Functional and anatomic organization of three-dimensional eye movements in rabbit cerebellar flocculus

1994 ◽  
Vol 72 (1) ◽  
pp. 31-46 ◽  
Author(s):  
J. Van der Steen ◽  
J. I. Simpson ◽  
J. Tan
Keyword(s):  
Eye Movements ◽  
White Matter ◽  
Coordinate System ◽  
Three Dimensional ◽  
Vertical Axis ◽  
Short Latency ◽  
The Other ◽  
Response Component ◽  
Electrical Microstimulation ◽  
Cerebellar Flocculus

1. The three -dimensional, binocular eye movements evoked by electrical microstimulation of the cerebellar flocculus of alert, pigmented rabbits were recorded using the scleral search coil technique. The components of these eye movements were obtained in reference to an orthogonal coordinate system consisting of a vertical axis and two horizontal axes at 45 degrees and 135 degrees azimuth. The azimuth coordinate was taken to increase to both sides from the 0 degrees reference in the direction of the nose. 2. Eye movements were evoked most readily by stimulation (0.2 -ms pulses at 200 Hz for 1 s, intensity < or = 20 microA) at loci in the deep granular layer and the white matter. They consisted of slow (5–20 deg/s) movements. The responses were either binocular, with the eye ipsilateral to the stimulated flocculus usually having the larger amplitude, or were monocular, in which case they were restricted to the ipsilateral eye. 3. The evoked responses were classified according to the combination of the largest measured component of rotation for the two eyes and its sense of rotation (clockwise, CW, or counterclockwise, CCW). Seventy -eight percent of the evoked eye movements could be placed in one of two classes. For one of these classes the largest response component was a short -latency abduction of the ipsilateral eye about its vertical axis (19%), whereas for the other class (59%), the largest response component was a short -latency CCW rotation of the ipsilateral (left) eye about its 135 degrees axis. This response was frequently (50%) accompanied by a smaller short -latency CW rotation of the contralateral (right) eye about its 45 degrees axis. 4. The two main classes of three -dimensional eye movements are associated differentially with anatomically distinguishable compartments that are revealed by acetylcholinesterase histochemistry. Of the five anatomically distinguishable compartments in the floccular white matter, three are predominant. The middle of these three compartments is associated with the vertical axis class of movements, whereas the two adjacent compartments are associated with the 135 degrees class of eye movements. The eye movement relation of the other two, smaller compartments, was not determined. 5. The spatial orientation of the rotation axes of the two main classes of evoked eye movements closely corresponds to that of the preferred axes of the visual climbing fiber input to the flocculus. This suggests that both are organized in a similar coordinate system.(ABSTRACT TRUNCATED AT 400 WORDS)

The effect of frontal eye field and superior colliculus lesions on saccadic latencies in the rhesus monkey

1987 ◽  
Vol 57 (4) ◽  
pp. 1033-1049 ◽  
Author(s):  
P. H. Schiller ◽  
J. H. Sandell ◽  
J. H. Maunsell
Keyword(s):  
Eye Movements ◽  
Superior Colliculus ◽  
Short Latency ◽  
The Other ◽  
Frontal Eye Field ◽  
Express Saccades ◽  
Unimodal Distribution ◽  
Other Hand ◽  
Eye Field ◽  
The Mean

Rhesus monkeys were trained to make saccadic eye movements to visual targets using detection and discrimination paradigms in which they were required to make a saccade either to a solitary stimulus (detection) or to that same stimulus when it appeared simultaneously with several other stimuli (discrimination). The detection paradigm yielded a bimodal distribution of saccadic latencies with the faster mode peaking around 100 ms (express saccades); the introduction of a pause between the termination of the fixation spot and the onset of the target (gap) increased the frequency of express saccades. The discrimination paradigm, on the other hand, yielded only a unimodal distribution of latencies even when a gap was introduced, and there was no evidence for short-latency "express" saccades. In three monkeys either the frontal eye field or the superior colliculus was ablated unilaterally. Frontal eye field ablation had no discernible long-term effects on the distribution of saccadic latencies in either the detection or discrimination tasks. After unilateral collicular ablation, on the other hand, express saccades obtained in the detection paradigm were eliminated for eye movements contralateral to the lesion, leaving only a unimodal distribution of latencies. This deficit persisted throughout testing, which in one monkey continued for 9 mo. Express saccades were not observed again for saccades contralateral to the lesion, and the mean latency of the contralateral saccades was longer than the mean latency of the second peak for the ipsiversive saccades. The latency distribution of saccades ipsiversive to the collicular lesion was unaffected except for a few days after surgery, during which time an increase in the proportion of express saccades was evident. Saccades obtained with the discrimination paradigm yielded a small but reliable increase in saccadic latencies following collicular lesions, without altering the shape of the distribution. Unilateral muscimol injections into the superior colliculus produced results similar to those obtained immediately after collicular lesions: saccades contralateral to the injection site were strongly inhibited and showed increased saccadic latencies. This was accompanied by a decrease of ipsilateral saccadic latencies and an increase in the number of saccades falling into the express range. The results suggest that the superior colliculus is essential for the generation of short-latency (express) saccades and that the frontal eye fields do not play a significant role in shaping the distribution of saccadic latencies in the paradigms used in this study.(ABSTRACT TRUNCATED AT 400 WORDS)

Measurement of the Shortening Effect on the Perceived Path of Stroboscopic Movement

Perception ◽  
1997 ◽  
Vol 26 (1_suppl) ◽  
pp. 288-288
Author(s):  
S Nozawa
Keyword(s):  
Three Dimensional ◽  
Vertical Axis ◽  
Horizontal Axis ◽  
The Other ◽  
Horizontal Line ◽  
Optimal Frequency ◽  
Stimulus Line ◽  
Factors Influencing ◽  
Parallel Motion ◽  
Axis I

When two vertical short lines are alternately flashed at certain SOAs, a shortening of the apparent path of the stroboscopic movement is perceived. In the experiments reported here, factors influencing the shortening effect were studied with lines created on a CRT display. Experiment 1 was designed to study the effect of SOA. Each stimulus line was always presented for 100 ms, but intervals were varied in the range from 25 to 800 ms. With short and long SOAs almost no shortening illusion was observed, whereas the SOA for optimal stroboscopic motion (200 ms) also produced the largest illusion (ca 16%). This agrees with the classic study by Scholz (1924 Psychologische Forschung5 219 – 272) who found the largest illusion (25%) at the optimal frequency for stroboscopic motion. Experiment 2 dealt with the effect of inversions (I), mirror reflections (M), and rotations (R) of the line during the stroboscopic movement (see Kolars and Pomerantz, 1971 Journal of Experimental Psychology87 99 – 108). The particular movements were signalled by means of a short horizontal line added to one end of each of the two vertical lines of experiment 1. The configurations were (1), signifying parallel motion in one plane; (2), locomotion with rotation around the vertical axis (M); (3), locomotion with rotation around the horizontal axis (I); and (4), locomotion with rotation in the plane of the display (R). In all these conditions, the shortening illusion was significantly larger than in experiment 1. The differences between the four conditions were not statistically significant, but the illusion under condition (1) seemed smaller than in the other three conditions. With SOAs for optimal stroboscopic motion, ‘rotation’ paths tended to appear three-dimensional.

Saccadic eye movements evoked by microstimulation of the fastigial nucleus of macaque monkeys

1988 ◽  
Vol 60 (3) ◽  
pp. 1036-1052 ◽  
Author(s):  
H. Noda ◽  
S. Murakami ◽  
J. Yamada ◽  
J. Tamada ◽  
Y. Tamaki ◽  
...  
Keyword(s):  
Eye Movements ◽  
White Matter ◽  
Purkinje Cells ◽  
Saccadic Eye Movements ◽  
The Other ◽  
Fastigial Nucleus ◽  
Threshold Region ◽  
Other Hand ◽  
Low Threshold ◽  
Stimulation Of

1. Systematic exploration throughout the deep cerebellar nuclei and white matter disclosed that the region from which saccadic eye movements (saccades) were evoked with weak currents (less than 10 microA) was confined to the fastigial nucleus and the adjacent white matter. 2. When an electrode for stimulation was advanced in the cerebellum, saccades were evoked in the direction of the stimulated side (ipsilateral saccades) as it entered the low-threshold region. In some tracks, particularly when the electrode was advanced in the medial portion of the fastigial nucleus, the direction of the evoked saccades changed from the ipsilateral to the contralateral. 3. The mappings with microstimulation disclosed that the ipsilateral saccades were elicited from a relatively wide region that included almost the full extent of the fastigial nucleus. The low-threshold region continued in the white matter caudally into vermal lobule VII and rostrally into the dorsal aspect of the brachium conjunctivum. On the other hand, the contralateral saccades were evoked from a relatively circumscribed region in the ventromedial portion of the fastigial nucleus. 4. The reversal in the direction of the horizontal component occurred always in a narrow zone in the core of the fastigial nucleus. The caudal part of this zone coincided with an ellipsoidal region where anterogradely labeled axons of the Purkinje cells terminated when HRP was injected into vermal lobule VII. 5. When bicuculline (0.2-1 microgram) was injected in the ellipsoidal region, the ipsilateral saccades evoked from the dorsocaudal aspect of the region were suppressed for several hours. On the other hand, the contralateral saccades evoked from the ventromedial portion of the fastigial nucleus were either unchanged or enhanced. 6. Because the ipsilateral saccades were suppressed by bicuculline, they were most probably evoked by stimulation of the presynaptic component of gamma-amino-butyric acid-(GABA) mediated synapses, namely the axons of Purkinje cells. 7. Because stimulation of the presynaptic component of the inhibitory synapses evoked ipsilateral saccades, activation of the postsynaptic component would evoke contralateral saccades. In fact, the distribution of the fastigial sites yielding contralateral saccades coincided with the course of axons of fastigial neurons arising in the ellipsoidal region. It is most likely, therefore, that the contralateral saccades were evoked by stimulation of fastigial neurons.(ABSTRACT TRUNCATED AT 400 WORDS)

Occlusion Constraints and Stereoscopic Slant

Perception ◽  
1997 ◽  
Vol 26 (1) ◽  
pp. 29-38 ◽  
Author(s):  
Jukka Häkkinen ◽  
Göte Nyman
Keyword(s):  
Binocular Vision ◽  
Retinal Image ◽  
Three Dimensional ◽  
Vertical Axis ◽  
The Other ◽  
Necessary Condition ◽  
Slant Perception ◽  
Frontoparallel Plane ◽  
Reduction Effect

In binocular vision horizontal magnification of one retinal image leads to a percept of three-dimensional slant around a vertical axis. It is demonstrated that the perception of slant is diminished when an occlusion interpretation is possible. A frontoparallel plane located in the immediate vicinity of a slanted surface in a location which allows a perception of occlusion reduces the magnitude of perceived slant significantly. When the same plane is placed on the other side, the slant perception is normal because there is no alternative occlusion interpretation. The results indicate that a common border between the occluder and a slanted surface is not a necessary condition for the reduction effect. If the edges are displaced and the edge of the slanted surface is placed in a location in which it could be occluded, the effect still appears.

Inertial representation of angular motion in the vestibular system of rhesus monkeys. II. Otolith-controlled transformation that depends on an intact cerebellar nodulus

1995 ◽  
Vol 73 (5) ◽  
pp. 1729-1751 ◽  
Author(s):  
D. E. Angelaki ◽  
B. J. Hess
Keyword(s):  
Semicircular Canal ◽  
Rhesus Monkeys ◽  
Spatial Organization ◽  
Dynamic Properties ◽  
Three Dimensional ◽  
Low Frequency ◽  
Vertical Axis ◽  
Angular Motion ◽  
Response Component ◽  
Temporal Properties

1. We recently studied the spatial representation of angular motion signals in rhesus monkeys by examining the orientation of postrotatory vestibuloocular responses during tilt of the head and body relative to gravity after constant-velocity rotation about an earth-vertical axis. We have reported that low-frequency angular motion signals in the vestibuloocular reflex (VOR) of rhesus monkeys are spatially transformed such that they remain invariant relative to gravity. In the present study we examine the properties of these inertial vestibular signals by employing similar stimulation conditions in animals with either selective semicircular canal plugging or selective lesions of cerebellar lobule X (nodulus) and ventral lobule IX (uvula). 2. We studied the spatial organization of postrotatory VOR in two rhesus monkeys that had either the lateral or one of the vertical canal pairs inactivated by plugging. In both monkeys, the spatiotemporal characteristics of postrotatory velocity after rotation in the plane of an intact canal pair and tilting in the plane of the plugged canal pair were indistinguishable from those of intact animals: postrotatory responses after tilts in the plane of the plugged canal pair were strongly damped, whereas an orthogonal response component was generated that rotated the eye velocity vector toward alignment with gravity. Thus otolith information rather than transient semicircular canal inputs that normally coexist during tilts seem to provide the necessary cues for the central transformation of semicircular canal signals. 3. We studied the three-dimensional VOR properties in two animals in which the cerebellar nodulus and ventral uvula were surgically ablated. After these lesions the temporal properties of the horizontal, vertical, and torsional VOR during earth-vertical-axis rotations were differentially affected. For horizontal VOR, the duration of postrotatory nystagmus was prolonged and the responses acquired strongly underdamped (i.e., oscillatory) properties. Similarly, sinusoidal responses were characterized by smaller phase leads after the lesion. For torsional VOR, the duration of postrotatory nystagmus was significantly shorter after the lesions, reaching postlesion values of 3.6 +/- 1.7 (SD) s and 6.4 +/- 1.1 s compared with prelesion values of 22.4 +/- 4.5 and 33.6 +/- 5.3 s for each animal. In addition, large phase leads characterized the torsional VOR during low-frequency sinusoidal stimulation. The dynamic properties of the vertical VOR in the lesioned animals, on the other hand, were indistinguishable from those in controls. 4. The cerebellar lesions affected the spatial organization of the horizontal and vertical/torsional systems in a differential way. Inertial transformation of lateral canal activity was only partially affected.(ABSTRACT TRUNCATED AT 400 WORDS)

scholarly journals Sensory Basis and Functional Role of Eye Movements Elicited During Locomotion in the Land Crab Cardisoma Guanhumi

1990 ◽  
Vol 154 (1) ◽  
pp. 99-118 ◽  
Author(s):  
W. JON P. BARNES ◽  
P. Barnes
Keyword(s):  
Eye Movements ◽  
Flow Field ◽  
Body Movement ◽  
Three Dimensional ◽  
Vertical Axis ◽  
The Body ◽  
Image Motion ◽  
Optokinetic Responses ◽  
Land Crabs ◽  
Cardisoma Guanhumi

Eye movements in the horizontal plane and the rotatory component of body movement have been continuously recorded in land crabs, Cardisoma guanhumi Latreille, walking freely in an arena. The results show that the eyes compensate for locomotor turns by moving in the opposite direction to the body, thus reducing the image motion of surrounding objects on the retina. Gains often approach unity, so that stabilization of the rotatory component of self-generated image motion is good. Of the three compensatory eye reflexes that could contribute to these responses, optokinetic responses play a major role, since the gain of the responses of freely walking blinded crabs was about half that of crabs that could see. Since blinded crabs held above a ball moved their eyes whenever they rotated the ball about a vertical axis (i.e. turned), a significant role for leg proprioceptor-driven eye movements is also presumed. It is unclear whether vestibular nystagmus, driven by the statocysts, also has a role to play. In contrast to the high-gain compensatory responses that accompany turns, the translatory component of locomotion elicits compensatory eye movements only under the most favourable circumstances, when the crab walks along a runway facing a set of stripes. Even then, the responses are of very low gain (0.02-0.09). Amongst several possible factors, this is partly because lateral ommatidia, which drive the optokinetic responses, will face the poles of the flow field during sideways walking, and partly because stationary contrasts (as occur at the poles of the flow field) reduce the gain of optokinetic responses. It is argued that, by compensating for turns but not translatory locomotor movements, crabs effectively separate the rotatory from the translatory components of the visual flow field around them. Since only the former can be used in course control, while only the latter provides information on ground speed and the three-dimensional layout of the environment, such a separation makes good functional sense.

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