scholarly journals The Effect of Neonatal Leptin Antagonism in Male Rat Offspring Is Dependent upon the Interaction between Prior Maternal Nutritional Status and Post-Weaning Diet

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
J. Beltrand ◽  
D. M. Sloboda ◽  
K. L. Connor ◽  
M. Truong ◽  
M. H. Vickers
Keyword(s):  
High Fat Diet ◽  
Experimental Studies ◽  
Male Rat ◽  
Obesity Risk ◽  
High Fat ◽  
Maternal Nutritional Status ◽  
Rat Offspring ◽  
Pregnancy And Lactation ◽  
Induced Changes ◽  
Plasma Leptin

Epidemiological and experimental studies report associations between overweight mothers and increased obesity risk in offspring. It is unclear whether neonatal leptin regulation mediates this association between overweight mothers and offspring obesity. We investigated the effect of neonatal treatment with a leptin antagonist (LA) on growth and metabolism in offspring of mothers fed either a control or a high fat diet. Wistar rats were fed either a control (CON) or a high fat diet (MHF) during pregnancy and lactation. Male CON and MHF neonates received either saline (S) or a rat-specific pegylated LA on days 3, 5, and 7. Offspring were weaned onto either a control or a high fat (hf) diet. At day 100, body composition, blood glucose,β-hydroxybutyrate and plasma leptin and insulin were determined. In CON and MHF offspring, LA increased neonatal bodyweights compared to saline-treated offspring and was more pronounced in MHF offspring. In the post-weaning period, neonatal LA treatment decreased hf diet-induced weight gain but only in CON offspring. LA treatment induced changes in body length, fat mass, body temperature, and bone composition. Neonatal LA treatment can therefore exert effects on growth and metabolism in adulthood but is dependent upon interactions between maternal and post-weaning nutrition.

scholarly journals Maternal High-Fat Diet Modulates Cnr1 Gene Expression in Male Rat Offspring

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2885
Author(s):  
Dawid Gawliński ◽  
Kinga Gawlińska ◽  
Irena Smaga
Keyword(s):  
Gene Expression ◽  
High Fat Diet ◽  
Cpg Islands ◽  
Male Offspring ◽  
Epigenetic Mechanism ◽  
Male Rat ◽  
High Fat ◽  
Rat Offspring ◽  
Pregnancy And Lactation ◽  
Cnr1 Gene

In recent years, strong evidence has emerged that exposure to a maternal high-fat diet (HFD) provokes changes in the structure, function, and development of the offspring’s brain and may induce several neurodevelopmental and psychiatric illnesses. The aims of this study were to evaluate the effects of a maternal HFD during pregnancy and lactation on depressive-like behavior and Cnr1 gene expression (encoding the CB1 receptor) in brain structures of rat offspring and to investigate the epigenetic mechanism involved in this gene expression. We found that a maternal HFD during pregnancy and lactation induced a depressive-like phenotype at postnatal days (PNDs) 28 and 63. We found that a maternal HFD decreased the Cnr1 mRNA levels in the prefrontal cortex with the increased levels of miR-212-5p and methylation of CpG islands at the Cnr1 promoter and reduced the level of Cnr1 gene expression in the dorsal striatum with an increased level of miR-154-3p in adolescent male offspring. A contrasting effect of a maternal HFD was observed in the hippocampus, where upregulation of Cnr1 gene expression was accompanied by a decrease of miR-154-3p (at PNDs 28 and 63) and miR-212-5p (at PND 63) expression and methylation of CpG islands at the Cnr1 promoter in male offspring. In summary, we showed that a maternal HFD during pregnancy and lactation triggered several epigenetic mechanisms in the brains of rat offspring, which may be related to long-lasting alterations in the next generation and produce behavioral changes in offspring, including a depressive-like phenotype.

High-fat diet induced changes in lumbar vertebra of the male rat offsprings

2016 ◽  
Vol 118 (7) ◽  
pp. 711-721 ◽  
Author(s):  
Zeljka Peric Kacarevic ◽  
Darija Snajder ◽  
Andela Maric ◽  
Nikola Bijelic ◽  
Olga Cvijanovic ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Lumbar Vertebra ◽  
Male Rat ◽  
High Fat ◽  
Induced Changes

Maternal high-fat diet during gestation and lactation alters hepatic gene expression in male rat offspring

Appetite ◽  
2011 ◽  
Vol 57 ◽  
pp. S15
Author(s):  
E.R. Ewald ◽  
B. Sun ◽  
R.H. Purcell ◽  
R.S. Lee ◽  
J.B. Potash ◽  
...  
Keyword(s):  
Gene Expression ◽  
High Fat Diet ◽  
Male Rat ◽  
Hepatic Gene Expression ◽  
High Fat ◽  
Rat Offspring

scholarly journals Maternal Melatonin Therapy Rescues Prenatal Dexamethasone and Postnatal High-Fat Diet Induced Programmed Hypertension in Male Rat Offspring

2015 ◽  
Vol 6 ◽  
Author(s):  
You-Lin Tain ◽  
Jiunn-Ming Sheen ◽  
Hong-Ren Yu ◽  
Chih-Cheng Chen ◽  
Mao-Meng Tiao ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Male Rat ◽  
High Fat ◽  
Rat Offspring

Perinatal exposure to chlorpyrifos and/or a high-fat diet is associated with liver damage in male rat offspring

2021 ◽  
pp. 203678
Author(s):  
Marion Guibourdenche ◽  
Hiba El Khayat El Sabbouri ◽  
Fidéline Bonnet ◽  
Narimane Djekkoun ◽  
Hafida Khorsi-Cauet ◽  
...  
Keyword(s):  
Liver Damage ◽  
High Fat Diet ◽  
Male Rat ◽  
Perinatal Exposure ◽  
High Fat ◽  
Rat Offspring

scholarly journals Maternal high-fat diet induces obesity and adrenal and thyroid dysfunction in male rat offspring at weaning

2012 ◽  
Vol 590 (21) ◽  
pp. 5503-5518 ◽  
Author(s):  
J. G. Franco ◽  
T. P. Fernandes ◽  
C. P. D. Rocha ◽  
C. Calviño ◽  
C. C. Pazos-Moura ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Thyroid Dysfunction ◽  
Male Rat ◽  
High Fat ◽  
Rat Offspring

scholarly journals Alteration of the Early Development Environment by Maternal Diet and the Occurrence of Autistic-like Phenotypes in Rat Offspring

2021 ◽  
Vol 22 (18) ◽  
pp. 9662
Author(s):  
Kinga Gawlińska ◽  
Dawid Gawliński ◽  
Ewelina Kowal-Wiśniewska ◽  
Małgorzata Jarmuż-Szymczak ◽  
Małgorzata Filip
Keyword(s):  
High Fat Diet ◽  
Maternal Obesity ◽  
Maternal Diet ◽  
Repetitive Behavior ◽  
Autism Spectrum ◽  
High Fat ◽  
Development Environment ◽  
Rat Offspring ◽  
Adolescent Offspring ◽  
Pregnancy And Lactation

Epidemiological and preclinical studies suggest that maternal obesity increases the risk of autism spectrum disorder (ASD) in offspring. Here, we assessed the effects of exposure to modified maternal diets limited to pregnancy and lactation on brain development and behavior in rat offspring of both sexes. Among the studied diets, a maternal high-fat diet (HFD) disturbed the expression of ASD-related genes (Cacna1d, Nlgn3, and Shank1) and proteins (SHANK1 and TAOK2) in the prefrontal cortex of male offspring during adolescence. In addition, a maternal high-fat diet induced epigenetic changes by increasing cortical global DNA methylation and the expression of miR-423 and miR-494. As well as the molecular changes, behavioral studies have shown male-specific disturbances in social interaction and an increase in repetitive behavior during adolescence. Most of the observed changes disappeared in adulthood. In conclusion, we demonstrated the contribution of a maternal HFD to the predisposition to an ASD-like phenotype in male adolescent offspring, while a protective effect occurred in females.

scholarly journals Maternal high-fat diet intensifies the metabolic response to stress in male rat offspring

2017 ◽  
Vol 14 (1) ◽  
Author(s):  
Roxana Karbaschi ◽  
Homeira Zardooz ◽  
Fariba Khodagholi ◽  
Leila Dargahi ◽  
Mina Salimi ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Metabolic Response ◽  
Male Rat ◽  
High Fat ◽  
Rat Offspring ◽  
Response To Stress
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