scholarly journals Combination Drug Delivery Approaches in Metastatic Breast Cancer

2012 ◽  
Vol 2012 ◽  
pp. 1-17 ◽  
Author(s):  
Jun H. Lee ◽  
Anjan Nan
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Metastatic Breast Cancer ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Single Agent ◽  
Metastatic Breast ◽  
Delivery Systems ◽  
Water Soluble ◽  
Combination Drug

Disseminated metastatic breast cancer needs aggressive treatment due to its reduced response to anticancer treatment and hence low survival and quality of life. Although in theory a combination drug therapy has advantages over single-agent therapy, no appreciable survival enhancement is generally reported whereas increased toxicity is frequently seen in combination treatment especially in chemotherapy. Currently used combination treatments in metastatic breast cancer will be discussed with their challenges leading to the introduction of novel combination anticancer drug delivery systems that aim to overcome these challenges. Widely studied drug delivery systems such as liposomes, dendrimers, polymeric nanoparticles, and water-soluble polymers can concurrently carry multiple anticancer drugs in one platform. These carriers can provide improved target specificity achieved by passive and/or active targeting mechanisms.

scholarly journals Liposomal Doxorubicin in the Treatment of Breast Cancer Patients: A Review

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Juan Lao ◽  
Julia Madani ◽  
Teresa Puértolas ◽  
María Álvarez ◽  
Alba Hernández ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Patients ◽  
Early Breast Cancer ◽  
Drug Delivery Systems ◽  
Liposomal Doxorubicin ◽  
Single Agent ◽  
Metastatic Breast ◽  
Delivery Systems ◽  
Breast Cancer Patients

Drug delivery systems can provide enhanced efficacy and/or reduced toxicity for anticancer agents. Liposome drug delivery systems are able to modify the pharmacokinetics and biodistribution of cytostatic agents, increasing the concentration of the drug released to neoplastic tissue and reducing the exposure of normal tissue. Anthracyclines are a key drug in the treatment of both metastatic and early breast cancer, but one of their major limitations is cardiotoxicity. One of the strategies designed to minimize this side effect is liposome encapsulation. Liposomal anthracyclines have achieved highly efficient drug encapsulation and they have proven to be effective and with reduced cardiotoxicity, as a single agent or in combination with other drugs for the treatment of either anthracyclines-treated or naïve metastatic breast cancer patients. Of particular interest is the use of the combination of liposomal anthracyclines and trastuzumab in patients with HER2-overexpressing breast cancer. In this paper, we discuss the different studies on liposomal doxorubicin in metastatic and early breast cancer therapy.

scholarly journals A mitochondria-targeted delivery system of doxorubicin and evodiamine for the treatment of metastatic breast cancer

RSC Advances ◽  
2019 ◽  
Vol 9 (63) ◽  
pp. 37067-37078
Author(s):  
Xiaoyan Tan ◽  
Yanlin Zhou ◽  
Li Shen ◽  
Han Jia ◽  
Xiaorong Tan
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Metastatic Breast Cancer ◽  
Therapeutic Effect ◽  
Delivery System ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
Metastatic Breast ◽  
Nano Drug Delivery ◽  
Targeted Delivery System

For mitochondria-targeted nano-drug delivery systems against cancer, effectively targeting and releasing the drug into mitochondria are the keys to improve the therapeutic effect.

scholarly journals Single-agent lapatinib for HER2-overexpressing advanced or metastatic breast cancer that progressed on first- or second-line trastuzumab-containing regimens

2009 ◽  
Vol 20 (6) ◽  
pp. 1026-1031 ◽  
Author(s):  
K.L. Blackwell ◽  
M.D. Pegram ◽  
E. Tan-Chiu ◽  
L.S. Schwartzberg ◽  
M.C. Arbushites ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Single Agent ◽  
Metastatic Breast ◽  
Second Line

Liposomes: Ideal drug delivery systems in breast cancer

2021 ◽  
Author(s):  
Sedighe Forouhari ◽  
Zahra Beygi ◽  
Zahra Mansoori ◽  
Sara Hajsharifi ◽  
Fatemeh Heshmatnia ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems

scholarly journals Low molecular mass chitosan as carrier for a hydrodynamically balanced system for sustained delivery of ciprofloxacin hydrochloride

2012 ◽  
Vol 62 (2) ◽  
pp. 237-250 ◽  
Author(s):  
Anurag Verma ◽  
Ashok Bansal ◽  
Amitava Ghosh ◽  
Jayanta Pandit
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Molecular Mass ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Water Soluble ◽  
Sustained Delivery ◽  
Ciprofloxacin Hydrochloride ◽  
Water Soluble Drug ◽  
Major Interest

Low molecular mass chitosan as carrier for a hydrodynamically balanced system for sustained delivery of ciprofloxacin hydrochloride Chitosan has become a focus of major interest in recent years due to its excellent biocompatibility, biodegradability and non-toxicity. Although this material has already been extensively investigated in the design of different types of drug delivery systems, it is still little explored for stomach specific drug delivery systems. The objective of the present investigation was to explore the potential of low molecular mass chitosan (LMCH) as carrier for a hydrodynamically balanced system (HBS) for sustained delivery of water soluble drug ciprofloxacin hydrochloride (CP). Various formulations were prepared by physical blending of drug and polymer(s) in varying ratios followed by encapsulation into hard gelatin capsules. All the formulations remained buoyant in 0.1 mol L-1 HCl (pH 1.2) throughout the experiment. Effect of addition of xanthan gum (XG) or ethyl cellulose (EC) on drug release was also investigated. Zero order drug release was obtained from the formulations containing LMCH alone or in combination with XG, and in one instance also with EC. Our results suggest that LMCH alone or in combination with XG is an excellent material for stomach specific sustained delivery of CP from hydrodynamically balanced single unit capsules.

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