Subcortical Modulation of High-Frequency (Gamma Band) Oscillating Potentials in Auditory Cortex

1997 ◽  
Vol 78 (2) ◽  
pp. 573-581 ◽  
Author(s):  
Barbara Brett ◽  
Daniel S. Barth
Keyword(s):  
Electrical Stimulation ◽  
Auditory Cortex ◽  
High Frequency ◽  
High Spatial Resolution ◽  
Electrode Array ◽  
Gamma Oscillations ◽  
Gamma Band ◽  
Nucleus Basalis ◽  
Subcortical Nuclei ◽  
Cortical Focus

Brett, Barbara and Daniel S. Barth. Subcortical modulation of high-frequency (gamma band) oscillating potentials in auditory cortex. J. Neurophysiol. 78: 573–581, 1997. The purpose of this study was to use depth electrical stimulation and retrograde horseradish peroxidase (HRP) labeling to determine what role certain subcortical nuclei play in the neurogenesis of high-frequency gamma (∼40 Hz) oscillations in rat auditory cortex. Evoked and spontaneous electrocortical oscillations were recorded with the use of a high-spatial-resolution multichannel epipial electrode array while electrical stimulation was delivered to the posterior intralaminar (PIL) region of the ventral acoustic thalamus and to the centrolateral nucleus (CL) and the nucleus basalis (NB), which have been previously implicated in the production of cortical gamma oscillations. PIL stimulation consistently evoked gamma oscillations confined to a location between primary and secondary auditory cortex, corresponding to the region where spontaneous gamma oscillations were also recorded. Stimulation of the CL and NB did not evoke gamma oscillations in auditory cortex. HRP placed in the cortical focus of evoked gamma oscillations labeled cell bodies in the PIL, and in more lateral regions of the ventral acoustic thalamus, which on subsequent stimulation also evoked gamma oscillations in auditory cortex. No cells were labeled in either the CL or NB. These results indicate that the PIL and the lateral regions of ventral acoustic thalamus provide anatomically distinct input to auditory cortex and may play an exclusive and modality-specific role in modulating gamma oscillations in the auditory system.

High frequency (gamma-band) oscillating potentials in rat somatosensory and auditory cortex

1995 ◽  
Vol 694 (1-2) ◽  
pp. 1-12 ◽  
Author(s):  
Kurt D. MacDonald ◽  
Daniel S. Barth
Keyword(s):  
Auditory Cortex ◽  
High Frequency ◽  
Gamma Band

scholarly journals Three-Dimensional Analysis of Spontaneous and Thalamically Evoked Gamma Oscillations in Auditory Cortex

1998 ◽  
Vol 79 (6) ◽  
pp. 2875-2884 ◽  
Author(s):  
William Sukov ◽  
Daniel S. Barth
Keyword(s):  
Auditory Cortex ◽  
Dimensional Analysis ◽  
Neural Circuit ◽  
Current Source ◽  
Three Dimensional ◽  
Electrode Array ◽  
Gamma Oscillations ◽  
Auditory Evoked Potential ◽  
Cell Populations ◽  
Cell Groups

Sukov, William and Daniel S. Barth. Three-dimensional analysis of spontaneous and thalamically evoked gamma oscillations in auditory cortex. J. Neurophysiol. 79: 2875–2884, 1998. The purpose of this study was to investigate interactions among laminar cell populations producing spontaneous and evoked high-frequency (∼40 Hz) gamma oscillations in auditory cortex. Electrocortical oscillations were recorded using a 64-channel epipial electrode array and a 16-channel linear laminar electrode array while electrical stimulation was delivered to the posterior intralaminar (PIL) nucleus. Spontaneous gamma oscillations, and those evoked by PIL stimulation, are confined to a location overlapping primary and secondary auditory cortex. Current source-density and principal components analysis of laminar recordings at this site indicate that the auditory evoked potential (AEP) complex is characterized by a stereotyped asynchronous activation of supra- and infragranular cell populations. Similar analysis of spontaneous and evoked gamma waves reveals a close spatiotemporal similarity to the laminar AEP, indicating rhythmic interactions between supra- and infragranular cell groups during these oscillatory phenomena. We conclude that neural circuit interactions producing the laminar AEP onset in auditory cortex are the same as those generating evoked and spontaneous gamma oscillations.

scholarly journals Plasticity in the Rat Posterior Auditory Field Following Nucleus Basalis Stimulation

2007 ◽  
Vol 98 (1) ◽  
pp. 253-265 ◽  
Author(s):  
Amanda C. Puckett ◽  
Pritesh K. Pandya ◽  
Raluca Moucha ◽  
WeiWei Dai ◽  
Michael P. Kilgard
Keyword(s):  
Receptive Field ◽  
Classical Conditioning ◽  
Auditory Cortex ◽  
High Frequency ◽  
Nucleus Basalis ◽  
Field Size ◽  
High Frequency Region ◽  
Cortical Areas ◽  
Frequency Tone ◽  
Auditory Field

Classical conditioning paradigms have been shown to cause frequency-specific plasticity in both primary and secondary cortical areas. Previous research demonstrated that repeated pairing of nucleus basalis (NB) stimulation with a tone results in plasticity in primary auditory cortex (A1), mimicking the changes observed after classical conditioning. However, few studies have documented the effects of similar paradigms in secondary cortical areas. The purpose of this study was to quantify plasticity in the posterior auditory field (PAF) of the rat after NB stimulation paired with a high-frequency tone. NB–tone pairing increased the frequency selectivity of PAF sites activated by the paired tone. This frequency-specific receptive field size narrowing led to a reorganization of PAF such that responses to low- and mid-frequency tones were reduced by 40%. Plasticity in A1 was consistent with previous studies—pairing a high-frequency tone with NB stimulation expanded the high-frequency region of the frequency map. Receptive field sizes did not change, but characteristic frequencies in A1 were shifted after NB–tone pairing. These results demonstrate that experience-dependent plasticity can take different forms in both A1 and secondary auditory cortex.

Comparison of evoked potentials and high-frequency (gamma-band) oscillating potentials in rat auditory cortex

1995 ◽  
Vol 74 (1) ◽  
pp. 96-112 ◽  
Author(s):  
M. N. Franowicz ◽  
D. S. Barth
Keyword(s):  
Steady State ◽  
Auditory Cortex ◽  
Evoked Potentials ◽  
Slow Wave ◽  
Gamma Oscillations ◽  
Gamma Band ◽  
Gamma Activity ◽  
Sharp Wave ◽  
Gamma Band Oscillations ◽  
40 Hz

1. Transient and steady-state (40 Hz) evoked potentials, as well as spontaneous and click-evoked gamma-band oscillations, were recorded from 15 lightly anesthetized rats using an 8 x 8 electrode epipial array covering auditory cortex and adjacent areas to determine and compare the spatiotemporal distributions of these four phenomena. 2. The transient evoked response replicated earlier findings in our laboratory, consisting of an initial biphasic sharp wave in area 41, a similar but delayed biphasic sharp wave in area 36, and more widely distributed slow-wave components. Spatiotemporal analysis supported a model of parallel and asynchronous activation of distinct groups of thalamocortical projections underlying the neurogenesis of these temporal components of the middle-latency auditory evoked potential (MAEP) complex. 3. The 40-Hz response to click trains was superimposed on a steady potential shift (SP), both of which were localized within primary auditory cortex. Epipial distributions of the SP were similar to those of the shortest-latency negative peak in area 41 recorded in the same animals, suggesting similar neural generators. The 40-Hz response was more focal and dissimilar from the SP and any other temporal components of the MAEP complex, suggesting that a unique subpopulation of cells underlies its neurogenesis. 4. Spontaneous gamma-band activity, as assessed by power spectrum analysis, was localized to primary and secondary auditory cortex but had a variable distribution between rats that did not conform to the cytoarchitectonic boundaries within subdivisions of this region. Digital movies computed for individual bursts of gamma-activity indicated a high degree of spatiotemporal variability within and between bursts. 5. Single-trial spectral analysis of click responses indicated an inhibition of gamma-band oscillations during most of the MAEP complex, with subsequent enhanced gamma-activity during the 300- to 350-ms slow-wave component that outlasted the MAEP by approximately 500 ms. The epipial distributions of prestimulus and enhanced poststimulus gamma-oscillations were the same. In contrast to the 40-Hz response to click trains, phase-locking of gamma-oscillations by the single click stimulus was not observed. 6. These results suggest that both the MAEP complex and the steady-state 40-Hz response with its associated SP are highly stereotyped in lightly anesthetized rodent cortex. Their spatiotemporal distributions are probably determined in large part by asynchronous activation of parallel thalamocortical projection systems. Our data suggest no direct link between either the MAEP or the steady-state 40-Hz response to spontaneous or evoked gamma-band oscillations in auditory cortex.(ABSTRACT TRUNCATED AT 400 WORDS)

Cellular Mechanisms of Thalamically Evoked Gamma Oscillations in Auditory Cortex

2001 ◽  
Vol 85 (3) ◽  
pp. 1235-1245 ◽  
Author(s):  
William Sukov ◽  
Daniel S. Barth
Keyword(s):  
Auditory Cortex ◽  
Field Potential ◽  
Electrode Array ◽  
Pyramidal Cells ◽  
Gamma Oscillations ◽  
Membrane Properties ◽  
Gamma Activity ◽  
Cellular Mechanisms ◽  
Gamma Frequency ◽  
Fast Oscillations

The purpose of this study was to clarify the neurogenesis of thalamically evoked gamma frequency (∼40 Hz) oscillations in auditory cortex by comparing simultaneously recorded extracellular and intracellular responses elicited with electrical stimulation of the posterior intralaminar nucleus of the thalamus (PIL). The focus of evoked gamma activity was located between primary and secondary auditory cortex using a 64-channel epipial electrode array, and all subsequent intracellular recordings and single-electrode field potential recordings were made at this location. These data indicate that PIL stimulation evokes gamma oscillations in auditory cortex by tonically depolarizing pyramidal cells in the supra- and infragranular layers. No cells revealed endogenous membrane properties capable of producing activity in the gamma frequency band when depolarized individually with injected current, but all displayed both sub- and supra-threshold responses time-locked to extracellular fast oscillations when the population was depolarized by PIL stimulation. We propose that cortical gamma oscillations may be produced and propagated intracortically by network interactions among large groups of neurons when mutually excited by modulatory input from the intralaminar thalamus and that these oscillations do not require specialized pacemaker cells for their neurogenesis.

scholarly journals Aberrant thalamocortical coherence in an animal model of tinnitus

2019 ◽  
Vol 121 (3) ◽  
pp. 893-907
Author(s):  
Paulo Vianney-Rodrigues ◽  
Benjamin D. Auerbach ◽  
Richard Salvi
Keyword(s):  
Auditory Cortex ◽  
Gamma Oscillations ◽  
Gamma Band ◽  
Oscillatory Activity ◽  
Alpha Power ◽  
Drug Induced ◽  
Medial Geniculate ◽  
Thalamocortical Oscillations ◽  
Gamma Band Activity ◽  
Band Activity

Electrophysiological and imaging studies from humans suggest that the phantom sound of tinnitus is associated with abnormal thalamocortical neural oscillations (dysrhythmia) and enhanced gamma band activity in the auditory cortex. However, these models have seldom been tested in animal models where it is possible to simultaneously assess the neural oscillatory activity within and between the thalamus and auditory cortex. To explore this issue, we used multichannel electrodes to examine the oscillatory behavior of local field potentials recorded in the rat medial geniculate body (MBG) and primary auditory cortex (A1) before and after administering a dose of sodium salicylate (SS) that reliably induces tinnitus. In the MGB, SS reduced theta, alpha, and beta oscillations and decreased coherence (synchrony) between electrode pairs in theta, alpha, and beta bands but increased coherence in the gamma band. Within A1, SS significantly increased gamma oscillations, decreased theta power, and decreased coherence between electrode pairs in theta and alpha bands but increased coherence in the gamma band. When coherence was measured between one electrode in the MGB and another in A1, SS decreased coherence in beta, alpha, and theta bands but increased coherence in the gamma band. SS also increased cross-frequency coupling between the phase of theta oscillations in the MGB and amplitude of gamma oscillations in A1. Altogether, our results suggest that SS treatment fundamentally alters the manner in which thalamocortical circuits communicate, leading to excessive cortical gamma power and synchronization, neurophysiological changes implicated in tinnitus. Our data provide support for elements of both the thalamocortical dysrhythmia (TD) and synchronization by loss of inhibition (SLIM) models of tinnitus, demonstrating that increased cortical gamma band activity is associated with both enhanced theta-gamma coupling as well as decreases alpha power/coherence between the MGB and A1. NEW & NOTEWORTHY There are no effective drugs to alleviate the phantom sound of tinnitus because the physiological mechanisms leading to its generation are poorly understood. Neural models of tinnitus suggest that it arises from abnormal thalamocortical oscillations, but these models have not been extensively tested. This article identifies abnormal thalamocortical oscillations in a drug-induced tinnitus model. Our findings open up new avenues of research to investigate whether cellular mechanisms underlying thalamocortical oscillations are causally linked to tinnitus.

ИССЛЕДОВАНИЯ АКУСТИЧЕСКИХ ХАРАКТЕРИСТИК ВЕРХНЕГО СЛОЯ МОРЯ МЕТОДОМ МНОГОЧАСТОТНОГО АКУСТИЧЕСКОГО ЗОНДИРОВАНИЯ

2020 ◽  
Author(s):  
V.A. Bulanov ◽  
I.V. Korskov ◽  
A.V. Storozhenko ◽  
S.N. Sosedko
Keyword(s):  
High Frequency ◽  
Wave Motion ◽  
High Spatial Resolution ◽  
Wind Waves ◽  
Acoustic Parameter ◽  
Sea Surface ◽  
Near Surface ◽  
Acoustical Properties ◽  
Acoustic Spectroscopy ◽  
Sea Bottom

Описано применение акустического зондирования для исследования акустических характеристик верхнего слоя моря с использованием широкополосных остронаправленных инвертированных излучателей,устанавливаемых на дно. В основу метода положен принцип регистрации обратного рассеяния и отраженияот поверхности моря акустических импульсов с различной частотой, позволяющий одновременно измерятьрассеяние и поглощение звука и нелинейный акустический параметр морской воды. Многочастотное зондирование позволяет реализовать акустическую спектроскопию пузырьков в приповерхностных слоях моря,проводить оценку газосодержания и получать данные о спектре поверхностного волнения при различных состояниях моря вплоть до штормовых. Применение остронаправленных высокочастотных пучков ультразвукапозволяет разделить информацию о планктоне и пузырьках и определить с высоким пространственным разрешением структуру пузырьковых облаков, образующихся при обрушении ветровых волн, и структуру планктонных сообществ. Участие планктона в волновом движении в толще морской воды позволяет определитьпараметры внутренних волн спектр и распределение по амплитудам в различное время.This paper represents the application of acoustic probingfor the investigation of acoustical properties of the upperlayer of the sea using broadband narrow-beam invertedtransducers that are mounted on the sea bottom. Thismethod is based on the principle of the recording of thebackscattering and reflections of acoustic pulses of differentfrequencies from the sea surface. That simultaneouslyallows measuring scattering and absorption of the soundand non-linear acoustic parameter of seawater. Multifrequencyprobing allows performing acoustic spectroscopy ofbubbles in the near-surface layer of the sea, estimating gascontent, and obtaining data on the spectrum of the surfacewaves in various states of the sea up to a storm. Utilizationof the high-frequency narrow ultrasound beams allows us toseparate the information about plankton and bubbles and todetermine the structure of bubble clouds, created during thebreaking of wind waves, along with the structure of planktoncommunities with high spatial resolution. The participationof plankton in the wave motion in the seawater columnallows determining parameters of internal waves, such asspectrum and distribution of amplitudes at different times.

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