scholarly journals Prognostic Impacts of Hypoxic Markers in Soft Tissue Sarcoma

Sarcoma ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Eivind Smeland ◽  
Thomas K. Kilvaer ◽  
Sveinung Sorbye ◽  
Andrej Valkov ◽  
Sigve Andersen ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Glucose Transporter ◽  
Soft Tissue Sarcomas ◽  
Tissue Microarrays ◽  
Prognostic Indicator ◽  
Prognostic Impact ◽  
Glut 1 ◽  
Negative Prognostic Factor ◽  
Univariate Analyses ◽  
Independent Negative Prognostic Factor

Background.We aimed to explore the prognostic impact of the hypoxia-induced factors (HIFαs) 1 and 2, the metabolic HIF-regulated glucose transporter GLUT-1, and carbonic anhydrase IX (CAIX) in non-gastrointestinal stromal tumor soft tissue sarcomas (non-GIST STS).Methods.Duplicate cores with viable tumor tissue from 206 patients with non-GIST STS were obtained and tissue microarrays were constructed. Immunohistochemistry (IHC) was used to evaluate expression of hypoxic markers.Results.In univariate analyses, GLUT-1 (P<0.001) and HIF-2α (P=0.032) expression correlated significantly with a poor disease-specific survival (DSS). In the multivariate analysis, however, only high expression of GLUT-1 (HR 1.7, CI 95% 1.1–2.7,P=0.021) was a significant independent prognostic indicator of poor DSS.Conclusion.GLUT-1 is a significant independent negative prognostic factor in non-GIST STS.

scholarly journals Platelet-Derived Growth Factors in Non-GIST Soft-Tissue Sarcomas Identify a Subgroup of Patients with Wide Resection Margins and Poor Disease-Specific Survival

Sarcoma ◽  
2010 ◽  
Vol 2010 ◽  
pp. 1-10 ◽  
Author(s):  
Thomas Karsten Kilvaer ◽  
Andrej Valkov ◽  
Sveinung W. Sorbye ◽  
Tom Donnem ◽  
Eivind Smeland ◽  
...  
Keyword(s):  
Growth Factors ◽  
Soft Tissue ◽  
Prognostic Markers ◽  
Soft Tissue Sarcomas ◽  
Tissue Microarrays ◽  
Wide Resection ◽  
Resection Margins ◽  
Prognostic Impact ◽  
Disease Specific Survival ◽  
Disease Specific

Background. Optimal treatment of nongastrointestinal stromal tumor soft-tissue sarcomas (non-GIST STSs) is resection with wide margins. This study investigates the prognostic impact of the angiogenesis-associated platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) in non-GIST STS patients with wide and nonwide resection margins.Method. Tumor samples and clinical data from 249 patients with non-GIST STS were obtained, and tissue microarrays were constructed for each specimen. Immunohistochemistry was used to evaluate the expression of PDGF-A, -B, -C, and -D and PDGFR-αand -β.Results. In the multivariate analysis of patients with wide resection margins, high expression of PDGF-B (, HR = 2.954, and 95% CI = 1.255–6.956) and the coexpression of PDGF-B and PDGFR-α(overall; , high-low/low-high; , HR = 2.678, 95% CI = 0.996–7.200, high/high; , HR = 3.930, 95% CI = 1.542–10.015) were independent negative prognostic markers for disease-specific survival.Conclusion.PDGF-B and the coexpression of PDGF-B and PDGFR-αare strong and independent prognostic factors in non-GIST STSs with wide resection margins.

scholarly journals Prognostic Implications of Glucose Transporter Protein-1 (Glut-1) Overexpression in Bone and Soft-Tissue Sarcomas

2007 ◽  
Vol 37 (12) ◽  
pp. 955-960 ◽  
Author(s):  
M. Endo ◽  
U. Tateishi ◽  
K. Seki ◽  
U. Yamaguchi ◽  
F. Nakatani ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Glucose Transporter ◽  
Soft Tissue Sarcomas ◽  
Glut 1 ◽  
Transporter Protein ◽  
Prognostic Implications

scholarly journals High Prevalence of 5T4/Trophoblast Glycoprotein in Soft Tissue Sarcomas

Cancers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 4841
Author(s):  
Patrick Groothuis ◽  
Nicola Penel ◽  
Antoine Italiano ◽  
Nuria Kotecki ◽  
Fred Dijcks ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Tumor Tissue ◽  
Staining Method ◽  
Soft Tissue Sarcomas ◽  
Tissue Microarrays ◽  
Histological Subtypes ◽  
Scoring Method ◽  
Drug Conjugates ◽  
High Prevalence ◽  
Quantitative Scoring

The expression of 5T4/trophoblast glycoprotein was evaluated in several histological subtypes of soft tissue sarcoma (STS) to determine whether the prevalence and level of expression of this membrane-associated glycoprotein is sufficient for use in targeted therapies. Tumor tissue microarrays containing cores from different histological subtypes of STS were stained using a standardized immunohistochemical staining method to detect 5T4; the level of staining was assessed using a semi-quantitative scoring method. No 5T4 staining was seen in the angiosarcomas and liposarcomas investigated in this study. 5T4 staining in the other STS subtypes was seen in more than 50% of cases, warranting further investigation into whether this antigen could evoke an anti-tumor immune response or can be used as target for the delivery of more potent toxins through antibody drug conjugates.

scholarly journals High expression of CD20+ lymphocytes in soft tissue sarcomas is a positive prognostic indicator

2012 ◽  
Vol 1 (1) ◽  
pp. 75-77 ◽  
Author(s):  
Sveinung W. Sorbye ◽  
Thomas Kilvaer ◽  
Andrej Valkov ◽  
Tom Donnem ◽  
Eivind Smeland ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Prognostic Indicator ◽  
High Expression

scholarly journals Prognostic Impact of Immunohistochemical Expression of Ezrin in Highly Malignant Soft Tissue Sarcomas

2005 ◽  
Vol 11 (17) ◽  
pp. 6198-6204 ◽  
Author(s):  
Wen-Hui Weng ◽  
Jan Åhlén ◽  
Kristina Åström ◽  
Weng-Onn Lui ◽  
Catharina Larsson
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Prognostic Impact ◽  
Immunohistochemical Expression ◽  
Malignant Soft Tissue

scholarly journals Expression Patterns of TOP2A and SIRT1 Are Predictive of Survival in Patients with High-Risk Soft Tissue Sarcomas Treated with a Neoadjuvant Anthracycline-Based Chemotherapy

Cancers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 4877
Author(s):  
Luc M. Berclaz ◽  
Annelore Altendorf-Hofmann ◽  
Hans Roland Dürr ◽  
Alexander Klein ◽  
Martin K. Angele ◽  
...  
Keyword(s):  
High Risk ◽  
Soft Tissue ◽  
Expression Patterns ◽  
Soft Tissue Sarcomas ◽  
Tissue Microarrays ◽  
Clinicopathological Parameters ◽  
Predictors Of Response ◽  
Significant Prolongation ◽  
Response To Chemotherapy ◽  
Pre Treatment

Molecular predictors of response to chemotherapy and survival have not been put into clinical practice in high-risk soft tissue sarcomas (HR-STS) by now. The expression of TOP2A and SIRT1 has implications for the mechanism of action of doxorubicin, which is the backbone of chemotherapy in HR-STS. Pre-treatment samples of 167 patients with HR-STS were collected. Protein expression levels of TOP2A and SIRT1 were evaluated with tissue microarrays and immunohistochemistry and correlated with clinicopathological parameters, including overall survival (OS). The expression of TOP2A and SIRT1 was seen in 47% and 60% of patients with HR-STS, respectively. TOP2A expression was associated with higher tumor grading and shorter 5-year OS. The expression of SIRT1 was correlated with a better 5- and 10-year OS. The combination of high SIRT1 and low TOP2A (“Top survivors”) significantly predicted a better OS compared to other biomarker combinations. A multivariate analysis confirmed the expression of SIRT1 and the “Top survivor” biomarker combination as independent predictive factors of OS. This is the first study to associate SIRT1 overexpression with a statistically significant prolongation of OS in HR-STS. Both individual markers and their combination can be used as predictive indicators for HR-STS patients scheduled for neoadjuvant anthracycline-based chemotherapy.

scholarly journals Prognostic impact of CD57, CD68, M-CSF, CSF-1R, Ki67 and TGF-beta in soft tissue sarcomas

2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Sveinung W Sorbye ◽  
Thomas K Kilvaer ◽  
Andrej Valkov ◽  
Tom Donnem ◽  
Eivind Smeland ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Prognostic Impact ◽  
Tgf Beta

scholarly journals Prognostic impact of peritumoral lymphocyte infiltration in soft tissue sarcomas

2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Sveinung W Sorbye ◽  
Thomas K Kilvaer ◽  
Andrej Valkov ◽  
Tom Donnem ◽  
Eivind Smeland ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Prognostic Impact ◽  
Lymphocyte Infiltration

Status of Surgical Margins and Prognosis in Adult Soft Tissue Sarcomas of the Extremities: A Series of Patients Treated at a Single Institution

2005 ◽  
Vol 23 (1) ◽  
pp. 96-104 ◽  
Author(s):  
A. Gronchi ◽  
P.G. Casali ◽  
L. Mariani ◽  
R. Miceli ◽  
M. Fiore ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Local Recurrence ◽  
Soft Tissue Sarcomas ◽  
Hazard Ratio ◽  
Surgical Margins ◽  
Prognostic Impact ◽  
Positive Surgical Margins ◽  
Positive Margins ◽  
Prognostic Effect ◽  
Marginal Status

Purpose To explore the prognostic effect of microscopic marginal status after surgery for extremity soft tissue sarcomas. Patients and Methods We analyzed 911 consecutive patients surgically treated throughout a 20-year span at a single referral center. Six hundred forty-two were first seen with a primary tumor, and 269, with a locally recurrent tumor. All patients underwent macroscopically complete resection. Microscopic marginal status was negative (tumor size > 1 mm) in 748 patients and positive (≤ 1 mm) in 163 patients. Median follow-up was 107 months. Results Patients with primary disease had a lower disease-specific mortality in comparison to those first examined for recurrence (25% v 37%, respectively, at 10 years). Size, malignancy grade, depth, histotype, and local recurrence had a statistically significant prognostic effect at multivariable analysis, while microscopically positive surgical margins had not, though a trend in favor of negative margins was observed. However, an extra risk was observed for patients with positive margins after 3 to 5 years (hazard ratio, 1.8 after 5 years v 0.8 before 5 years). In patients treated for a local recurrence, the prognostic impact of positive margins was higher (hazard ratio, 1.6). Conclusion Positive surgical margins had a weak adverse prognostic effect, which was more pronounced for those patients escaping an early relapse. This would seem to justify a policy of surgical adequacy in adult soft tissue sarcomas, though clinical decision making in borderline presentations for conservative surgery might be reasonably flexible and shared with the patient. Once a local relapse has occurred, the impact of local treatments seems more critical.

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