Cancers in Togo from 1984 to 2008: Epidemiological and Pathological Aspects of 5251 Cases

Objective. To describe the epidemiological and histological aspects of cancers in Togo.Materials and Methods. We made a retrospective review of the epidemiological and pathological features of cancers observed from 1984 to 2008 at the laboratory of pathology of CHU-TOKOIN in Lomé, Togo.Results. During our study period, we found 5251 cases of cancers with an annual average frequency of 210 cases. The sex ratio, male/female, was 0.9 and the average age of occurring was 45.3 years. This average age was 46.9 years for men and 43.8 years for women. The most frequent cancers for men were prostate cancer (12.9%), nonmelanoma skin cancer (10.4%), and gastric cancer (10.3%). For women it was breast cancer (27.1%), cervix cancer (11.2%) and non-Hodgkin lymphoma (6.3%). Histologically, it was carcinomas in 68.1% of the cases, sarcomas in 11% of the cases and non-Hodgkin lymphomas in 12.6% of the cases. Children cancers were primarily Burkitt lymphoma (27.9% of cases) and retinoblastoma (8.5% of cases).Conclusion. This study shows that cancers are frequent in Togo and emphasizes on the necessity of having a cancer register for the prevention and the control of this disease in Togo.

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Association between nonalcoholic fatty liver disease and extrahepatic cancers: a systematic review and meta-analysis

10.21203/rs.3.rs-16707/v2 ◽

2020 ◽

Author(s):

Shou-Sheng Liu ◽

Xue-Feng Ma ◽

Jie Zhao ◽

Shui-Xian Du ◽

Jie Zhang ◽

...

Keyword(s):

Breast Cancer ◽

Prostate Cancer ◽

Gastric Cancer ◽

Pancreatic Cancer ◽

Colorectal Adenomas ◽

Cochrane Library ◽

Extrahepatic Cholangiocarcinoma ◽

Nonalcoholic Fatty Liver ◽

Esophagus Cancer ◽

Cancer Prostate

Abstract Background: NAFLD is tightly associated with various diseases such as diabetes, cardiovascular disease, kidney disease, and cancer. Previous studies had investigated the association between NAFLD and various extrahepatic cancers, but the available data to date is not conclusive. The aim of this study was to investigate the association between NAFLD and various extrahepatic cancers comprehensively. Methods: Searches were conducted of various electronic databases (PubMed, EMBASE, Medline, and the Cochrane Library) to identify observational studies published between 1996 and January 2020 which investigated the association between NAFLD and extrahepatic cancers. The pooled OR/HR/IRR of the association between NAFLD and various extrahepatic cancers were analyzed. Results: A total of 26 studies were included to investigate the association between NAFLD and various extrahepatic cancers. As the results shown, the pooled OR values of the risk of colorectal cancer and adenomas in patients with NAFLD were 1.72 (95%CI: 1.40-2.11) and 1.38 (95%CI: 1.22-1.56), respectively. The pooled OR values of the risk of intrahepatic cholangiocarcinoma and extrahepatic cholangiocarcinoma in patients with NAFLD were 2.40 (95%CI: 1.75-3.31) and 2.24 (95%CI: 1.58-3.17), respectively. The pooled OR value of the risk of breast cancer in patients with NAFLD was 1.68 (95%CI: 1.44-1.97). In addition, NAFLD was also tightly associatied with the risk of gastric cancer, pancreatic cancer, prostate cancer, and esophagus cancer. Conclusions: NAFLD could significantly increase the development risk of colorectal adenomas and cancer, intrahepatic and extrahepatic cholangiocarcinoma, breast cancer, gastric cancer, pancreatic cancer, prostate cancer, and esophagus cancer.

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1053 Sleep Duration And Timing Associated With History Of Breast Prostate And Skin Cancer: Data From A Nationally-representative Sample

SLEEP ◽

10.1093/sleep/zsaa056.1049 ◽

2020 ◽

Vol 43 (Supplement_1) ◽

pp. A400-A400

Author(s):

B Piro ◽

S Garland ◽

P Jean-Pierre ◽

B Gonzalez ◽

A Seixas ◽

...

Keyword(s):

Breast Cancer ◽

Prostate Cancer ◽

Skin Cancer ◽

Cancer Survivors ◽

Sleep Duration ◽

Sleep Disturbances ◽

Sleep Problems ◽

Cancer Type ◽

Cancer Data ◽

History Of

Abstract Introduction Sleep disturbances are a common problem among cancer survivors. Also, cancer patients can have altered circadian rhythms and these changes can continue to affect the patient long after the conclusion of their treatment. This analysis aims to investigate how the sleep and wake times of cancer survivors differ from the rest of the population, depending on the type of cancer. Methods Data from the 2015-2016 National Health and Nutrition Examination Survey were used. Population-weighted data on N=5,581 individuals provided complete data. History of breast, prostate, and skin cancer (melanoma or other) was self-reported. Sleep duration was self-reported in half-hour increments, and typical bedtime and waketime was self-reported. Covariates included age, sex, and race/ethnicity. Weighted linear regressions with sleep duration, bedtime and waketime were examined, with each cancer type as predictor. Results Prevalence was 1.7% for prostate cancer, 1.5% for breast cancer, 2.3% for non-melanoma skin cancer, and 0.8% for melanoma. In adjusted analyses, prostate cancer was associated with an additional 26.5 minutes of average total sleep (95%CI 2.2,50.9, p=0.03), a 23.1 bedtime minutes earlier (95%CI -40.4,-5.8, p=0.009), and no difference in waketime. Breast cancer was associated with a bedtime that was 41.1 minutes later (95%CI 10.3,72.0, p=0.009) and a waketime that was 48.7 minutes later (95%CI 12.5,84.9, p=0.008), but no difference in sleep duration. No statistically significant effects were seen for either type of skin cancer, melanoma or non-melanoma. Conclusion Prostate cancer was associated with an earlier bedtime and associated increased sleep time. Breast cancer, on the other hand, was associated with a phase delay of the sleep period but no change in sleep duration. Skin cancer was not associated with differences in sleep duration or timing. These findings may have implications for not only treatment of sleep problems in different types of cancer, but also possible circadian mechanisms. Support Dr. Grandner is supported by R01MD011600

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Second primary malignancies in gastric cancer: A U.S. population-based study.

Journal of Clinical Oncology ◽

10.1200/jco.2015.33.3_suppl.191 ◽

2015 ◽

Vol 33 (3_suppl) ◽

pp. 191-191

Author(s):

Binay Kumar Shah ◽

Amit Khanal

Keyword(s):

Breast Cancer ◽

Prostate Cancer ◽

Gastric Cancer ◽

Thyroid Cancer ◽

Myeloid Leukemia ◽

Population Based ◽

Second Primary ◽

Population Based Study ◽

Gastrointestinal Malignancies ◽

Second Primary Malignancies

191 Background: Risk of second primary malignancies (SPM) is not known in gastric cancer. In this population based study, we analyzed rates of SPM in gastric cancer. Methods: We selected adult (≥18 years) patients with gastric cancer as first primary malignancy diagnosed from January 1992 to December 2011 from Surveillance, Epidemiology and End Result 13 database. We used SEER*stat’s multiple primary standardized incidence ratio (MP-SIR) session to calculate the risk of SPM diagnosed 6 months after the diagnosis of index gastric cancer. Results: Among 31,818 patients with first primary gastric cancer, 1674 (5.26%) developed 1,839 SPM with observed/expected (O/E) ratio of 1.09 (95% CI = 1.05-1.15, p<0.0001) and excess risk of 16.15 per 10,000 population. The median time to first SPM from the time of diagnosis of stomach cancer was 49 months (range 6 months to 19.08 years). There was significantly increased risk of gastrointestinal malignancies [O/E ratio 1.65 (CI=1.53-1.79, p<0.001)], thyroid cancer [O/E ratio 1.98 (CI=1.32-2.84, p<0.01)] and myeloid leukemia [O/E ratio 1.47(CI=1-2.09, p<0.05)]. Interestingly, there was significantly decreased risk of melanoma, breast cancer and prostate cancer. Conclusions: Our study showed that patients with gastric cancer are at higher risk of gastrointestinal malignancies, thyroid cancer and myeloid leukemia. Similarly, risk of melanoma, breast cancer and prostate cancer in patients with gastric cancer is lower than general population.

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The risk of development of multiple primary malignant tumors involving the thyroid gland

Kazan medical journal ◽

10.17816/kmj1555 ◽

2012 ◽

Vol 93 (4) ◽

pp. 616-623

Author(s):

Z A Afanas’eva ◽

S F Bakunin

Keyword(s):

Breast Cancer ◽

Prostate Cancer ◽

Thyroid Cancer ◽

Relative Risk ◽

Skin Cancer ◽

Thyroid Gland ◽

Malignant Tumors ◽

Uterine Cancer ◽

Second Malignancy ◽

Number Of Patients

Aim. To determine the relative risk of developing other malignant tumors in patients with thyroid cancer and and the risk of developing thyroid cancer in patients with other malignancies. Methods. A retrospective analysis of 116 patients with multiple neoplasia including thyroid gland involvement was conducted for the period from 1973 to 2010. In order to estimate the relative risk of development of multiple neoplasias including thyroid gland lesions used was the following formula: relative risk = [a / (a + b)] / [c / (c + d)], where a is the number of patients with thyroid cancer with a second malignancy; b is the number of patients with thyroid cancer without a second malignancy; c is the number of patients in the population affected by the same malignant disease, as patients in group a; d is the number of people in the population without any cancer-related pathology. Results. In patients with carcinomas of the thyroid gland the relative risk is higher than in the general population for developing metachronous lymphoma (41.8 for men, 31.7 for women), renal cell carcinoma (55.6 for men, 18.5 for women), prostate cancer (35.7), lung and bronchus cancer (18.8 for women), melanoma (17.1 for women), colon cancer (16.7 for women), cervical cancer (15.8), uterine cancer (11.8), breast cancer (11.5 for women), skin cancer (9.5 in women) and the simultaneous development of renal cell carcinoma (33.8 for men and 46.3 for women), prostate cancer (24.4), melanoma (20.6 for women), cancer of the esophagus (19.4 for men, 17.8 for women), colon cancer (19.0 for men), lymphomas (12.8 for men), cervical cancer (11.3), breast cancer (11.0 for women), skin cancer (8.5 for women). The relative risk of developing metachronous cancer of the thyroid gland is higher than that in the population in patients with melanoma (108.0 in men, 50.4 for women), with malignant neoplasms of the lymphoid tissue (40.2 for men, 40.8 for women), uterine cancer (11.8), skin cancer (8.7 in women), breast cancer (8.0 for women). Conclusion. During preventive medical examinations of patients with thyroid cancer the relative risk of developing subsequent cancers must be taken into account for early diagnosis of multiple neoplasias.

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COMPARATIVE ANALYSIS OF COST OF DRUG THERAPY OF THE MOST HIGH-COST ONCOLOGICAL DISEASES IN MOSCOW

Malignant tumours ◽

10.18027/2224-5057-2018-8-2-12-20 ◽

2018 ◽

Vol 8 (2) ◽

pp. 12-20

Author(s):

К. I. Poliakova ◽

M. E. Holownia-Voloskova ◽

M. Yu. Byakhov ◽

T. N. Ermolaeva ◽

A. G. Fisun ◽

...

Keyword(s):

Breast Cancer ◽

Prostate Cancer ◽

Drug Therapy ◽

Health Department ◽

Point Of View ◽

Cancer Register ◽

Number Of Patients ◽

Oncological Diseases ◽

Moscow City ◽

Therapy Costs

Objectives.According to literature and experts, prostate cancer (PC), breast cancer (BC), colon cancer (CC), melanoma (MEL) and renal cell carcinoma (RCC) are the most high-cost oncological diseases. The aim of our study was to calculate the charges for each of these nosologies from the point of view of Moscow’s budget and compare them with each other.Methods.To assess the annual costs of drug therapy in Moscow in patients with PC, BC, CC, MEL and RCC there has been developed an analytical model in MS Excel software, considering the data of Cancer Register, as well as literature sources.Results.There has been estimated that if the costs of drug therapy for all five of assessed types of cancer are taken as 100 %, then the most costly is BC (41 % of costs), then MEL (20 %), RCC (15 %), CC (13 %) and PC (12 %). There has been also calculated, that if the number of patients with all five types of assessed cancer undergoing drug therapy, we would consider as 100 %, the highest percentage of them is in BC (50 % of all patients), then PC (36 %), CC (9 %), MEL (3 %) and RCC (1 %).Conclusions. The structure of drug therapy costs in patients with PC, BC, MEL, CC and RCC in Moscow shows that the most expensive is the treatment of patients with melanoma (for 3 % of patients Moscow City Health Department spends 20 % of charges) and RCC (1 % of patients spends 15 % of charges).

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Cancer incidence in the Krasnoyarsk Krai

Russian Journal of Oncology ◽

10.18821/1028-9984-2015-21-1-76-80 ◽

2016 ◽

Vol 21 (1-2) ◽

pp. 76-80 ◽

Cited By ~ 2

Author(s):

Andrey A. Modestov ◽

I. P Safontsev ◽

R. A Zukov ◽

E. V Slepov ◽

M. P Klimenok ◽

...

Keyword(s):

Breast Cancer ◽

Prostate Cancer ◽

Gastric Cancer ◽

Cancer Incidence ◽

Malignant Tumors ◽

Morbidity Rate ◽

Krasnoyarsk Krai ◽

Medium Term ◽

Cancer Incidence Rate ◽

Term Forecast

The paper is devoted to the study of the incidence of malignant tumors in the Krasnoyarsk Krai throughout 2005-2014. The greatest increase in incidence in the region during the study period - 58.5% was determined in women. There was established the gain in the incidence in the region by 39.5%, as well as there was revealed the advancement on leading localizations. On the basis of established trends there was made calculation for medium-term forecast of the morbidity rate in the region. By 2020, there is expected the gain in the incidence in the Krai by 1.5 times: breast cancer - by 17%, skin cancer - by 22%, lung cancer - by 21.6%, prostate cancer - by 19.6%; for gastric cancer incidence rate will decrease by 5.9%.

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Night work and cancer: A systematic review and meta-analysis.

Journal of Clinical Oncology ◽

10.1200/jco.2013.31.15_suppl.1604 ◽

2013 ◽

Vol 31 (15_suppl) ◽

pp. 1604-1604

Author(s):

Lanhua Tang ◽

Meizuo Zhong ◽

Jin Huang ◽

Shushan Zhao

Keyword(s):

Breast Cancer ◽

Prostate Cancer ◽

Colorectal Cancer ◽

Systematic Review ◽

Malignant Melanoma ◽

Cancer Colorectal ◽

Meta Analysis ◽

Night Work ◽

Cancer Cervix ◽

Non Hodgkin Lymphoma

1604 Background: The association between night work (or shift work) and cancers has been studied for decades. However, researches investigating the association have yielded inconsistent results. Methods: A systematic review and meta-analysis was performed to investigate whether night work is a risk factor for different kinds of cancer. PubMed and Cochrane library search were independently conducted by two authors from January 1960 to January 2013 using keywords related to night work and cancer. According to between-studies heterogeneity, pooled risk ratios (RR) were estimated with fixed or random effects models by STATA 12.0 software. Sensitivity analysis and publication bias were also analyzed. Results: A total of 33 studies were identified according to the inclusion criteria. The aggregate estimate for all cancers combined was [1.35, (1.24-1.47)] with a similar signiﬁcant elevation of breast cancer [1.36, (1.21-1.52)], ovary cancer [1.24, (1.08-1.43)] risk among female, and malignant melanoma [1.58, (1.03-2.44)]. No significant risks were observed as regard to patients with prostate cancer, colorectal cancer, cervix cancer and non-Hodgkin lymphoma. Sensitivity analyses indicated no change in all results but malignant melanoma and colorectal cancer. The RRs became significant differences after removing one study from the colorectal cancer [1.60, (1.70-2.18)]. No publication bias was observed in this meta-analysis. Conclusions: The current meta-analysis suggested that night work played an important role in breast cancer, ovary cancer, and malignant melanoma. However, it might be premature to consider night work as a risk factor for prostate cancer, colorectal cancer, cervix cancer and non-Hodgkin lymphoma. [Table: see text]

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Association between nonalcoholic fatty liver disease and extrahepatic cancers: a systematic review and meta-analysis

10.21203/rs.3.rs-16707/v1 ◽

2020 ◽

Author(s):

Shou-Sheng Liu ◽

Xue-Feng Ma ◽

Jie Zhao ◽

Shui-Xian Du ◽

Jie Zhang ◽

...

Keyword(s):

Breast Cancer ◽

Prostate Cancer ◽

Gastric Cancer ◽

Observational Studies ◽

Pancreas Cancer ◽

Colorectal Adenomas ◽

Cochrane Library ◽

Extrahepatic Cholangiocarcinoma ◽

Esophagus Cancer ◽

Cancer Prostate

Abstract Background NAFLD was tightly associated with various diseases such as diabetes, cardiovascular disease, kidney disease and cancer. Previous studies had investigated the association between NAFLD and various extrahepatic cancers, but the conclusions were remains to be improved. The aim of this study was to investigate the association between NAFLD and various extrahepatic cancer comprehensively. Methods Electronic databases PubMed, EMBASE, Medline, and the Cochrane Library were searched for observational studies published from 1996 to January 2020. Observational studies that reflected the association between NAFLD and extrahepatic cancers were included in this study. The pooled OR/HR/IRR of the association between NAFLD and various extrahepatic cancers were analyzed. Results A total of 26 studies were included for investigating the association between NAFLD and various extrahepatic cancers. As the result shown, the pooled OR values of the risk of colorectal cancer and adenomas in patients with NAFLD were 1.72 (95%CI: 1.40-2.11) and 1.38 (95%CI: 1.22-1.56), respectively. The pooled OR values of the risk of intrahepatic cholangiocarcinoma and extrahepatic cholangiocarcinoma in patients with NAFLD were 2.40 (95%CI: 1.75-3.31) and 2.24 (95%CI: 1.58-3.17), respectively. The pooled OR value of the risk of breast cancer in patients with NAFLD was 1.68 (95%CI: 1.44-1.97). In addition, NAFLD was also tightly associatied with the risk of gastric cancer, pancreas cancer, prostate cancer, and esophagus cancer. Conclusions NAFLD could significantly increase the development risk of colorectal adenomas and cancer, intrahepatic and extrahepatic cholangiocarcinoma, breast cancer, gastric cancer, pancreas cancer, prostate cancer, and esophagus cancer.

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Supplemental Carotenoids Prevent Skin Cancer by Benzo(a)Pyrene, Breast Cancer by Puva, and Gastric Cancer by MNNG. Relevance in Human Chemoprevention

Vitamins and Cancer ◽

10.1007/978-1-4612-5006-7_9 ◽

1986 ◽

pp. 139-159

Author(s):

L. Santamaria ◽

A. Bianchi ◽

A. Arnaboldi ◽

L. Andreoni ◽

G. Santagati ◽

...

Keyword(s):

Breast Cancer ◽

Gastric Cancer ◽

Skin Cancer

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Cancer incidence in UK electricity generation and transmission workers, 1973–2015

Occupational Medicine ◽

10.1093/occmed/kqz082 ◽

2019 ◽

Vol 69 (5) ◽

pp. 342-351 ◽

Cited By ~ 1

Author(s):

T M Sorahan

Keyword(s):

Breast Cancer ◽

Prostate Cancer ◽

Lung Cancer ◽

Small Intestine ◽

Skin Cancer ◽

Cancer Incidence ◽

Electricity Generation ◽

Occupational Exposures ◽

Nasal Cancer ◽

Cancer Morbidity

Abstract Background Long-term health outcomes in cohorts of workers from the electricity supply industry have been studied. Aims The aim of the study was to examine updated cancer incidence findings among a cohort of UK electricity generation and transmission workers. Methods Cancer morbidity experienced by 81 616 employees of the former Central Electricity Generating Board of England and Wales was investigated for the period 1973–2015. All employees had worked for at least 6 months with some employment between 1973 and 1982. Standardized registration ratios (SRRs) were calculated based on national rates. Results Overall cancer morbidity was slightly below expectation in males. Significant excesses were found in male workers for mesothelioma (observed [Obs] 763, SRR 326), skin cancer (non-melanoma) (Obs 5616, SRR 106), and prostate cancer (Obs 4298, SRR 106), and in female workers for cancer of the small intestine (Obs 13, SRR 220), nasal cancer (Obs 11, SRR 407), and breast cancer (Obs 758, SRR 110). More detailed analyses showed important contrasts, particularly for mesothelioma, lung cancer, skin cancer, prostate cancer and breast cancer. Conclusions A clear occupational excess of mesothelioma was not matched by a corresponding excess of asbestos-induced lung cancer. Confident interpretation of the excesses of cancers of the nasal cavities and small intestine is not possible, although occupational exposures received in this industry may well not be involved. An excess of skin cancer in transmission workers may be associated with outdoor working.

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