scholarly journals Case studies in neuroscience: deep brain stimulation changes upper limb cortical motor maps in dystonia

2020 ◽  
Vol 124 (1) ◽  
pp. 268-273
Author(s):  
Nicholas D. J. Strzalkowski ◽  
Rachel E. Sondergaard ◽  
Liu Shi Gan ◽  
Zelma H. T. Kiss
Keyword(s):  
Deep Brain Stimulation ◽  
Upper Limb ◽  
Brain Stimulation ◽  
Magnetic Stimulation ◽  
Limb Muscle ◽  
Time Points ◽  
Cortical Motor ◽  
Motor Maps ◽  
Pars Interna ◽  
Deep Brain

Neuronavigated robotic transcranial magnetic stimulation was used to investigate changes in upper limb muscle representation in a cervical dystonia patient before and at four time points up to 314 days after globus pallidus pars interna deep brain stimulation (GPi-DBS). GPi-DBS altered excitability and motor cortical representation of upper limb muscles; however, these changes were not associated with clinical improvement.

Effect of Subthalamic Deep Brain Stimulation on Upper Limb Dexterity in Patients with Parkinson Disease

2018 ◽  
Vol 115 ◽  
pp. e206-e217 ◽  
Author(s):  
Takao Nozaki ◽  
Tetsuya Asakawa ◽  
Kenji Sugiyama ◽  
Yuki Koda ◽  
Ayumi Shimoda ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Parkinson Disease ◽  
Upper Limb ◽  
Brain Stimulation ◽  
Deep Brain

scholarly journals Influence of basal ganglia on upper limb locomotor synergies. Evidence from deep brain stimulation and L-DOPA treatment in Parkinson's disease

Brain ◽  
2008 ◽  
Vol 131 (12) ◽  
pp. 3410-3420 ◽  
Author(s):  
P. Crenna ◽  
I. Carpinella ◽  
L. Lopiano ◽  
A. Marzegan ◽  
M. Rabuffetti ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Basal Ganglia ◽  
Upper Limb ◽  
Brain Stimulation ◽  
Deep Brain

scholarly journals Targeting neuroplasticity in patients with neurodegenerative diseases using brain stimulation techniques

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Ti-Fei Yuan ◽  
Wei-Guang Li ◽  
Chencheng Zhang ◽  
Hongjiang Wei ◽  
Suya Sun ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Transcranial Magnetic Stimulation ◽  
Synaptic Transmission ◽  
Neurodegenerative Diseases ◽  
Brain Stimulation ◽  
Clinical Studies ◽  
Magnetic Stimulation ◽  
Novel Approach ◽  
Clinical Tools ◽  
Deep Brain

AbstractDeficits in synaptic transmission and plasticity are thought to contribute to the pathophysiology of Alzheimer’s disease (AD) and Parkinson’s disease (PD). Several brain stimulation techniques are currently available to assess or modulate human neuroplasticity, which could offer clinically useful interventions as well as quantitative diagnostic and prognostic biomarkers. In this review, we discuss several brain stimulation techniques, with a special emphasis on transcranial magnetic stimulation and deep brain stimulation (DBS), and review the results of clinical studies that applied these techniques to examine or modulate impaired neuroplasticity at the local and network levels in patients with AD or PD. The impaired neuroplasticity can be detected in patients at the earlier and later stages of both neurodegenerative diseases. However, current brain stimulation techniques, with a notable exception of DBS for PD treatment, cannot serve as adequate clinical tools to assist in the diagnosis, treatment, or prognosis of individual patients with AD or PD. Targeting the impaired neuroplasticity with improved brain stimulation techniques could offer a powerful novel approach for the treatment of AD and PD.

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