(s):  
Cerebrospinal Fluid ◽  
Choroid Plexus ◽  
Lateral Ventricle ◽  
Fourth Ventricle ◽  
Third Ventricle ◽  
Neurological Deficits ◽  
Cerebral Aqueduct ◽  
Outflow Obstruction ◽  
The Third ◽  
Choroid Plexus Cyst

AbstractChoroid plexus cysts consist of abnormal folds of the choroid plexus that typically resolve prior to birth. Rarely, these cysts persist and may cause outflow obstruction of cerebrospinal fluid. We present a 5-month-old male born term who presented with lethargy, vomiting, and a bulging anterior fontanelle. Magnetic resonance imaging showed one large choroid plexus cyst had migrated from the right lateral ventricle through the third ventricle and cerebral aqueduct into the fourth ventricle causing outflow obstruction. The cyst was attached to the lateral ventricle choroid plexus by a pedicle. The cyst was endoscopically retrieved from the fourth ventricle intact and then fenestrated and coagulated along with several other smaller cysts. Histologic examination confirmed the mass was a choroid plexus cyst. The patient did well after surgery and did not require any cerebrospinal fluid diversion. Nine months after surgery, the patient continued to thrive with no neurological deficits. This case is the first we have found in the literature of a lateral ventricular choroid plexus cyst migrating into the fourth ventricle and the youngest of any migrating choroid plexus cyst. Only three other cases of a migrating choroid plexus cyst have been documented and those only migrated into the third ventricle. New imaging advances are making these cysts easier to identify, but may still be missed on routine sequences. High clinical suspicion for these cysts is necessary for correct treatment of this possible cause of hydrocephalus.

Endoscopic Treatment of a Fourth Ventricle Arachnoid Cyst via the Third Ventricle: A Case Report

2014 ◽  
Vol 10 (2) ◽  
pp. E374-E378 ◽  
Author(s):  
Matteo Martinoni ◽  
Francesco Toni ◽  
Mariella Lefosse ◽  
Eugenio Pozzati ◽  
Anna Federica Marliani ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Arachnoid Cyst ◽  
Fourth Ventricle ◽  
Fluid Dynamic ◽  
Third Ventricle ◽  
Arachnoid Cysts ◽  
Complete Excision ◽  
The Third ◽  
Neurosurgical Treatment ◽  
Cerebrospinal Fluid Dynamic

Abstract BACKGROUND AND IMPORTANCE: Arachnoid cysts within the fourth ventricle have rarely been reported in the literature. Different procedures have been performed to restore a normal cerebrospinal fluid dynamic or pressure, including shunting and partial or complete excision of the cyst by open microsurgery. Cerebrospinal fluid shunts give only partial improvement of symptoms and are prone to malfunctions. The microsurgical excision of the cyst seems to offer the best chance of success. CLINICAL PRESENTATION: We report the case of a fourth ventricle arachnoid cyst successfully treated with a complete endoscopic cerebral procedure via the third ventricle. CONCLUSION: Endoscopic fenestration of fourth ventricle arachnoid cysts may be considered an effective neurosurgical treatment.

Meningioma of the anterior part of the third ventricle

1981 ◽  
Vol 56 (3-4) ◽  
pp. 219-231 ◽  
Author(s):  
J. M. Cabezudo ◽  
J. Vaquero ◽  
R. Garc�a-de-Sola ◽  
E. Areitio ◽  
G. Bravo
Keyword(s):  
Anterior Part ◽  
Third Ventricle ◽  
The Third
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