scholarly journals A mitochondria-targeted delivery system of doxorubicin and evodiamine for the treatment of metastatic breast cancer

RSC Advances ◽  
2019 ◽  
Vol 9 (63) ◽  
pp. 37067-37078
Author(s):  
Xiaoyan Tan ◽  
Yanlin Zhou ◽  
Li Shen ◽  
Han Jia ◽  
Xiaorong Tan
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Metastatic Breast Cancer ◽  
Therapeutic Effect ◽  
Delivery System ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
Metastatic Breast ◽  
Nano Drug Delivery ◽  
Targeted Delivery System

For mitochondria-targeted nano-drug delivery systems against cancer, effectively targeting and releasing the drug into mitochondria are the keys to improve the therapeutic effect.

scholarly journals Combination Drug Delivery Approaches in Metastatic Breast Cancer

2012 ◽  
Vol 2012 ◽  
pp. 1-17 ◽  
Author(s):  
Jun H. Lee ◽  
Anjan Nan
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Metastatic Breast Cancer ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Single Agent ◽  
Metastatic Breast ◽  
Delivery Systems ◽  
Water Soluble ◽  
Combination Drug

Disseminated metastatic breast cancer needs aggressive treatment due to its reduced response to anticancer treatment and hence low survival and quality of life. Although in theory a combination drug therapy has advantages over single-agent therapy, no appreciable survival enhancement is generally reported whereas increased toxicity is frequently seen in combination treatment especially in chemotherapy. Currently used combination treatments in metastatic breast cancer will be discussed with their challenges leading to the introduction of novel combination anticancer drug delivery systems that aim to overcome these challenges. Widely studied drug delivery systems such as liposomes, dendrimers, polymeric nanoparticles, and water-soluble polymers can concurrently carry multiple anticancer drugs in one platform. These carriers can provide improved target specificity achieved by passive and/or active targeting mechanisms.

Co-administration of biocompatible self-assembled polylactic acid–hyaluronic acid block copolymer nanoparticles with tumor-penetrating peptide-iRGD for metastatic breast cancer therapy

2018 ◽  
Vol 6 (19) ◽  
pp. 3163-3180 ◽  
Author(s):  
Caifeng Deng ◽  
Xiaohong Xu ◽  
Drunp Tashi ◽  
Yongmei Wu ◽  
Bingyin Su ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hyaluronic Acid ◽  
Metastatic Breast Cancer ◽  
Block Copolymer ◽  
Cancer Therapy ◽  
Polylactic Acid ◽  
Targeted Delivery ◽  
Metastatic Breast ◽  
Chemotherapeutic Drugs ◽  
Breast Cancer Therapy

The safe and efficient targeted delivery of chemotherapeutic drugs has remained a challenge in metastatic breast cancer therapy.

scholarly journals PO80 NEUTROPENIA MAY BE A PREDICTION MARKER OF THERAPEUTIC EFFECT IN METASTATIC BREAST CANCER PATIENTS TREATED WITH ERIBULIN

The Breast ◽  
2013 ◽  
Vol 22 ◽  
pp. S47
Author(s):  
Yuri Yoshimura ◽  
Yukiko Kajiwara ◽  
Mariko Kochi ◽  
Miho Kono ◽  
Mitsuya Ito ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Cancer Patients ◽  
Therapeutic Effect ◽  
Metastatic Breast ◽  
Breast Cancer Patients

Targeted delivery of microRNA-145 to metastatic breast cancer by peptide conjugated branched PEI gene carrier

2013 ◽  
Vol 21 (11) ◽  
pp. 1201-1209 ◽  
Author(s):  
Hwa Jeong Lee ◽  
Ran Namgung ◽  
Won Jong Kim ◽  
Jae Il Kim ◽  
In-Kyu Park
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Targeted Delivery ◽  
Metastatic Breast ◽  
Gene Carrier

Thioaptamer-conjugated CD44-targeted delivery system for the treatment of breast cancer in vitro and in vivo

2015 ◽  
Vol 24 (4) ◽  
pp. 359-371 ◽  
Author(s):  
Wei Fan ◽  
Xiang Wang ◽  
Baoyue Ding ◽  
Haimin Cai ◽  
Xudong Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Delivery System ◽  
Targeted Delivery ◽  
Targeted Delivery System
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