Frontoparietal regions may become hypoactive after intermittent theta burst stimulation over the contralateral homologous cortex in humans

2013 ◽  
Vol 110 (12) ◽  
pp. 2849-2856 ◽  
Author(s):  
Xiaofei He ◽  
Yue Lan ◽  
Guangqing Xu ◽  
Yurong Mao ◽  
Zhenghong Chen ◽  
...  
Keyword(s):  
Posterior Parietal Cortex ◽  
Spatial Neglect ◽  
Attention Network Test ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Attention Network ◽  
Real Right ◽  
The Real ◽  
Interhemispheric Competition ◽  
Theta Burst

Brain injury to the dorsal frontoparietal networks, including the posterior parietal cortex (PPC) and dorsolateral prefrontal cortex (DLPFC), commonly cause spatial neglect. However, the interaction of these different regions in spatial attention is unclear. The aim of the present study was to investigate whether hyperexcitable neural networks can cause an abnormal interhemispheric inhibition. The Attention Network Test was used to test subjects following intermittent theta burst stimulation (iTBS) to the left or right frontoparietal networks. During the Attention Network Test task, all subjects tolerated each conditioning iTBS without any obvious iTBS-related side effects. Subjects receiving real-right-PPC iTBS showed significant enhancement in both alerting and orienting efficiency compared with those receiving either sham-right-PPC iTBS or real-left-PPC iTBS. Moreover, subjects exposed to the real-right-DLPFC iTBS exhibited significant improvement in both alerting and executive control efficiency, compared with those exposed to either the sham-right-DLPFC or real-left-DLPFC conditioning. Interestingly, compared with subjects exposed to the sham-left-PPC stimuli, subjects exposed to the real-left-PPC iTBS had a significant deficit in the orienting index. The present study indicates that iTBS over the contralateral homologous cortex may induce the hypoactivity of the right PPC through interhemispheric competition in spatial orienting attention.

Effects of High-Definition Transcranial Direct Current Stimulation and Theta Burst Stimulation for Modulating the Posterior Parietal Cortex

2019 ◽  
Vol 25 (09) ◽  
pp. 972-984
Author(s):  
Tian Gan ◽  
Stevan Nikolin ◽  
Colleen K. Loo ◽  
Donel M. Martin
Keyword(s):  
Working Memory ◽  
Parietal Cortex ◽  
Direct Current ◽  
Posterior Parietal Cortex ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
High Definition ◽  
Attention Task ◽  
Posterior Parietal ◽  
Theta Burst

AbstractObjectives:Noninvasive brain stimulation methods, including high-definition transcranial direct current stimulation (HD-tDCS) and theta burst stimulation (TBS) have emerged as novel tools to modulate and explore brain function. However, the relative efficacy of these newer stimulation approaches for modulating cognitive functioning remains unclear. This study investigated the cognitive effects of HD-tDCS, intermittent TBS (iTBS) and prolonged continuous TBS (ProcTBS) and explored the potential of these approaches for modulating hypothesized functions of the left posterior parietal cortex (PPC).Methods:Twenty-two healthy volunteers attended four experimental sessions in a cross-over experimental design. In each session, participants either received HD-tDCS, iTBS, ProcTBS or sham, and completed cognitive tasks, including a divided attention task, a working memory maintenance task and an attention task (emotional Stroop test).Results:The results showed that compared to sham, HD-tDCS, iTBS and ProcTBS caused significantly faster response times on the emotional Stroop task. The effect size (Cohen’sd) wasd= .32 for iTBS (p< .001), .21 for ProcTBS (p= .01) and .15 for HD-tDCS (p= .044). However, for the performance on the divided attention and working memory maintenance tasks, no significant effect of stimulation was found.Conclusions:The results suggest that repetitive transcranial magnetic stimulation techniques, including TBS, may have greater efficacy for modulating cognition compared with HD-tDCS, and extend existing knowledge about specific functions of the left PPC.

scholarly journals Theta Burst Stimulation Enhances Connectivity of the Dorsal Attention Network in Young Healthy Subjects: An Exploratory Study

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Lubomira Anderkova ◽  
Dominik Pizem ◽  
Patricia Klobusiakova ◽  
Martin Gajdos ◽  
Eva Koritakova ◽  
...  
Keyword(s):  
Exploratory Study ◽  
Healthy Subjects ◽  
Inferior Frontal Gyrus ◽  
Superior Parietal Lobule ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Attention Network ◽  
Dorsal Attention Network ◽  
Parietal Lobule ◽  
Theta Burst

We examined effects of theta burst stimulation (TBS) applied over two distinct cortical areas (the right inferior frontal gyrus and the left superior parietal lobule) on the Stroop task performance in 20 young healthy subjects. Neural underpinnings of the behavioral effect were tested using fMRI. A single session of intermittent TBS of the left superior parietal lobule induced certain cognitive speed enhancement and significantly increased resting-state connectivity of the dorsal attention network. This is an exploratory study that prompts further research with multiple-session TBS in subjects with cognitive impairment.

scholarly journals Theta burst stimulation improves overt visual search in spatial neglect independently of attentional load

Cortex ◽  
2015 ◽  
Vol 73 ◽  
pp. 317-329 ◽  
Author(s):  
Dario Cazzoli ◽  
Clive R. Rosenthal ◽  
Christopher Kennard ◽  
Giuseppe A. Zito ◽  
Simone Hopfner ◽  
...  
Keyword(s):  
Visual Search ◽  
Spatial Neglect ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Attentional Load ◽  
Theta Burst

scholarly journals Theta burst stimulation reduces disability during the activities of daily living in spatial neglect

Brain ◽  
2012 ◽  
Vol 135 (11) ◽  
pp. 3426-3439 ◽  
Author(s):  
D. Cazzoli ◽  
R. M. Muri ◽  
R. Schumacher ◽  
S. von Arx ◽  
S. Chaves ◽  
...  
Keyword(s):  
Activities Of Daily Living ◽  
Daily Living ◽  
Spatial Neglect ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Theta Burst

scholarly journals Behavioral Differences Across Theta Burst Stimulation Protocols. A Study on the Sense of Agency in Healthy Humans

2021 ◽  
Vol 15 ◽  
Author(s):  
Giuseppe A. Zito ◽  
Yulia Worbe ◽  
Jean-Charles Lamy ◽  
Joel Kälin ◽  
Janine Bühler ◽  
...  
Keyword(s):  
Posterior Parietal Cortex ◽  
Treatment Options ◽  
Random Order ◽  
Sense Of Agency ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Healthy Humans ◽  
Before And After ◽  
The Right ◽  
Theta Burst

BackgroundTheta burst stimulation (TBS) is a non-invasive brain stimulation method. Various stimulation protocols have been proposed, for instance, stimulation at 50 Hz with pattern at 5 Hz, or at 30 Hz with pattern at 6 Hz. To identify better stimulation parameters for behavioral applications, we investigated the effects of 50-Hz continuous TBS (cTBS) on the sense of agency (SoA), and compared them with a previously published study with 30-Hz cTBS.MethodsBased on power analysis from a previous sample using two applications of 30-Hz cTBS, we recruited 20 healthy subjects in a single-blind, Vertex-controlled, randomized, crossover trial. Participants were stimulated with one application of 50-Hz cTBS over the right posterior parietal cortex (rPPC), a key area for agency processing, and the vertex, in a random order. A behavioral task targeting the SoA was done before and after stimulation. After controlling for baseline differences across samples, we studied the effect of stimulation in the two protocols separately.ResultsCompared to the previously published 30-Hz protocol, 50-Hz cTBS over the rPPC did not reveal significant changes in the SoA, similar to sham Vertex stimulation.ConclusionOne application of 50-Hz cTBS was not sufficient to elicit behavioral effects, compared to two applications of 30-Hz cTBS, as previously described. This may be due to a mechanism of synaptic plasticity, consolidated through consecutive stimulation cycles. Our results are relevant for future studies aiming at modulating activity of the rPPC in cognitive domains other than agency, and in patients affected by abnormal agency, who could benefit from treatment options based on TBS.

The effect of theta-burst stimulation on unilateral spatial neglect following stroke: a systematic review

2018 ◽  
Vol 33 (2) ◽  
pp. 183-194 ◽  
Author(s):  
Andreea Cotoi ◽  
Magdalena Mirkowski ◽  
Jerome Iruthayarajah ◽  
Rachel Anderson ◽  
Robert Teasell
Keyword(s):  
Systematic Review ◽  
Adverse Events ◽  
Spatial Neglect ◽  
Inclusion Criteria ◽  
Theta Burst Stimulation ◽  
Stimulation Protocol ◽  
Burst Stimulation ◽  
Unilateral Spatial Neglect ◽  
Treatment Characteristics ◽  
Theta Burst

Objective: To evaluate the effectiveness of theta-burst stimulation for the treatment of stroke-induced unilateral spatial neglect. Data sources: A systematic literature search was conducted from the inception of each database to 30 June 2018 using CINAHL, EMBASE, PubMed, PsycINFO, and Scopus. Review methods: Articles were included if theta-burst stimulation was used to treat neglect following a stroke. The additional a priori inclusion criteria were as follows: (1) ⩾3 adult (⩾18 years) participants, (2) ⩾50% stroke population, and (3) peer-reviewed journal articles published in English. Extracted data included study and treatment characteristics, results, and adverse events. Results: Nine studies met the inclusion criteria, generating a total of 148 participants. Eight studies evaluated a continuous stimulation protocol and one study investigated an intermittent stimulation protocol. Overall, both protocols significantly improved neglect severity when compared against placebo or active controls ( P < 0.05). Adding smooth pursuit training to theta-burst stimulation did not improve neglect relative to when the stimulation was delivered alone ( P > 0.05). There was inconsistent reporting of neglect terminology, outcome measures, and adverse events. The treatment characteristics were heterogeneous among the trials. Conclusion: This systematic review found that theta-burst stimulation seems to improve post-stroke unilateral spatial neglect, but because the evidence is limited to a few small studies with varied and inconsistent protocols and use of terminology, no firm conclusion on effectiveness can be drawn.

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