Formate: A Critical Intermediate for Chloride Transport in the Proximal Tubule
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Recent experiments unexpectedly suggest that formate plays a critical role in chloride transport across cell membranes. In particular, active uptake of chloride in the renal proximal tubule cell occurs by chloride-formate exchange. Formate recycles from lumen to cell via nonionic diffusion of uncharged formic acid. In this manner, small amounts of formate can facilitate resorption of large quantities of chloride.
1987 ◽
Vol 96
(2)
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pp. 107-119
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1987 ◽
Vol 408
(5)
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pp. 491-496
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2012 ◽
Vol 303
(2)
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pp. F266-F278
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1985 ◽
Vol 124
(3)
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pp. 411-423
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1997 ◽
Vol 272
(44)
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pp. 28142-28148
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1991 ◽
Vol 107
(1)
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pp. 54-62
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