GSTT1 Gene Deletion Is Associated with Lung Cancer in Mexican Patients

Glutathione S-transferase (GST) is a dimeric detoxifying isoenzyme, involved in the deactivation of carcinogens, several tobacco-derived carcinogens, and xenobiotics. It catalyzes the reduction of glutathione to its thioester; thus, deficiency in GST activity due to homozygous deletion of the GSTT1 gene (null genotype) may play a role in the induction of lung cancer by smoking.We studied the distribution of GSTT1 gene deletion in peripheral blood DNA samples from 178 healthy controls (41 nonsmokers, 63 passive smokers and 74 smokers) and 52 lung cancer patients. Comparisons between groups showed that there was an increased lung cancer risk for individuals with the GSTT1 null genotype. Cancer patients showed significant differences when compared with controls: nonsmokers, passive smokers, and smokers. Twenty-one percent of lung cancer patients carried the deletion versus 2% among nonsmokers not exposed to passive smoking, 6% among passive smokers, and 5% among smokers. Thus, there is a significant association between this genotype and the possibility to risk of developing lung cancer.

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miR-146a and miR-196a-2 genes polymorphisms and its circulating levels in lung cancer patients

The Journal of Biochemistry ◽

10.1093/jb/mvz044 ◽

2019 ◽

Vol 166 (4) ◽

pp. 323-329 ◽

Cited By ~ 2

Author(s):

Randa H Mohamed ◽

Heba F Pasha ◽

Doaa M Gad ◽

Mostafa M Toam

Keyword(s):

Lung Cancer ◽

Cancer Risk ◽

Cancer Patients ◽

Lung Cancer Risk ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Lung Cancer Patients ◽

Increased Risk ◽

Increase Risk ◽

Circulating Levels

AbstractRecently, MicroRNAs polymorphisms and their serum expression have been linked to increase risk of various cancers. The aim of this study was to elucidate the association between single nucleotide polymorphisms of miR-146a and miR-196a-2 and their serum expression and lung cancer risk. One hundred and twenty lung cancer patients and 120 health controls were included in this study. Genotyping and expression for miR-146a and miR-196a-2 were performed using polymerase chain reaction (PCR)-restriction fragment length polymorphism and quantitative real-time PCR. Individuals carrying miR-146a CG and CC genotypes had significantly increased risk for lung cancer than those carrying miR-146a GG genotype. MiR-146a expression significantly decreased in miR-146a CG and CC genotypes carriers as compared with GG genotype carriers. MiR-196a-2 CT and TT genotypes were significantly associated with increased lung cancer while the highest expression of MiR-196a-2 was detected in miR-196a-2 CC genotype carriers. Serum miR-146a was significantly decreased in lung cancer patients while serum miR-196a-2 expression was significantly increased in lung cancer patients. In conclusion, miR-146a and miR-196a-2 genes polymorphisms and their circulating levels were associated with lung cancer risk in Egyptians and may be helpful in early detection of lung cancer.

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Analysis of BIM (BCL-2 like 11 gene) deletion polymorphism in Chinese non-small cell lung cancer patients

Thoracic Cancer ◽

10.1111/1759-7714.12119 ◽

2014 ◽

Vol 5 (6) ◽

pp. 509-516 ◽

Cited By ~ 7

Author(s):

Jia Zhong ◽

Zheng-Xiang Li ◽

Jun Zhao ◽

Jian-Chun Duan ◽

Hua Bai ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cancer Patients ◽

Cell Lung Cancer ◽

Gene Deletion ◽

Small Cell ◽

Small Cell Lung ◽

Deletion Polymorphism ◽

Lung Cancer Patients

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GLUTATHIONE S-TRANSFERASE M1 AND T1 POLYMORPHISMS PREVALENCE IN LUNG CANCER PATIENTS IN MALANG, INDONESIA

Respirology ◽

10.1111/resp.13206_28 ◽

2017 ◽

Vol 22 ◽

pp. 16-16

Keyword(s):

Lung Cancer ◽

Cancer Patients ◽

Glutathione S Transferase ◽

Lung Cancer Patients

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Influence of CMTM8 polymorphisms on Lung Cancer Susceptibility in the Chinese Han Population

10.21203/rs.3.rs-34577/v1 ◽

2020 ◽

Author(s):

Jiamin Wu ◽

Yao Sun ◽

Zichao Xiong ◽

Fanglin Niu ◽

Yuanwei Liu ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Risk ◽

Cancer Patients ◽

Lung Cancer Risk ◽

Lung Squamous Cell Carcinoma ◽

Chinese Han Population ◽

Chinese Han ◽

Han Population ◽

Lung Cancer Patients ◽

Increased Risk

Abstract Objective: Lung cancer is the leading cause of cancer-related mortality worldwide and CMTM8 is a potential tumor suppressor gene, which is down-regulated in lung cancer. The objective of this research was to assess the association of CMTM8 genetic polymorphisms with lung cancer risk in Chinese Han population.Methods: To evaluate the correlation between CMTM8 polymorphisms and lung cancer risk, Agena MassArray platform was used for genotype determination among 509 lung cancer patients and 506 controls. Multiple genetic models, stratification analysis and haploview analysis was used by calculating odds ratio (OR) and 95% confidence intervals (CIs).Results: Significant associations were detected between CMTM8 rs6771238 and an increased lung cancer risk in codominant (adjusted OR = 1.57, 95%CI: 1.01-2.42, p = 0.044) and dominant (adjusted OR = 1.54, 95%CI: 1.01-2.36, p = 0.047)models. After gender stratification analysis,weobserved that rs6771238 was related to an increased risk of lung squamous cell carcinoma, while rs6771238 was associated with anincreased risk of lung adenocarcinoma. Rs9835916 and rs1077868 were correlated with lung cancer staging.Rs9835916 was linked to increased risk of lymph node metastasis in lung cancer patients. Conclusions: Our study firstly reported that the CMTM8 polymorphisms were a risk factors for lung cancer, which suggested the potential roles of CMTM8 in the development of lung cancerin Chinese Han population.

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