scholarly journals Kimura’s disease as an uncommon cause of post auricular swelling

2020 ◽  
Vol 6 (9) ◽  
pp. 1737
Author(s):  
Chandre Gowda Bendiganahalli Venkate Gowda ◽  
Madhuri Gandham
Keyword(s):  
Immunoglobulin E ◽  
Neck Region ◽  
Unknown Etiology ◽  
Kimura’S Disease ◽  
Histopathological Diagnosis ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Tissue Eosinophilia ◽  
Common Causes ◽  
Rule Out

<p>Kimura’s disease (KD) is a rare chronic inflammatory disorder of unknown etiology, primarily seen in young Asian males. In India, only 200 cases have been reported worldwide since its histopathological diagnosis. The disease is characterized by painless subcutaneous swelling in head &amp; neck region, blood and tissue eosinophilia and raised Immunoglobulin E (IgE) levels. A systematic multidisciplinary approach is mandatory to rule out the other common causes of post auricular lymphadenopathy. The diagnosis of KD can be difficult and misleading and patients with this disease are often evaluated using avoidable procedures by just not being aware of KD. Here, we present a case of a 20 year old male who presented with nodular swellings in the bilateral post auricular region. The diagnosis of KD was done based on characteristic histopathologic finding in conjunction with peripheral eosinophilia.</p>

scholarly journals Kimura Disease of the Parotid Gland: Management Approach

2022 ◽  
Vol 4 (1) ◽  
pp. 01-03
Author(s):  
Hafeza MS ◽  
Vanitha Palanisamy
Keyword(s):  
Parotid Gland ◽  
Frozen Section ◽  
Neck Region ◽  
Unknown Etiology ◽  
Management Approach ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Parotid Neoplasm ◽  
The Right

Here we present a 43-years old Malay man with Kimura’s disease of the right parotid gland. Asian men have a predisposition for this chronic inflammatory disorder of unknown etiology mostly presenting at the head and neck region. The management in dealing with this patient is not straight forward as the presentation mimics a subcutaneous tumor-like mass in which main differential diagnosis includes lymphoproliferative disorders and parotid neoplasm. Moreover, cytological investigation is inadequate, and this necessitates the use intra-operative frozen section prior to tumor debulking. Without proper investigation, misdiagnosis can occur and potentially expose the patient to unnecessary extensive surgical procedures. Here we discuss step by step approach in managing this patient.

scholarly journals Kimura's Disease

2009 ◽  
Vol 2009 ◽  
pp. 1-4 ◽  
Author(s):  
Cláudia Savassi Guimaraes ◽  
Natalie Moulton-Levy ◽  
Allen Sapadin ◽  
Claudia Vidal
Keyword(s):  
Immunoglobulin E ◽  
Elevated Serum ◽  
Punch Biopsy ◽  
Unknown Etiology ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Lymphoid Follicles ◽  
Chronic Inflammatory Disorder ◽  
Subcutaneous Nodules ◽  
Good Improvement

Kimuras disease is a chronic inflammatory disorder of unknown etiology. It is rare in the West, but endemic in Asia. It typically presents as solitary or multiple subcutaneous nodules, that slowly increase in size. The lesions are variably painful and pruritic. It often accompanied by regional lymphadenopathy, raised serum eosinophil counts, and markedly elevated serum immunoglobulin E levels. Histologically, the lesions are characterized by reactive lymphoid follicles with eosinophilic infiltration and an increased amount of postcapillary venules. The optimal treatment for KD remains controversial. Although the condition seldom resolves spontaneously, malignant transformation has not been reported to date, and the prognosis is good. We describe a male patient with a 4-year pruritic progressive “bump” in front of his left ear. On physical examination, the patient had 2 discrete lesions on the left side of his face near his ear. Postauricularly, there was a3×5cm erythematous to violaceous, indurated nodule. Preauricularly, there was a similar, but smaller cyst-like nodule. Punch biopsy showed a superficial and deep nodular and interstitial infiltrate, reactive lymphoid follicles with a dense infiltration of eosinophils and areas of eosinophilic follicle lysis. The patient received intralesional triamcinolone acetonide injections 10 mg/cc behind left ear with a good improvement.

scholarly journals Rituximab Treatment in a Patient with Kimura Disease and Membranous Nephropathy: Case Report

2021 ◽  
pp. 116-123
Author(s):  
Roald Vissing-Uhre ◽  
Alastair Hansen ◽  
Susanne Frevert ◽  
Ditte Hansen
Keyword(s):  
Case Report ◽  
Membranous Nephropathy ◽  
Neck Region ◽  
Renal Diseases ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Kimura Disease ◽  
Chronic Inflammatory Disorder ◽  
Eosinophil Granulocytes ◽  
Anti Cd20

Kimura disease (KD) is a chronic, inflammatory disorder with slowly developing subcutaneous tumor-like swellings, often occurring in the head and neck region. KD is diagnosed based on histology, elevated levels of immunoglobulin type E, and increased peripheral eosinophil granulocytes. KD may coexist with glomerular renal diseases, and this case report is based on a patient with KD-associated membranous nephropathy. Patients with membranous nephropathy without KD have demonstrated responsiveness to treatment with monoclonal anti-CD20 antibodies. This case report is the first to investigate the effect of rituximab treatment in a patient with KD-associated membranous nephropathy. A 30-year-old Italian man living in Denmark was diagnosed with Kimura’s disease based on subcutaneous nodules with eosinophil angiolymphoid hyperplasia. The patient was admitted to the hospital due to nephrotic syndrome. Serology showed eosinophil granulocytosis and negative PLA2-receptor antibody. Renal biopsy showed membranous nephropathy, and the patient was treated with systemic methylprednisolone followed by cyclosporin and then cyclophosphamide with only partial remission. Ultimately, treatment with intravenous rituximab was initiated, which resulted in overall remission and no nephrotic relapses at 30 months of follow-up. Thus, intravenous rituximab effectively decreased proteinuria and prevented nephrotic relapses in a patient with treatment-refractory membranous nephropathy due to KD.

scholarly journals Kimura’s disease: a diagnostic and therapeutic enigma

2018 ◽  
Vol 6 (6) ◽  
pp. 2176
Author(s):  
Vinay Bharat ◽  
Abhishek Gupta ◽  
Rani Bansal ◽  
Priya Gupta ◽  
Mamta Gupta
Keyword(s):  
Lymph Nodes ◽  
Elevated Serum ◽  
Neck Region ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Neck Swelling ◽  
Peripheral Eosinophilia ◽  
Head And Neck Region ◽  
Chronic Inflammatory Disorder ◽  
Reactive Hyperplasia

Kimura’s disease is a rare chronic inflammatory disorder present in 2nd and 3rd decade. It has a predilection for head and neck region presenting as a slowly growing painless swelling. It is usually accompanied by peripheral eosinophilia and elevated serum IgE and hence it was initially thought to be of allergic origin. Histologically the lesions are characterized by reactive hyperplasia of lymph nodes, eosinophilic infiltration and increase in postcapillary venules. Authors have reported a male patient with a slowly growing right sided neck swelling which is recurring even after course of steroids and excision done twice at an interval of 6 months. Kimura’s disease although a benign Lymphoid disorder but the incidence of recurrence despite taking treatment is a cause of much concern for the patient.

Eosinophilic chronic rhinosinusitis and concurrent Kimura’s disease treated with mepolizumab

2021 ◽  
Vol 14 (1) ◽  
pp. e232627
Author(s):  
Jacqueline Ho ◽  
Sophie Walter ◽  
Richard J Harvey
Keyword(s):  
English Language ◽  
Cervical Lymphadenopathy ◽  
Upper Airway ◽  
Neck Region ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Head And Neck Region ◽  
Chronic Inflammatory Disorder ◽  
First Case ◽  
Eosinophilic Chronic Rhinosinusitis

Kimura’s disease is a rare, benign, chronic inflammatory disorder characterised by its eosinophilic infiltrate. Patients often present with one or more progressively enlarging subcutaneous lymph nodes in the head and neck region or enlarging salivary glands. We describe the case of a 26-year-old man presenting with severe peripheral eosinophilia and upper airway inflammatory symptoms, who later developed cervical lymphadenopathy and formally diagnosed with Kimura’s disease. Based on our English-language MEDLINE literature search, to our knowledge this is the first case report describing treatment of Kimura’s disease with mepolizumab.

scholarly journals Kimura’s disease: a rare cause of facial mass in a caucasian male patient

2020 ◽  
Vol 6 (4) ◽  
pp. 20200099
Author(s):  
Célia Peixoto Sousa ◽  
Elsa Fonseca ◽  
Bárbara Viamonte ◽  
João Calheiros Lobo ◽  
António Madureira
Keyword(s):  
Immunoglobulin E ◽  
Neck Region ◽  
High Serum ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Peripheral Eosinophilia ◽  
Review Of The Literature ◽  
Head And Neck Region ◽  
Caucasian Male ◽  
Subcutaneous Mass

Kimura’s disease is an uncommon inflammatory disorder of unclear aetiology, mainly affecting young Asian descent males among their second and fourth decades of life. The disease typically emerges as a long-standing and painless subcutaneous mass lesion in the head and neck region, frequently associated with swelling of major salivary glands, particularly the parotid gland, and regional lymphadenopathy. Peripheral eosinophilia and high serum immunoglobulin E are also characteristic findings. We report a case and describe the imaging and pathological features of the disease in a 19-year-old Caucasian male, with review of the literature.

scholarly journals Kimura’s disease: an extremely rare case report in an elderly male, followed by Hodgkin’s disease

2021 ◽  
Vol 2 (1) ◽  
pp. 156-159
Author(s):  
Nupur Rastogi
Keyword(s):  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Unknown Etiology ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Elderly Male ◽  
Chronic Inflammatory Disorder ◽  
Rare Case Report ◽  
Generalized Lymphadenopathy ◽  
Indian Male

Kimura disease is a benign rare chronic inflammatory disorder of unknown etiology. The disease is mainly endemic in Asia, cases have been reported in Europe and America. The present case is of a 75 year Indian male who presented with cervical and axillary lymphadenopathy. Ultrasonography was done which showed multiple peritoneal lymph nodes. Peripheral smear showed eosinophilia. Cytomorphology and histopathology showed features of Hodgkin’s disease. S IgE level was raised. 5 years earlier patient had presented with similar complaints of generalized lymphadenopathy, raised IgE level, peripheral eosinophilia. FNAC of cervical lymph node done earlier showed cytomorphology of Reactive Lymphadenitis. Biopsy showed histology of Kimura’s disease.

scholarly journals Kimura's disease in a young Balkan male

2009 ◽  
Vol 66 (1) ◽  
pp. 66-68 ◽  
Author(s):  
Maja Jovicic-Milentijevic ◽  
Marin Basic ◽  
Aleksandar Petrovic
Keyword(s):  
Immunoglobulin E ◽  
Histopathological Examination ◽  
Neck Mass ◽  
Definitive Diagnosis ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Asian Men ◽  
Left Neck ◽  
Peripheral Blood Eosinophilia

Introduction. Kimura's disease is a rare, chronic inflammatory disorder of unknown cause, mainly seen in young Asian men. To our knowledge it has not been reported previously in persons from the Balkan countries. Case report. We presented a 15-year-old male with Kimura's disease manifested as chronic left neck mass. The diagnosis was based on the histopathological findings of the excised lesion. Peripheral blood eosinophilia and raised serum Immunoglobulin E (IgE) level supported the diagnosis. Conclusion. The presented patient confirmed the fact that Kimura's disease could occur in different ethnic groups. Histopathological examination, should be performed prior to making the definitive diagnosis.

scholarly journals KIMURA DISEASE : CASE REPORT AND BRIEF REVIEW OF LITERATURE

2018 ◽  
Author(s):  
Harshi Dhingra ◽  
Ruchi Nagpal ◽  
Asif Baliyan ◽  
Sathyavathi R Alva
Keyword(s):  
Diagnostic Procedure ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Review Of Literature ◽  
Review Of The Literature ◽  
Kimura Disease ◽  
Chronic Inflammatory Disorder ◽  
Tissue Eosinophilia ◽  
Disease Case ◽  
Invasive Diagnostic Procedure

Kimura disease is a rare chronic inflammatory disorder of unknown cause, primarily seen in young Asian males. The disease is characterized by painless subcutaneous swelling, blood and tissue eosinophilia and raised IgE levels. Early diagnosis of Kimura’s disease may spare the patient from unnecessary invasive diagnostic procedure. We describe a case of Kimura disease in a 14-year old male presenting with left submandibular swelling and also provide a brief review of the literature. 

scholarly journals A rare cause of bilateral postaural lymphadenopathy: Kimura’s disease

2018 ◽  
Vol 4 (3) ◽  
pp. 843
Author(s):  
Ankur Batra ◽  
Megha Goyal ◽  
Sachin Goel ◽  
Lakshmi Vaid
Keyword(s):  
Young Men ◽  
Unknown Etiology ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Histopathological Features ◽  
Asian Race ◽  
Indian Male ◽  
Atypical Manifestation

<p>Kimura’s disease (KD) is a chronic inflammatory disorder with angiolymphatic proliferation of unknown etiology, usually affecting young men of Asian race but is rare in other races. Affected Indians are very rare. Herein, we present an atypical manifestation of Kimura’s disease occurring in an Indian male who presented with bilateral postaural lymphadenopathy. The diagnosis of Kimura’s disease can be very difficult and misleading; it is important not to ignore histopathological features.</p>

Sign in / Sign up

Export Citation Format

Share Document