scholarly journals The Beneficial Effect of Direct Peritoneal Resuscitation on Septic Shock in Rats

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Xingjun Luo ◽  
Daolin Jian ◽  
Zuojun Lv
Keyword(s):  
Septic Shock ◽  
Inflammatory Response ◽  
Beneficial Effect ◽  
Multiple Organ Failure ◽  
Hemorrhagic Shock ◽  
Clinical Problem ◽  
Multiple Organ ◽  
Cellular Viability ◽  
Internal Organs ◽  
Organ Systems

The high mortality associated with conventionally resuscitated septic shock and the subsequent multiple-organ failure remain a very significant and costly clinical problem. Conventional simple intravenous resuscitation (CR) from septic shock often fails to restore the progressive splanchnic vasoconstriction and hypoperfusion, and fails to reverse gut-derived systemic inflammatory response and fluid sequestration. Numerous interventions have been used to protect organ systems and cellular viability from the lethal injury accompanying hypoperfusion and ischemia but none of these efforts have been sufficient to halt or reverse the main course of the pathophysiology noted with conventional resuscitated shock. Recently, some studies have found that in hemorrhagic shock, direct peritoneal resuscitation (DPR) not only produces sustained hyperperfusion in viscera but also has immunomodulatory and anti-fluid sequestration effects. Although the etiology and pathogenesis of septic shock and hemorrhagic shock differ, both kinds of shock result in hypoperfusion of the intestines and other internal organs. In this paper, we seek to determine whether DPR has a similar therapeutic effect on septic shock/resuscitation.

scholarly journals COVID-19, septic shock and syndrome of disseminated intravascular coagulation syndrome. Part 1

2020 ◽  
Author(s):  
Victoria O. Bitsadze ◽  
Jamilya Kh. Khizroeva ◽  
Alexander Makatsariya ◽  
Ekaterina V Slukhanchuk ◽  
Maria V Tretyakova ◽  
...  
Keyword(s):  
Septic Shock ◽  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Disseminated Intravascular Coagulation ◽  
Critical Condition ◽  
Multiple Organ ◽  
Systemic Inflammatory Response ◽  
Intravascular Coagulation

The pandemic of a new coronavirus infection (Coronavirus Disease 2019, COVID-19) caused by SARS-CoV-2 became a real challenge to humanity and the medical community in 2020 and raised a number of medical, social and even philosophical questions. An almost avalanche-like increase in the number of infected people in a short time, due to the high contagiousness of viral infection, allowed us to identify groups of patients with mild, moderate and severe forms of the disease. Doctors around the world are faced with an acute problem of treating a large number of patients in critical conditions caused by COVID-19. From the currently available information on clinical cases of COVID-19, it follows that COVID-19 patients in critical condition have a clinical picture of disseminated intravascular coagulation (DIC), septic shock with the development of multiple organ failure. The first part of the article discusses the pathogenesis of non-specific universal biological responses of the body in critical condition - from the Sanarelli-Schwartzman phenomenon to the DIC, septic shock, systemic inflammatory response syndrome and the so-called neutrophil extracellular traps (NETs). The questions of cytokine storm in severe forms of systemic inflammatory response syndrome (SIRS), the role of inflammation in the activation of coagulation, and the relationship between inflammation and thrombosis are discussed. Modern ideas about the mechanisms of so-called NETosis, their role in the occurrence of immunothrombosis and inflammation-induced thrombosis in autoimmune diseases - vasculitis, antiphospholipid syndrome, and systemic lupus erythematosus is highlighted. The article discusses the possibility of participation of ADAMTS-13 metalloproteinase in the pathogenesis of multiple organ failure in severe endotheliopathy in patients with viral septic shock.

Possible role of increased oxidant stress in multiple organ failure after systemic inflammatory response syndrome

2003 ◽  
Vol 31 (4) ◽  
pp. 1048-1052 ◽  
Author(s):  
Takeshi Motoyama ◽  
Kazufumi Okamoto ◽  
Ichirou Kukita ◽  
Masamichi Hamaguchi ◽  
Yoshihiro Kinoshita ◽  
...  
Keyword(s):  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Oxidant Stress ◽  
Multiple Organ ◽  
Systemic Inflammatory Response

scholarly journals Improving the therapy of generalized forms of Meningococcal infection in children using extracorporeal hemocorrection

2021 ◽  
Vol 20 (2) ◽  
pp. 49-56
Author(s):  
K. V. Markova ◽  
E. Yu. Skripchenko ◽  
K. V. Serednyakov ◽  
Yu. V. Lobzin ◽  
N. V. Skripchenko ◽  
...  
Keyword(s):  
Septic Shock ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Multiple Organ ◽  
Meningococcal Infection ◽  
Basic Drug ◽  
Inflammatory Reactions ◽  
Clinical Center ◽  
Refractory Septic Shock ◽  
Group 2

Invasive meningococcal infection is a significant cause of death, reaching 80% in septic shock. The Pediatric Research and Clinical Center for Infectious Diseases (PRCCID) has developed an algorithm for the treatment of children with invasive meningococcal infection with refractory septic shock and multiple organ failure syndrome, which includes basic drug therapy with polymyxin hemoperfusion in combination with extended methods of extracorporeal hemocorrection.Purpose: to evaluate the effectiveness of extracorporeal hemocorrection operations in children with invasive meningococcal infection with refractory septic shock and multiple organ failure syndrome.Materials and research methods: to the intensive care unit of the PRCCID for the analyzed period 2006—2020 34 children were hospitalized with invasive meningococcal infection with refractory septic shock and multiple organ failure syndrome. Two groups were formed: Group 1 — children admitted to the PRCCID in the period 2014—2020 (n = 23), who underwent polymyxin hemoperfusion simultaneously with extended methods of extracorporeal hemocorrection, group 2 — children hospitalized in 2006—201 3 (n = 1 1), methods of extracorporeal hemocorrection were not performed. The Mann-Whitney U-test and ANOVA were used to evaluate the results.Results and discussion: the use of extracorporeal hemocorrection operations in the complex therapy of invasive forms of meningococcal infection with refractory septic shock and multiple organ failure syndrome in children provides stabilization of central hemodynamics, reduces clinical and laboratory inflammatory reactions, helps to reduce the dose of vasopressor drugs and parameters of respiratory support, and also increases patient survival rate by 82.6%.

The Injured Child Is Resistant to Multiple Organ Failure: A Different Inflammatory Response?

2002 ◽  
Vol 53 (6) ◽  
pp. 1058-1063 ◽  
Author(s):  
Casey M. Calkins ◽  
Denis D. Bensard ◽  
Ernest E. Moore ◽  
Robert C. McIntyre ◽  
Christopher C. Silliman ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Multiple Organ ◽  
Injured Child

MODERN ASPECTS OF CCHF PATHOGENESIS

Vestnik ◽  
2021 ◽  
pp. 228-231
Author(s):  
Ф.А. Бердалиева ◽  
Г.Н. Абуова ◽  
Т.В. Полукчи ◽  
Д.С. Алиев ◽  
С.П. Ауезханов
Keyword(s):  
Inflammatory Response ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Causal Relationship ◽  
Vascular System ◽  
Multiple Organ ◽  
High Potential ◽  
Target Cells ◽  
Present Stage ◽  
Relationship Of

На современном этапе в вопросах причинно-следственной связи патофизиологических, иммунологических, биохимических и других процессов, обуславливающих механизм возникновения и течения ККГЛ определены основные векторы: повреждение вирусом клеток - мишеней ( эндотелий сосудистой системы в органах и тканях, моноцитарные макрофаги, гепатоциты и др.); высокий потенциал вируса к репликации; стремительная вирусемия; развертывание локального и генерализованного иммуновоспалительного ответа; нарушение гемостаза и гемодинамики; развитие ДВС синдрома; синдрома полиорганной недостаточности. At the present stage, the main vectors have been identified in the causal relationship of pathophysiological, immunological, biochemical and other processes that determine the mechanism of the occurrence and course of CCGL: damage to target cells by the virus ( endothelium of the vascular system in organs and tissues, monocytic macrophages, hepatocytes, etc.); high potential of the virus for replication; rapid viremia; deployment of a local and generalized immuno-inflammatory response; violation of hemostasis and hemodynamics; development of DIC syndrome; multiple organ failure.

Impact of Age on Septic Shock and Multiple Organ Failure

2018 ◽  
Vol 227 (4) ◽  
pp. e113-e114
Author(s):  
Norma M. Smalls ◽  
Maria F. Nunez ◽  
Gezzer Ortega ◽  
Delaram J. Taghipour
Keyword(s):  
Septic Shock ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Multiple Organ

scholarly journals Infective Endocarditis: Inflammatory Response, Genetic Susceptibility, Oxidative Stress, and Multiple Organ Failure

2019 ◽  
Author(s):  
Pedro Eduardo Alvarado Rubio MD ◽  
Roberto Brugada Molina MD ◽  
Pedro Eduardo Alvarado Ávila MD ◽  
Alejandro González Mora MD ◽  
Cesar Augusto González López MD
Keyword(s):  
Oxidative Stress ◽  
Infective Endocarditis ◽  
Inflammatory Response ◽  
Multiple Organ Failure ◽  
Genetic Susceptibility ◽  
Organ Failure ◽  
Multiple Organ

Septic Shock, Multiple Organ Failure, and Disseminated Intravascular Coagulation

CHEST Journal ◽  
1992 ◽  
Vol 101 (3) ◽  
pp. 816-823 ◽  
Author(s):  
Francois Fourrier ◽  
Claude Chopin ◽  
Jenny Goudemand ◽  
Sylvie Hendrycx ◽  
Claudine Caron ◽  
...  
Keyword(s):  
Septic Shock ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Disseminated Intravascular Coagulation ◽  
Multiple Organ ◽  
Intravascular Coagulation
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