scholarly journals Kimura's Disease

2009 ◽  
Vol 2009 ◽  
pp. 1-4 ◽  
Author(s):  
Cláudia Savassi Guimaraes ◽  
Natalie Moulton-Levy ◽  
Allen Sapadin ◽  
Claudia Vidal
Keyword(s):  
Immunoglobulin E ◽  
Elevated Serum ◽  
Punch Biopsy ◽  
Unknown Etiology ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Lymphoid Follicles ◽  
Chronic Inflammatory Disorder ◽  
Subcutaneous Nodules ◽  
Good Improvement

Kimuras disease is a chronic inflammatory disorder of unknown etiology. It is rare in the West, but endemic in Asia. It typically presents as solitary or multiple subcutaneous nodules, that slowly increase in size. The lesions are variably painful and pruritic. It often accompanied by regional lymphadenopathy, raised serum eosinophil counts, and markedly elevated serum immunoglobulin E levels. Histologically, the lesions are characterized by reactive lymphoid follicles with eosinophilic infiltration and an increased amount of postcapillary venules. The optimal treatment for KD remains controversial. Although the condition seldom resolves spontaneously, malignant transformation has not been reported to date, and the prognosis is good. We describe a male patient with a 4-year pruritic progressive “bump” in front of his left ear. On physical examination, the patient had 2 discrete lesions on the left side of his face near his ear. Postauricularly, there was a3×5cm erythematous to violaceous, indurated nodule. Preauricularly, there was a similar, but smaller cyst-like nodule. Punch biopsy showed a superficial and deep nodular and interstitial infiltrate, reactive lymphoid follicles with a dense infiltration of eosinophils and areas of eosinophilic follicle lysis. The patient received intralesional triamcinolone acetonide injections 10 mg/cc behind left ear with a good improvement.

Kimura Disease

2007 ◽  
Vol 131 (4) ◽  
pp. 650-651
Author(s):  
Mohammad Abuel-Haija ◽  
Matthew T. Hurford
Keyword(s):  
Immunoglobulin E ◽  
Subcutaneous Tissue ◽  
Elevated Serum ◽  
Unknown Etiology ◽  
Systemic Steroid ◽  
Inflammatory Disorder ◽  
Kimura Disease ◽  
Chronic Inflammatory Disorder ◽  
Systemic Steroid Therapy ◽  
Peripheral Blood Eosinophilia

Abstract Kimura disease is a benign rare chronic inflammatory disorder of unknown etiology that involves the lymph nodes and subcutaneous tissue of the head and neck regions. Elevated serum immunoglobulin E levels and peripheral blood eosinophilia are also common. This disease is most common in middle-aged Asian men. Although the etiology is unknown, it most probably represents an aberrant chronic immune response. Treatment for Kimura disease includes surgical resection and regional or systemic steroid therapy. Cytotoxic therapy and radiation have also been utilized. The disease has an excellent prognosis, although it may recur locally.

scholarly journals Kimura’s Disease in a Caucasian Female: A Very Rare Cause of Lymphadenopathy

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Ewa Osuch-Wójcikiewicz ◽  
Antoni Bruzgielewicz ◽  
Magdalena Lachowska ◽  
Agata Wasilewska ◽  
Kazimierz Niemczyk
Keyword(s):  
Elevated Serum ◽  
Unknown Etiology ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Benign Condition ◽  
Case Presentation ◽  
Chronic Inflammatory Disorder ◽  
Angiolymphoid Hyperplasia ◽  
Caucasian Female

Introduction. Kimura’s disease is a rare chronic inflammatory disorder characterized by the head and neck lymphadenopathy often accompanied by eosinophilia and elevated serum IgE. It is benign condition with unknown etiology usually affecting young men of Asian race. Affected Caucasians are very rare.Case Presentation. We report a clinically and histopathologically typical case of this disease in a 40-year-old Caucasian female. In differential diagnosis particular attention has been paid to angiolymphoid hyperplasia with eosinophilia and neoplasms.Conclusion. The diagnosis of Kimura’s disease can be very difficult and misleading; it is important not to ignore histopathological features. The presented patient has been under follow-up with no more symptoms of the disease for the last 1.5 years.

scholarly journals Kimura’s disease as an uncommon cause of post auricular swelling

2020 ◽  
Vol 6 (9) ◽  
pp. 1737
Author(s):  
Chandre Gowda Bendiganahalli Venkate Gowda ◽  
Madhuri Gandham
Keyword(s):  
Immunoglobulin E ◽  
Neck Region ◽  
Unknown Etiology ◽  
Kimura’S Disease ◽  
Histopathological Diagnosis ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Tissue Eosinophilia ◽  
Common Causes ◽  
Rule Out

<p>Kimura’s disease (KD) is a rare chronic inflammatory disorder of unknown etiology, primarily seen in young Asian males. In India, only 200 cases have been reported worldwide since its histopathological diagnosis. The disease is characterized by painless subcutaneous swelling in head &amp; neck region, blood and tissue eosinophilia and raised Immunoglobulin E (IgE) levels. A systematic multidisciplinary approach is mandatory to rule out the other common causes of post auricular lymphadenopathy. The diagnosis of KD can be difficult and misleading and patients with this disease are often evaluated using avoidable procedures by just not being aware of KD. Here, we present a case of a 20 year old male who presented with nodular swellings in the bilateral post auricular region. The diagnosis of KD was done based on characteristic histopathologic finding in conjunction with peripheral eosinophilia.</p>

scholarly journals Kimura’s disease: a diagnostic and therapeutic enigma

2018 ◽  
Vol 6 (6) ◽  
pp. 2176
Author(s):  
Vinay Bharat ◽  
Abhishek Gupta ◽  
Rani Bansal ◽  
Priya Gupta ◽  
Mamta Gupta
Keyword(s):  
Lymph Nodes ◽  
Elevated Serum ◽  
Neck Region ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Neck Swelling ◽  
Peripheral Eosinophilia ◽  
Head And Neck Region ◽  
Chronic Inflammatory Disorder ◽  
Reactive Hyperplasia

Kimura’s disease is a rare chronic inflammatory disorder present in 2nd and 3rd decade. It has a predilection for head and neck region presenting as a slowly growing painless swelling. It is usually accompanied by peripheral eosinophilia and elevated serum IgE and hence it was initially thought to be of allergic origin. Histologically the lesions are characterized by reactive hyperplasia of lymph nodes, eosinophilic infiltration and increase in postcapillary venules. Authors have reported a male patient with a slowly growing right sided neck swelling which is recurring even after course of steroids and excision done twice at an interval of 6 months. Kimura’s disease although a benign Lymphoid disorder but the incidence of recurrence despite taking treatment is a cause of much concern for the patient.

scholarly journals Kimura Disease of the Parotid Gland: Management Approach

2022 ◽  
Vol 4 (1) ◽  
pp. 01-03
Author(s):  
Hafeza MS ◽  
Vanitha Palanisamy
Keyword(s):  
Parotid Gland ◽  
Frozen Section ◽  
Neck Region ◽  
Unknown Etiology ◽  
Management Approach ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Parotid Neoplasm ◽  
The Right

Here we present a 43-years old Malay man with Kimura’s disease of the right parotid gland. Asian men have a predisposition for this chronic inflammatory disorder of unknown etiology mostly presenting at the head and neck region. The management in dealing with this patient is not straight forward as the presentation mimics a subcutaneous tumor-like mass in which main differential diagnosis includes lymphoproliferative disorders and parotid neoplasm. Moreover, cytological investigation is inadequate, and this necessitates the use intra-operative frozen section prior to tumor debulking. Without proper investigation, misdiagnosis can occur and potentially expose the patient to unnecessary extensive surgical procedures. Here we discuss step by step approach in managing this patient.

scholarly journals Kimura’s disease: an extremely rare case report in an elderly male, followed by Hodgkin’s disease

2021 ◽  
Vol 2 (1) ◽  
pp. 156-159
Author(s):  
Nupur Rastogi
Keyword(s):  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Unknown Etiology ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Elderly Male ◽  
Chronic Inflammatory Disorder ◽  
Rare Case Report ◽  
Generalized Lymphadenopathy ◽  
Indian Male

Kimura disease is a benign rare chronic inflammatory disorder of unknown etiology. The disease is mainly endemic in Asia, cases have been reported in Europe and America. The present case is of a 75 year Indian male who presented with cervical and axillary lymphadenopathy. Ultrasonography was done which showed multiple peritoneal lymph nodes. Peripheral smear showed eosinophilia. Cytomorphology and histopathology showed features of Hodgkin’s disease. S IgE level was raised. 5 years earlier patient had presented with similar complaints of generalized lymphadenopathy, raised IgE level, peripheral eosinophilia. FNAC of cervical lymph node done earlier showed cytomorphology of Reactive Lymphadenitis. Biopsy showed histology of Kimura’s disease.

scholarly journals Kimura's disease in a young Balkan male

2009 ◽  
Vol 66 (1) ◽  
pp. 66-68 ◽  
Author(s):  
Maja Jovicic-Milentijevic ◽  
Marin Basic ◽  
Aleksandar Petrovic
Keyword(s):  
Immunoglobulin E ◽  
Histopathological Examination ◽  
Neck Mass ◽  
Definitive Diagnosis ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Asian Men ◽  
Left Neck ◽  
Peripheral Blood Eosinophilia

Introduction. Kimura's disease is a rare, chronic inflammatory disorder of unknown cause, mainly seen in young Asian men. To our knowledge it has not been reported previously in persons from the Balkan countries. Case report. We presented a 15-year-old male with Kimura's disease manifested as chronic left neck mass. The diagnosis was based on the histopathological findings of the excised lesion. Peripheral blood eosinophilia and raised serum Immunoglobulin E (IgE) level supported the diagnosis. Conclusion. The presented patient confirmed the fact that Kimura's disease could occur in different ethnic groups. Histopathological examination, should be performed prior to making the definitive diagnosis.

scholarly journals Branch Retinal Vein Occlusion in a Case of Sarcoidosis

2021 ◽  
Vol 13 (1) ◽  
pp. 146-151
Author(s):  
Ruchi Shrestha ◽  
Ranju Kharel Sitaula ◽  
Pratap Karki ◽  
Sagun Narayan Joshi
Keyword(s):  
Retinal Vein Occlusion ◽  
Branch Retinal Vein Occlusion ◽  
Elevated Serum ◽  
Vascular Complication ◽  
Unknown Etiology ◽  
Inflammatory Disorder ◽  
Hilar Lymphadenopathy ◽  
Chronic Inflammatory Disorder ◽  
Vein Occlusion ◽  
Bilateral Hilar Lymphadenopathy

Abstract: Background: Sarcoidosis is a chronic inflammatory disorder characterized by non-caseation granuloma. It is an inflammatory disorder of unknown etiology. Sarcoidosis has variable ocular presentations   from anterior uveitis to rare venous occlusions. Case: We present a rare case of sarcoidosis with bilateral hilar lymphadenopathy and a compatible uveitis. Positive findings of mutton fat keratic precipitates, Koeppes nodule, posterior synechiae, trabecular meshwork nodules, Candle wax dripping sign, Branch retinal vein occlusion and choroidal granuloma in one eye supported the diagnosis of sarcoidosis. Elevated serum acetylcholine esterase and bilateral hilar lymphadenopathy also confirmed the diagnosis of sarcoidosis. Observation: The patient responded well to oral steroids and laser photocoagulation of the vein occlusion area. The patient developed complications of steroid like Herpes Zooster of abdomen and avascular necrosis of femur. Conclusion: Branch Retinal Vein Occlusion is a rare vascular complication in ocular sarcoidosis. Systemic steroids and laser for vein occlusion is mainstay of treatment. Physician must be aware of serious complications of steroid therapy, as seen in this case. Keyword: Sarcoidosis, Branch retinal vein occlusion, Steroids.

scholarly journals A rare cause of bilateral postaural lymphadenopathy: Kimura’s disease

2018 ◽  
Vol 4 (3) ◽  
pp. 843
Author(s):  
Ankur Batra ◽  
Megha Goyal ◽  
Sachin Goel ◽  
Lakshmi Vaid
Keyword(s):  
Young Men ◽  
Unknown Etiology ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Histopathological Features ◽  
Asian Race ◽  
Indian Male ◽  
Atypical Manifestation

<p>Kimura’s disease (KD) is a chronic inflammatory disorder with angiolymphatic proliferation of unknown etiology, usually affecting young men of Asian race but is rare in other races. Affected Indians are very rare. Herein, we present an atypical manifestation of Kimura’s disease occurring in an Indian male who presented with bilateral postaural lymphadenopathy. The diagnosis of Kimura’s disease can be very difficult and misleading; it is important not to ignore histopathological features.</p>

scholarly journals Bilateral Posterior Auricular Masses: A Case of Kimura’s Disease

2021 ◽  
pp. 014556132110455
Author(s):  
Fengyang Xie ◽  
Yan Kou ◽  
ShuaiJun Zhang ◽  
Li Shi ◽  
Jie Han ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Immunoglobulin E ◽  
Elevated Serum ◽  
Asian Population ◽  
Chronic Inflammatory Disease ◽  
Unknown Etiology ◽  
Kimura’S Disease ◽  
Subcutaneous Tissues ◽  
Adults And Children ◽  
Blood Eosinophils

Kimura’s disease (KD) is currently considered a rare chronic inflammatory disease of unknown etiology. It is more common in the Asian population, especially in young and middle-aged men, and can involve the lymph nodes, salivary glands, and subcutaneous tissues. It has been reported in adults and children, and is often accompanied by elevated peripheral blood eosinophils and elevated serum immunoglobulin E (IgE). Herein, we report a case of KD in a 46-year-old man with bilateral masses behind the ears since childhood that had gradually enlarged over 40 years. The patient’s peripheral blood eosinophils were elevated, and interestingly, homocysteine levels were also elevated. After surgical resection of the bilateral posterior auricular masses, follow-up over 5 years indicated good recovery and no signs of recurrence.

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