In VitroCytotoxic Potential of Essential Oils ofEucalyptus benthamiiand Its Related Terpenes on Tumor Cell Lines

EucalyptusL. is traditionally used for many medicinal purposes. In particular, someEucalyptusspecies have currently shown cytotoxic properties. Local Brazilian communities have used leaves ofE. benthamiias a herbal remedy for various diseases, including cancer. Considering the lack of available data for supporting this cytotoxic effect, the goal of this paper was to study thein vitrocytotoxic potential of the essential oils from young and adult leaves ofE. benthamiiand some related terpenes (α-pinene, terpinen-4-ol, andγ-terpinene) on Jurkat, J774A.1 and HeLa cells lines. Regarding the cytotoxic activity based on MTT assay, the essential oils showed improved results thanα-pinene andγ-terpinene, particularly for Jurkat and HeLa cell lines. Terpinen-4-ol revealed a cytotoxic effect against Jurkat cells similar to that observed for volatile oils. The results of LDH activity indicated that cytotoxic activity of samples against Jurkat cells probably involved cell death by apoptosis. The decrease of cell DNA content was demonstrated due to inhibition of Jurkat cells proliferation by samples as a result of cytotoxicity. In general, the essential oils from young and adult leaves ofE. benthamiipresented cytotoxicity against the investigated tumor cell lines which confirms their antitumor potential.

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A Lipoaminopeptaibol Secreted by Alkalophilic Fungus Emericellopsis alkalina Demonstrates a Strong Cytotoxic Effect against Tumor Cell Lines

Proceedings ◽

10.3390/proceedings2019022004 ◽

2019 ◽

Vol 22 (1) ◽

pp. 4

Author(s):

Eugene Rogozhin ◽

Vera Sadykova

Keyword(s):

Tumor Cell ◽

Cytotoxic Activity ◽

Cell Lines ◽

Cytotoxic Effect ◽

Antimicrobial Effect ◽

Antitumor Antibiotic ◽

Tumor Cell Lines ◽

Normal Cells ◽

Hela Cell Lines

Soil fungi are known to produce and secrete antibiotics with a strong antimicrobial effect towards eukaryotic organisms. In many occasions, these compounds belong to peptides that are products of non-ribosomal biosynthesis and are called peptaibols. Many peptaibols are cytotoxic and some of them suppress tumor cell lines much better than normal cells by inducing calcium-mediated apoptosis. The main antimicrobial lipoaminopeptaibol—emericellipsin A—isolated from the fungus Emericellopsis alkalina strain VKPM F-1428, which demonstrates promising antifungal activity against different fungal taxons,has been found to exhibit selective cytotoxic activity against HepG2 and Hela cell lines (EC50 2.8 and 0.5 μM, respectively) in MTT assays in vitro. This result corresponds to the standard antitumor antibiotic doxorubicin, which has an EC50 value of 440 nM. In a fibroblast toxicity test, emericellipsin A exhibited less cytotoxic activity than doxorubicin (EC50 14 and 0.34 μM, respectively). Therefore, it is less toxic to normal cells than doxirubicin (~40 times), but it yields a more potent cytotoxic effect on tumor cell lines. That is why emericellipsin A can be considered for future more detailed investigations to be an effective antitumor substance.

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Cytotoxic Effect of Brassica oleracea Extract on two Tumor Cell Lines in vitro

Journal of Al-Nahrain University-Science ◽

10.22401/jnus.16.1.20 ◽

2013 ◽

Vol 16 (1) ◽

pp. 137-142

Author(s):

Farooq I. Mohammed ◽

◽

Farah T. Abdullah ◽

Shaimaa Y. Abdulfttah ◽

◽

...

Keyword(s):

Tumor Cell ◽

Brassica Oleracea ◽

Cell Lines ◽

Cytotoxic Effect ◽

Tumor Cell Lines

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Synthesis and in vitro cytotoxic activity of novel hexahydro-2H-pyrido[1,2-b]isoquinolines against human brain tumor cell lines

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(97)10114-7 ◽

1997 ◽

Vol 7 (23) ◽

pp. 2945-2950 ◽

Cited By ~ 6

Author(s):

Axel Monsees ◽

Sabine Laschat ◽

Marc Hotfilder ◽

Johannes Wolff ◽

Klaus Bergander ◽

...

Keyword(s):

Brain Tumor ◽

Tumor Cell ◽

Human Brain ◽

Cytotoxic Activity ◽

Cell Lines ◽

Tumor Cell Lines ◽

Human Brain Tumor ◽

Brain Tumor Cell

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Statins potentiate cytostatic/cytotoxic activity of sorafenib but not sunitinib against tumor cell lines in vitro

Cancer Letters ◽

10.1016/j.canlet.2009.06.022 ◽

2010 ◽

Vol 288 (1) ◽

pp. 57-67 ◽

Cited By ~ 22

Author(s):

Jacek Bil ◽

Lukasz Zapala ◽

Dominika Nowis ◽

Marek Jakobisiak ◽

Jakub Golab

Keyword(s):

Tumor Cell ◽

Cytotoxic Activity ◽

Cell Lines ◽

Tumor Cell Lines

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The ability to overcome multidrug resistance of tumor cell lines by novel acridine cytostatics with condensed heterocyclic rings.

Acta Biochimica Polonica ◽

10.18388/abp.2002_3824 ◽

2002 ◽

Vol 49 (1) ◽

pp. 87-92 ◽

Cited By ~ 7

Author(s):

Maria M Bontemps-Gracz ◽

Agnieszka Kupiec ◽

Ippolito Antonini ◽

Edward Borowski

Keyword(s):

Multidrug Resistance ◽

Tumor Cell ◽

Cytotoxic Activity ◽

Cell Lines ◽

Human Tumor ◽

Heterocyclic Ring ◽

Tumor Cell Lines ◽

Human Tumor Cell Lines

Two recently synthesized groups of acridine cytostatics containing fused heterocyclic ring(s): pyrazoloacridines (PAC) and pyrazolopyrimidoacridines (PPAC) were tested in regard to their in vitro cytotoxic activity towards a panel of sensitive and resistant human tumor cell lines. The obtained results corroborate our earlier hypothesis on the essential role of heterocyclic ring fused to the acridine moiety in the ability of acridine cytostatics to overcome multidrug resistance of tumor cells. The presence, location and kind of substituents considerably influenced both the cytotoxic activity of the derivatives and their ability to overcome multidrug resistance. The same factors also affected the cytostatics ability to differentiate between tumor cell lines with various types of drug exporting pumps.

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Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-e][1,2,4]triazine Derivatives

Molecules ◽

10.3390/molecules25173948 ◽

2020 ◽

Vol 25 (17) ◽

pp. 3948

Author(s):

Zofia Bernat ◽

Anna Szymanowska ◽

Mateusz Kciuk ◽

Katarzyna Kotwica-Mojzych ◽

Mariusz Mojzych

Keyword(s):

Tumor Cell ◽

Cytotoxic Activity ◽

Cell Lines ◽

Cancer Chemotherapy ◽

Cytotoxic Effect ◽

Therapeutic Agents ◽

Tumor Cell Lines ◽

Anticancer Properties ◽

Triazine Derivatives ◽

Micromolar Range

This review focuses on the cytotoxic effect of new synthetic pyrazolo[4,3-e][1,2,4]triazine derivatives against different tumor cell lines. Some annulated pyrazolotriazines i.e., pyrazolo[4,3-e][1,2,4]triazolo[4,3-b][1,2,4]triazines and pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine demonstrated significant broad cytotoxic activity in micromolar range concentration, which could have excellent potential to be new candidate therapeutic agents in cancer chemotherapy.

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