scholarly journals Exercise Increases Insulin Content and Basal Secretion in Pancreatic Islets in Type 1 Diabetic Mice

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Han-Hung Huang ◽  
Kevin Farmer ◽  
Jill Windscheffel ◽  
Katie Yost ◽  
Mary Power ◽  
...  

Exercise appears to improve glycemic control for people with type 1 diabetes (T1D). However, the mechanism responsible for this improvement is unknown. We hypothesized that exercise has a direct effect on the insulin-producing islets. Eight-week-old mice were divided into four groups: sedentary diabetic, exercised diabetic, sedentary control, and exercised control. The exercised groups participated in voluntary wheel running for 6 weeks. When compared to the control groups, the islet density, islet diameter, andβ-cell proportion per islet were significantly lower in both sedentary and exercised diabetic groups and these alterations were not improved with exercise. The total insulin content and insulin secretion were significantly lower in sedentary diabetics compared to controls. Exercise significantly improved insulin content and insulin secretion in islets in basal conditions. Thus, some improvements in exercise-induced glycemic control in T1D mice may be due to enhancement of insulin content and secretion in islets.

2013 ◽  
Author(s):  
P. Osborn ◽  
C. A. Berg ◽  
A. E. Hughes ◽  
P. Pham ◽  
D. J. Wiebe

2019 ◽  
Vol 34 (6) ◽  
pp. 646-655
Author(s):  
Madison F. Knight ◽  
Michelle M. Perfect

2018 ◽  
Author(s):  
Elena Makhlina ◽  
Tatiana Mokhort ◽  
Yana Navmenova ◽  
Marina Kaplieva ◽  
Irina Savosteeva

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1065-P ◽  
Author(s):  
ANASTASIOS KOUTSOVASILIS ◽  
ALEXIOS SOTIROPOULOS ◽  
ANASTASIA ANTONIOU ◽  
VASILIOS KORDINAS ◽  
DESPINA PAPADAKI ◽  
...  

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1061-P
Author(s):  
SANJEEV N. MEHTA ◽  
DAVIDA F. KRUGER ◽  
BRUCE W. BODE ◽  
JENNIFER E. LAYNE ◽  
BONNIE DUMAIS ◽  
...  

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 378-P
Author(s):  
ANNA R. KAHKOSKA ◽  
JAMIE CRANDELL ◽  
KIMBERLY A. DRISCOLL ◽  
MICHAEL R. KOSOROK ◽  
DAVID M. MAAHS ◽  
...  

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 756-P
Author(s):  
RAVI REDDY ◽  
AMANDA WITTENBERG ◽  
DEBORAH BRANIGAN ◽  
KERRI WINTERS-STONE ◽  
JESSICA R. CASTLE ◽  
...  

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 110-OR
Author(s):  
MARIA J. REDONDO ◽  
MEGAN V. WARNOCK ◽  
LAURA E. BOCCHINO ◽  
SUSAN GEYER ◽  
ALBERTO PUGLIESE ◽  
...  

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