scholarly journals Gastric Mucosal Changes Caused by Lugol's Iodine Solution Spray: Endoscopic Features of 64 Cases on Screening Esophagogastroduodenoscopy

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Daisuke Tsurumaru ◽  
Takashi Utsunomiya ◽  
Shuji Matsuura ◽  
Masahiro Komori ◽  
Satoshi Kawanami ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Gastric Body ◽  
Gastric Disease ◽  
Iodine Solution ◽  
Lugol’S Iodine ◽  
Reticular Pattern ◽  
Before And After ◽  
Mucosal Changes ◽  
Greater Curvature ◽  
Gastric Mucosal Changes

Aim. To clarify the endoscopic mucosal change of the stomach caused by Lugol's iodine solution spray on screening esophagogastroduodenoscopy (EGD).Methods. Sixty-four consecutive patients who underwent EGD for esophageal squamous cell carcinoma screening were included in this study. The records for these patients included gastric mucosa findings before and after Lugol's iodine solution was sprayed. The endoscopic findings of the greater curvature of the gastric body were retrospectively analyzed based on the following findings: fold thickening, exudates, ulcers, and hemorrhage.Results. Mucosal changes occurred after Lugol's solution spray totally in 51 patients (80%). Fold thickening was observed in all 51 patients (80%), and a reticular pattern of white lines was found on the surface of the thickened gastric folds found in 28 of the patients (44%). Exudates were observed in 6 patients (9%).Conclusion. The gastric mucosa could be affected by Lugol's iodine; the most frequent endoscopic finding of this effect is gastric fold thickening, which should not be misdiagnosed as a severe gastric disease.

scholarly journals CDX2 Protein as a Surrogate Marker of Gastric Mucosal Atrophy

2021 ◽  
Vol 10 (3) ◽  
pp. 60-67
Author(s):  
M. N. Parygina ◽  
S. I. Mozgovoi ◽  
A. G. Shimanskaya ◽  
A. V. Kononov
Keyword(s):  
Logistic Regression ◽  
Gastric Mucosa ◽  
Chronic Gastritis ◽  
Regression Models ◽  
Surrogate Marker ◽  
Gastric Body ◽  
Quantitative Index ◽  
Diagnostic Quality ◽  
Logistic Regression Models ◽  
Greater Curvature

The aim of the study is to develop an approach to assess the severity of the gastric mucosa (GM) atrophy based on the immunohistochemical (IHC) technique to improve diagnostic quality of the stage of chronic gastritis (CG) and to implement predictive assessment of risk factors of gastric cancer development.Material and methods. The study included 155 cases of CG selected in accordance with Operational Link for Gastritis Assessment (OLGA)-system (2 samples of antral gastric mucosa (GM), 1 sample of angular GM and 2 samples of corpus GM). All biopsy samples were examined using histological and IHC (CDX2) techniques. An expression semi-quantitative index was developed to characterize CDX2. The results obtained were statistically processed using the Mann-Whitney and Kruskal-Wallis tests, the Spearman correlation coefficient, and the construction of logistic regression models.Results. It was found that the value of the CDX2 index assessed within the GM biopsy samples positively correlates with the gradation of atrophy (r=0.665 (p<0.001)). A positive correlation remains between the CDX2sum index, calculated by summing the CDX2 index values at each of the GM points, and the stage of chronic gastritis according to the OLGA classification (r=0.70 (p<0.01)). When assessing the contribution of changes at each point of biopsy sampling and retrospective correlation of the CDX2 index at two points of the GM and the stage of chronic gastritis, the greatest correlation was found for points 3 (stomach angle) and 5 (greater curvature of the gastric body), at three points – for points 1 (greater curvature antrum), 3 and 5 (r=0.592 (p<0.01)). Logistic regression models were built to predict the stage of chronic gastritis based on the CDX2 index in the specified combinations of points. The following model was chosen as the optimal one: to take biopsies at three points (1, 3, 5) and assess their CDX2 index, with sensitivity equal 80.4%, specificity equal 82.8% and diagnostic accuracy equal 83.9%.Conclusion. The CDX2 semi-quantitative index can be used to evaluate GM atrophy. The performed regression analysis demonstrates its predictive role. The constructed regression model based on the CDX2 semi-quantitative index calculation at two/three points of GM allows increasing predictive value of biopsy investigations and accuracy of stratified assessment of the gastric adenocarcinoma risk development in patients with CG.

COMPARATIVE STUDY OF PATHOLOGICAL FINDINGS AND TRACE ELEMENTS PROFILES OF GASTRIC MUCOSA IN BENIGN GASTRIC DISEASE

1998 ◽  
Vol 08 (02n03) ◽  
pp. 115-123
Author(s):  
S. TSUNODA ◽  
M. ITO ◽  
S. SAKURAI ◽  
M. YUKAWA
Keyword(s):  
Trace Elements ◽  
Gastric Ulcer ◽  
Gastric Mucosa ◽  
Internal Standard ◽  
Endoscopic Examination ◽  
Gastric Body ◽  
Control Group ◽  
Gastric Disease ◽  
Pixe Analysis ◽  
Ulcer Group

The purpose of this study is to clarity how trace elements in gastric mucosa, reflex bile acid and inflammation of gastric mucosa relate to environment of Helicobacter Pylori. Subjects were 33 patients who had colonic endoscopic examination. 11 gastric ulcer and 14 duodenal ulcer patients were chosen as subjects of the study. The control group had 8 members who had no localized lesions. Trace elements were measured by PIXE analysis which use Pd as internal standard. Cu and Zn , especially Zn , were found in large amount in gastric body and antrum. Zn value for the antrum was higher than that for the gastric body. Especially, the values of Zn for antrum showed significant differences between grade I, II and grade III of inflammatory cell infiltration. In gastric ulcer group, the value of Cu indicated high at gastric body and low at antrum. On the other hand, the values of Zn were low at both gastric body and antrum. Particularly, development of atrophy in antrum requires less than one in gastric body; therefore, trace elements decreased in gastric ulcer group.

scholarly journals Vonoprazan-Associated Gastric Mucosal Redness in Non-Helicobacter pylori-Infected and Helicobacter pylori-Eradicated Stomach

2021 ◽  
pp. 751-758
Author(s):  
Kimitoshi Kubo ◽  
Noriko Kimura ◽  
Ryosuke Watanabe ◽  
Masayuki Higashino ◽  
Momoko Tsuda ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Basement Membrane ◽  
Parietal Cell ◽  
Inflammatory Cell ◽  
Gastric Body ◽  
Pathological Features ◽  
Pathological Findings ◽  
Vacuolar Degeneration ◽  
Greater Curvature

Vonoprazan-associated gastric mucosal redness is rare, and its endoscopic and pathological features remain poorly described. We report 4 cases of vonoprazan-associated gastric mucosal redness, that is, 2 cases each in non-<i>Helicobacter pylori</i>-infected and -eradicated stomach. In all cases, esophagogastroduodenoscopy demonstrated spotty and linear redness newly appearing in the greater curvature of the gastric body after initiation of vonoprazan but disappearing after its discontinuation. A tissue biopsy taken from the gastric mucosa with redness revealed various pathological findings and included inflammatory cell infiltration, parietal cell protrusions, oxyntic gland dilatations, congestion, focal hemorrhage with congestion beneath the basement membrane, and vacuolar degeneration of parietal cells. To our knowledge, this is the second report describing the endoscopic and pathological features of vonoprazan-associated gastric mucosal redness.

PORTAL HYPERTENSIVE GASTROPATHY: A COMPREHENSIVE REVIEW

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Shabir Shiekh ◽  
Showkat Kadla ◽  
Bilal Khan ◽  
Nisar Shah
Keyword(s):  
Gastrointestinal Bleeding ◽  
Beta Blockers ◽  
Secondary Prophylaxis ◽  
Deficiency Anemia ◽  
Portal Hypertensive Gastropathy ◽  
Shunt Surgery ◽  
Comprehensive Review ◽  
Mucosal Changes ◽  
Gi Bleed ◽  
Gastric Mucosal Changes

Portal hypertensive gastropathy (PHG) encompasses the gastric mucosal changes occurring in the setting of portal hypertension,both cirrhotic and non-cirrhotic. Its significance lies in causing acute gastrointestinal bleeding and insidious chronic blood loss presenting as iron deficiency anemia. Diagnosis of PHG is straight-forward, made endoscopically often characterized by  a mosaic-like pattern resembling ‘snake-skin’, with or without red spots. Treatment of acute GI bleed is hemodynamic stabilization, vasoconstrictor therapy, antibiotic prophylaxis, non-selective beta-blockers. Endoscopic treatment like APC has a small role. In severe cases, TIPS and shunt surgery can be offered. Secondary prophylaxis of PHG bleeding with non-selective b-blockers is recommended. Keywords: Portal hypertension­, Gastrointestinal bleeding, Cirrhosis, Beta-blockers

Effect of topically applied povidone-iodine on transient evoked otoacoustic emissions in guinea pigs

2003 ◽  
Vol 117 (9) ◽  
pp. 700-703 ◽  
Author(s):  
Recep Yagiz ◽  
Abdullah Tas ◽  
Cem Uzun ◽  
Mustafa Kemal Adali ◽  
Muhsin Koten ◽  
...  
Keyword(s):  
Middle Ear ◽  
Guinea Pigs ◽  
Otoacoustic Emissions ◽  
Povidone Iodine ◽  
Positive Control ◽  
Middle Ear Surgery ◽  
Iodine Solution ◽  
Before And After ◽  
Transiently Evoked Otoacoustic Emissions ◽  
Povidone Iodine Solution

The possible cochlear toxicity of topically applied povidone-iodine solution was investigated in guinea pigs by measuring transiently evoked otoacoustic emissions (TEOAEs). Seven adult pigmented guinea pigs (14 ears) with a normal acoustic pinna reflex were used. After the baseline TEOAE measurements, 0.1mL of povidone-iodine solution was applied transtympanically into the middle ear in the study group. Saline solution and gentamicin were used as negative and positive control, respectively. TEOAE measurements were repeated on the 10th day, and four weeks after the first application. Tympanometric measurements were also carried out for both ears of all animals at the end of the study. Responses in all ears, which had povidone-iodine applied to them, disappeared in a way similar to those recorded in gentamicin-treated ears. Tympanometric measurements at the end of the study showed ’type A’ tympanograms in all ears of all animals. The present study showed that povidone-iodine could have a cochleotoxic effect in guinea pigs. A study in humans with TEOAE before and after middle-ear surgery, where povidone-iodine can reach into the middle-ear cavity, may be useful for evaluating this result for clinical practice.

Gastric mucosal changes of tuberculosis

1942 ◽  
Vol 9 (12) ◽  
pp. 407-411 ◽  
Author(s):  
Donovan C. Browne ◽  
Gordon Mchardy ◽  
Carl Wilen
Keyword(s):  
Mucosal Changes ◽  
Gastric Mucosal Changes

scholarly journals Successful revision surgery for very late-onset stomal obstruction following Gomez gastroplasty: a case report

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yudai Hojo ◽  
Yasunori Kurahashi ◽  
Toshihiko Tomita ◽  
Tsutomu Kumamoto ◽  
Tatsuro Nakamura ◽  
...  
Keyword(s):  
Revision Surgery ◽  
Preoperative Diagnosis ◽  
Late Onset ◽  
Staple Line ◽  
Weight Loss Surgery ◽  
Wedge Resection ◽  
Gastric Pouch ◽  
Sudden Onset ◽  
Gastric Body ◽  
Greater Curvature

Abstract Background Gomez gastroplasty, which was developed in the 1970s as one of the gastric restrictive surgeries for severe obesity, partitions the stomach using a stapler from the lesser towards the greater curvature at the upper gastric body, leaving a small channel. This procedure is no longer performed due to poor outcomes, but surgeons can encounter late-onset complications even decades after the surgery. Here, we report a case of very late-onset stomal obstruction following Gomez gastroplasty which was successfully treated by revision surgery. Case presentation A 58-year-old man was referred to our institution with sudden-onset nausea and vomiting. He underwent weight loss surgery in the USA in 1979, but the details of the surgery were unclear. Esophagogastroduodenoscopy demonstrated a stoma at the greater curvature of the upper gastric body, and fluoroscopy showed retention of contrast medium in the fundus and poor outflow through the stoma. Abdominal computed tomography revealed a staple line partitioning the stomach. Considering these preoperative investigation findings and the period during which the surgery was performed, the patient was diagnosed with very late-onset stomal obstruction following Gomez gastroplasty. Supporting the preoperative diagnosis, the surgical findings revealed a staple line extending from the lesser towards the greater curvature of the upper gastric body and a channel reinforced by a running seromuscular suture on the greater curvature. Moreover, gastric torsion caused by the enlarged proximal gastric pouch was found. Re-gastroplasty involving wedge resection of the original channel was performed followed by construction of a new channel. Postoperative course was uneventful, and the patient no longer had symptoms of stomal obstruction after revision surgery. Conclusions Re-gastroplasty was safe and feasible for very late-onset stomal obstruction following Gomez gastroplasty. Accurate preoperative diagnosis based on the patient’s interview and the investigation findings was important for surgical planning. A careful follow-up is required to prevent excessive weight regain after revision surgery.

Sign in / Sign up

Export Citation Format

Share Document