scholarly journals Aerobic exercise capacity is maintained over a 5-year period in mild-to-moderate chronic kidney disease: A longitudinal study

2019 ◽  
Author(s):  
Helena Wallin ◽  
Eva Jansson ◽  
Carin Wallquist ◽  
Britta Hylander Rössner ◽  
Stefan H Jacobson ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Heart Rate ◽  
Renal Function ◽  
Kidney Disease ◽  
Haemoglobin Level ◽  
Aerobic Exercise ◽  
Exercise Capacity ◽  
Peak Heart Rate ◽  
Aerobic Exercise Capacity ◽  
Over Time

Abstract Background: Aerobic exercise capacity is reduced in non-dialysis chronic kidney disease (CKD), but little is known about the magnitude of changes in exercise capacity over time. In a 5-year-prospective study, we evaluated exercise capacity and known determinants of exercise capacity in patients with mild-to-moderate CKD attending a specialist nephrology clinic. Methods: We included 52 individuals with CKD stage 2–3 and 54 age- and sex-matched healthy controls. Peak workload was assessed through a maximal cycle exercise test. Muscle strength and lean body mass, cardiac function, vascular stiffness, renal function and haemoglobin level were evaluated. Tests were repeated after 5 years. Statistical analysis of longitudinal data was performed using linear mixed models. Results: Exercise capacity did not change significantly over time in either CKD individuals or controls, although the absolute workload levels were significantly lower in CKD individuals. Renal function decreased in both groups, with a faster decline in CKD (p = 0.05 between groups). Peak heart rate, haemoglobin level, handgrip strength, lean body mass and cardiovascular function did not decrease significantly over time in CKD individuals. Physical activity level increased over 5 years only in the CKD group. Conclusions: Aerobic exercise capacity and peak heart rate are maintained over 5 years in a group of patients with well-controlled CKD grade 2–3, despite a slight reduction in glomerular filtration rate, mirroring the lack of progression of cardiovascular and muscular dysfunction in this group.

scholarly journals Aerobic exercise capacity is maintained over a 5-year period in mild-to-moderate chronic kidney disease: a longitudinal study

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Helena Wallin ◽  
Eva Jansson ◽  
Carin Wallquist ◽  
Britta Hylander Rössner ◽  
Stefan H. Jacobson ◽  
...  
Keyword(s):  
Physical Activity ◽  
Chronic Kidney Disease ◽  
Heart Rate ◽  
Renal Function ◽  
Aerobic Exercise ◽  
Exercise Capacity ◽  
Activity Level ◽  
Peak Heart Rate ◽  
Aerobic Exercise Capacity ◽  
Over Time

Abstract Background Aerobic exercise capacity is reduced in non-dialysis chronic kidney disease (CKD), but the magnitude of changes in exercise capacity over time is less known. Our main hypothesis was that aerobic ExCap would decline over 5 years in individuals with mild-to-moderate CKD along with a decline in renal function. A secondary hypothesis was that such a decline in ExCap would be associated with a decline in muscle strength, cardiovascular function and physical activity. Methods We performed a 5-year-prospective study on individuals with mild-to-moderate CKD, who were closely monitored at a nephrology clinic. Fiftytwo individuals with CKD stage 2–3 and 54 age- and sex-matched healthy controls were included. Peak workload was assessed through a maximal cycle exercise test. Muscle strength and lean body mass, cardiac function, vascular stiffness, self-reported physical activity level, renal function and haemoglobin level were evaluated. Tests were repeated after 5 years. Statistical analysis of longitudinal data was performed using linear mixed models. Results Exercise capacity did not change significantly over time in either the CKD group or controls, although the absolute workloads were significantly lower in the CKD group. Only in a CKD subgroup reporting low physical activity at baseline, exercise capacity declined. Renal function decreased in both groups, with a larger decline in CKD (p = 0.05 between groups). Peak heart rate, haemoglobin level, handgrip strength, lean body mass and cardiovascular function did not decrease significantly over time in CKD individuals. Conclusions On a group level, aerobic exercise capacity and peak heart rate were maintained over 5 years in patients with well-controlled mild-to-moderate CKD, despite a slight reduction in glomerular filtration rate. In line with the maintained exercise capacity, cardiovascular and muscular function were also preserved. In individuals with mild-to-moderate CKD, physical activity level at baseline seems to have a predictive value for exercise capacity at follow-up.

scholarly journals Aerobic exercise capacity is maintained over a 5-year period in mild-to-moderate chronic kidney disease: A longitudinal study

2020 ◽  
Author(s):  
Helena Wallin ◽  
Eva Jansson ◽  
Carin Wallquist ◽  
Britta Hylander Rössner ◽  
Stefan H Jacobson ◽  
...  
Keyword(s):  
Physical Activity ◽  
Chronic Kidney Disease ◽  
Heart Rate ◽  
Renal Function ◽  
Aerobic Exercise ◽  
Exercise Capacity ◽  
Activity Level ◽  
Peak Heart Rate ◽  
Aerobic Exercise Capacity ◽  
Over Time

Abstract Background: Aerobic exercise capacity is reduced in non-dialysis chronic kidney disease (CKD), but little is known about the magnitude of changes in exercise capacity over time. Our main hypothesis was that aerobic ExCap would decline over 5 years in individuals with mild-to-moderate CKD along with a decline in renal function. A secondary hypothesis was that such a decline in ExCap would be associated with a decline in muscle strength, cardiovascular function and physical activity. Methods: We performed a 5-year-prospective study on individuals with mild-to-moderate CKD, who were closely monitored at a nephrology clinic. Fiftytwo individuals with CKD stage 2–3 and 54 age- and sex-matched healthy controls were included. Peak workload was assessed through a maximal cycle exercise test. Muscle strength and lean body mass, cardiac function, vascular stiffness, self-reported physical activity level, renal function and haemoglobin level were evaluated. Tests were repeated after 5 years. Statistical analysis of longitudinal data was performed using linear mixed models.Results: Exercise capacity did not change significantly over time in either the CKD group or controls, although the absolute workloads were significantly lower in the CKD group. Only in a CKD subgroup reporting low physical activity at baseline, exercise capacity declined. Renal function decreased in both groups, with a faster decline in CKD (p = 0.05 between groups). Peak heart rate, haemoglobin level, handgrip strength, lean body mass and cardiovascular function did not decrease significantly over time in CKD individuals. Conclusions: On a group level, aerobic exercise capacity and peak heart rate were maintained over 5 years in patients with well-controlled mild-to-moderate CKD, despite a slight reduction in glomerular filtration rate, mirroring the lack of progression of cardiovascular and muscular dysfunction in this group. In patients with mild-to-moderate CKD, physical activity level at baseline seems to have a predictive value for exercise capacity at follow-up.

Aerobic Exercise Capacity In Mild-to-moderate Chronic Kidney Disease Is Maintained Over A 5 Year-period

2018 ◽  
Vol 50 (5S) ◽  
pp. 359
Author(s):  
Helena Wallin ◽  
Anette Rickenlund ◽  
Maria E. Eriksson ◽  
Eva Jansson ◽  
Carin Wallquist ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Aerobic Exercise ◽  
Exercise Capacity ◽  
Aerobic Exercise Capacity ◽  
Moderate Chronic Kidney Disease

Relationship of Ambulatory Blood Pressure and the Heart Rate Profile with Renal Function Parameters in Hypertensive Patients with Chronic Kidney Disease

2012 ◽  
Vol 34 (4) ◽  
pp. 264-269 ◽  
Author(s):  
Tomohiko Kanaoka ◽  
Kouichi Tamura ◽  
Masato Ohsawa ◽  
Mai Yanagi ◽  
Sona Haku ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
Heart Rate ◽  
Renal Function ◽  
Kidney Disease ◽  
Ambulatory Blood Pressure ◽  
Hypertensive Patients ◽  
Rate Profile ◽  
Relationship Of

scholarly journals Association Between Renal Function and Troponin T Over Time in Stable Chronic Kidney Disease Patients

2019 ◽  
Vol 8 (21) ◽  
Author(s):  
Nicholas C. Chesnaye ◽  
Karolina Szummer ◽  
Peter Bárány ◽  
Olof Heimbürger ◽  
Hasan Magin ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Kidney Disease ◽  
Troponin T ◽  
Over Time

Heart rate variability as a predictor of rapid renal function deterioration in chronic kidney disease patients

Nephrology ◽  
2019 ◽  
Vol 24 (8) ◽  
pp. 806-813 ◽  
Author(s):  
Yu‐Hsiang Chou ◽  
Wei‐Lieh Huang ◽  
Chin‐Hao Chang ◽  
Cheryl C. H. Yang ◽  
Terry B. J. Kuo ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Renal Function ◽  
Kidney Disease ◽  
Renal Function Deterioration

scholarly journals Acute exercise does not impair renal function in nondialysis chronic kidney disease patients regardless of disease stage

2017 ◽  
Vol 313 (2) ◽  
pp. F547-F552 ◽  
Author(s):  
Davi A. Santana ◽  
Jacques R. Poortmans ◽  
Egidio Lima Dórea ◽  
Juliana Bannwart de Andrade Machado ◽  
Alan Lins Fernandes ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Kidney Disease ◽  
Aerobic Exercise ◽  
Acute Exercise ◽  
Exercise Bout ◽  
Peak Oxygen Uptake ◽  
Disease Stage ◽  
Moderate Intensity ◽  
Impair Renal Function

Exercise has been overlooked as a potential therapy in chronic kidney disease (CKD), mainly because of a lack of understanding on its safety aspects. Notably, there are no data on renal function after exercise in CKD considering its stages. We investigated the acute effects of a 30-min moderate-intensity aerobic exercise bout on glomerular filtration rate (GFR) and albuminuria in 22 nondialysis CKD patients divided into: CKD stages 1 and 2 (CKD1–2) and CKD stages 3 and 4 (CKD3–4). Eleven body mass index-, age-, and sex-matched healthy individuals served as control (CON). Blood and urine samples were collected before, immediately after, and up to 90 min postexercise for creatinine and albumin assessments. GFR was determined by creatinine clearance (GFRCr-Cl). All CKD patients had significantly lower peak oxygen uptake than CON. CKD1–2 and CKD3–4 had increasingly higher serum creatinine than CON (9.6 ± 2.6, 25.6 ± 1.01, and 7.5 ± 1.4 mg/l, respectively); however, no within-group changes in serum or urinary creatinine were observed across time. GFRCr-Cl was decreased in CKD1–2 and CKD3–4 compared with CON (91 ± 17 ml·min−1·1.73 m−2; 34 ± 15 ml·min−1·1.73 m−2; 122 ± 20 ml·min−1·1.73 m−2, respectively). Most importantly, exercise did not affect GFRCr-Cl in none of the groups across time. Albuminuria was significantly higher in CKD3–4 (297 ± 284 µg/min) than in CON (5.4 ± 1.4 µg/min), but no within-group changes were observed after exercise. In conclusion, a single 30-min moderate-intensity aerobic exercise bout does not impair renal function in nondialysis CKD patients, regardless of disease stage, supporting the notion that exercise training can be safe in this disease.

scholarly journals Physical activity is associated with improved aerobic exercise capacity over time in adults with congenital heart disease

2013 ◽  
Vol 168 (5) ◽  
pp. 4685-4691 ◽  
Author(s):  
Ana Ubeda Tikkanen ◽  
Alexander R. Opotowsky ◽  
Ami B. Bhatt ◽  
Michael J. Landzberg ◽  
Jonathan Rhodes
Keyword(s):  
Physical Activity ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Aerobic Exercise ◽  
Exercise Capacity ◽  
Congenital Heart ◽  
Aerobic Exercise Capacity ◽  
Over Time

scholarly journals STRATIFICATION OF NEPHROCEREBRAL AND CARDIOVASCULAR RISK IN CHRONIC GLOMERULONEPHRITIS (LITERATURE REVIEW)

2018 ◽  
Vol 8 (6) ◽  
pp. 418-423 ◽  
Author(s):  
I. T. Murkamilov ◽  
I. S. Sabirov ◽  
Zh. A. Murkamilova ◽  
V. V. Fomin ◽  
A. I. Sabirova ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Heart Rate ◽  
Renal Function ◽  
Cardiovascular Diseases ◽  
Kidney Disease ◽  
Cerebrovascular Diseases ◽  
The Body ◽  
Chronic Glomerulonephritis ◽  
Increased Risk

This article analyzes the literature data concerning the origin and progression of cerebrovascular and cardiac diseases in renal dysfunction. Cardiovascular diseases and chronic kidney disease have common “traditional” risk factors, while the population growth in patients with renal impairment is currently mainly due to secondary renal damage in socially important diseases such as obesity, hypertension, atherosclerosis, type 2 diabetes, ischemic heart disease and chronic heart failure. The presented data of scientific researches testify to the direct correlation correlation between the decrease of the renal function and the increased risk of cardioand cerebrovascular diseases and death, irrespective of other risk factors. Obesity and associated biological substrates are independent risk factors for persistent impairment of kidney function and an increase in the body mass index causes direct damage to the kidneys, due to the disrupted synthesis of fat cytokines by various cytokines with nephrotoxic action, and also mediated — by inducing the development of diabetes mellitus 2 type and arterial hypertension, which are the most frequent risk factors for chronic kidney disease and cardiovascular diseases. The presented data on the role of endothelial dysfunction in impaired renal function, which contributes to the formation of atherosclerosis, and the increase in the severity of the atherosclerotic process contributes to an increase in the sever ity of renal failure. Literature data on the value of the heart rate are also presented. The increase in the heart rate can lead to atherosclerotic densification of the arteries, which is associated with an increase in the rate of spread of the pulse wave with a violation of the mechanisms of autoregulation of the blood flow in the brain and kidneys.

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