Central indomethacin enhances volume-dependent vasopressin release
1984 ◽
Vol 247
(6)
◽
pp. R1017-R1021
Keyword(s):
The effect of centrally administered indomethacin on hemorrhage-induced vasopressin release was studied in the morphine-sedated, urethan/chloralose-anesthetized dog. Ventriculocisternal perfusion of indomethacin 1) significantly reduced the amount of prostaglandin E2 in the effluent from the cisterna magna, 2) significantly enhanced the vasopressin response to volume depletion, and led to a greater fall in mean arterial blood pressure during severe hemorrhage. The results suggest that central prostaglandins may have an inhibitory effect on vasopressin secretion during volume depletion.
1991 ◽
Vol 261
(2)
◽
pp. R420-R426
1991 ◽
Vol 260
(5)
◽
pp. E780-E786
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1974 ◽
Vol 41
(3)
◽
pp. 350-355
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1985 ◽
Vol 249
(2)
◽
pp. R281-R284
1995 ◽
Vol 269
(1)
◽
pp. H80-H85
◽
1992 ◽
Vol 263
(5)
◽
pp. R1030-R1034
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