scholarly journals Bilateral Posterior Auricular Masses: A Case of Kimura’s Disease

2021 ◽  
pp. 014556132110455
Author(s):  
Fengyang Xie ◽  
Yan Kou ◽  
ShuaiJun Zhang ◽  
Li Shi ◽  
Jie Han ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Immunoglobulin E ◽  
Elevated Serum ◽  
Asian Population ◽  
Chronic Inflammatory Disease ◽  
Unknown Etiology ◽  
Kimura’S Disease ◽  
Subcutaneous Tissues ◽  
Adults And Children ◽  
Blood Eosinophils

Kimura’s disease (KD) is currently considered a rare chronic inflammatory disease of unknown etiology. It is more common in the Asian population, especially in young and middle-aged men, and can involve the lymph nodes, salivary glands, and subcutaneous tissues. It has been reported in adults and children, and is often accompanied by elevated peripheral blood eosinophils and elevated serum immunoglobulin E (IgE). Herein, we report a case of KD in a 46-year-old man with bilateral masses behind the ears since childhood that had gradually enlarged over 40 years. The patient’s peripheral blood eosinophils were elevated, and interestingly, homocysteine levels were also elevated. After surgical resection of the bilateral posterior auricular masses, follow-up over 5 years indicated good recovery and no signs of recurrence.

scholarly journals Kimura's Disease

2009 ◽  
Vol 2009 ◽  
pp. 1-4 ◽  
Author(s):  
Cláudia Savassi Guimaraes ◽  
Natalie Moulton-Levy ◽  
Allen Sapadin ◽  
Claudia Vidal
Keyword(s):  
Immunoglobulin E ◽  
Elevated Serum ◽  
Punch Biopsy ◽  
Unknown Etiology ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Lymphoid Follicles ◽  
Chronic Inflammatory Disorder ◽  
Subcutaneous Nodules ◽  
Good Improvement

Kimuras disease is a chronic inflammatory disorder of unknown etiology. It is rare in the West, but endemic in Asia. It typically presents as solitary or multiple subcutaneous nodules, that slowly increase in size. The lesions are variably painful and pruritic. It often accompanied by regional lymphadenopathy, raised serum eosinophil counts, and markedly elevated serum immunoglobulin E levels. Histologically, the lesions are characterized by reactive lymphoid follicles with eosinophilic infiltration and an increased amount of postcapillary venules. The optimal treatment for KD remains controversial. Although the condition seldom resolves spontaneously, malignant transformation has not been reported to date, and the prognosis is good. We describe a male patient with a 4-year pruritic progressive “bump” in front of his left ear. On physical examination, the patient had 2 discrete lesions on the left side of his face near his ear. Postauricularly, there was a3×5cm erythematous to violaceous, indurated nodule. Preauricularly, there was a similar, but smaller cyst-like nodule. Punch biopsy showed a superficial and deep nodular and interstitial infiltrate, reactive lymphoid follicles with a dense infiltration of eosinophils and areas of eosinophilic follicle lysis. The patient received intralesional triamcinolone acetonide injections 10 mg/cc behind left ear with a good improvement.

scholarly journals Topical Application of Herbal Mixture Extract Inhibits Ovalbumin- or 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Soon Re Kim ◽  
Han-Seok Choi ◽  
Hye Sook Seo ◽  
Youn Kyung Choi ◽  
Yong Cheol Shin ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Topical Application ◽  
Immunoglobulin E ◽  
Elevated Serum ◽  
Ethanol Extract ◽  
Inflammatory Cells ◽  
Skin Lesions ◽  
Serum Ige ◽  
Beneficial Effects ◽  
Blood Eosinophils

KM110329 is four traditional herbal medicine mixtures with anti-inflammatory properties. Atopic dermatitis (AD) is an inflammatory skin disease associated with enhanced T-helper2 (Th2) lymphocyte response to allergens that results in elevated serum eosinophil and Immunoglobulin E (IgE) levels and leukocyte infiltration in atopic skin sites. In this study, we investigated the effect of topical application of KM110329 ethanol extract on the ovalbumin (OVA) or 2,4-dinitrochlorobenzene- (DNCB-) induced AD mouse models. For that purpose, we observed the effects of KM110329 on blood eosinophils, skin mast cells, production of serum IgE, and expression of cytokine mRNA in the atopic dermatitis skin lesions of OVA allergen- or DNCB-treated BALB/c mice. KM110329 significantly reduced blood eosinophils cell numbers in OVA or DNCB-treated BALB/c mice. Histological analyses demonstrated decreased mast cell count as well as dermal infiltration by inflammatory cells. In the skin lesions, mRNA expression of interleukine (IL)-4, IL-13, and IL-17 was inhibited by KM110329. KM110329 also suppressed the production of serum IgE level in both the OVA- and DNCB-induced atopic dermatitis model. Taken together, our results showed that topical application of KM110329 extracts exerts beneficial effects in AD symptoms, suggesting that KM110329 might be a useful candidate for the treatment of AD.

scholarly journals Kimura's Disease: A Case Report

2000 ◽  
Vol 79 (3) ◽  
pp. 195-199 ◽  
Author(s):  
Sebastian J. Karavattathayyil ◽  
John R. Krause
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Lymph Nodes ◽  
Head And Neck ◽  
Salivary Glands ◽  
Immunoglobulin E ◽  
Elevated Serum ◽  
Neck Region ◽  
Kimura’S Disease ◽  
Head And Neck Region

Kimura's disease is a rare, idiopathic condition that usually affects young men of Asian descent. The disease is characterized by swelling and lesions in the head and neck region, with involvement of the subcutaneous soft tissue, major salivary glands, and lymph nodes. Patients almost always have eosinophilia and elevated serum immunoglobulin E levels. The diagnosis is established by biopsy. Kimura's disease is usually self-limiting. Its etiology is unknown but is thought to be a manifestation of an aberrant allergic response. In this paper, we describe the case of a 30-year-old patient who was diagnosed with Kimura's disease at our institution.

scholarly journals Kimura’s disease with recurrent bilateral lacrimal gland involvement in a male Japanese child successfully treated with cyclosporine A

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Keisuke Sugimoto ◽  
Takuji Enya ◽  
Yuichi Morimoto ◽  
Rina Oshima ◽  
Kohei Miyazaki ◽  
...  
Keyword(s):  
Cyclosporine A ◽  
Chronic Inflammatory Disease ◽  
Unknown Etiology ◽  
Kimura’S Disease ◽  
Upper Eyelid ◽  
Laboratory Findings ◽  
Eyelid Swelling ◽  
Old Japanese ◽  
Subcutaneous Mass ◽  
The Masses

Abstract Background Kimura’s disease (KD) is a rare chronic inflammatory disease of unknown etiology. Clinically, KD is characterized by nodular subcutaneous masses, that are typically localized to the neck and head. Involvement of the lacrimal glands and limbs is uncommon and seldom reported. Case presentation We report a case of a 4-year-old Japanese boy presenting with bilateral upper eyelid swelling with nodular subcutaneous lesions and peripheral eosinophilia. Based on clinical, histopathological, and laboratory findings, the patient was diagnosed with KD. An itchy subcutaneous mass on the left arm developed at the age of 14 years. Treatment with steroids was effective. However, as the steroids were tapered after the patient developed side effects, the masses relapsed within a few months. Treatment with cyclosporine A was then initiated, which led to an improvement of clinical features and serial levels of cytokines. Conclusions We report a rare case of KD with a peculiar clinical presentation. The patient responded well to treatment with cyclosporine A.

scholarly journals Kimura’s disease affecting multiple body parts in a 57-year-old female patient: a case report

2019 ◽  
Vol 15 (1) ◽  
Author(s):  
Bo Yu ◽  
Guoxing Xu ◽  
Xiaofan Liu ◽  
Wen Yin ◽  
Hao Chen ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Chest Wall ◽  
Immunoglobulin E ◽  
The Body ◽  
Unknown Etiology ◽  
Kimura’S Disease ◽  
Body Parts ◽  
Tissue Mass ◽  
Left Chest ◽  
The Right

Abstract Background Kimura’s disease (KD) is a rare chronic inflammatory disease with unknown etiology. It usually manifests as a painless soft tissue mass or subcutaneous nodule on one side of the patient’s head and/or neck and rarely affects multiple parts of the body. The disease is more common among young Asian males. Case presentation A 57-year-old Chinese woman complained of multiple masses on her body surface. Ultrasonography was used to examine the retroperitoneal, bilateral neck, bilateral supraclavicular, bilateral axillary, and bilateral inguinal superficial lymph nodes. Enlargement of multiple lymph nodes was found in all areas. Many solid nodules were also found in the right parotid gland and right posterior neck area, respectively. Numerous solid nodules were seen on the left chest wall. Laboratory tests showed that the percentage of eosinophils in the whole blood was 39.40%, total immunoglobulin E (IgE) level was > 5000 kU/L, and serum special IgE to Phadiatop (inhaled allergens) and fx5 (food allergens) were 1.01 and 1.04 kUA/L, respectively. After a complete examination, the masses located in the right neck, retroauricular and left axillary regions, and left chest wall were resected directly. Postoperative pathological findings revealed KD. Conclusions The case discussed in this study is extremely rare and did not meet the common affected areas and age characteristics of KD. This presentation can be used to improve disease awareness among physicians.

scholarly journals Unusual presentation of Kimura’s disease: a case series

2017 ◽  
Vol 3 (4) ◽  
pp. 535
Author(s):  
Aarti S. Salunke ◽  
Ravindranath B. Chavan ◽  
Vasudha A. Belgaumkar ◽  
Neelam Bhatt
Keyword(s):  
Case Series ◽  
Neck Region ◽  
Chronic Inflammatory Disease ◽  
Good Prognosis ◽  
Unknown Etiology ◽  
Kimura’S Disease ◽  
Peripheral Eosinophilia ◽  
Unusual Site ◽  
Head And Neck Region ◽  
Subcutaneous Nodules

<p style="margin-bottom: 0in; line-height: 100%;" align="JUSTIFY">Kimura’s disease is a rare chronic inflammatory disease of unknown etiology, presenting as painless subcutaneous nodules with lymphadenopathy and peripheral eosinophilia, mainly disturbing the head and neck region. It mainly affects Asian males in their 2nd to 4th decade of life. Kimura’s disease, although difficult to diagnose clinically, should be considered in the differential diagnosis of patients who have a primary lymphadenopathy with eosinophilia with or without subcutaneous nodules. It should be investigated accordingly as the disease has an indolent course and good prognosis. Herein we report two cases of Kimura’s disease, of which one had unusual site of involvement. </p>

scholarly journals Kimura’s Disease With Recurrent Bilateral Lacrimal Gland Involvement in a Male Japanese Child Successfully Treated With Cyclosporine A

2021 ◽  
Author(s):  
Keisuke Sugimoto ◽  
Takuji Enya ◽  
Yuichi Morimoto ◽  
Rina Oshima ◽  
Kohei Miyazaki ◽  
...  
Keyword(s):  
Cyclosporine A ◽  
Chronic Inflammatory Disease ◽  
Unknown Etiology ◽  
Kimura’S Disease ◽  
Upper Eyelid ◽  
Laboratory Findings ◽  
Eyelid Swelling ◽  
Old Japanese ◽  
Subcutaneous Mass ◽  
The Masses

Abstract BackgroundKimura’s disease (KD) is a rare chronic inflammatory disease of unknown etiology. Clinically, KD is characterized by nodular subcutaneous masses, typically localized to the neck and head. Involvement of the lacrimal glands and limbs is uncommon and seldom reported. Case presentationWe report a case of a 4-year-old Japanese boy presenting with bilateral upper eyelid swelling with nodular subcutaneous lesions and peripheral eosinophilia. Based on clinical, histopathological, and laboratory findings, the patient was diagnosed with KD. An itchy subcutaneous mass on the left arm developed at the age of 14 years. Treatment with steroids was effective, but the masses relapsed within a few months as the steroids were tapered after the patient developed side effects. Treatment with cyclosporine A was initiated, which led to the improvement of clinical features and serial levels of cytokines. ConclusionsWe report a rare case of KD with a peculiar clinical presentation. The patient responded well to treatment with CsA.

Kimura's disease: clinicopathological study of eight cases

2013 ◽  
Vol 127 (2) ◽  
pp. 170-174 ◽  
Author(s):  
R P S Punia ◽  
R Aulakh ◽  
S Garg ◽  
R Chopra ◽  
H Mohan ◽  
...  
Keyword(s):  
Head And Neck ◽  
Chronic Inflammatory Disease ◽  
Benign Disease ◽  
Kimura’S Disease ◽  
Major Salivary Gland ◽  
Blood Eosinophilia ◽  
Histological Features ◽  
Subcutaneous Tissues ◽  
The Mean ◽  
Peripheral Blood Eosinophilia

AbstractBackground:Kimura's disease is a rare, localised, chronic inflammatory disease. This benign disease involves subcutaneous tissues, the major salivary gland, and lymph nodes primarily in the head and neck area.Method:Clinical details and stained slides of all cases reported as Kimura's disease over a 10-year period were reviewed.Results:There were eight cases of Kimura's disease. The mean age of patients was 22.8 years. One case showed associated nephrotic syndrome and two cases were associated with peripheral blood eosinophilia. All cases showed the typical histopathological features of Kimura's disease.Conclusion:Kimura's disease was first reported in China in 1937. The cause of Kimura's disease is unknown and many theories have been proposed. The eight cases reported here illustrate some of the variations in the mode of presentation and in the histological features of Kimura's disease. Kimura's disease should be considered in the differential diagnosis of patients who present with head and neck swellings and lymphadenopathy, and investigated accordingly.

scholarly journals Kimura’s disease mimicking thoracic spine dumbbell neurogenic tumor: a case report and literature review

BMC Surgery ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Siwei Bi ◽  
Jun Gu ◽  
Chenggong Hu
Keyword(s):  
Thoracic Spine ◽  
Neck Region ◽  
Chronic Inflammatory Disease ◽  
Neurogenic Tumor ◽  
Unknown Etiology ◽  
Kimura’S Disease ◽  
Neurogenic Tumors ◽  
Laboratory Examinations ◽  
First Time

Abstract Background Kimura’s disease is a rare, benign chronic inflammatory disease of unknown etiology that mostly affects Asians. The disease typically presents as subcutaneous masses in the head or neck region that are predominantly found in the preauricular and submandibular areas. Case presentation A 7-year-old boy presenting with paralysis of both lower extremities and a thoracic spine dumbbell mass was initially diagnosed with a neurogenic tumor, but the pathological and laboratory examinations confirmed the diagnosis of Kimura’s disease. The paralysis symptom disappeared rapidly, but the patient had developed a recurrent mass in the cervical vertebral canal at the 9-month follow-up. Conclusion To our knowledge, no prior published literature has revealed Kimura’s disease cases that mimic dumbbell neurogenic tumors. Here, we report such a case of Kimura’s disease for the first time and provide a brief review of the literature.

Kimura Disease

2007 ◽  
Vol 131 (4) ◽  
pp. 650-651
Author(s):  
Mohammad Abuel-Haija ◽  
Matthew T. Hurford
Keyword(s):  
Immunoglobulin E ◽  
Subcutaneous Tissue ◽  
Elevated Serum ◽  
Unknown Etiology ◽  
Systemic Steroid ◽  
Inflammatory Disorder ◽  
Kimura Disease ◽  
Chronic Inflammatory Disorder ◽  
Systemic Steroid Therapy ◽  
Peripheral Blood Eosinophilia

Abstract Kimura disease is a benign rare chronic inflammatory disorder of unknown etiology that involves the lymph nodes and subcutaneous tissue of the head and neck regions. Elevated serum immunoglobulin E levels and peripheral blood eosinophilia are also common. This disease is most common in middle-aged Asian men. Although the etiology is unknown, it most probably represents an aberrant chronic immune response. Treatment for Kimura disease includes surgical resection and regional or systemic steroid therapy. Cytotoxic therapy and radiation have also been utilized. The disease has an excellent prognosis, although it may recur locally.

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