SP065DIMETHYL FUMARATE TREATMENT PREVENTS PRENATAL DEXAMETHASONE AND POSTNATAL HIGH FAT DIET INDUCED PROGRAMMED HYPERTENSION IN MALE RAT OFFSPRING

In recent years, strong evidence has emerged that exposure to a maternal high-fat diet (HFD) provokes changes in the structure, function, and development of the offspring’s brain and may induce several neurodevelopmental and psychiatric illnesses. The aims of this study were to evaluate the effects of a maternal HFD during pregnancy and lactation on depressive-like behavior and Cnr1 gene expression (encoding the CB1 receptor) in brain structures of rat offspring and to investigate the epigenetic mechanism involved in this gene expression. We found that a maternal HFD during pregnancy and lactation induced a depressive-like phenotype at postnatal days (PNDs) 28 and 63. We found that a maternal HFD decreased the Cnr1 mRNA levels in the prefrontal cortex with the increased levels of miR-212-5p and methylation of CpG islands at the Cnr1 promoter and reduced the level of Cnr1 gene expression in the dorsal striatum with an increased level of miR-154-3p in adolescent male offspring. A contrasting effect of a maternal HFD was observed in the hippocampus, where upregulation of Cnr1 gene expression was accompanied by a decrease of miR-154-3p (at PNDs 28 and 63) and miR-212-5p (at PND 63) expression and methylation of CpG islands at the Cnr1 promoter in male offspring. In summary, we showed that a maternal HFD during pregnancy and lactation triggered several epigenetic mechanisms in the brains of rat offspring, which may be related to long-lasting alterations in the next generation and produce behavioral changes in offspring, including a depressive-like phenotype.

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Maternal high-fat diet intensifies the metabolic response to stress in male rat offspring

Nutrition & Metabolism ◽

10.1186/s12986-017-0177-3 ◽

2017 ◽

Vol 14 (1) ◽

Cited By ~ 4

Author(s):

Roxana Karbaschi ◽

Homeira Zardooz ◽

Fariba Khodagholi ◽

Leila Dargahi ◽

Mina Salimi ◽

...

Keyword(s):

High Fat Diet ◽

Metabolic Response ◽

Male Rat ◽

High Fat ◽

Rat Offspring ◽

Response To Stress

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Maternal Manganese Restriction Increases Susceptibility to High-Fat Diet-Induced Dyslipidemia and Altered Adipose Function in WNIN Male Rat Offspring

Experimental Diabetes Research ◽

10.1155/2011/486316 ◽

2011 ◽

Vol 2011 ◽

pp. 1-11 ◽

Cited By ~ 7

Author(s):

Manisha Ganeshan ◽

Pothaganti B. Sainath ◽

Inagadapa J. Naga Padmavathi ◽

Lagishetty Venu ◽

Yedla Durga Kishore ◽

...

Keyword(s):

Body Composition ◽

Lipid Metabolism ◽

High Fat Diet ◽

Control Diet ◽

Male Rat ◽

Restricted Diet ◽

High Fat ◽

Rat Offspring ◽

Ad Libitum ◽

Fat Feeding

Growthin uterois largely a reflection of nutrient and oxygen supply to the foetus. We studied the effects of Mn restrictionper se, maternal Mn restriction, and postnatal high-fat feeding in modulating body composition, lipid metabolism and adipocyte function in Wistar/NIN (WNIN) rat offspring. Female weanling, WNIN rats receivedad libitumfor 4 months, a control or Mn-restricted diet and were mated with control males. Some restricted mothers were rehabilitated with control diet from conception (MnRC) or parturition (MnRP), and their offspring were raised on control diet. Some restricted offspring were weaned onto control diet (MnRW), while others continued on restricted diet throughout (MnR). A set of offspring from each group was fed high-fat diet from 9 months onwards. Body composition, adipocytes function, and lipid metabolism were monitored in male rat offspring at regular intervals. Maternal manganese restriction increased the susceptibility of the offspring to high-fat-induced adiposity, dyslipidaemia, and a proinflammatory state but did not affect their glycemic or insulin status.

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