scholarly journals The Role of Free Tissue Transfer in Merkel Cell Carcinoma of the Head and Neck

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Aldo V. Londino III ◽  
Brett A. Miles
Keyword(s):  
Cell Carcinoma ◽  
Head And Neck ◽  
Merkel Cell Carcinoma ◽  
Free Tissue Transfer ◽  
Standard Of Care ◽  
Surgical Excision ◽  
Merkel Cell ◽  
Tissue Transfer ◽  
Reconstructive Option

Merkel cell carcinoma (MCC) is an uncommon neuroendocrine malignancy with a propensity for the head and neck. It typically presents asymptomatically in elderly Caucasians and is characterized by early local and regional spread. There is currently limited data on the appropriate algorithm for treatment of MCC. However, multimodal therapy with wide surgical excision with or without radiation therapy has become standard of care. The location of the primary tumor and intensive adjuvant therapy is often required, provides a challenge to the reconstructive head and neck surgeon. Occasionally, free tissue transfer reconstructive techniques are employed in the reconstruction of MCC defects. This paper will discuss the role of free tissue transfer as a reconstructive option after surgery for advanced head and neck MCC.

scholarly journals Nonmelanoma Cutaneous Head and Neck Cancer and Merkel Cell Carcinoma: Current Concepts, Advances, and Controversies

2015 ◽  
Vol 33 (29) ◽  
pp. 3338-3345 ◽  
Author(s):  
Sandro V. Porceddu ◽  
Michael J. Veness ◽  
Alexander Guminski
Keyword(s):  
Cell Carcinoma ◽  
Head And Neck ◽  
Merkel Cell Carcinoma ◽  
Surgical Excision ◽  
Current Evidence ◽  
Ageing Population ◽  
Merkel Cell ◽  
Tumor Boards ◽  
Solar Radiation Exposure ◽  
Cure Rates

Nonmelanoma skin cancer (NMSC) is the most common cancer worldwide and the most frequently observed malignancy in whites. Approximately 75% to 80% are basal cell carcinomas and 20% to 25% are squamous cell carcinomas. Incidence is increasing, partly reflecting an ageing population, and NMSC is more commonly seen in men. The predominant causative agent is ultraviolet solar radiation exposure, with the majority of cases occurring on the head and neck. Surgical excision is typically the treatment of choice, providing histopathologic information, high cure rates, and acceptable cosmetic and functional outcomes. Radiation therapy is reserved for cases where surgery is not the preferred choice or for high-risk cases where adjuvant therapy is recommended. Although overall mortality rates are low, patients with complex cases such as those with immunosuppression should be considered for management within multidisciplinary tumor boards. In contrast, Merkel cell carcinoma is a rare and aggressive malignancy, frequently arising on the head and neck in older whites, with a poorer prognosis. This article focuses on the current evidence guiding practice, recent advances, and areas of controversy in NMSC and Merkel cell carcinoma of the head and neck.

scholarly journals Secondary Merkel Cell Carcinoma Manifested in the Parotid

2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
M. Basati ◽  
K. Kassam ◽  
A. Messiha
Keyword(s):  
Cell Carcinoma ◽  
Head And Neck ◽  
Merkel Cell Carcinoma ◽  
Maxillofacial Surgery ◽  
Neck Region ◽  
Surgical Excision ◽  
Malignant Tumour ◽  
Selective Neck Dissection ◽  
Merkel Cell

Background. Merkel cell carcinoma of the head and neck is a rare and aggressive malignant tumour. Both the dermatological and surgical colleagues should be aware of this entity as lesions usually present on sun exposed areas of the skin such as the head and neck.Main Observation and Treatment. A 69-year-old male originally presented to the maxillofacial surgery department with a growing lesion on the left eyebrow. Histological analysis confirmed Merkel cell carcinoma and consequently surgical excision was carried out. A follow-up PET/CT scan 2 years later demonstrated a hotspot in the left parotid gland. Fine needle aspiration and cytology revealed Merkel cell carcinoma. A subtotal parotidectomy left side with ipsilateral selective neck dissection levels I to III was carried out.Conclusions. Potential secondary Merkel cell carcinoma in the head and neck region should be taken into account when planning short- and long-term follow up for previously diagnosed patients. This followup should involve both dermatological and surgical colleagues.

scholarly journals The Role of Adjuvant Therapy in the Management of Head and Neck Merkel Cell Carcinoma

2015 ◽  
Vol 141 (2) ◽  
pp. 137 ◽  
Author(s):  
Michelle M. Chen ◽  
Sanziana A. Roman ◽  
Julie A. Sosa ◽  
Benjamin L. Judson
Keyword(s):  
Adjuvant Therapy ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Merkel Cell Carcinoma ◽  
Merkel Cell

scholarly journals Merkel Cell Carcinoma of the Head and Neck: A Single Institutional Experience

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
G. Morand ◽  
D. Vital ◽  
T. Pézier ◽  
D. Holzmann ◽  
M. Roessle ◽  
...  
Keyword(s):  
Lymph Node ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Merkel Cell Carcinoma ◽  
Adjuvant Radiotherapy ◽  
Interdisciplinary Approach ◽  
Surgical Excision ◽  
Merkel Cell ◽  
Tertiary Center ◽  
Lymph Node Evaluation

Merkel cell carcinoma (MCC) is a rare cutaneous malignancy occurring mostly in older immunocompromized Caucasian males. A growing incidence of MCC has been reported in epidemiological studies. Treatment of MCC usually consists of surgical excision, pathological lymph node evaluation, and adjuvant radiotherapy. This paper reports the experience of a single tertiary center institution with 17 head and neck Merkel cell carcinoma patients. Median followup for the cohort was 37.5 months. After five years, recurrence-free survival, disease specific survival, and overall survival were 85%, 90%, and 83%, respectively. Our limited data support the use of adjuvant radiotherapy. We also report two cases of MCC located at the vestibule of the nose and two cases of spontaneous regression after diagnostic biopsy. About 40% of our patients were referred to our center for surgical revision and pathological lymph node evaluation. Increased awareness of MCC and an interdisciplinary approach are essential in the management of MCC.

scholarly journals Merkel Cell Carcinoma of the Head and Neck: Epidemiology, Pathogenesis, Current State of Treatment and Future Directions

Cancers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 3506
Author(s):  
Mehran Behruj Yusuf ◽  
Grant McKenzie ◽  
Abbas Rattani ◽  
Paul Tennant ◽  
Jeffrey Bumpous ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Head And Neck ◽  
Merkel Cell Carcinoma ◽  
Merkel Cell ◽  
Cell Of Origin ◽  
Current State ◽  
Risk Patients ◽  
Rapid Pace ◽  
Serology Testing

Merkel cell carcinoma (MCC) is a rare, cutaneous neuroendocrine malignancy with increasing incidence. The skin of the head and neck is a common subsite for MCC with distinctions in management from other anatomic areas. Given the rapid pace of developments regarding MCC pathogenesis (Merkel cell polyoma virus (MCPyV)-positive or virus-negative, cell of origin), diagnosis, staging and treatment, and up to date recommendations are critical for optimizing outcomes. This review aims to summarize currently available literature for MCC of the head and neck. The authors reviewed current literature, including international guidelines regarding MCC pathogenesis, epidemiology, diagnosis, staging, and treatment. Subsequently recommendations were derived including the importance of baseline imaging, MCPyV serology testing, primary site surgery, nodal evaluation, radiotherapy, and the increasing role of immune modulating agents in MCC. MCPyV serology testing is increasingly important with potential distinctions in treatment response and surveillance between virus-positive and virus-negative MCC. Surgical management continues to balance optimizing local control with minimal morbidity. Similarly, radiotherapy continues to have importance in the adjuvant, definitive, and palliative setting for MCC of the head and neck. Immunotherapy has changed the paradigm for advanced MCC, with increasing work focusing on optimizing outcomes for non-responders and high-risk patients, including those with immunosuppression.

scholarly journals Merkel Cell Carcinoma from Molecular Pathology to Novel Therapies

2021 ◽  
Vol 22 (12) ◽  
pp. 6305
Author(s):  
Karolina Stachyra ◽  
Monika Dudzisz-Śledź ◽  
Elżbieta Bylina ◽  
Anna Szumera-Ciećkiewicz ◽  
Mateusz J. Spałek ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Progression Free Survival ◽  
Standard Of Care ◽  
Surgical Excision ◽  
Lymph Node Biopsy ◽  
Merkel Cell ◽  
First Line Therapy ◽  
Mutation Burden ◽  
Node Metastases

Merkel cell carcinoma (MCC) is an uncommon and highly aggressive skin cancer. It develops mostly within chronically sun-exposed areas of the skin. MCPyV is detected in 60–80% of MCC cases as integrated within the genome and is considered a major risk factor for MCC. Viral negative MCCs have a high mutation burden with a UV damage signature. Aberrations occur in RB1, TP53, and NOTCH genes as well as in the PI3K-AKT-mTOR pathway. MCC is highly immunogenic, but MCC cells are known to evade the host’s immune response. Despite the characteristic immunohistological profile of MCC, the diagnosis is challenging, and it should be confirmed by an experienced pathologist. Sentinel lymph node biopsy is considered the most reliable staging tool to identify subclinical nodal disease. Subclinical node metastases are present in about 30–50% of patients with primary MCC. The basis of MCC treatment is surgical excision. MCC is highly radiosensitive. It becomes chemoresistant within a few months. MCC is prone to recurrence. The outcomes in patients with metastatic disease are poor, with a historical 5-year survival of 13.5%. The median progression-free survival is 3–5 months, and the median overall survival is ten months. Currently, immunotherapy has become a standard of care first-line therapy for advanced MCC.

The essential role of radiation therapy in securing locoregional control of merkel cell carcinoma

1990 ◽  
Vol 19 (3) ◽  
pp. 583-591 ◽  
Author(s):  
William H. Morrison ◽  
Lester J. Peters ◽  
Elvio G. Silva ◽  
Charles D. Wendt ◽  
K.Kian Ang ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Essential Role ◽  
Locoregional Control ◽  
Merkel Cell
Sign in / Sign up

Export Citation Format

Share Document