Applications of Fourier transform infrared spectroscopy, Fourier transform infrared microscopy and near-infrared spectroscopy to cancer research

Glycogen levels in human lung and colorectal cancerous tissues were measured by the Fourier transform (FT-IR) spectroscopic method. Reliability of this method was confirmed by chemical analyses of the same tissues used for the FT-IR spectroscopic measurements, suggesting that this spectroscopic method has a high specificity and sensitivity in discriminating human cancerous tissues from noncancerous tissues. The glycogen levels in the tissues were compared with the clinical, histological and histopathological factors of the cancer, demonstrating that glycogen is a critical factor in understanding the biological nature of neoplastic diseases. Furthermore, direct measurement of a very small amount of tissue by a FT-IR microscope suggested that it could be used as a diagnostic instrument for various tissue samples obtained via a fine needle biopsy procedure. The progressive alterations in rat mammary gland tumors were investigated by a near-infrared (NIR) spectrometer with a fiber optic probe. A lipid band due to the first overtone ofn-alkane was used to quantitatively evaluate malignant changes in the tumors. NIR spectroscopy may offer the potential for non‒invasive,in vivodiagnosis of human cancers.

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Identification of Large Isotope Anomalies in Quartz by Infrared Spectroscopy

Applied Spectroscopy ◽

10.1177/0003702819842558 ◽

2019 ◽

Vol 73 (7) ◽

pp. 767-773

Author(s):

Ryan C. Ogliore ◽

Cosette Dwyer ◽

Michael J. Krawczynski ◽

Hélène Couvy ◽

Max Eisele ◽

...

Keyword(s):

Fourier Transform ◽

Infrared Spectroscopy ◽

Fourier Transform Infrared Spectroscopy ◽

Isotope Composition ◽

Fourier Transform Infrared ◽

Spectroscopic Technique ◽

Far Field ◽

Ft Ir ◽

Ir Spectroscopic ◽

Quartz Grains

We report an infrared (IR) spectroscopic technique to detect quartz grains with large isotope anomalies. We synthesized isotopically doped quartz and used Fourier transform infrared spectroscopy (FT-IR) in two different instruments: a traditional far-field instrument and a neaSpec nanoFT-IR, to quantify the shift in the peak of the Si–O stretch near 780 cm−1 as a function of isotope composition, and the uncertainty in this shift. From these measurements, we estimated the minimum detectable isotope anomaly using FT-IR. The described technique can be used to nondestructively detect very small (30 nm) presolar grains. In particular, supernova grains, which can have very large isotope anomalies, are detectable by this method.

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In vivo study of the state of order of the membranes of Gram-negative bacteria by Fourier-transform infrared spectroscopy (FT-IR)

FEBS Letters ◽

10.1016/0014-5793(91)81339-a ◽

1991 ◽

Vol 294 (1-2) ◽

pp. 43-46 ◽

Cited By ~ 33

Author(s):

Christian Schultz ◽

Dieter Naumann

Keyword(s):

Fourier Transform ◽

Infrared Spectroscopy ◽

Fourier Transform Infrared Spectroscopy ◽

Fourier Transform Infrared ◽

The State ◽

In Vivo Study ◽

Gram Negative Bacteria ◽

Gram Negative ◽

Ft Ir

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An FT-IR spectroscopic study of the role of hydrogen bonding in the formation of liquid crystallinity for mixtures containing bipyridines and 4-pentoxybenzoic acid

RSC Advances ◽

10.1039/c6ra17819g ◽

2016 ◽

Vol 6 (110) ◽

pp. 108164-108179 ◽

Cited By ~ 46

Author(s):

Alfonso Martinez-Felipe ◽

Andrew G. Cook ◽

Jordan P. Abberley ◽

Rebecca Walker ◽

John M. D. Storey ◽

...

Keyword(s):

Hydrogen Bonding ◽

Fourier Transform ◽

Infrared Spectroscopy ◽

Spectroscopic Study ◽

Fourier Transform Infrared Spectroscopy ◽

Fourier Transform Infrared ◽

Liquid Crystallinity ◽

Ft Ir ◽

Ir Spectroscopic

The relationships between liquid crystallinity and hydrogen bonding are studied in mixtures containing 4-pentoxybenzoic acid, 5OBA, and five bipyridines, XBiPy, with spacers having different flexibilities, by Fourier transform infrared spectroscopy.

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