scholarly journals High resolution1H and13C NMR and mass spectral studies of substituted dipyridylpyridazine

2002 ◽  
Vol 16 (1) ◽  
pp. 37-41 ◽  
Author(s):  
Arab K. El-Qisairi
Keyword(s):  
Mass Spectra ◽  
Spectral Studies ◽  
Laser Desorption Ionization ◽  
Mass Spectral ◽  
Flight Mass Spectrometry ◽  
Chca Matrix ◽  
Complete Assignment ◽  
Pyridazine Derivatives ◽  
Solution Matrix ◽  
C Nmr

Total assignment of the1H and13C NMR spectra of 3,6-bis(2'-pyridyl)pyridazine derivatives (n-dppn) have been recorded at 400 and 100 MHz, respectively.1Based on these data, the complete assignment of the13C NMR chemical shift values was made by a13C{1H} decoupling. The spectra clearly show that then-dppn ligands exist in thecis–cisconformation at least in solution. Matrix assisted laser desorption ionization (MALDI) and time-of-flight mass spectrometry (TOFMS) are used to record the mass spectra of then-dppn ligands. α-Cyano-4-hydroxycinnamic acid (CHCA) matrix promoted the molecular ion detection when 180 pmol ofn-dppn is introduced into the TOFMS.

Synthesis and Pharmacological Activities of Some New 2-[1-Heptyl-3-(4- methoxybenzyl)-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]acetohydrazide Derivatives

2014 ◽  
Vol 69 (9-10) ◽  
pp. 969-981 ◽  
Author(s):  
Olcay Bekircan ◽  
Emre Mentese ◽  
Serdar Ulker
Keyword(s):  
Nmr Spectroscopy ◽  
Elemental Analysis ◽  
Lipase Activity ◽  
Spectral Studies ◽  
Antituberculosis Activity ◽  
Pharmacological Activities ◽  
Mass Spectral ◽  
H Nmr ◽  
Acetohydrazide Derivative ◽  
C Nmr

Abstract In the present investigation, the key intermediate acetohydrazide derivative 5 was synthesized starting from 3-(4-methoxybenzyl)-4-amino-4,5-dihydro-1,2,4-triazol-5-one (1) by a four-step reaction. Thiosemicarbazides 6a-f and arylidenehydrazide derivatives 8a-d were obtained from compound 5. The cyclization of compounds 6a-f in the presence of NaOH resulted in the formation of compounds 7a-f. The compounds were characterized by IR, 1H NMR, 13C NMR spectroscopy, elemental analysis and mass spectral studies. The compounds were tested for their anti-lipase, anti-α-glucosidase and anti-mycobacterial activities. Compounds 6b and 8c exhibited excellent anti-lipase activity, and compound 8d showed excellent anti-a-glucosidase activity. Compounds 3 and 4 exhibited good antituberculosis activity

scholarly journals Synthesis, Antioxidant, Antimicrobial, Antimycobacterial, and Cytotoxic Activities of Azetidinone and Thiazolidinone Moieties Linked to Indole Nucleus

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
A. R. Saundane ◽  
Prabhaker Walmik
Keyword(s):  
Spectral Studies ◽  
Cytotoxic Activities ◽  
Mass Spectral ◽  
H Nmr ◽  
Excellent Activity ◽  
C Nmr

2-N-(2-Phenyl-1H-indol-3-yl)imino-4-arylthiazoles (3a–c) were used as key synthons for the preparation of (4-arylthiazol-2-yl)-4-(2-phenyl-1H-indol-3-yl)azetidin-2-ones (4a–c) and 3-(4-arylthiazol-2-yl)-2-(2-phenyl-1H-indol-3-yl)thiazolidin-4-ones (5a–c). These newly synthesized compounds have been characterized with the help of IR,1H NMR,13C NMR, and mass spectral studies. All compounds were screened for their antioxidant, antimicrobial, antimycobacterial, and cytotoxic activities. Some of the compounds displayed excellent activity.

A novel synthesis of 2,4,6-trithiaheptane and its conversion into 2,6-bis(methylthio)thiane. Spectral properties of some thiaalkanes

1981 ◽  
Vol 59 (2) ◽  
pp. 326-332 ◽  
Author(s):  
J. Stuart Grossert ◽  
Donald L. Hooper ◽  
William M. Neaves
Keyword(s):  
Long Range ◽  
Spectral Properties ◽  
Mass Spectra ◽  
Fragmentation Pathway ◽  
Coupling Constants ◽  
Spectral Studies ◽  
Proton Coupling ◽  
Novel Synthesis ◽  
C Nmr

2,4,6-Trithiaheptane (1a) has been prepared by lithium tetrahydridoaluminate reduction of the methiodide of 1,3,5-trithiane (2). Treatment of 1a with strong bases permitted formation of 3-alkylated derivatives (3) which could in turn be converted into diastereomeric mixtures of 3,5-dialkyl derivatives (4). A two-step alkylation of 1a with 1-bromo-3-chloropropane led to the formation of 2,6-bis(methylthio)thiane (5). Proton and 13C nmr spectral studies on these compounds, including the measurement of long-range carbon–proton coupling constants, are described; their mass spectra showed elimination of methanethiol as a characteristic major fragmentation pathway.

scholarly journals Synthesis, Characterization, and Thermal and Antimicrobial Activities of Some Novel Organotin(IV): Purine Base Complexes

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Reena Jain ◽  
Rajeev Singh ◽  
N. K. Kaushik
Keyword(s):  
Antimicrobial Agents ◽  
Rhizopus Oryzae ◽  
Antimicrobial Activities ◽  
Spectral Studies ◽  
Purine Base ◽  
Mass Spectral ◽  
E Coli ◽  
Kinetic And Thermodynamic Parameters ◽  
C Nmr

A new series of organotin(IV) complexes with purine bases theophylline (HL1) and theobromine (L2) of the types R3Sn(L1), R2Sn(L1)Cl, R3Sn(L2)Cl, and R2Sn(L2)Cl2(R = C6H5CH2–;p-ClC6H4CH2–) have been synthesized in anhydrous THF. The complexes were characterized by elemental analysis, conductance measurements, molecular weight determinations, UV-vis, IR,1H,13C NMR, and mass spectral studies. Various kinetic and thermodynamic parameters of these complexes have also been determined using TG/DTA technique. The thermal decomposition techniques indicate the formation of SnO2as a residue. The results show that the ligands act as bidentate, forming a five-member chelate ring. All the complexes are 1 : 1 metal-ligand complexes. In order to assess their antimicrobial activity, the ligands and their corresponding complexes have also been testedin vitroagainst bacteria (E. coli, S. aureus, andP. pyocyanea) and fungi (Rhizopus oryzaeandAspergillus flavus). All the complexes exhibit remarkable activity, and the results provide evidence that the studied complexes might indeed be a potential source of antimicrobial agents.

Infrared, N.M.R. and mass spectral studies on 3-Amino-4-aryl-5-aryl(or alkyl)imino-4,5-dihydro-1,2,4-thiadiazoles

1975 ◽  
Vol 28 (3) ◽  
pp. 591 ◽  
Author(s):  
CP Joshua ◽  
KN Rajasekharan
Keyword(s):  
Spectral Data ◽  
Structure Elucidation ◽  
Mass Spectra ◽  
Spectral Studies ◽  
Mass Spectral ◽  
Fragmentation Patterns ◽  
Chemical Evidence

Some 3-amino-4-aryl-5-aryl(or alkyl)imino-4,5-dihydro-1,2,4-thiadiazol, previously prepared and assigned structures on chemical evidence, are now confirmed in structure by a detailed study of their spectra. While i.r, and n.m.r, spectral data confirm the nature of the ring present in these compounds, mass spectra confirm the assignment of substituents on the ring. Mass spectra of these compounds exhibit specific fragmentation patterns and consequently are useful in structure elucidation of substituted 4,5-dihydro-1,2,4-thiadiazoles.

Synthesis of phenethanolamine derivatives with potential β-adrenergic antagonistic activity

1975 ◽  
Vol 28 (5) ◽  
pp. 1023 ◽  
Author(s):  
SJ Pasaribu ◽  
LR Williams
Keyword(s):  
Magnetic Resonance ◽  
Ring Opening ◽  
Proton Magnetic Resonance ◽  
Mass Spectra ◽  
Antagonistic Activity ◽  
Spectral Studies ◽  
Aryl Ring ◽  
Mass Spectral

The mass spectra of bromonitroacetophenones, intermediates in the synthesis of phenethanolamine derivatives containing a nitro and bromo group in the aryl ring, have been studied. The acetophenones were converted into the corresponding α,β-epoxystyrenes, which were then treated with various amines, and proton magnetic resonance and mass spectral studies were used to confirm the direction of ring opening and purity of the products.

Mass spectral studies of aromatic aza analogues of juvabione

1986 ◽  
Vol 51 (12) ◽  
pp. 2879-2883
Author(s):  
R. K. Mahajan ◽  
Neelam Gupta ◽  
Satinder K. Uppal
Keyword(s):  
Mass Spectra ◽  
Spectral Studies ◽  
Fragmentation Pattern ◽  
Mass Spectral ◽  
Secondary Amides

Mass spectra of title compounds I-VI have been studied with a view to comparing the fragmentation pattern of secondary amides in different structural environments.

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