Production and degradation of calcitriol in renal failure rats

1987 ◽  
Vol 253 (5) ◽  
pp. F1015-F1019 ◽  
Author(s):  
C. H. Hsu ◽  
S. Patel ◽  
E. W. Young ◽  
R. U. Simpson
Keyword(s):  
Renal Failure ◽  
Linear Regression Analysis ◽  
Renal Tissue ◽  
Sham Operation ◽  
Metabolic Clearance ◽  
Severe Renal Failure ◽  
Group 3 ◽  
Group 2 ◽  
Remnant Kidney ◽  
Group 1

We studied the metabolism of calcitriol in renal failure achieved by nephrectomy in three groups of rats. Group 1 (n = 7) had sham operation of nephrectomy. Group 2 (n = 8) had unilateral nephrectomy. Group 3 (n = 7) had 5/6 nephrectomy. Metabolic clearance rate (MCR) and production rate (PR) of calcitriol were studied 3 wk after the surgery. Serum creatinine concentrations were increased after nephrectomy for groups 2 and 3. Endogenous plasma levels of calcitriol were not different between the rats with renal failure and the controls. MCR of calcitriol were decreased in renal failure rats compared with controls (group 1, 0.24 +/- 0.01; group 2, 0.20 +/- 0.01, P less than 0.01; group 3, 0.16 +/- 0.01 ml.min-1.kg-1, P less than 0.001). The MCR of calcitriol was correlated with the endogenous creatinine clearance by linear regression analysis (r = 0.72, P less than 0.001). The PR of calcitriol were also decreased in renal failure; however, the decreases were much less than the amount of renal tissue removed. We concluded that production of calcitriol is decreased in the remnant kidney. The decreased synthesis is associated with decreased degradation of calcitriol resulting in normal concentrations of calcitriol in mild to moderately severe renal failure.

scholarly journals Pathomorphology of adaptive changes in the remaining kidney in the early postoperative period after nephrectomy

2020 ◽  
Vol 10 (1) ◽  
pp. 19-24
Author(s):  
Igor Sergeevich Shormanov ◽  
Marina S. Los ◽  
Maxim V. Kosenko ◽  
Natalia S. Shormanova
Keyword(s):  
Postoperative Period ◽  
Morphological Changes ◽  
Renal Tissue ◽  
Early Postoperative Period ◽  
Left Group ◽  
White Rats ◽  
Group 3 ◽  
Group 2 ◽  
Single Kidney ◽  
Group 1

Objective. To study the adaptive capacity of a single remaining kidney in the early postoperative period of nephrectomy in an experiment. Materials and methods. The experiment involved 35 laboratory white rats, which were divided into three experimental groups. Group 1 (n = 5) intact animals, group 2 (n = 15) animals underwent nephrectomy on the left; group 3 (n = 15) animals underwent nephrectomy and additionally were created 90 minute hypoxic hypoxia. Histological material was collected on the 5th, 21st and 60th days after surgery. Results. Characteristic morphological changes in the only remaining kidney were an increase in the size of the glomeruli and a decrease in their number. Nephron fibrosis was detected, accompanied by increased production of antigens by the tubular epithelium, which is likely a response to a cascade increase in oxidative stress and increased release of cytokines that stimulate the production of intrarenal collagen. Conclusion. Nephrectomy and hypoxia are provocateurs for the development of systemic distress syndrome, the result of which is the formation of a vicious pathogenetic circle, which reduces the functionality of the renal tissue. This can be considered as one of the early preclinical mechanisms for the initiation of single kidney disease in the future.

scholarly journals Role of Dietary Potassium in the Hyperaldosteronism and Hypertension of the Remnant Kidney Model

2000 ◽  
Vol 11 (4) ◽  
pp. 625-631 ◽  
Author(s):  
HASSAN N. IBRAHIM ◽  
THOMAS H. HOSTETTER
Keyword(s):  
Plasma Aldosterone ◽  
Potassium Intake ◽  
Group 4 ◽  
Protein Excretion ◽  
Dietary Potassium ◽  
Group 3 ◽  
Group 2 ◽  
Potassium Restriction ◽  
Remnant Kidney ◽  
Group 1

Abstract. The remnant kidney model of progressive renal disease is marked by arterial hypertension, especially when produced by nephrectomy and partial infarction. Hyperaldosteronism sustains much of the hypertension, but the stimuli to the increased aldosterone levels are uncertain. It is hypothesized that the hyperaldosteronism attending this model stems from the combination of fixed dietary potassium load in the face of reduced filtration on the one hand, and persistent renin secretion from the scarred remnant kidney on the other. This hypothesis predicted that dietary potassium restriction would lower aldosterone and BP in this model. To test this prediction, two groups of rats with a remnant kidney were studied. Group 1 consumed 0.4 ± 0.06 mEq (mean ± SD) of potassium chloride daily, and group 2 ate 4.8 ± 1.0 mEq daily. Two sham-operated groups with intact kidneys also were studied. Group 3 consumed 1.7 ± 0.2 mEq daily and group 4 ate 15.2 ± 1.4 mEq daily. These levels of intake were designed to provide at least as much potassium per liter of GFR in the sham groups as in the remnant kidney rats. Systolic BP (SBP), 24-h protein excretion, plasma aldosterone levels, 24-h urinary aldosterone excretion, and plasma renin activity (PRA) were determined in all groups at 2 wk. At 4 wk, after SBP and protein excretion measurements, remnant kidneys were perfusion-fixed for morphometric analysis. SBP was normal in both sham-operated groups and was not different between the groups (113 ± 13versus117 ± 2 mmHg, group 3versusgroup 4). In the remnant animals, SBP at 2 wk followed potassium intake: Group 1 had a lower SBP than group 2 (140 ± 26versus170 ± 34 mmHg,P= 0.005). The same SBP pattern persisted at 4 wk (153 ± 25versus197 ± 27 mmHg, group 1versusgroup 2,P= 0.0006). However, 24-h urinary protein excretion was not different between the two groups with remnant kidneys at either 2 or 4 wk. Both plasma and 24-h urinary aldosterone excretion at 2 wk followed potassium intake (120 ± 124versus580 ± 442 pg/ml for plasma aldosterone, group 1versusgroup 2,P= 0.03, and 2.6 ± 1.8versus23.2 ± 9.8 ng/d for urinary aldosterone, group 1versusgroup 2,P= 0.0001). PRA, however, followed a reverse pattern in which dietary potassium restriction resulted in higher levels (16 ± 6versus6 ± 3 ng angiotensin I/ml per h, group 1versusgroup 2,P= 0.01). A similar pattern for PRA and aldosterone excretion was also observed in the sham groups, in which lower potassium intake also resulted in a significantly higher PRA and lower aldosterone excretion. The constancy of BP in the sham groups likely reflects their lack of nephron reduction and greater sodium excretory capacity. Morphometric analysis in remnant animals revealed no significant difference between the two dietary groups in the prevalence of glomerular sclerosis, glomerular volume, or interstitial volume. It is concluded that dietary potassium is a potent determinant of hypertension in the remnant kidney model probably through the actions of aldosterone and that the high aldosterone secretion in this model is a function of the dietary potassium load. In this model, reduction in nephron number is also critical in promoting hypertension in conjunction with hyperaldosteronism.

scholarly journals Subtotal splenectomy preserving the lower pole in rats: technical, morphological and functional aspects

2006 ◽  
Vol 21 (5) ◽  
pp. 321-327 ◽  
Author(s):  
Danilo Nagib Salomão Paulo ◽  
Isabel Cristina Andreatta Lemos Paulo ◽  
Mitre Kalil ◽  
Paulo Merçon Vargas ◽  
Alcino Lázaro da Silva ◽  
...  
Keyword(s):  
White Pulp ◽  
Sham Operation ◽  
Lower Pole ◽  
Lipid Levels ◽  
Significant Difference ◽  
Group 3 ◽  
Group 2 ◽  
Total Splenectomy ◽  
Subtotal Splenectomy ◽  
Group 1

PURPOSE: To assess the possibility of preserving the lower pole of the spleen, supplied by the inferior lobar vessels and segmental vessels, or by vessels of the gastrosplenic ligament, in subtotal splenectomy; to study the viability and function of the lower pole of the spleen. METHODS: Thirty-six male Wistar rats were used in this study. Said animals weighed 273-390 g ( 355.2 ± 30.5 g ), and were randomly distributed into three groups. Group 1 comprised ten animals which were submitted to exploratory laparotomy with spleen manipulation (sham operation). Group 2 comprised 16 animals which were submitted to total splenectomy. Group 3 comprised ten animals which were submitted to subtotal splenectomy, preserving the lower pole of the spleen. Blood was collected from all animals before and 90 days after surgery to measure the levels of cholesterol and triglycerides. The animals were sacrificed 90 days after surgery. Spleens and remaining spleens were removed for macroscopic and microscopic examination. RESULTS: Surgery was performed with no complications in all groups. Six animals died in group 2. Spleens of groups 1 and 2, and lower poles of group 3 were macroscopically viable. Apparent white pulp hyperplasia was observed in group 1. In group 3, slight inflammation and capsular fibrosis were observed at the incision site, as well as diffuse hemosiderosis in the red pulp. Average mass of remaining spleen was 35.84% ± 4.31%. No significant difference was observed between preoperative and late postoperative lipid levels in groups 1 and 3 (p > 0.05). Late postoperative lipid levels significantly increased in group 2. CONCLUSIONS: Preservation of the lower pole of the spleen (supplied by gastrosplenic vessels or inferior lobar vessels and segmental vessels) was possible with subtotal splenectomy. The lower pole was macroscopically and microscopically viable in all cases. Subtotal splenectomy preserving the lower pole prevented changes in lipid levels, which were observed in rats submitted to total splenectomy. Plasma lipid levels in rats submitted to subtotal splenectomy were similar to those observed in sham operated rats.

scholarly journals P330 Blunted heart rate reserve during vasodilator stress echocardiography in diabetic and renal failure patients

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
M Bellino ◽  
D Ferraro ◽  
A Silverio ◽  
A P Peluso ◽  
L Soriente ◽  
...  
Keyword(s):  
Heart Rate ◽  
Renal Failure ◽  
Renal Function ◽  
Autonomic Dysfunction ◽  
Wall Motion ◽  
Beta Blockers ◽  
Cardiac Autonomic Dysfunction ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Abstract Funding Acknowledgements None Background A blunted heart rate reserve (HRR) during dipyridamole stress echo (SE) is a marker of cardiac autonomic dysfunction associated with poor outcome, independently of inducible ischemia, underlying coronary artery disease (CAD) and beta-blocker therapy. Patients with diabetes and/or renal failure have higher prevalence of underlying autonomic dysfunction. Aim. To assess the value of HRR in patients undergoing dipyridamole SE. Methods We prospectively recruited a sample of 61 patients with known or suspected CAD (mean age 75 ± 10 years; 34 males, 55,7%; 50% on beta-blockers at the time of testing). Coexistent atrial fibrillation or previous pacemaker implantation were considered as exclusion criteria. Three groups were identified a priori: non-diabetic with normal renal function (n = 43, Group 1); diabetics, with normal renal function (n = 14, Group 2); severely impaired renal function on dialysis (n = 4, Group 3). All patients underwent dipyridamole SE (0.84 mg/kg in 10"). Wall motion score Index (WMSI) was calculated with a 17-segment score of left ventricle, each segment scored from 1= normal to 4= dyskinetic. HRR was measured by ECG as the peak/rest HR ratio. Results A positive SE (stress WMSI> rest WMSI) was present in 2 patients of Group 1 (4.7%), 4 of Group 2 (28.6%) and no patient in Group 3. Heart rate was different, although not significant, among the 3 groups both at rest (66.1 ± 11.1 vs 64.6 ± 8.5 vs 79.0 ± 8.0, p = 0.050) and at peak stress (83.8 ± 12.6 vs 75.3 ± 10.3 vs 86.5 ± 11.1, p = 0.059). Of note, HRR was statistically different among groups (1.29 ± 0.20 vs 1.19 ± 0.14 vs 1.09 ± 0.06, p < 0.047; see figure). There was no difference in HRR between patients off and on-beta-blockers (1.19 ± 0.16 vs 1.24 ± 0.24, p = 0.421) and with or without positive SE (1.20 ± 0.14 vs 1.25 ± 0.20, p = 0.530). Overall, HRR ≤ 1.17 (median value) was reported in 39.5% of Group 1, 71.4% of Group 2, and 100% of Group 3 pts (p = 0.024). No significant correlations between HRR and peak WMSI (p = 0.183) or age (0.062) were reported. Conclusion HRR is frequently abnormal in patients referred for SE testing, especially in presence of concomitant diabetes and advanced renal failure. The blunted chronotropic response is a simple, imaging independent marker of cardiac autonomic dysfunction and may usefully complement the conventional evaluation with regional wall motion abnormalities during vasodilator SE. Abstract P330 Figure title: HRR box plots

Correlation of ADAMTS-13 Activity with Response to Plasma Exchange in Patients Diagnosed with Thrombotic Thrombocytopenic Purpura.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 3921-3921
Author(s):  
Elham Abbasi ◽  
David Yawn ◽  
Christopher Leveque ◽  
Leticia Nolasco ◽  
Jose Lopez ◽  
...  
Keyword(s):  
Renal Failure ◽  
Plasma Exchange ◽  
The Other ◽  
Thrombocytopenic Purpura ◽  
Platelet Counts ◽  
Activity Group ◽  
Associated Conditions ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Abstract Deficiency of the von Willebrand factor (VWF)-cleaving metalloprotease ADAMTS-13 is assumed to be the proximate cause of thrombotic thrombocytopenic purpura (TTP), a potentially devastating microvascular thrombotic disorder. Lack of the enzyme leads to the plasma accumulation of unusually large and extraordinarily adhesive VWF multimers (ULVWF), which clump platelets and precipitate microvascular thrombosis, thrombocytopenia, microangiopathic hemolytic anemia, and systemic tissue infarction. Thus, accurate assessment of ADAMTS-13 activity should aid in differentiating TTP from other similar syndromes, and could help predict which patients will benefit from plasma exchange. We retrospectively reviewed the cases of 38 patients diagnosed with TTP between 1998 and 2004 in The Methodist Hospital in Houston, TX, recording comorbid conditions, response to plasma exchange, and ADAMTS-13 activity. All patients had ADAMTS-13 activity measured and received plasma exchange. ADAMTS-13 activity was determined by the capacity of patient plasma to cleave ULVWF derived from the supernatants of cultured umbilical vein endothelial cells. Response to plasma exchange was assessed by platelet counts and serum LDH levels. Those designated as having responded to therapy achieved platelet counts above 150,000 per ml. Ten of the 38 patients had no response to plasma exchange. Of these, all had associated conditions (e.g., transplantation, drugs, vasculitis) and 8 had normal ADAMTS-13 activity. Of the 28 who responded to therapy, 21 had no associated conditions. ADAMTS-13 activity was absent in 23 and low (6% and 12%) in 2. We assessed ADAMTS-13 activity in response to therapy in the patients divided into three groups: those without detectable activity (Group 1, 25 patients); those with low but detectable activity (Group 2, 2 patients); and those with normal activity (Group 3, 11 patients). In group 1, 65% had an inhibitor of ADAMTS-13 activity. Twenty three (92%) responded to plasma exchange, the other 2 had received bone marrow transplantation. Thirteen of the 23 responders required less than 6 exchanges; the other 10 required more than 6 exchanges, and 9 had fluctuating platelet counts during therapy. In 6 of the 9, the platelets fluctuations correlated with the LDH levels and ADAMTS-13 activities; the other 3 had intercurrent infections and the platelet counts did not correlate with their LDH levels or ADAMTS-13 activities. ADAMTS-13 activity values increased with plasma exchange in 23 of 25 patients. Mortality in group 1 was 8%; 32% of patients relapsed and none had renal failure requiring hemodialysis. Both patients in group 2 responded to fewer than 7 plasma exchanges. All patients in group 3 had associated conditions. Three of 11 (27%) responded to therapy. Mortality was 36% and no patient relapsed. Forty five percent of group 3 patients had renal failure requiring hemodialysis. The median number of plasma exchanges in this group was 15 (range 7–23). We conclude that assay of ADAMTS-13 activity is predictive of response to plasma exchange, and may distinguish patients with true TTP from those with disorders that have similar clinical and laboratory manifestations. Patients with low or absent activity responded to therapy with increasing ADAMTS-13 activity, platelet counts, and declining LDH levels.

Tubular Function in Glycerol Induced Acute Renal Failure in Rats: Effect of Saline Loading and Prior Acute Renal Failure

1982 ◽  
Vol 62 (6) ◽  
pp. 667-676 ◽  
Author(s):  
C. Westenfelder ◽  
P. A. Crawford ◽  
R. K. Hamburger ◽  
R. L. Baranowski ◽  
N. A. Kurtzman
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Blood Urea Nitrogen ◽  
Tubular Function ◽  
Failure Group ◽  
Nitrogen Levels ◽  
Saline Loading ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

1. Chronic saline loading and prior induction of acute renal failure are manoeuvres which have been reported to protect against the development of acute renal failure. The underlying mechanisms are unclear. The purpose of the present study was to examine the effect of these protective manoeuvres on glomerular filtration rate (GFR) and proximal and distal tubular function in the glycerol-induced model of acute renal failure. 2. Acute renal failure was induced (50% glycerol, 10 ml/kg body wt. intramuscularly) in three groups of rats: group 1, water drinking; group 2, saline loaded (1% NaCl as drinking fluid for 5 weeks); group 3, rechallenged 7–15 days after a first dose of glycerol, when blood urea nitrogen levels had returned to normal. Control animals in group 3 received only the first glycerol injection, then, like the controls in groups 1 and 2, they were given 0.9% NaCl solution (10 ml/kg body wt. intramuscularly). All animals were then studied 24 h after glycerol or saline injection. 3. Glycerol caused a significant fall in GFR in all three groups (78% group 1; 64% group 2; 59% group 3); blood urea nitrogen levels rose significantly. Saline-loaded animals with acute renal failure (group 2) exhibited glycosuria with normal blood-sugar levels and a striking depression in maximal tubular glucose reabsorption. The capacity to reabsorb HCO−3 was depressed both before and during HCO−3 loading. Distal acidification as assessed by the urine to blood gradient of Pco2 (U—B Pco2) was normal during HCO−3 loading (urine pH 7.8). The presence of hyperchloraemic metabolic acidosis demonstrated that these animals developed proximal renal tubular acidosis. Glycerol-reinjected rats with acute renal failure (group 3) reabsorbed glucose and HCO−3 normally and exhibited normal distal tubule acidification. 4. We conclude from these data that a prior episode of acute renal failure protects proximal tubules against a second glycerol challenge, whereas chronic saline loading is without this protective effect. Both the underlying mechanism for this tubular cell resistance (against a second glycerol challenge) and the role of proximal tubular function in the pathogenesis of acute renal failure remain unclear.

In-vivo evaluation of the effect of cyanoacrylate on prosthetic vascular graft infection – does cyanoacrylate increase the severity of infection?

VASA ◽  
2020 ◽  
Vol 49 (4) ◽  
pp. 281-284
Author(s):  
Atıf Yolgosteren ◽  
Gencehan Kumtepe ◽  
Melda Payaslioglu ◽  
Cuneyt Ozakin
Keyword(s):  
Vascular Graft ◽  
Graft Infection ◽  
Vascular Graft Infection ◽  
Group 4 ◽  
Significant Difference ◽  
Group 3 ◽  
Group 2 ◽  
Prosthetic Vascular Graft Infection ◽  
Group 1

Summary. Background: Prosthetic vascular graft infection (PVGI) is a complication with high mortality. Cyanoacrylate (CA) is an adhesive which has been used in a number of surgical procedures. In this in-vivo study, we aimed to evaluate the relationship between PVGI and CA. Materials and methods: Thirty-two rats were equally divided into four groups. Pouch was formed on back of rats until deep fascia. In group 1, vascular graft with polyethyleneterephthalate (PET) was placed into pouch. In group 2, MRSA strain with a density of 1 ml 0.5 MacFarland was injected into pouch. In group 3, 1 cm 2 vascular graft with PET piece was placed into pouch and MRSA strain with a density of 1 ml 0.5 MacFarland was injected. In group 4, 1 cm 2 vascular graft with PET piece impregnated with N-butyl cyanoacrylate-based adhesive was placed and MRSA strain with a density of 1 ml 0.5 MacFarland was injected. All rats were scarified in 96th hour, culture samples were taken where intervention was performed and were evaluated microbiologically. Bacteria reproducing in each group were numerically evaluated based on colony-forming unit (CFU/ml) and compared by taking their average. Results: MRSA reproduction of 0 CFU/ml in group 1, of 1410 CFU/ml in group 2, of 180 200 CFU/ml in group 3 and of 625 300 CFU/ml in group 4 was present. A statistically significant difference was present between group 1 and group 4 (p < 0.01), between group 2 and group 4 (p < 0.01), between group 3 and group 4 (p < 0.05). In terms of reproduction, no statistically significant difference was found in group 1, group 2, group 3 in themselves. Conclusions: We observed that the rate of infection increased in the cyanoacyrylate group where cyanoacrylate was used. We think that surgeon should be more careful in using CA in vascular surgery.

Abnormal Haemostasis and Blood Viscosity in Malignant Hypertension

1984 ◽  
Vol 52 (03) ◽  
pp. 253-255 ◽  
Author(s):  
C Isles ◽  
G D O Lowe ◽  
B M Rankin ◽  
C D Forbes ◽  
N Lucie ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Viscosity ◽  
Renal Damage ◽  
Antithrombin Iii ◽  
Plasma Viscosity ◽  
Malignant Hypertension ◽  
Fibrin Deposition ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

SummaryWe have previously shown abnormalities of haemostasis suggestive of intravascular coagulation in patients with malignant hypertension, a condition associated with retinopathy and renal fibrin deposition. To determine whether such abnormalities are specific to malignant hypertension, we have measured several haemostatic and haemorheological variables in 18 patients with malignant hypertension (Group 1), 18 matched healthy controls (Group 2), and 18 patients with non-malignant hypertension (Group 3) matched for renal pathology, blood pressure and serum creatinine with Group 1. Both Groups 1 and 3 had increased mean levels of fibrinogen, factor VIIIc, beta-thrombo- globulin, plasma viscosity and blood viscosity (corrected for haematocrit); and decreased mean levels of haematocrit, antithrombin III and platelet count. Mean levels of fast antiplasmin and alpha2-macroglobulin were elevated in Group 1 but not in Group 3. We conclude that most blood abnormalities are not specific to malignant hypertension; are also present in patients with non-malignant hypertension who have similar levels of blood pressure and renal damage; and might result from renal damage as well as promoting further renal damage by enhancing fibrin deposition. However increased levels of fibrinolytic inhibitors in malignant hypertension merit further investigation in relation to removal of renal fibrin.

Features of postoperative period in patients with chronic venous insufficiency: phlebectomy versus thermal ablation

2020 ◽  
pp. 64-75
Author(s):  
E. Burleva ◽  
O. Smirnov ◽  
S. Tyurin
Keyword(s):  
Postoperative Period ◽  
Chronic Venous Insufficiency ◽  
Thermal Ablation ◽  
Venous Insufficiency ◽  
Clinical Symptoms ◽  
Varicose Veins ◽  
Statistical Processing ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

The purpose of the study was to conduct a comparative assessment of the course of the postoperative period after phlebectomy and thermal ablation in patients with varicose veins of the lower extremities in the system of the great saphenous vein (GSV) with class C2 of chronic venous insufficiency (CVI) — CEAP class C2. Materials and methods: 455 patients (455 limbs) with CEAP class C2. Group 1 (n = 154) received stripping + minimally invasive phlebectomy; Group 2 — endovenous laser ablation (EVLA) of GSV trunk + sclerotherapy of varicose veins; 3 group (n = 150) — radiofrequency ablation (RFA) of the GSV + sclerotherapy. All patients were united by a single tactical solution — the elimination of pathological vertical reflux in GSV. In each group, patients were with similar hemodynamic profile were selected (Group 1 = 63; Group 2 = 61; Group 3 = 61). The course of the postoperative period (from 2 days to 2 months) was compared for pain (visual analog scale — VAS), clinical symptoms of chronic venous insufficiency, degree of satisfaction (Darvall questionnaire), and duration of disability. Statistical processing was carried out using Excel programs for Windows XP, MedCalc® (version 11.4.2.0., Mariakerke, Belgium). Results: Postoperative pain is more pronounced (during day 1 for Group 1–4.0, Group 2–3.0, Group 3–2.0) and more prolonged (up to 4 days) after open surgeries (p < 0.05). The dynamics of the clinical symptoms of CVI (including varicose syndrome and use of compression therapy) could not be fully evaluated in connection with the ongoing sclerotherapy procedures for patients of Groups 2 and 3. Satisfaction of patients with aesthetic aspects was higher than expected in all groups. Reliable statistical differences proved decrease in days of disability (Group 1–14; Group 2–4; Group 3–3) and earlier return to physical activities and work in patients after thermal ablation in comparison with phlebectomy. Conclusion: The study shows that all three methods for eliminating vertical reflux in the GSV can be proposed for a large category of patients with CEAP of class C3 and C2. Medical and social rehabilitation of patients using endovascular thermal ablation technologies proceeds faster, which is beneficial both for the patients and for society.

Analysis of the quality of early diagnostics of cardiovascular diseases in students of educational institutions of Khabarovsk (according to the data of preventive examinations)

2020 ◽  
pp. 13-16
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Diseases ◽  
Sinus Tachycardia ◽  
Blood Pressure Level ◽  
Educational Institutions ◽  
Conduction Disturbances ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

To identify the prevalence of early pathology of cardiovascular diseases, a survey of 400 200 girls) in the age group 15 and 17 years old was conducted as a part of routine medical of the level of blood pressure (BP) was carried out, with the calculation of the average level pressure on the basis of three separate measurements estimated by percentile tables for a registration of a standard resting ECG in 12 leads. According to the results of the survey, into 3 groups: with an increase in blood pressure above 95 ‰ (group 1 – 16 people), which recorded in males (p<0,05); Group 2 (67 people) – adolescents with a normal blood pressure level and group 3 of adolescents with a decrease in blood pressure below 5 ‰ changes in the form of rhythm and conduction disturbances were noted in almost every a predominance of sinus tachycardia in the first group. In the third group of adolescents, form of ectopic rhythm and pacemaker migration were significantly more frequently only 78 % of adolescents were referred for consultation and in-depth examination by a pediatric cardiologist.

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