Calcineurin A-α suppression drives nuclear factor-κB-mediated NADPH oxidase-2 upregulation
Keyword(s):
A long-term consequence of calcineurin inhibitors (CNIs) is oxidative damage and nephrotoxicity. This study indicates that NF-κB is a novel calcineurin-regulated transcription factor that is activated with calcineurin inhibition, thereby driving oxidative damage in CNI nephropathy. These findings provide additional evidence of divergent calcineurin signaling pathways and suggest that selective CNIs could improve the long-term outcomes of patients by mitigating renal side effects.
2018 ◽
Vol 12
(5)
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pp. 1681-1691
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2003 ◽
Vol 77
(5)
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pp. 1220-1228
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Keyword(s):
2007 ◽
Vol 11
(2)
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pp. 109-110
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2019 ◽
Vol 20
(5)
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pp. 1241
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