scholarly journals Chronic endurance exercise training offsets the age-related attenuation in contraction-induced rapid vasodilation

2016 ◽  
Vol 120 (11) ◽  
pp. 1335-1342 ◽  
Author(s):  
William E. Hughes ◽  
Kenichi Ueda ◽  
Darren P. Casey
Keyword(s):  
Older Adults ◽  
Exercise Training ◽  
Rapid Onset ◽  
Blood Velocity ◽  
Single Muscle ◽  
Chronic Exercise ◽  
Vascular Conductance ◽  
Endurance Exercise Training ◽  
Age Related ◽  
Leg Exercise

Aging is associated with attenuated contraction-induced rapid onset vasodilation (ROV). We sought to examine whether chronic exercise training would improve ROV in older adults. Additionally, we examined whether a relationship between cardiorespiratory fitness and ROV exists in young and older adults. Chronically exercise-trained older adults ( n = 16; 66 ± 2 yr, mean ± SE) performed single muscle contractions in the forearm and leg at various intensities. Brachial and femoral artery diameter and blood velocity were measured using Doppler ultrasound. Vascular conductance (VC) was calculated as the quotient of blood flow (ml/min) and mean arterial pressure (mmHg). These data were compared with our previously published work from an identical protocol in 16 older untrained (66 ± 1 yr, mean ± SE) and 14 young (23 ± 1 yr) adults. Peak (ΔVCpeak) and total vasodilator (VCtotal) responses were greater in trained compared with untrained older adults across leg exercise intensities ( P < 0.05). There were no differences in responses between trained older and young adults in the arm or leg at any exercise intensity ( P > 0.05). Comparison of ΔVCpeak in a subset of subjects at an absolute workload in the leg revealed that trained older adults exhibited augmented responses relative to untrained older adults. Exercise capacity (V̇o2 peak) was associated with ΔVCpeak and VCtotal across arm ( r = 0.59–0.64) and leg exercise intensities ( r = 0.55–0.68, P < 0.05) in older adults. Our data demonstrate that 1) chronic exercise training improves ROV in the arm and leg of trained older adults, such that age-related differences in ROV are abolished, and 2) VO2peak is associated with ΔVCpeak responses in both limbs of older adults.

scholarly journals Habitual exercise training in older adults offsets the age-related prolongation in leg vasodilator kinetics during single-limb lower body exercise

2018 ◽  
Vol 125 (3) ◽  
pp. 746-754 ◽  
Author(s):  
William E. Hughes ◽  
Nicholas T. Kruse ◽  
Kenichi Ueda ◽  
Darren P. Casey
Keyword(s):  
Older Adults ◽  
Steady State ◽  
Exercise Training ◽  
Rapid Onset ◽  
Exponential Model ◽  
Knee Extension ◽  
Mean Response Time ◽  
Age Related ◽  
Duty Cycles ◽  
Habitual Exercise

We tested the hypothesis that aging is associated with prolonged leg vasodilator kinetics and habitual exercise training in older adults improves these responses relative to untrained older adults. Additionally, we examined the relationship between contraction-induced rapid onset vasodilation (ROV) and vasodilator kinetics. Young ( n = 10), older untrained ( n = 13), and older trained ( n = 14) adults performed single and rhythmic knee-extension contractions at 20% and 40% work-rate maximum (WRmax). Femoral artery diameter and mean blood velocity were measured by Doppler ultrasound. Vascular conductance (VC; ml·min−1·mmHg−1) was calculated using blood flow (ml/min) and mean arterial pressure (mmHg). The primary outcome was the kinetic response (mean response time; MRT), modeled using an exponential model, expressed as the number of duty cycles to change 63% of the steady-state amplitude. There were no age- or training-related differences in VC MRT between the groups at 20% WRmax. Older untrained adults exhibited prolonged VC MRT at 40% WRmax relative to young (37 ± 16 vs. 24 ± 10 duty-cycles; P < 0.05) and older trained adults (37 ± 16 vs. 23 ± 14 duty-cycles; P < 0.05). There were no differences in VC MRT between young and older trained adults at 40% WRmax ( P = 0.96). There were no associations between peak ROV and VC MRT at 20% or 40% WRmax ( r = −0.08 and 0.22; P = 0.67 and 0.20, respectively) in the group as a whole. Our data suggest 1) advancing age prolongs leg vasodilator kinetics; 2) habitual exercise training in older adults offsets this age-related prolongation; and 3) contraction-induced ROV is not related to vasodilator kinetics within a group of young and older adults. NEW & NOTEWORTHY Aging is associated with reductions in exercise hyperemia and vasodilation at the onset of exercise, as well as during steady-state exercise. Habitual endurance exercise training offsets these age-related reductions. We found that aging prolongs vasodilator kinetics in the leg of older untrained but not older trained adults. Finally, our results demonstrate that contraction-induced rapid vasodilation is not associated with vasodilator kinetics within the leg of young and older adults.

Controlled Endurance Exercise Training and VO 2max Changes in Older Adults: A Meta‐Analysis

2005 ◽  
Vol 8 (4) ◽  
pp. 217-225 ◽  
Author(s):  
Guoyuan Huang ◽  
Cheryl A. Gibson ◽  
Zung V. Tran ◽  
Wayne H. Osness
Keyword(s):  
Older Adults ◽  
Exercise Training ◽  
Endurance Exercise ◽  
Meta Analysis ◽  
Endurance Exercise Training

scholarly journals Randomized, four-arm, dose-response clinical trial to optimize resistance exercise training for older adults with age-related muscle atrophy

2017 ◽  
Vol 99 ◽  
pp. 98-109 ◽  
Author(s):  
Michael J. Stec ◽  
Anna Thalacker-Mercer ◽  
David L. Mayhew ◽  
Neil A. Kelly ◽  
S. Craig Tuggle ◽  
...  
Keyword(s):  
Older Adults ◽  
Clinical Trial ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Muscle Atrophy ◽  
Dose Response ◽  
Resistance Exercise Training ◽  
Age Related

scholarly journals Effect of Dynamic Eccentric Leg Exercise Training on Functional Fitness and Arterial Stiffness in Older Adults

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
John J. Durocher ◽  
Sarah E. LewAllen ◽  
Carley B. Maanika ◽  
Steven J. Elmer ◽  
Lavanya Rajeshkumar ◽  
...  
Keyword(s):  
Older Adults ◽  
Exercise Training ◽  
Arterial Stiffness ◽  
Functional Fitness ◽  
Leg Exercise

scholarly journals Sex-Related Differences in Rapid-Onset Vasodilation: Impact of Aging

2020 ◽  
Author(s):  
Brady E. Hanson ◽  
Michael J. Joyner ◽  
Darren P. Casey
Keyword(s):  
Blood Flow ◽  
Older Women ◽  
Muscle Blood Flow ◽  
Rapid Onset ◽  
Young Group ◽  
Voluntary Contraction ◽  
Single Muscle ◽  
Vasodilatory Response ◽  
Age Related ◽  
Forearm Vascular Conductance

Rapid-onset vasodilation (ROV) in response to a single muscle contraction is attenuated with aging. Moreover, sex-related differences in muscle blood flow and vasodilation during dynamic exercise have been observed in young and older adults. The purpose of the present study was to explore if sex-related differences in ROV exist in young (n=36, 25±1 yr) and older (n=32, 66±1 yr) adults. Subjects performed single forearm contractions at 10%, 20%, and 40% maximal voluntary contraction. Brachial artery blood velocity and diameter were measured with Doppler ultrasound, and forearm vascular conductance (ml·min-1·100 mmHg-1) was calculated from blood flow (ml·min-1) and mean arterial pressure (mmHg) and used as a measure of ROV. Peak ROV was attenuated in women across all relative intensities in the young and older groups (P<0.05). In a subset of subjects with similar absolute workloads (~5 kg and ~11kg), age-related differences in ROV were observed among both women and men (P<0.05). However, only older women demonstrated an attenuated peak ROV compared to men (91±6 vs. 121±11 ml·min-1·100 mmHg-1, P<0.05), a difference not observed in the young group (134±8 vs. 154±11 ml·min-1·100 mmHg-1, P=0.15). Additionally, examining the slope of peak ROV across contraction intensities indicated a blunted response in older women compared to their young counterparts (P<0.05), with no differences observed between older and young men (P=0.38). Our data suggest that sex-related differences in the rapid vasodilatory response to single muscle contractions exist in older but not young adults, such that older women have a blunted response compared to older men.

scholarly journals Muscular Atrophy and Sarcopenia in the Elderly: Is There a Role for Creatine Supplementation?

Biomolecules ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 642 ◽  
Author(s):  
Dolan ◽  
Artioli ◽  
Pereira ◽  
Gualano
Keyword(s):  
Older Adults ◽  
Exercise Training ◽  
Energy Demand ◽  
Muscular Atrophy ◽  
Training Stimulus ◽  
Creatine Supplementation ◽  
The Elderly ◽  
High Energy ◽  
Age Related ◽  
And Function

Sarcopenia is characterized by a loss of muscle mass, quality, and function, and negatively impacts health, functionality, and quality of life for numerous populations, particularly older adults. Creatine is an endogenously produced metabolite, which has the theoretical potential to counteract many of the morphological and metabolic parameters underpinning sarcopenia. This can occur through a range of direct and indirect mechanisms, including temporal and spatial functions that accelerate ATP regeneration during times of high energy demand, direct anabolic and anti-catabolic functions, and enhanced muscle regenerating capacity through positively impacting muscle stem cell availability. Studies conducted in older adults show little benefit of creatine supplementation alone on muscle function or mass. In contrast, creatine supplementation as an adjunct to exercise training seems to augment the muscle adaptive response to the training stimulus, potentially through increasing capacity for higher intensity exercise, and/or by enhancing post-exercise recovery and adaptation. As such, creatine may be an effective dietary strategy to combat age-related muscle atrophy and sarcopenia when used to complement the benefits of exercise training.

scholarly journals Response to Endurance Exercise Training in Older Adults with Heart Failure with Preserved or Reduced Ejection Fraction

2017 ◽  
Vol 65 (8) ◽  
pp. 1698-1704 ◽  
Author(s):  
Ambarish Pandey ◽  
Dalane W. Kitzman ◽  
Peter Brubaker ◽  
Mark J. Haykowsky ◽  
Timothy Morgan ◽  
...  
Keyword(s):  
Heart Failure ◽  
Older Adults ◽  
Exercise Training ◽  
Ejection Fraction ◽  
Endurance Exercise ◽  
Reduced Ejection Fraction ◽  
Endurance Exercise Training

Effect of Controlled Endurance Exercise Training on VO2max Changes in Older Adults

2004 ◽  
Vol 36 (Supplement) ◽  
pp. S142
Author(s):  
Guoyuan Huang ◽  
Cheryl A. Gibson ◽  
Zung Vu Tran ◽  
Wayne H. Osness
Keyword(s):  
Older Adults ◽  
Exercise Training ◽  
Endurance Exercise ◽  
Endurance Exercise Training

Decline in VO2max with aging in master athletes and sedentary men

1990 ◽  
Vol 68 (5) ◽  
pp. 2195-2199 ◽  
Author(s):  
M. A. Rogers ◽  
J. M. Hagberg ◽  
W. H. Martin ◽  
A. A. Ehsani ◽  
J. O. Holloszy
Keyword(s):  
Heart Rate ◽  
Exercise Training ◽  
Maximal Heart Rate ◽  
Master Athletes ◽  
Endurance Exercise Training ◽  
Age Related ◽  
O2 Pulse ◽  
Rate Of Decline ◽  
Sedentary Subjects

Fifteen well-trained master endurance athletes [62.0 +/- 2.3 (SE) yr] and 14 sedentary control subjects (61.4 +/- 1.4 yr) were reevaluated after an average follow-up period of approximately 8 yr to obtain information regarding the effects of physical activity on the age-related decline in maximal O2 uptake capacity (VO2max). The master athletes had been training for 10.2 +/- 2.9 yr before initial testing and continued to train during the follow-up period. The sedentary subjects' VO2max declined by an average of 3.3 ml.kg-1.min-1 (33.9 +/- 1.7 vs. 30.6 +/- 1.6, P less than 0.001) over the course of the study, a decline of 12% per decade. In these subjects maximal heart rate declined 8 beats/min (171 vs. 163) and maximal O2 pulse decreased from 0.20 to 0.18 ml.kg-1.beat (P less than 0.05). The master athletes' VO2 max decreased by an average of 2.2 ml.kg-1.min-1 (54.0 +/- 1.7 vs. 51.8 +/- 1.8, P less than 0.05), a 5.5% decline per decade. The master athletes' maximal heart rate was unchanged (171 +/- 3 beats/min) and their maximal O2 pulse decreased from 0.32 to 0.30 ml.kg-1.beat (P less than 0.05). These findings provide evidence that the age-related decrease in VO2max of master athletes who continue to engage in regular vigorous endurance exercise training is approximately one-half the rate of decline seen in age-matched sedentary subjects. Furthermore our results suggest that endurance exercise training may reduce the rate of decline in maximal heart rate that typically occurs as an individual ages.

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