scholarly journals Reproducible improvement in endothelial function following two separate periods of high-intensity interval training in young men

2020 ◽  
Vol 129 (4) ◽  
pp. 725-731
Author(s):  
J. S. Williams ◽  
M. Del Giudice ◽  
B. J. Gurd ◽  
K. E. Pyke
Keyword(s):  
Endothelial Function ◽  
High Intensity ◽  
Interval Training ◽  
Flow Mediated Dilation ◽  
Group Level ◽  
High Intensity Interval Training ◽  
Subject Variability ◽  
High Intensity Interval ◽  
Second Period ◽  
Subject Differences

This is the first study examining endothelial function [flow-mediated dilation (FMD)] following repeated periods of high-intensity interval training (HIIT). Two periods of HIIT separated by detraining resulted in reproducible group-level improvements in FMD. Despite considerable between-subject variability in FMD adaptation, individual FMD changes with the first HIIT period predicted FMD changes in the second period. This indicates the existence of reproducible between-subject differences in susceptibility to FMD improvement with HIIT.

scholarly journals High-intensity interval training attenuates endothelial dysfunction in a Dahl salt-sensitive rat model of heart failure with preserved ejection fraction

2015 ◽  
Vol 119 (6) ◽  
pp. 745-752 ◽  
Author(s):  
Volker Adams ◽  
Marcia Alves ◽  
Tina Fischer ◽  
Natale Rolim ◽  
Sarah Werner ◽  
...  
Keyword(s):  
Heart Failure ◽  
Endothelial Dysfunction ◽  
Ejection Fraction ◽  
Endothelial Function ◽  
High Intensity ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
Molecular Alterations ◽  
Modified Proteins ◽  
High Intensity Interval

Heart failure patients with preserved left ventricular ejection fraction (HFpEF) have endothelial dysfunction, but the underlying molecular mechanisms remain unknown. In addition, whether exercise training improves endothelial function in HFpEF is still controversial. The present study therefore aimed to determine the functional and molecular alterations in the endothelium associated with HFpEF, while further assessing the effects of high-intensity interval training (HIT). Female Dahl salt-sensitive rats were randomized for 28 wk into the following groups: 1) control: fed 0.3% NaCl; 2) HFpEF: fed 8% NaCl; and 3) HFpEF + HIT: animals fed 8% NaCl and HIT treadmill exercise. Echocardiography and invasive hemodynamic measurements were used to assess diastolic dysfunction. Endothelial function of the aorta was measured in vitro. Expression of endothelial nitric oxide synthase (eNOS), nicotinamide adenine dinucleotide phosphate-oxidase [NAD(P)H oxidase], and advanced glycation end product (AGE)-modified proteins were quantified by Western blot, and zymography quantified matrix metalloproteinase (MMP) activity. In this model of HFpEF, endothelium-dependent and -independent vasodilation was impaired. However, this was prevented by HIT. In HFpEF protein expression of eNOS was reduced by 47%, but MMP-2 and MMP-9 activity was elevated by 186 and 68%. The expression of AGE-modified proteins was increased by 106%. All of these changes were prevented by HIT. Endothelial function was impaired in this model of HFpEF, which was associated with reduced expression of eNOS, increased MMP activity, and increased AGE-modified proteins. HIT was able to attenuate both these functional and molecular alterations. These findings therefore suggest HFpEF induces endothelial dysfunction, but this is reversible by HIT.

scholarly journals Effect of High-Intensity Interval Training on Endothelial Function in Type 2 Diabetic Females

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Shiva Abdi ◽  
Vahid Tadibi ◽  
Dariush Sheikholeslami-Vatani
Keyword(s):  
Type 2 Diabetes ◽  
Body Composition ◽  
Endothelial Function ◽  
Lipid Profile ◽  
High Intensity ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
High Intensity Interval ◽  
Circulating Levels

Background: Flow-mediated dilation (FMD) is a noninvasive approach to examine endothelial function. Objectives: The purpose of this study was to investigate the effect of 12 weeks of high-intensity interval training (HIIT) on FMD and circulating levels of adropin and nitric oxide (NO) in females with type 2 diabetes. Methods: Thirty females with type 2 diabetes were randomly assigned into two equal groups of HIIT and control. The exercise program consisted of three sessions a week for 12 weeks. Each training session included 4 × 4-minute running intervals at 85 - 95% of maximal heart rate (HRmax) with 3-minute active recoveries at 50 - 60% of HRmax. Circulating levels of adropin, NO, glucose, HbA1c, insulin, HOMA-IR, as well as lipid profile, and body composition parameters were measured before and after the intervention. Results: A significant increase of FMD% was observed after the intervention in the HIIT group (P = 0.001). In addition, the circulation levels of adropin and NO enhanced as a result of HIIT (P = 0.012 and P < 0.001, respectively). There were also significant positive effects on the levels of lipid profile (except for HDL), FBS, and HbA1c; as well as on the insulin resistance and the body composition variables. There were no significant changes in the control group except an increase in the total cholesterol levels (P < 0.01). Conclusions: The results showed that 12 weeks of the HIIT program could improve the endothelial function, glucose-related indices, lipid profile, and body composition variables in females with type 2 diabetes.

Sign in / Sign up

Export Citation Format

Share Document