How Could SNARE Proteins Open a Fusion Pore?
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The SNARE (Soluble NSF Attachment protein REceptor) complex, which in mammalian neurosecretory cells is composed of the proteins synaptobrevin 2 (also called VAMP2), syntaxin, and SNAP-25, plays a key role in vesicle fusion. In this review, we discuss the hypothesis that, in neurosecretory cells, fusion pore formation is directly accomplished by a conformational change in the SNARE complex via movement of the transmembrane domains.
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2007 ◽
Vol 18
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pp. 2852-2863
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2012 ◽
Vol 23
(23)
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pp. 4611-4622
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2001 ◽
Vol 155
(6)
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pp. 969-978
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2010 ◽
Vol 21
(13)
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pp. 2297-2305
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2012 ◽
Vol 92
(4)
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pp. 1915-1964
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2008 ◽
Vol 118
(21)
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pp. 2146-2155
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