scholarly journals Eosinophilic Enteritis with Ascites in a Patient with Overlap Syndrome

2009 ◽  
Vol 2009 ◽  
pp. 1-3 ◽  
Author(s):  
Spyros Aslanidis ◽  
Athina Pyrpasopoulou ◽  
Kostas Soufleris ◽  
Eirini Kazantzidou ◽  
Stella Douma
Keyword(s):  
Abdominal Pain ◽  
Lupus Erythematosus ◽  
Rare Case ◽  
Hypereosinophilic Syndrome ◽  
Eosinophilic Gastroenteritis ◽  
Overlap Syndrome ◽  
Gastrointestinal Involvement ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Clinical Conditions

Gastrointestinal involvement is frequent in patients with systemic lupus erythematosus (SLE). Eosinophilic gastroenteritis, however, has only rarely been described in rheumatological conditions, despite its reported connection to autoimmune diseases, such as hypereosinophilic syndrome, vasculitides, and systemic mastoidosis. It presents typically with abdominal pain and diarrhea and is only exceptionally associated with ascites. Diagnosis can be problematic, as several other clinical conditions (malignancies, infection/tuberculosis, and inflammatory bowel diseases) have to be ruled out. It is basically a nonsurgical disease, with excellent recovery on conservative treatment. We report the rare case of a young woman with overlap syndrome who presented with abdominal pain and ascites. The diagnosis of eosinophilic enteritis was made based on clinical, radiological, and laboratory criteria. The patient was treated with corticosteroids with excellent response.

scholarly journals A Rare Case of Gastric Crohn’s Disease Complicated by Gastric Carcinoma

2018 ◽  
pp. 1-6
Author(s):  
Marwah Sami M Hussain ◽  
Bandar Idrees Ali ◽  
Abdullah Alzahrani
Keyword(s):  
Gastric Cancer ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Inflammatory Bowel Diseases ◽  
Rare Case ◽  
Small Bowel Adenocarcinoma ◽  
Disease Case ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Upper Gastrointestinal

Background: Inflammatory bowel diseases are strongly associated with colorectal cancer. In addition, a few cases reported with gastric and small bowel adenocarcinoma in gastroduodenal Crohn’s disease. Case report: We reported a case of a 47-Year-old female, who was referred to our surgical department and after a routine gastroscopy which revealed a lesion. Biopsy confirmed gastric well-differentiated adenocarcinoma of limited gastric Crohn’s disease, for a patient on regular anti Crohn’s medication. The patient underwent varying laparoscopic distal gastrectomy. She received adjuvant chemotherapy treatment and thereafter, she was cancer free within the period of 3- years of regular follow up. Conclusion: The only way to diagnose such lesions of a rare case of gastric cancer in a patient with Crohn’s disease is to regularly carry out upper gastrointestinal examinations. Keywords: Inflammatory bowel diseases, Crohn’s disease, Upper gastrointestinal tract Crohn’s disease, Gastric cancer

Anhedonia in irritable bowel syndrome and in inflammatory bowel diseases and its relationship with abdominal pain

2019 ◽  
Vol 31 (3) ◽  
pp. e13531 ◽  
Author(s):  
Luna Carpinelli ◽  
Cristina Bucci ◽  
Antonella Santonicola ◽  
Fabiana Zingone ◽  
Carolina Ciacci ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Inflammatory Bowel Diseases ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Irritable Bowel

scholarly journals Multifocal Osteonecrosis Secondary to Chronic Alcohol Ingestion

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Kazu Matsumoto ◽  
Hiroyasu Ogawa ◽  
Haruhiko Akiyama
Keyword(s):  
Lupus Erythematosus ◽  
Rare Case ◽  
Corticosteroid Treatment ◽  
Chronic Alcohol ◽  
Coagulation Disorders ◽  
Connective Tissue Disorders ◽  
Systemic Lupus ◽  
Related Literature ◽  
Inflammatory Bowel ◽  
Chronic Alcohol Ingestion

Multifocal osteonecrosis is a relatively rare disorder with an estimated incidence of around 3% among patients diagnosed as having osteonecrosis. Multifocal osteonecrosis is caused by the several conditions including corticosteroid treatment, coagulation disorders, connective tissue disorders including systemic lupus erythematosus (SLE), inflammatory bowel disease, renal transplantation, and underlying malignancies. Alcohol abuse is one of the risk factors for osteonecrosis, and alcohol-induced osteonecrosis is 5% among all the osteonecrosis. Furthermore, the overall incidence of alcohol-induced multifocal osteonecrosis was approximately 6% among all the osteonecrosis induced by the alcohol. Therefore, here, we report an extremely rare case of alcohol-induced multifocal osteonecrosis involving three joints (two knees and one hip) and review the related literature.

scholarly journals Winning the Battle after Three Years of Suffering: A Case of a Refractory Pyoderma Gangrenosum Treatment Challenge

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Isra Ibrahim ◽  
Hammam Shereef ◽  
Ahmed Hashim ◽  
Heba Habbal ◽  
Raai Mahmood ◽  
...  
Keyword(s):  
Pyoderma Gangrenosum ◽  
Lupus Erythematosus ◽  
Ivig Therapy ◽  
Inflammatory Disorder ◽  
Therapeutic Challenge ◽  
Hematological Disorders ◽  
Bowel Diseases ◽  
History Of ◽  
Inflammatory Bowel ◽  
The Right

Pyoderma gangrenosum is an uncommon inflammatory disorder characterized by neutrophilic infiltration of the skin. It can present as skin papules or pustules that progress into painful ulcers. 30–40% of the cases are associated with other systemic diseases such as inflammatory bowel diseases, rheumatoid arthritis, and proliferative hematological disorders. Uniquely, this condition has been associated with systemic lupus erythematosus (SLE). The rarity of this disorder poses a diagnostic and therapeutic challenge. We present a case of a 55-year-old female with a history of SLE and chronic right leg ulcer, presented with increased pain from the ulcer associated with a mild flare of her cutaneous lupus; examination revealed circumferential skin ulcer measuring about 25 cm extending around the right leg above the ankle with prominent fibrinous material and surrounding erythema. Blood work showed elevated WBC with neutrophilic predominance. Serology revealed a positive ANA, elevated RNP, smith, and SSA/Ro antibodies with normal anti-CCP level. Skin biopsy was taken, and it showed a diffuse neutrophilic and lymphocytic infiltrate consistent with the diagnosis of pyoderma gangrenosum. The patient was then treated with topical and systemic steroids and sequentially with dapsone, methotrexate, mycophenolate, and cyclosporine for over a two-year period but failed to show any improvement. Therefore, a trial of intravenous immunoglobulin (IVIG) therapy was attempted and produced a dramatic response after two-month infusions characterized by shrinking in the size of the ulcer and resolving pain. We believe that refractory PG poses a therapeutic challenge, and despite a lack of specific guidelines, IVIG can be attempted if initial suppressive treatment fails to show signs of improvement.

scholarly journals COLD ANTIBODY-MEDIATED AUTOIMMUNE HEMOLYTIC ANEMIA IN A PATIENT WITH OVERLAP SYNDROME OF SYSTEMIC LUPUS ERYTHEMATOSUS WITH SJOGREN’S SYNDROME

2019 ◽  
pp. 3-4
Author(s):  
INDIRA BAIRY ◽  
ANUPAM BERWAL ◽  
CHARANTHEJREDDY V ◽  
MUKHYAPRANA PRABHU
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Female Patient ◽  
Hemolytic Anemia ◽  
Lupus Erythematosus ◽  
Autoimmune Hemolytic Anemia ◽  
Blood Cells ◽  
Rare Case ◽  
Autoimmune Disorder ◽  
Overlap Syndrome ◽  
Systemic Lupus

Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder commonly seen in females characterized by multisystem inflammation with the production of an array of antibodies. Hematological disturbances are common in SLE specifically autoimmune hemolytic anemia (AIHA) which results from the development of autoantibodies directed against antigens on the surface of patient’s own red blood cells. Here, we present a rare case of a 50-year-old female patient presenting with cold antibody-mediated AIHA.

scholarly journals Characteristics of mucosal-associated invariant T cells and their roles in immune diseases

2021 ◽  
Author(s):  
Asako Chiba ◽  
Goh Murayama ◽  
Sachiko Miyake
Keyword(s):  
T Cells ◽  
Lupus Erythematosus ◽  
Cell Receptor ◽  
Mait Cells ◽  
Histocompatibility Complex ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Human Immune ◽  
Derivatives Of ◽  
Riboflavin Synthesis

Abstract Mucosal-associated invariant T (MAIT) cells are a subset of innate-like T cells that express a semi-invariant T cell receptor and are restricted by the molecule major histocompatibility complex class I-related molecule 1 (MR1). MAIT cells recognize biosynthetic derivatives of the riboflavin synthesis pathway present in microbes. MAIT cells have attracted increased interest related to various immune responses because of their unique features including their abundance in humans, nonpeptidic antigens, and ability to respond to antigenic and non-antigenic stimuli. The numbers of circulating MAIT cells are decreased in many immune diseases such as multiple sclerosis, systemic lupus erythematosus, and inflammatory bowel diseases. However, the remaining MAIT cells have an increased cytokine-producing capacity and activated status, which is related to disease activity. Additionally, MAIT cells have been observed at sites of inflammation including the kidneys, synovial fluid and intestinal mucosa. These findings suggest their involvement in the pathogenesis of immune diseases. In this mini-review, we summarize the recent findings of MAIT cells in human immune diseases and animal models, and discuss their role and potential as a therapeutic target.

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