scholarly journals Tenofovir Nephrotoxicity: 2011 Update

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Beatriz Fernandez-Fernandez ◽  
Ana Montoya-Ferrer ◽  
Ana B. Sanz ◽  
Maria D. Sanchez-Niño ◽  
Maria C. Izquierdo ◽  
...  
Keyword(s):  
Significant Risk ◽  
Kidney Injury ◽  
Transcriptase Inhibitor ◽  
Proximal Tubular Cell ◽  
Tubular Cell ◽  
Tubular Dysfunction ◽  
Cell Secretion ◽  
Risk Patients ◽  
Proximal Tubular ◽  
Reverse Transcriptase Inhibitor

Tenofovir is an acyclic nucleotide analogue reverse-transcriptase inhibitor structurally similar to the nephrotoxic drugs adefovir and cidofovir. Tenofovir is widely used to treat HIV infection and approved for treatment of hepatitis B virus. Despite initial cell culture and clinical trials results supporting the renal safety of tenofovir, its clinical use is associated with a low, albeit significant, risk of kidney injury. Proximal tubular cell secretion of tenofovir explains the accumulation of the drug in these mitochondria-rich cells. Tenofovir nephrotoxicity is characterized by proximal tubular cell dysfunction that may be associated with acute kidney injury or chronic kidney disease. Withdrawal of the drug leads to improvement of analytical parameters that may be partial. Understanding the risk factors for nephrotoxicity and regular monitoring of proximal tubular dysfunction and serum creatinine in high-risk patients is required to minimize nephrotoxicity. Newer, structurally similar molecular derivatives that do not accumulate in proximal tubules are under study.

scholarly journals Author Correction: Altered proximal tubular cell glucose metabolism during acute kidney injury is associated with mortality

2020 ◽  
Vol 2 (9) ◽  
pp. 989-989
Author(s):  
David Legouis ◽  
Sven-Erick Ricksten ◽  
Anna Faivre ◽  
Thomas Verissimo ◽  
Karim Gariani ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Glucose Metabolism ◽  
Kidney Injury ◽  
Proximal Tubular Cell ◽  
Tubular Cell ◽  
Proximal Tubular ◽  
Cell Glucose

scholarly journals Altered proximal tubular cell glucose metabolism during acute kidney injury is associated with mortality

2020 ◽  
Vol 2 (8) ◽  
pp. 732-743
Author(s):  
David Legouis ◽  
Sven-Erick Ricksten ◽  
Anna Faivre ◽  
Thomas Verissimo ◽  
Karim Gariani ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Glucose Metabolism ◽  
Kidney Injury ◽  
Proximal Tubular Cell ◽  
Tubular Cell ◽  
Proximal Tubular ◽  
Cell Glucose

scholarly journals Hypokalemia: A potentially life-threatening complication of tenofovir therapy

2017 ◽  
Vol 5 ◽  
pp. 2050313X1774101 ◽  
Author(s):  
Abhilash Koratala ◽  
Rupam Ruchi
Keyword(s):  
Cardiac Arrest ◽  
Fanconi Syndrome ◽  
Transcriptase Inhibitor ◽  
Tubular Dysfunction ◽  
Nucleotide Analog ◽  
Life Threatening ◽  
Proximal Tubular ◽  
Life Threatening Complication ◽  
Renal Proximal Tubular ◽  
Reverse Transcriptase Inhibitor

Tenofovir is a nucleotide analog reverse transcriptase inhibitor approved for the treatment of HIV and hepatitis B infections. It is widely prescribed and an integral part of the recommended regimens for the treatment of HIV infection in antiretroviral-naive patients. Tenofovir is implicated in renal proximal tubular dysfunction, which can be associated with Fanconi syndrome and hypokalemia. When the hypokalemia is severe, it can lead to life-threatening complications. We describe the case of a 59-year-old woman who suffered a cardiac arrest secondary to severe hypokalemia from tenofovir use.

scholarly journals Nephrotoxicity Of Polymyxin B: Experimental Study In Cells And Implications For Nursing Practice

2014 ◽  
Vol 48 (2) ◽  
pp. 272-277 ◽  
Author(s):  
Luciana Barros de Moura Neiva ◽  
Fernanda Teixeira Borges ◽  
Mirian Watanabe ◽  
Edson de Andrade Pessoa ◽  
Dulce Aparecida Barbosa ◽  
...  
Keyword(s):  
Fluorescent Dyes ◽  
Cell Damage ◽  
Kidney Injury ◽  
In Vitro Study ◽  
Polymyxin B ◽  
Concentration Cell ◽  
Tubular Cells ◽  
Risk Patients ◽  
Proximal Tubular

The aim of the study was to characterize the cell damage mechanisms involved in the pathophysiology of cytotoxicity of polymyxin B in proximal tubular cells (LLC - PK1) and discuss about the nurses interventions to identify at risk patients and consider prevention or treatment of nephrotoxicity acute kidney injury. This is a quantitative experimental in vitro study, in which the cells were exposed to 375μM polymyxin B sulfate concentration. Cell viability was determined by exclusion of fluorescent dyes and morphological method with visualization of apoptotic bodies for fluorescence microscopy. Cells exposed to polymyxin B showed reduced viability, increased number of apoptotic cells and a higher concentration of the enzyme lactate dehydrogenase. The administration of polymyxin B in vitro showed the need for actions to minimize adverse effects such as nephrotoxicity.


scholarly journals Sex Differences in Renal Proximal Tubular Cell Homeostasis

2016 ◽  
Vol 27 (10) ◽  
pp. 3051-3062 ◽  
Author(s):  
Thomas Seppi ◽  
Sinikka Prajczer ◽  
Maria-Magdalena Dörler ◽  
Oliver Eiter ◽  
Daniel Hekl ◽  
...  
Keyword(s):  
Sex Differences ◽  
Proximal Tubular Cell ◽  
Tubular Cell ◽  
Cell Homeostasis ◽  
Renal Proximal Tubular Cell ◽  
Proximal Tubular ◽  
Renal Proximal Tubular

scholarly journals Proximal Tubular Cell Alkalinization Induced by Na+-Glucose Cotransport.

1995 ◽  
Vol 45 (5) ◽  
pp. 785-799 ◽  
Author(s):  
Nobuko HAGIWARA ◽  
Takahiro KUBOTA ◽  
Manabu KUBOKAWA ◽  
Mamoru FUJIMOTO
Keyword(s):  
Proximal Tubular Cell ◽  
Tubular Cell ◽  
Proximal Tubular
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