scholarly journals Multiple Symmetric Lipomatosis: A Review of 3 Cases

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Emilio Mevio ◽  
Michele Sbrocca ◽  
Mauro Mullace ◽  
Silvia Viglione ◽  
Niccolò Mevio
Keyword(s):  
Mediterranean Area ◽  
Upper Body ◽  
Cervical Region ◽  
Unknown Etiology ◽  
Surgical Removal ◽  
Upper Aerodigestive Tract ◽  
Madelung's Disease ◽  
Madelung’S Disease ◽  
History Of ◽  
Symmetrical Lipomatosis

Multiple symmetrical lipomatosis, or Madelung's disease, is a rare disease of unknown etiology. It is characterized by the presence of loose adipose tissue deposits localized in the cervical region and in the upper body. The neoformations grow slowly and their initial consequence is purely esthetic. They can, however, lead to compression of the laryngotacheal area and of the esophagus. This disease usually affects middle-aged males from the Mediterranean area with a history of alcohol abuse. Although most cases have been sporadic, a few authors have indicated that the disorder may be hereditary. It is thought that this pathology originates from an alteration in lipid metabolism. Since the patients were asymptomatic temperance and diet was proposed, surgical removal of the lipomatose mass is the treatment of choice in case of complications due to fat mass compression on upper aerodigestive tract. The authors present three cases of Madelung's disease with different and particular manifestations.

scholarly journals Madelung’s disease: case series and literature review

2018 ◽  
Vol 18 (1) ◽  
pp. 30-34
Author(s):  
H Pedan ◽  
E Behanova ◽  
V Calkovsky ◽  
A Hajtman
Keyword(s):  
Head And Neck ◽  
Current Knowledge ◽  
Case Series ◽  
Neck Surgery ◽  
Unknown Etiology ◽  
Madelung's Disease ◽  
Madelung’S Disease ◽  
Disease Case ◽  
History Of ◽  
Review Current

Abstract Madelung’s disease also called benign symmetric lipomatosis is a rare disorder of unknown etiology. The disease affects almost exclusively middle-aged men with a history of multi-year alcohol abuse. The major symptom is presence of non-encapsulated benign fat masses, especially in the area of the head and neck. Limited head and neck movement, dysphagia, and dyspnea may appear as well. The diagnosis is clinical and is supported by imaging methods, often elevated hepatic enzymes in blood serum, and histological examination with finding of mature adipose tissue without signs of proliferation. Therapeutic methods involve liposuction or excision which is a method of choice nowadays. In this article the authors review current knowledge, research state, and present five cases of the Madelung’s disease occurring within the last 10 years at the Clinic of Otorhinolaryngology and Head and Neck Surgery in Martin, Slovakia.

scholarly journals Madelung’s Disease: A Clinical Case and Review of Literature

2013 ◽  
Vol 4 (4) ◽  
pp. 33-35
Author(s):  
Chau Su Niang
Keyword(s):  
Clinical Case ◽  
Medical Science ◽  
Mediterranean Area ◽  
Science Volume ◽  
Unknown Aetiology ◽  
Review Of Literature ◽  
Madelung's Disease ◽  
Madelung’S Disease ◽  
History Of ◽  
Asian Male

Madelung’s disease is a rare disease of unknown aetiology. This disease usually affects middle-aged males from Mediterranean area with history of alcohol abuse. We describe an Asian male presented with typical features of Madelung’s disease. Asian Journal of Medical Science, Volume-4 (2013), Pages 33-35 DOI: http://dx.doi.org/10.3126/ajms.v4i4.7968 

Madelung’s disease: A case report of laryngeal localization and a review of the literature

2021 ◽  
Vol 2 (3) ◽  
Author(s):  
Fabrizia Elli ◽  
◽  
Marco Stacchini ◽  
Alberto Daniele Arosio ◽  
Roberta Priola ◽  
...  
Keyword(s):  
Close Association ◽  
Anterior Part ◽  
Rare Condition ◽  
Surgical Removal ◽  
Resonance Imaging ◽  
Madelung's Disease ◽  
Madelung’S Disease ◽  
Ultrasound Computed Tomography ◽  
Keywords Lipoma ◽  
False Vocal

Madelung’s Disease (MD), also known as benign multiple symmetric lipomatosis or Launois-Bensaude syndrome, is a rare condition. The characteristic feature is the presence of numerous diffuse lipomas at the level of the neck or upper limbs. The etiology is unknown, but a close association with ethyl abuse has been observed. The use of radiological examinations such as ultrasound, computed tomography and magnetic resonance imaging is helpful for the differential diagnosis. There are two classifications mainly used: The Enzi classification and the Donhauser classification. In this article we present a case of MD with laryngeal localization. A 50-year-old man was referred to our department complaining of dysphonia for about 6 months. An abnormal and diffuse enlargement of the anterior part of the neck was noticed, compatible with “Madelung’s Collar”. Fiberoptic examination of the larynx revealed the presence of a lipomatous-like neoformation of the left false vocal cord. The patient underwent surgical removal of the laryngeal neoformation with transoral laser microsurgery. With this article we suggest a possible diagnostic and therapeutic procedure for the treatment of laryngeal lipomatosis. Keywords: Lipoma; TML; Larynx; Dysphonia; ENT

scholarly journals Multiple Symmetric Lipomatosis: A Diagnostic Dilemma

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Mladen Mimica ◽  
Danijel Pravdic ◽  
Emina Nakas-Icindic ◽  
Maja Karin ◽  
Emil Babic ◽  
...  
Keyword(s):  
Rare Condition ◽  
Fat Distribution ◽  
Diagnostic Dilemma ◽  
Disease Etiology ◽  
Neck Masses ◽  
Multiple Symmetric Lipomatosis ◽  
Madelung's Disease ◽  
Madelung’S Disease ◽  
High Incidence ◽  
History Of

Introduction. Multiple symmetric lipomatosis, or Madelung's disease, is a rare condition which is characterized with large symmetrical accumulation of noncapsulated fat tissue in upper arms, neck, and shoulder areas. The disease etiology is unknown, with the highest incidence in the Mediterranean region.Case Presentation. Here, we present the case of Madelung's disease with symmetric fat distribution throughout the neck and history of alcoholism. The patient was treated from several diseases associated with alcoholism and hospitalized several times, but the diagnosis of Madelung's disease was omitted. The thyroid gland disease was excluded, while enlargement of the neck adipose tissue was attributed to obesity.Conclusions. This study points out possible diagnostic mistakes when a physician is not aware of a differentiation diagnosis of symmetrically enlarged neck masses, especially in geographic regions with high incidence of this disease.

Benign symmetrical lipomatosis (madelung's disease)

1981 ◽  
Vol 3 (3) ◽  
pp. 240-243 ◽  
Author(s):  
Louis C. Argenta ◽  
Kenneth D. McClatchey ◽  
William J. Ferrell ◽  
M. Haskell Newman
Keyword(s):  
Madelung's Disease ◽  
Madelung’S Disease ◽  
Benign Symmetrical Lipomatosis ◽  
Symmetrical Lipomatosis

scholarly journals Benign symmetrical lipomatosis (Madelung’S disease)

2000 ◽  
Vol 52 (3) ◽  
pp. 295-297
Author(s):  
S. P. S. Yadav ◽  
Jagat Singh ◽  
Rupender K. Ranga ◽  
R. K. Yadev
Keyword(s):  
Madelung's Disease ◽  
Madelung’S Disease ◽  
Benign Symmetrical Lipomatosis ◽  
Symmetrical Lipomatosis

scholarly journals Multiple Symmetrical Lipomatosis: Madelung’s Disease

2016 ◽  
Vol 7 (5) ◽  
pp. 178-180
Author(s):  
Margarida Carvalho ◽  
Pedro Palma ◽  
Filipa Silva ◽  
Marta Patacho ◽  
Fatima Coelho
Keyword(s):  
Madelung's Disease ◽  
Madelung’S Disease ◽  
Symmetrical Lipomatosis

Proptosis of the eye: a potential form of Madelung’s disease

2021 ◽  
Vol 14 (9) ◽  
pp. e243669
Author(s):  
Shayan Soomro ◽  
Kimia Ziahosseini ◽  
Poonam Sharma
Keyword(s):  
Adipose Tissue ◽  
Case Report ◽  
Optic Nerve ◽  
Medical History ◽  
Madelung's Disease ◽  
Madelung’S Disease ◽  
Potential Form ◽  
History Of ◽  
The Stability ◽  
Genetic Form

Madelung’s disease is a rare disorder characterised by excessive and symmetrical deposits of adipose tissue, typically in the cervicofacial region. Alcohol is a known cause of the condition, however, there are reports that this condition is genetically inherited. Lipomatosis of the orbit has been described in the alcoholic Madelung’s disease, however, in our case report, we believe this is the first reported instance of proptosis caused by the genetic form of the condition. We present a 69-year-old woman, with a medical history of genetic Madelung’s disease, who presented with bilateral proptosis worse in her right eye. Her ocular examination was normal apart from exophthalmometry, showing bilateral proptosis. This was confirmed by an MRI, which further showed intraorbital fat deposition bilaterally. Due to the stability of her condition, no treatment was deemed necessary. We highlight the importance of monitoring for progressive optic nerve compromise and liposarcomatous malignant transformation.

A case of multiple symmetrical lipomatosis (Madelung’s disease)

1999 ◽  
Vol 26 (3) ◽  
pp. 349-353 ◽  
Author(s):  
Setsuko Morinaka ◽  
Tomonobu Sato ◽  
Hirofumi Miyoshi ◽  
Kazumasa Iwashita
Keyword(s):  
Madelung's Disease ◽  
Madelung’S Disease ◽  
Symmetrical Lipomatosis
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