scholarly journals Acute exercise does not impair renal function in nondialysis chronic kidney disease patients regardless of disease stage

2017 ◽  
Vol 313 (2) ◽  
pp. F547-F552 ◽  
Author(s):  
Davi A. Santana ◽  
Jacques R. Poortmans ◽  
Egidio Lima Dórea ◽  
Juliana Bannwart de Andrade Machado ◽  
Alan Lins Fernandes ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Kidney Disease ◽  
Aerobic Exercise ◽  
Acute Exercise ◽  
Exercise Bout ◽  
Peak Oxygen Uptake ◽  
Disease Stage ◽  
Moderate Intensity ◽  
Impair Renal Function

Exercise has been overlooked as a potential therapy in chronic kidney disease (CKD), mainly because of a lack of understanding on its safety aspects. Notably, there are no data on renal function after exercise in CKD considering its stages. We investigated the acute effects of a 30-min moderate-intensity aerobic exercise bout on glomerular filtration rate (GFR) and albuminuria in 22 nondialysis CKD patients divided into: CKD stages 1 and 2 (CKD1–2) and CKD stages 3 and 4 (CKD3–4). Eleven body mass index-, age-, and sex-matched healthy individuals served as control (CON). Blood and urine samples were collected before, immediately after, and up to 90 min postexercise for creatinine and albumin assessments. GFR was determined by creatinine clearance (GFRCr-Cl). All CKD patients had significantly lower peak oxygen uptake than CON. CKD1–2 and CKD3–4 had increasingly higher serum creatinine than CON (9.6 ± 2.6, 25.6 ± 1.01, and 7.5 ± 1.4 mg/l, respectively); however, no within-group changes in serum or urinary creatinine were observed across time. GFRCr-Cl was decreased in CKD1–2 and CKD3–4 compared with CON (91 ± 17 ml·min−1·1.73 m−2; 34 ± 15 ml·min−1·1.73 m−2; 122 ± 20 ml·min−1·1.73 m−2, respectively). Most importantly, exercise did not affect GFRCr-Cl in none of the groups across time. Albuminuria was significantly higher in CKD3–4 (297 ± 284 µg/min) than in CON (5.4 ± 1.4 µg/min), but no within-group changes were observed after exercise. In conclusion, a single 30-min moderate-intensity aerobic exercise bout does not impair renal function in nondialysis CKD patients, regardless of disease stage, supporting the notion that exercise training can be safe in this disease.

scholarly journals Renal Function Responses To Steady-state Moderate-intensity And High-intensity Interval Exercise In Mid-spectrum Chronic Kidney Disease

2019 ◽  
Vol 51 (Supplement) ◽  
pp. 73
Author(s):  
Jeffrey S. Forsse ◽  
Matthew N. Peterson ◽  
Zacharias Papadakis ◽  
Nicholas Schwedock ◽  
Burritt W. Hess ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Steady State ◽  
Kidney Disease ◽  
High Intensity ◽  
Moderate Intensity ◽  
Interval Exercise ◽  
High Intensity Interval

scholarly journals The effect of percutaneous nephrolithotomy in patients with chronic kidney disease in northeast India population

2021 ◽  
Vol 8 (5) ◽  
pp. 1458
Author(s):  
Phanindra Mohan Deka ◽  
Manharsinh Rajput ◽  
Priyanku Sarma
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Kidney Disease ◽  
Renal Stone ◽  
Operative Time ◽  
Stone Disease ◽  
Disease Stage ◽  
Renal Stone Disease ◽  
Stone Free Rate ◽  
Free Rate

Background: Renal stone disease is a recognized precursor for renal deterioration, if untreated, it can lead to renal failure. With advances in the PCNL, the effect on patients with established renal insufficiency remains under reported. So, we aimed to evaluate the efficacy as well as safety of PCNL in chronic kidney disease patients.Methods: This retrospective cohort study included patients admitted in our hospital from January 2016 to December 2018, which were diagnosed with urolithiasis and chronic kidney disease and treated by PCNL. Patients with GFR <60 ml/min/1.73 m2 in non-obstructed renal stone disease who underwent PCNL were included. We studied the change in renal function, complete stone free rate (SFR) complications stone composition, operative time and hospital stay.Results: The study comprised 50 patients (M/F-32/18) of CKD who underwent PCNL. Mean operative time was 90.50±12.57minutes in group 1 and 98.00±12.35 minutes in group 2. One or more complications were noted in 12 patients (24%) after PCNL. At a mean follow-up of 18 months, renal function stage had improved in 24 patients (48%) and it was maintained in 13 (26%). Worse CKD with an increase in disease stage was noted in 13 patients (26%). Association between hypertension, diabetes and postoperative deterioration in kidney function wasn’t significant statistically (p=0.9). The stone-free rate at postoperative month 3 was 76%.Conclusions: PCNL has a favourable outcome in patients with chronic kidney disease stage III/IV, with a good calculus clearance rate and improved kidney function.

Abstract 15081: Determinants of Improvement in Renal Function Among Patients With Chronic Kidney Disease Who Participated in Cardiac Rehabilitation

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Tetsuo Arakawa ◽  
Reon Kumasaka ◽  
Michio Nakanishi ◽  
Kazuyasu Nakao ◽  
Shigefumi Fukui ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Kidney Disease ◽  
Cardiac Rehabilitation ◽  
Estimated Glomerular Filtration Rate ◽  
Peak Oxygen Uptake ◽  
Cardiac Patients ◽  
Lower Baseline ◽  
Younger Age ◽  
Fourth Quartile

Background: The safety and efficacy of cardiac rehabilitation (CR) in patients with chronic kidney disease (CKD) have not been established. There are conflicting reports about the effects of exercise on renal function in CKD patients, and there have been no studies about the determinants of change in renal function. The aims of this study are 1) to clarify the effect of CR and 2) to investigate the determinants of change in renal function in cardiac patients with CKD. Methods: A total of 759 consecutive cardiac patients with CKD (estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2) who participated in CR were studied. All patients underwent measurements of eGFR and peak oxygen uptake (PVO2) before and 3 months after CR. Patients were divided into quartiles based on their change in eGFR. We compared the characteristics of patients in the first quartile (improved eGFR group) and the fourth quartile (worsened eGFR group). Results: Overall, after 3-months CR program, eGFR (47.4 to 49.8 ml/min/1.73 m2, p<0.0001) and PVO2 (1108 to 1237 ml/min, p<0.0001) increased and BNP decreased (253 to 195pg/ml, p<0.0001) significantly. The improved eGFR patients (n=190, eGFR 48.4 to 62.3 ml/min/1.73m 2 ) were younger (65.5 vs. 71.4 years, p<0.0001). They also had higher body mass index (BMI, 23.2 vs. 22.3 kg/m2, p<0.0001), higher LVEF (44% vs 39%, p<0.001), higher PVO2 (73.2% vs. 65.4%, p<0.0001), and lower BNP (206 pg/ml vs. 297 pg/ml, p<0.0001) than the worsened eGFR group (n=190, eGFR 48.4 to 41.6 ml/min/1.73 m2). A lower proportion of the improved eGFR group had heart failure (13% vs. 39%, p<0.001). There were similar levels of statistically significant improvement in PVO2 after CR in both groups. In the multiple regression analysis, younger age, higher BMI, higher baseline PVO2, lower baseline eGFR, and greater improvement in PVO2 after CR were independent determinants of eGFR improvement. Conclusion: In cardiac patients with CKD, CR improved exercise tolerance without worsening renal function. Greater improvement in PVO2 was associated with greater improvement in eGFR after CR, suggesting that CR has a protective effect on the kidney in these patients.

scholarly journals Aerobic exercise capacity is maintained over a 5-year period in mild-to-moderate chronic kidney disease: A longitudinal study

2019 ◽  
Author(s):  
Helena Wallin ◽  
Eva Jansson ◽  
Carin Wallquist ◽  
Britta Hylander Rössner ◽  
Stefan H Jacobson ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Heart Rate ◽  
Renal Function ◽  
Kidney Disease ◽  
Haemoglobin Level ◽  
Aerobic Exercise ◽  
Exercise Capacity ◽  
Peak Heart Rate ◽  
Aerobic Exercise Capacity ◽  
Over Time

Abstract Background: Aerobic exercise capacity is reduced in non-dialysis chronic kidney disease (CKD), but little is known about the magnitude of changes in exercise capacity over time. In a 5-year-prospective study, we evaluated exercise capacity and known determinants of exercise capacity in patients with mild-to-moderate CKD attending a specialist nephrology clinic. Methods: We included 52 individuals with CKD stage 2–3 and 54 age- and sex-matched healthy controls. Peak workload was assessed through a maximal cycle exercise test. Muscle strength and lean body mass, cardiac function, vascular stiffness, renal function and haemoglobin level were evaluated. Tests were repeated after 5 years. Statistical analysis of longitudinal data was performed using linear mixed models. Results: Exercise capacity did not change significantly over time in either CKD individuals or controls, although the absolute workload levels were significantly lower in CKD individuals. Renal function decreased in both groups, with a faster decline in CKD (p = 0.05 between groups). Peak heart rate, haemoglobin level, handgrip strength, lean body mass and cardiovascular function did not decrease significantly over time in CKD individuals. Physical activity level increased over 5 years only in the CKD group. Conclusions: Aerobic exercise capacity and peak heart rate are maintained over 5 years in a group of patients with well-controlled CKD grade 2–3, despite a slight reduction in glomerular filtration rate, mirroring the lack of progression of cardiovascular and muscular dysfunction in this group.

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