scholarly journals Genetic loci associated with nonobstructive coronary artery disease in Caucasian women

2016 ◽  
Vol 48 (1) ◽  
pp. 12-20 ◽  
Author(s):  
Liming Weng ◽  
Kent D. Taylor ◽  
Yii-Der Ida Chen ◽  
George Sopko ◽  
Sheryl F. Kelsey ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Genetic Variants ◽  
Chromosome 6 ◽  
Single Nucleotide ◽  
Logistic Regression Models ◽  
Nonobstructive Coronary Artery Disease ◽  
Marker Single Nucleotide Polymorphism ◽  
Caucasian Women ◽  
Artery Disease

Nonobstructive coronary artery disease (CAD) in women is associated with adverse cardiovascular (CV) outcomes; however, information regarding genetic variants that predispose women to nonobstructive CAD is lacking. Women from the Women's Ischemia Syndrome Evaluation (WISE) Study and the St. James Women Take Heart (WTH) Study were genotyped with the Cardio-MetaboChip. WISE enrolled women with symptoms and signs of ischemia referred for coronary angiography; WTH enrolled asymptomatic, community-based women without heart disease. Analyses were conducted with a case (WISE) - control (WTH) design and multivariate logistic regression models to investigate genetic variation associated with likelihood of nonobstructive CAD. One genetic marker, single nucleotide polymorphism (SNP) rs2301753 on chromosome 6 in RNF39, achieved chip-wide significance for nonobstructive CAD ( P < 9.5 × 10−7). After adjusting for baseline characteristics, we found no variants achieved chip-wide significance. However, SNP rs2301753 on chromosome 6 in RNF39 was associated with reduced likelihood of nonobstructive CAD [odds ratio (OR) 0.42 and 95% confidence interval (CI) of 0.29 to 0.68], at a nominal level of P = 5.6 × 10−6, while SNP rs12818945 in the ATP2B1 locus on chromosome 12 was associated with increased odds for nonobstructive CAD (OR 2.38 and 95% CI of 1.63 to 3.45) and nominal P = 5.8 × 10−6. The functions of RNF39 and ATP2B1 raise the possibility that genes involved in cardio-dysfunction may contribute to nonobstructive CAD in Caucasian women and may provide insights into novel approaches for therapy and prevention. If replicated, incorporation of these genetic variants into diagnostic evaluation may identify women at high risk for nonobstructive CAD.

scholarly journals Association of the PSRC1 rs599839 Variant with Coronary Artery Disease in a Mexican Population

Medicina ◽  
2020 ◽  
Vol 56 (9) ◽  
pp. 427
Author(s):  
Martha Eunice Rodríguez-Arellano ◽  
Jacqueline Solares-Tlapechco ◽  
Paula Costa-Urrutia ◽  
Helios Cárdenas-Hernández ◽  
Marajael Vallejo-Gómez ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Logistic Regression ◽  
Coronary Artery ◽  
Multiple Logistic Regression Analysis ◽  
Mexican Population ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Major Health Problem ◽  
Logistic Regression Models ◽  
Artery Disease

Background and Objectives: Coronary artery disease (CAD) is a major health problem in México. The identification of modifiable risk factors and genetic biomarkers is crucial for an integrative and personalized CAD risk evaluation. In this work, we aimed to validate in a Mexican population a set of eight selected polymorphisms previously associated with CAD, myocardial infarction (MI), or dyslipidemia. Materials and Methods: A sample of 907 subjects (394 CAD cases and 513 controls) 40–80 years old was genotyped for eight loci: PSRC1 (rs599839), MRAS (rs9818870), BTN2A1 (rs6929846), MTHFD1L (rs6922269), CDKN2B (rs1333049), KIAA1462 (rs3739998), CXCL12 (rs501120), and HNF1A (rs2259816). The association between single nucleotide polymorphisms (SNPs) and CAD was evaluated by logistic regression models. Results: Multiple logistic regression analysis with adjustment by age, gender, and body mass index showed that rs599839 was significantly associated with CAD (ORADD = 0.72, p = 0.009; ORDOM = 0.66, p = 0.007). Conclusions: The PSRC1 rs599839 polymorphism shows a significant protective association with CAD in this sample of the Mexican population.

scholarly journals Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease

2010 ◽  
Vol 30 (11) ◽  
pp. 2264-2276 ◽  
Author(s):  
Dawn M. Waterworth ◽  
Sally L. Ricketts ◽  
Kijoung Song ◽  
Li Chen ◽  
Jing Hua Zhao ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Genetic Variants ◽  
Lipid Levels ◽  
Artery Disease

Genetic variants of PON1 , GSTM1 , GSTT1 , and locus 9p21.3, and the risk for premature coronary artery disease in Yucatan, Mexico

2021 ◽  
Author(s):  
Igrid García‐González ◽  
Gerardo Pérez‐Mendoza ◽  
Alberto Solís‐Cárdenas ◽  
Jorge Flores‐Ocampo ◽  
Luis Fernando Herrera‐Sánchez ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Genetic Variants ◽  
Premature Coronary Artery Disease ◽  
Artery Disease

scholarly journals Mechanisms of Myocardial Infarction in Patients With Nonobstructive Coronary Artery Disease

2019 ◽  
Vol 12 (11) ◽  
pp. 2210-2221 ◽  
Author(s):  
Maksymilian P. Opolski ◽  
Mateusz Spiewak ◽  
Magdalena Marczak ◽  
Artur Debski ◽  
Paul Knaapen ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Nonobstructive Coronary Artery Disease ◽  
Artery Disease

scholarly journals The rs4783961 and rs708272 genetic variants of the CETP gene are associated with coronary artery disease, but not with restenosis after coronary stenting

2021 ◽  
Author(s):  
Gilberto Vargas-Alarcón ◽  
Oscar Pérez-Méndez ◽  
Rosalinda Posadas-Sánchez ◽  
Marco A. Peña-Duque ◽  
Marco A. Martínez-Ríos ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Genetic Variants ◽  
Coronary Stenting ◽  
Artery Disease

scholarly journals Prognostic Value of Atherosclerotic Extent in Diabetic Patients with Nonobstructive Coronary Artery Disease

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Yipu Ding ◽  
Zinuan Liu ◽  
Guanhua Dou ◽  
Xia Yang ◽  
Xi Wang ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
High Risk ◽  
Prognostic Value ◽  
Risk Scores ◽  
Plaque Burden ◽  
Major Adverse Cardiovascular Events ◽  
Diabetic Patients ◽  
Nonobstructive Coronary Artery Disease ◽  
Artery Disease

Background and Objective. Atherosclerotic extent was proved to be associated with adverse cardiac events. Risk scores derived by coronary computed tomography angiography (CCTA) could identify high-risk group among patients with nonobstructive coronary artery disease (CAD), but the ability is still uncertain in the presence of diabetes mellitus (DM). The purpose of this study was to investigate the prognostic value of the atherosclerotic extent shown by CCTA in diabetic patients with nonobstructive CAD. Methods and Results. 813 DM patients (mean age 58.9 ± 9.9 years, 48.1% male) referred for CCTA due to suspected CAD in 2015-2017 were consecutively included. During a median follow-up of 31.77 months, 50 major adverse cardiovascular events (MACEs) (6.15%) were experienced, including 2 cardiovascular deaths, 14 nonfatal myocardial infarctions, 27 unstable anginas requiring hospitalization, and 7 strokes. Three groups were defined based on coronary stenosis combined with Leiden score as normal, nonobstructive Leiden < 5 , and nonobstructive Leiden ≥ 5 . Cox models were used to assess the prognosis of plaque burden within these groups. An incremental incidence of MACE rates was observed. After adjustment for age, gender, and presence of high-risk plaque, the group of Leiden ≥ 5 showed a higher risk than Leiden < 5 (HR: 1.88, 95% CI: 1.03-3.42, p = 0.039 ). Similar results were observed when segment involvement score (SIS) was used for sensitivity analysis. Conclusion. Atherosclerotic extent was associated with the prognosis of DM patients with nonobstructive coronary artery disease, highlighting the importance of better risk stratification and management.

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