Effect of topically applied povidone-iodine on transient evoked otoacoustic emissions in guinea pigs

2003 ◽  
Vol 117 (9) ◽  
pp. 700-703 ◽  
Author(s):  
Recep Yagiz ◽  
Abdullah Tas ◽  
Cem Uzun ◽  
Mustafa Kemal Adali ◽  
Muhsin Koten ◽  
...  
Keyword(s):  
Middle Ear ◽  
Guinea Pigs ◽  
Otoacoustic Emissions ◽  
Povidone Iodine ◽  
Positive Control ◽  
Middle Ear Surgery ◽  
Iodine Solution ◽  
Before And After ◽  
Transiently Evoked Otoacoustic Emissions ◽  
Povidone Iodine Solution

The possible cochlear toxicity of topically applied povidone-iodine solution was investigated in guinea pigs by measuring transiently evoked otoacoustic emissions (TEOAEs). Seven adult pigmented guinea pigs (14 ears) with a normal acoustic pinna reflex were used. After the baseline TEOAE measurements, 0.1mL of povidone-iodine solution was applied transtympanically into the middle ear in the study group. Saline solution and gentamicin were used as negative and positive control, respectively. TEOAE measurements were repeated on the 10th day, and four weeks after the first application. Tympanometric measurements were also carried out for both ears of all animals at the end of the study. Responses in all ears, which had povidone-iodine applied to them, disappeared in a way similar to those recorded in gentamicin-treated ears. Tympanometric measurements at the end of the study showed ’type A’ tympanograms in all ears of all animals. The present study showed that povidone-iodine could have a cochleotoxic effect in guinea pigs. A study in humans with TEOAE before and after middle-ear surgery, where povidone-iodine can reach into the middle-ear cavity, may be useful for evaluating this result for clinical practice.

scholarly journals Conjunctival Flora Before and After Application of 5% Povidone-Iodine Solution

10.5772/27588 ◽  
2011 ◽  
Author(s):  
Virginia Vanzzini-Zago ◽  
Jorge Villar-Kuri ◽  
Victor Flores ◽  
Alcantara Castro ◽  
Perez Balbuena Ana Lili
Keyword(s):  
Povidone Iodine ◽  
Iodine Solution ◽  
Before And After ◽  
Conjunctival Flora ◽  
Povidone Iodine Solution

Implantation on the Suture Material and Efficacy of Povidone-iodine Solution

1997 ◽  
Vol 29 (6) ◽  
pp. 473-480 ◽  
Author(s):  
A. Tsunoda ◽  
M. Shibusawa ◽  
Y. Tsunoda ◽  
H. Choh ◽  
M. Takata ◽  
...  
Keyword(s):  
Povidone Iodine ◽  
Suture Material ◽  
Iodine Solution ◽  
Povidone Iodine Solution

scholarly journals An Adverse Reaction in the Pediatric Sleep Laboratory

2016 ◽  
Vol 2016 ◽  
pp. 1-2 ◽  
Author(s):  
Diana Reppucci ◽  
Debra Medin ◽  
Suhail Al-Saleh ◽  
Mary Jane Smith ◽  
Jill Barter ◽  
...  
Keyword(s):  
Adverse Reaction ◽  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Povidone Iodine ◽  
Central Sleep Apnea ◽  
Positive Pressure ◽  
Apnea Hypopnea Index ◽  
Iodine Solution ◽  
Allergic Contact ◽  
Povidone Iodine Solution

We present a case of a 15-month-old boy with Cornelia de Lange Syndrome (NIPBL gene mutation). On a PSG, central sleep apnea (central apnea-hypopnea index of 19/hour) and nocturnal hypoventilation (transcutaneous CO2> 50 mmHg for 53% of the night) were found. A positive pressure initiation study was aborted because the patient developed a serious adverse reaction. The differential diagnosis included a skin fragility condition versus an allergic contact dermatitis to the interface; this could be from the povidone-iodine solution used to clean the NiPPV interface or from the plastic of the interface itself. A skin biopsy was performed which was normal. The reaction was likely secondary to an allergic contact dermatitis from the povidone-iodine solution used to clean the NiPPV interface. The patient is currently tolerating NiPPV.

scholarly journals Perbandingan Daya Hambat Larutan Antiseptik Povidone iodine dengan Ekstrak Daun Sirih terhadap Candida albicans secara In Vitro

2015 ◽  
Vol 4 (3) ◽  
Author(s):  
Septriana Putri ◽  
Aziz Djamal ◽  
Rahmatini Rahmatini ◽  
Cimi Ilmiawati
Keyword(s):  
Candida Albicans ◽  
Leaf Extract ◽  
Vaginal Discharge ◽  
Povidone Iodine ◽  
Inhibitory Effect ◽  
Iodine Solution ◽  
Betel Leaf ◽  
Post Hoc ◽  
Povidone Iodine Solution

Abstrak Candida albicansb (C. albicans) adalah salah satu mikroorganisme penyebab masalah kesehatan reproduksi wanita, yaitu keputihan (fluor albus). Penggunaan larutan povidone iodine dan bahan alam seperti ekstrak daun sirih menjadi pilihan masyarakat sebagai pembersih alat kewanitaan. Tujuan penelitian ini adalah untuk membandingkandaya hambat larutan antiseptik povidone iodine dan ekstrak daun sirih terhadap jamur C. albicans secara in vitro. Penelitian dilakukan terhadap lima isolat jamur C. albicans dengan larutan kontrol akuades.Perlakuan terdiri dari povidone iodine, ekstrak daun sirih dengan konsentrasi 5%, 10%, dan 20%.Hasil penelitian menunjukkan bahwa povidone iodine memiliki daya hambat terhadap C. albicans. Ekstrak daun sirih dengan konsentrasi 5% dan 10% tidak memiliki daya hambat terhadap C. albicans, namun ekstrak daun sirih konsentrasi 20% memiliki daya hambat terhadap C. albicans. Analisis statistik dengan uji ANOVA yang dilanjutkan dengan uji Post-hoc menunjukkan perbedaan bermakna antara daya hambat larutan povidone iodine dan ekstrak daun sirih 20% terhadap kontrol(p < 0.05).Larutan povidone iodine memiliki daya hambat dua kali lebih besar terhadap pertumbuhan C. albicans dibandingkan ekstrak daun sirih 20%. Dari penelitian ini dapat disimpulkan bahwa larutan povidone iodine dan ekstrak daun sirih 20% dapat menghambat pertumbuhan jamur C. albicans secara in vitro. Kata kunci: povidone iodine, ekstrak daun sirih, Candida albicansAbstract Candida albicans (C. albicans) is one of the frequent causes of  reproductive health problems in women, namely vaginal discharge (fluor albus). The antiseptic solution, povidone iodine, is still an option to overcome vaginal discharge. The use of natural materials such as betel (Piper betle L.) leaves extract also become a popular choice as adouche for women. The objective of this study was to compare the inhibitory activity of povidone iodine solution and betel leaf extract against the growth of C. albicans in vitro. We used five different isolates of C. albicans with distilled water as control. Each isolate was treated with povidone iodine solution, betel leaf extract at concentration of 5%, 10%,and 20%. The results showed that povidone iodine had inhibitory effect on C. albicans. Betel leaf extract at concentration of 5% and 10% did not have inhibitory effectwhile betel leaf extract at concentration of 20% hadinhibitory effect on C. albicans. Analysis by ANOVA followed by Post-hoc tests showed a significant difference in inhibitory activity of povidone iodine and betel leaf extract at 20% concentration compared to control (p < 0,05). Povidone iodine solution showed twice as much as inhibitory effect on C. albicans compared to betel leaf extract (20% concentration). It is concluded that povidone iodine solution and betel leaf extract at 20% concentration can inhibit the growth of C. albicans in vitro.Keywords: povidone iodine, betel leaf extract, Candida albicans

scholarly journals The Difference in Incision Wound Closure Time Between 10% Povidone-iodine Solution and Chloramphenicol 2% Ointment in Swiss Webster Mice

2020 ◽  
Vol 2 (6) ◽  
Author(s):  
Selina Wissen ◽  
Borman Sumaji ◽  
Dian Lesmana
Keyword(s):  
Wound Closure ◽  
Povidone Iodine ◽  
Iodine Solution ◽  
Closure Time ◽  
The Difference ◽  
Incision Wound ◽  
Povidone Iodine Solution

Luka adalah cedera fisik yang mengakibatkan rusaknya kulit. Penanganan luka diperlukan untuk mencegah terjadinya infeksi. Agen topikal untuk luka insisi ekstraoral yang umumnya tersedia di puskesmas dan klinik-klinik kesehatan umum maupun gigi yaitu solutiopovidone iodine 10% dan unguentum kloramfenikol 2%. Tujuan penelitian ini adalah untuk mengetahui apakah terdapat perbedaan waktu penutupan luka insisi yang diaplikasikan solutiopovidone iodine 10% dengan unguentum kloramfenikol 2% pada mencit Swiss Webster. Penelitian ini bersifat eksperimental laboratorik, menggunakan 30 ekor mencit Swiss Webster yang dibagi menjadi 2 kelompok. Kelompok I adalah luka insisi pada paha kanan mencit dan diaplikasikan solutiopovidone iodine 10%. Kelompok II adalah luka insisi pada paha kiri mencit dan diaplikasikan unguentum kloramfenikol 2%. Data yang diukur adalah rerata waktu penutupan luka insisi untuk kedua kelompok, kemudian dianalisis menggunakan uji non parametrik Mann-Whitney. Rerata waktu penutupan luka insisi yang diaplikasikan solutiopovidone iodine 10% adalah 5,07±0,691 hari, dan yang diaplikasikan unguentum kloramfenikol 2% adalah 5,03±0,765 hari. Simpulan penelitian adalah tidak terdapat perbedaan waktu penutupan luka insisi yang diaplikasikan solutio povidone iodine 10% dengan unguentum kloramfenikol 2% pada mencit Swiss Webster.   Kata kunci: waktu penutupan luka, luka insisi, solutio povidone iodine 10%, unguentum kloramfenikol 2%  

scholarly journals COMPARATIVE STUDY OF PRE-CAESAREAN VAGINAL WASH WITH 5% POVIDONE – IODINE SOLUTION VERSUS NO WASH IN PREVENTING POSTOPERATIVE INFECTION.

2020 ◽  
pp. 44-46
Author(s):  
Sonali Deshpande ◽  
Shrinivas Gadappa ◽  
Dhanashree Lahane ◽  
Sandeep Mannikatti
Keyword(s):  
Surgical Site Infection ◽  
Wound Infection ◽  
Povidone Iodine ◽  
Prophylactic Antibiotic ◽  
Control Group ◽  
Site Infection ◽  
Iodine Solution ◽  
Interventional Group ◽  
Vaginal Wash ◽  
Povidone Iodine Solution

Objective: To evaluate the efficacy of pre-cesarean vaginal wash using 5% Povidone Iodine solution on rate of post-cesarean section (CS) surgical site infection and compared with No swabbing. Method: A Prospective Randomized controlled Trial was conducted in department of Obstetrics and Gynecology in Government medical college, Aurangabad. In interventional group, vaginal swabbing with a gauze pieces impregnated with 5% Povidone Iodine solution was done for 30 seconds. The swabbing of vagina was not performed in cases assigned to control group, however the standard surgical preparation of abdomen was done in a usual manner for both group. All subject received prophylactic antibiotic cover. Collected data was complied in pre-designed proforma and analysis was done using SPSS 15. Result: The risk of post operative fever and wound infection was significantly reduced in interventional group. No measure difference was noted in seroma and composite wound infection. Also less duration of hospital stay in interventional group was noted. No adverse effect of use of Povidone iodine was reported in the interventional group. Conclusion: Vaginal swabbing with 5% Povidone-iodine pre- LSCS is inexpensive and simple intervention even for low resource setting to decrease surgical site infection.

scholarly journals Remedying Contact Dermatitis in Broiler Chickens with Novel Flooring Treatments

Animals ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1761
Author(s):  
Nathan Freeman ◽  
Frank A. M. Tuyttens ◽  
Alexa Johnson ◽  
Victoria Marshall ◽  
An Garmyn ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Treatment Effect ◽  
Broiler Chickens ◽  
Povidone Iodine ◽  
Iodine Solution ◽  
Gait Impairment ◽  
Welfare Issue ◽  
Povidone Iodine Solution ◽  
Preventative Approach

Contact dermatitis (footpad dermatitis (FPD), hock burns, and breast dermatitis) is a welfare issue for broiler chickens, causing pain and behavioral restrictions. Once lesions develop, often nothing is done to remedy the issue for the affected flock. Our objective was to evaluate novel flooring treatments at the flock level by providing preventative and remedial treatments against contact dermatitis, plumage soiling, and gait impairment. Broilers (n = 546) were housed in 42 pens, with 13 birds/pen. The flooring treatments (four) included used litter (NEG), new pine shavings replaced regularly (POS), a mat filled with 1% povidone-iodine solution (MAT), and the iodine mat placed on a slatted floor (SLAT). Flooring treatments were provided from day one of age (preventative approach; PREV) or day 29 (remedial approach; REM). Contact dermatitis, soiling, gait, and weight were recorded weekly (seven birds/pen). Results showed a treatment effect for all measures, dependent on bird age. Overall, the POS treatment resulted in the best welfare outcomes (FPD, hock burns, and gait). The worst contact dermatitis was found in the MAT and SLAT groups. NEG birds showed little contact dermatitis, opposite to expectations. Weights were lower for PREV-POS in week seven only. The treatments with povidone-iodine were deemed ineffective against contact dermatitis. Access to clean litter prevented and remedied contact dermatitis, and a comparable approach may be commercially feasible.

scholarly journals Il trattamento topico con una matrice contenente mesoglicano in associazione ad acido ialuronico nella gestione delle ulcere cutanee croniche degli arti inferiori/Topical treatment with a matrix containing mesoglycan in association with hyaluronic acid in the management of chronic skin ulcers of the lower limbs

2019 ◽  
Vol 3 (2) ◽  
Author(s):  
Rolando Tasinato ◽  
Paolo Zangrande
Keyword(s):  
Hyaluronic Acid ◽  
Povidone Iodine ◽  
Sono State ◽  
Lower Limbs ◽  
Iodine Solution ◽  
Skin Ulcers ◽  
Vascular Origin ◽  
Chronic Skin ◽  
Wound Bed Preparation ◽  
Povidone Iodine Solution

Un’ulcera cutanea cronica degli arti inferiori rappresenta l’epifenomeno di varie situazioni patologiche che possono coinvolgere, a vari livelli e con diversi gradi di interessamento, i sistemi venoso, arterioso e linfatico della gamba. Recentemente sono state pubblicate numerose evidenze secondo cui i glicosaminoglicani (GAG) svolgono un ruolo importante nella riepitelizzazione delle ulcere cutanee croniche degli arti inferiori, in particolare per quanto riguarda le ulcere ad eziopatogenesi vascolare venosa o mista. In questo articolo riportiamo la nostra esperienza nel trattamento delle ulcere cutanee croniche degli arti inferiori con una metodica che prevede il debridement secondo il protocollo TIME, antisepsi con una soluzione di iodopovidone al 10% la successiva l’applicazione di una medicazione bioattiva contenente GAG e acido ialuronico. Questa metodica è stata confrontata con un’analoga metodica che prevede sempre lo stesso tipo di debridement e di antisepsi con soluzione di iodopovidone al 10% affiancata a una medicazione non bioattiva. A chronic skin ulcer in the lower limbs represents the epiphenomenon of pathologies that may involve, at various levels, the venous, arterial, lymphatic and nervous systems of the leg, which must be identified and adequately treated. Recently, there has been increasing evidence that glycosaminoglycans (GAGs) play a role in the re-epithelialization of chronic skin ulcerative wounds of the lower limbs, particularly as regards ulcers of venous and arterial vascular origin. In this paper we report our experience in the treatment of chronic skin ulcers with debridement according to the TIME Wound Bed Preparation protocol with application of a bioactive dressing containing GAGs and hyaluronic acid, compared to a technique using a standard dressing involving the cleansing of the wound with 10% povidone iodine solution.

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