scholarly journals Analysis of the alteration in the optical configuration of Raman spectrometer: Optimization of signal-to-noise ratio (SNR) in a specific wavelength range of clinical interest

2008 ◽  
Vol 22 (6) ◽  
pp. 467-474 ◽  
Author(s):  
João Carlos Lázaro ◽  
Carlos J. de Lima ◽  
Leonardo M. Moreira ◽  
Landulfo Silveira Jr. ◽  
Nelson J. F. da Silveira ◽  
...  
Keyword(s):  
Signal To Noise Ratio ◽  
Spectral Lines ◽  
Optical Parameters ◽  
Signal To Noise ◽  
Minimum Width ◽  
Raman Spectrometer ◽  
System A ◽  
Optical Configuration ◽  
Noise Ratio

The present article is focused on the optimization of the optical parameters of a Raman spectrometer in order to obtain a minimum width of its spectral lines. In this way, using as reference the width of a fingerprint band of a calcified biological tissue, a spectral line without distortion or any loss of resolution was identified. This optimization is employed with the aim of improvement of the signal-to-noise ratio (SNR). A great improvement in the efficiency of the spectral collect was obtained, which can reduce significantly the time of diagnosis of target tissues, such as the calcified coronarian tissue. Therefore, the potential application of this new spectroscopic system increases the efficiency and precision, favoring the security of this technique to futurein vivoapplications. The excellent results obtained in this work become this spectroscopic system a powerful tool to the clinical diagnosis of several diseases.

scholarly journals Signal-to-noise ratio in the membrane potential of the owl's auditory coincidence detectors

2012 ◽  
Vol 108 (10) ◽  
pp. 2837-2845 ◽  
Author(s):  
Go Ashida ◽  
Kazuo Funabiki ◽  
Paula T. Kuokkanen ◽  
Richard Kempter ◽  
Catherine E. Carr
Keyword(s):  
Neural Circuit ◽  
Signal To Noise Ratio ◽  
Phase Locking ◽  
Low Frequency ◽  
Membrane Potentials ◽  
Signal To Noise ◽  
Theoretical Predictions ◽  
Noise Ratio ◽  
Band Limited

Owls use interaural time differences (ITDs) to locate a sound source. They compute ITD in a specialized neural circuit that consists of axonal delay lines from the cochlear nucleus magnocellularis (NM) and coincidence detectors in the nucleus laminaris (NL). Recent physiological recordings have shown that tonal stimuli induce oscillatory membrane potentials in NL neurons (Funabiki K, Ashida G, Konishi M. J Neurosci 31: 15245–15256, 2011). The amplitude of these oscillations varies with ITD and is strongly correlated to the firing rate. The oscillation, termed the sound analog potential, has the same frequency as the stimulus tone and is presumed to originate from phase-locked synaptic inputs from NM fibers. To investigate how these oscillatory membrane potentials are generated, we applied recently developed signal-to-noise ratio (SNR) analysis techniques (Kuokkanen PT, Wagner H, Ashida G, Carr CE, Kempter R. J Neurophysiol 104: 2274–2290, 2010) to the intracellular waveforms obtained in vivo. Our theoretical prediction of the band-limited SNRs agreed with experimental data for mid- to high-frequency (>2 kHz) NL neurons. For low-frequency (≤2 kHz) NL neurons, however, measured SNRs were lower than theoretical predictions. These results suggest that the number of independent NM fibers converging onto each NL neuron and/or the population-averaged degree of phase-locking of the NM fibers could be significantly smaller in the low-frequency NL region than estimated for higher best-frequency NL.

scholarly journals The first data release of LAMOST low-resolution single-epoch spectra

2021 ◽  
Vol 21 (10) ◽  
pp. 249
Author(s):  
Zhong-Rui Bai ◽  
Hao-Tong Zhang ◽  
Hai-Long Yuan ◽  
Dong-Wei Fan ◽  
Bo-Liang He ◽  
...  
Keyword(s):  
Radial Velocity ◽  
Signal To Noise Ratio ◽  
Time Lag ◽  
Spectral Lines ◽  
Low Resolution ◽  
Signal To Noise ◽  
Data Release ◽  
Repeat Exposure ◽  
Noise Ratio ◽  
Single Epoch

Abstract LAMOST Data Release 5, covering ∼17 000 deg2 from –10° to 80° in declination, contains 9 million co-added low-resolution spectra of celestial objects, each spectrum combined from repeat exposure of two to tens of times during Oct 2011 to Jun 2017. In this paper, we present the spectra of individual exposures for all the objects in LAMOST Data Release 5. For each spectrum, the equivalent width of 60 lines from 11 different elements are calculated with a new method combining the actual line core and fitted line wings. For stars earlier than F type, the Balmer lines are fitted with both emission and absorption profiles once two components are detected. Radial velocity of each individual exposure is measured by minimizing χ 2 between the spectrum and its best template. The database for equivalent widths of spectral lines and radial velocities of individual spectra are available online. Radial velocity uncertainties with different stellar type and signal-to-noise ratio are quantified by comparing different exposure of the same objects. We notice that the radial velocity uncertainty depends on the time lag between observations. For stars observed in the same day and with signal-to-noise ratio higher than 20, the radial velocity uncertainty is below 5km s−1, and increases to 10 km s−1 for stars observed in different nights.

scholarly journals Sequential average segmented microscopy for high signal-to-noise ratio motion-artifact-free in vivo heart imaging

2013 ◽  
Vol 4 (10) ◽  
pp. 2095 ◽  
Author(s):  
Claudio Vinegoni ◽  
Sungon Lee ◽  
Paolo Fumene Feruglio ◽  
Pasquina Marzola ◽  
Matthias Nahrendorf ◽  
...  
Keyword(s):  
Signal To Noise Ratio ◽  
Motion Artifact ◽  
High Signal ◽  
Signal To Noise ◽  
Heart Imaging ◽  
Noise Ratio

Effect of microcosmic optical parameters of dopants on the signal-to-noise ratio in doubly doped LiNbO3 crystals

Optik ◽  
2005 ◽  
Vol 116 (9) ◽  
pp. 423-428
Author(s):  
Cuixia Dai ◽  
Liren Liu ◽  
De’an Liu ◽  
Yu Zhou
Keyword(s):  
Signal To Noise Ratio ◽  
Optical Parameters ◽  
Signal To Noise ◽  
Noise Ratio

scholarly journals Self-Reset Image Sensor With a Signal-to-Noise Ratio Over 70 dB and Its Application to Brain Surface Imaging

2021 ◽  
Vol 15 ◽  
Author(s):  
Thanet Pakpuwadon ◽  
Kiyotaka Sasagawa ◽  
Mark Christian Guinto ◽  
Yasumi Ohta ◽  
Makito Haruta ◽  
...  
Keyword(s):  
Neural Activity ◽  
Signal To Noise Ratio ◽  
Image Sensor ◽  
Oxide Semiconductor ◽  
High Signal ◽  
Unstable State ◽  
Signal To Noise ◽  
Compact Size ◽  
Noise Ratio

In this study, we propose a complementary-metal-oxide-semiconductor (CMOS) image sensor with a self-resetting system demonstrating a high signal-to-noise ratio (SNR) to detect small intrinsic signals such as a hemodynamic reaction or neural activity in a mouse brain. The photodiode structure was modified from N-well/P-sub to P+/N-well/P-sub to increase the photodiode capacitance to reduce the number of self-resets required to decrease the unstable stage. Moreover, our new relay board was used for the first time. As a result, an effective SNR of over 70 dB was achieved within the same pixel size and fill factor. The unstable state was drastically reduced. Thus, we will be able to detect neural activity. With its compact size, this device has significant potential to become an intrinsic signal detector in freely moving animals. We also demonstrated in vivo imaging with image processing by removing additional noise from the self-reset operation.

Artifacts by Misalignment of Cardiac Magnetic Resonance Phased-array Coil Elements: From Simulation to In vivo Test

2019 ◽  
Vol 15 (3) ◽  
pp. 301-307
Author(s):  
Daniele De Marchi ◽  
Alessandra Flori ◽  
Nicola Martini ◽  
Giulio Giovannetti
Keyword(s):  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Phased Array ◽  
Signal To Noise Ratio ◽  
Whole Body ◽  
Signal To Noise ◽  
Phased Array Coil ◽  
Noise Ratio ◽  
Array Coil

Background: Cardiac magnetic resonance evaluations generally require a radiofrequency coil setup comprising a transmit whole-body coil and a receive coil. In particular, radiofrequency phased-array coils are employed to pick up the signals emitted by the nuclei with high signal-tonoise ratio and a large region of sensitivity. Methods: Literature discussed different technical issues on how to minimize interactions between array elements and how to combine data from such elements to yield optimum Signal-to-Noise Ratio images. However, image quality strongly depends upon the correct coil position over the heart and of one array coil portion with respect to the other. Results: In particular, simple errors in coil positioning could cause artifacts carrying to an inaccurate interpretation of cardiac magnetic resonance images. Conclusion: This paper describes the effect of array elements misalignment, starting from coil simulation to cardiac magnetic resonance acquisitions with a 1.5 T scanner. </P><P> Phased-array coil simulation was performed using the magnetostatic approach; moreover, phantom and in vivo experiments with a commercial 8-elements cardiac phased-array receiver coil permitted to estimate signal-to-noise ratio and B1 mapping for aligned and shifted coil.

Development and Characterization of an Electrocochleography-Guided Robotics-Assisted Cochlear Implant Array Insertion System

2021 ◽  
pp. 019459982110492
Author(s):  
Allan M. Henslee ◽  
Christopher R. Kaufmann ◽  
Matt D. Andrick ◽  
Parker T. Reineke ◽  
Viral D. Tejani ◽  
...  
Keyword(s):  
Cochlear Implant ◽  
Real Time ◽  
Signal To Noise Ratio ◽  
Electrode Array ◽  
High Signal ◽  
Animal Testing ◽  
Signal To Noise ◽  
Noise Ratio ◽  
Hearing Outcomes

Objective Electrocochleography (ECochG) is increasingly being used during cochlear implant (CI) surgery to detect and mitigate insertion-related intracochlear trauma, where a drop in ECochG signal has been shown to correlate with a decline in hearing outcomes. In this study, an ECochG-guided robotics-assisted CI insertion system was developed and characterized that provides controlled and consistent electrode array insertions while monitoring and adapting to real-time ECochG signals. Study Design Experimental research. Setting A research laboratory and animal testing facility. Methods A proof-of-concept benchtop study evaluated the ability of the system to detect simulated ECochG signal changes and robotically adapt the insertion. Additionally, the ECochG-guided insertion system was evaluated in a pilot in vivo sheep study to characterize the signal-to-noise ratio and amplitude of ECochG recordings during robotics-assisted insertions. The system comprises an electrode array insertion drive unit, an extracochlear recording electrode module, and a control console that interfaces with both components and the surgeon. Results The system exhibited a microvolt signal resolution and a response time <100 milliseconds after signal change detection, indicating that the system can detect changes and respond faster than a human. Additionally, animal results demonstrated that the system was capable of recording ECochG signals with a high signal-to-noise ratio and sufficient amplitude. Conclusion An ECochG-guided robotics-assisted CI insertion system can detect real-time drops in ECochG signals during electrode array insertions and immediately alter the insertion motion. The system may provide a surgeon the means to monitor and reduce CI insertion–related trauma beyond manual insertion techniques for improved CI hearing outcomes.

Method to Determine Tissue Fluorescence Efficiency in vivo and Predict Signal-to-Noise Ratio for Spectrometers

1998 ◽  
Vol 52 (7) ◽  
pp. 943-951 ◽  
Author(s):  
E. V. Trujillo ◽  
D. R. Sandison ◽  
U. Utzinger ◽  
N. Ramanujam ◽  
M. Follen Mitchell ◽  
...  
Keyword(s):  
Signal To Noise Ratio ◽  
Optical Design ◽  
Tissue Type ◽  
Excitation Wavelength ◽  
Cervical Tissue ◽  
Signal To Noise ◽  
Fluorescence Efficiency ◽  
Tissue Fluorescence ◽  
Noise Ratio

Recent clinical trials have demonstrated the potential of fluorescence spectroscopy for in vivo diagnosis of pathology. There is significant potential to reduce the cost and complexity of instrumentation to measure tissue spectra; however, careful analysis is required to maximize performance and minimize cost. One measure of performance is the signal-to-noise ratio (SNR) of the resulting data. This paper describes a method to predict the SNR of a given optical design for a particular tissue application. In order to calculate the expected SNR, two pieces of information are required: (1) the throughput and inherent noise of the system and (2) a quantitative relationship between the illumination energy and the resulting tissue fluorescence available for collection, which we define as the tissue fluorescence efficiency (FE). We present a method to calculate the fluorescence efficiency of tissue from in vivo measurements of tissue fluorescence. We report FE measurements of the normal and precancerous human cervix in vivo at 337, 380, and 460 nm excitation. We also present and evaluate a method to estimate the throughput and noise of various spectrometers and predict the expected SNR for tissue spectra by using the measured tissue FE. For squamous cervical tissue, as the degree of the disease increases, FE decreases, and as the excitation wavelength increases, FE decreases. Cervical tissue FE varies more than two orders of magnitude, depending on the tissue type and on the excitation wavelength used. Our SNR calculations, based on measured values of tissue FE, demonstrate agreement within a factor of 1.3 of the measured SNR on average. This method can be used to estimate the performance of different spectrometer designs for clinical use.

scholarly journals DISPOSABLE SYSTEM FOR IN-VIVO MECHANICAL CHARACTERIZATION OF SOFT TISSUES BASED ON VOLUME MEASUREMENT

2018 ◽  
Vol 18 (04) ◽  
pp. 1850037 ◽  
Author(s):  
SEYED ALI ELAHI ◽  
NATHANAEL CONNESSON ◽  
YOHAN PAYAN
Keyword(s):  
Mechanical Properties ◽  
Soft Tissues ◽  
Signal To Noise Ratio ◽  
Volume Measurement ◽  
Optical Measurements ◽  
Signal To Noise ◽  
Noise Ratio ◽  
Apex Height

In-vivo characterization of soft tissues is a key step toward biomechanical simulation and planning of intra-operative assisted surgery. To achieve this, aspiration method is a standard technique: tissue is aspirated through a hole while measuring the pressure and associated apex height. An inverse problem is then solved to identify the material mechanical properties. In the literature, the apex height is usually measured using a camera, which induces design difficulties, in particular in regards on the required sterilization process for in-vivo measurements. In this paper, the idea is to replace the apex height optical measurement by the measurement of the aspirated tissue volume. The proposed method enables to reduce the system head to a simple tube: sterilizations becomes easy and the system is disposable after use. The proposed system is thus the simplest, lightest and cheapest one could achieve. It is also to the authors knowledge the first time ever in aspiration method that the aspired volume is the extracted data. As the data signal-to-noise ratio is the main factor impacting any applied inverse method when extracting the mechanical properties, the aim of this work is to assess and compare the experimental signal-to-noise ratio in the raw volume measurements obtained either optically or with the method proposed. Explicit results of inverse methods using volumes as input data are not presented in this paper for concision purpose. The effects on accuracy of various experimental parameters has been investigated and quantified: the volume measurement has proved to present a same order or even better signal-to-noise ratio compared to optical measurements.

scholarly journals Stable, Intelligible Ultrasonic Strain Imaging

Ultrasound ◽  
2008 ◽  
Vol 16 (4) ◽  
pp. 187-192 ◽  
Author(s):  
Andrew Gee ◽  
Joel Lindop ◽  
Graham Treece ◽  
Richard Prager ◽  
Susan Freeman
Keyword(s):  
Breast Biopsy ◽  
Signal To Noise Ratio ◽  
Strain Imaging ◽  
Time Averaging ◽  
Post Processing ◽  
Signal To Noise ◽  
Processing Strategies ◽  
Improved Stability ◽  
Noise Ratio

Background: Freehand quasistatic strain imaging can reveal qualitative information about tissue stiffness with good spatial accuracy. Clinical trials, however, repeatedly cite instability and variable signal-to-noise ratio as significant drawbacks. Methods: This study investigates three post-processing strategies for quasistatic strain imaging. Normalization divides the strain by an estimate of the stress field, the intention being to reduce sensitivity to variable applied stress. Persistence aims to improve the signal-to-noise ratio by time-averaging multiple frames. The persistence scheme presented in this article operates at the pixel level, weighting each frame's contribution by an estimate of the strain precision. Precision-based display presents the clinician with an image in which regions of indeterminate strain are obscured behind a colour wash. This is achieved using estimates of strain precision that are faithfully propagated through the various stages of signal processing. Results and discussion: The post-processing strategy is evaluated qualitatively on scans of a breast biopsy phantom and in vivo head and neck examinations. Strain images processed in this manner are observed to benefit from improved stability and signal-to-noise ratio. There are, however, limitations. In unusual though conceivable circumstances, the normalization procedure might suppress genuine stiffness variations evident in the unprocessed strain images. In different circumstances, the raw strain images might fail to capture significant stiffness variations, a situation that no amount of post-processing can improve. Conclusion: The clinical utility of freehand quasistatic strain imaging can be improved by normalization, precision-weighted pixel-level persistence and precision-based display. The resulting images are stable and generally exhibit a better signal-to-noise ratio than any of the original, unprocessed strain images.

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