scholarly journals Thyroid Hormone and Wound Healing

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Joshua D. Safer
Keyword(s):  
Wound Healing ◽  
Thyroid Hormone ◽  
Thyroid Disease ◽  
Hair Growth ◽  
Therapeutic Potential ◽  
Hormone Action ◽  
Review Of The Literature ◽  
Thyroid Hormone Action

Although thyroid hormone is one of the most potent stimulators of growth and metabolic rate, the potential to use thyroid hormone to treat cutaneous pathology has never been subject to rigorous investigation. A number of investigators have demonstrated intriguing therapeutic potential for topical thyroid hormone. Topical T3has accelerated wound healing and hair growth in rodents. Topical T4has been used to treat xerosis in humans. It is clear that the use of thyroid hormone to treat cutaneous pathology may be of large consequence and merits further study. This is a review of the literature regarding thyroid hormone action on skin along with skin manifestations of thyroid disease. The paper is intended to provide a context for recent findings of direct thyroid hormone action on cutaneous cellsin vitroandin vivowhich may portend the use of thyroid hormone to promote wound healing.

scholarly journals The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo

2008 ◽  
Vol 105 (49) ◽  
pp. 19544-19549 ◽  
Author(s):  
I. Astapova ◽  
L. J. Lee ◽  
C. Morales ◽  
S. Tauber ◽  
M. Bilban ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Action ◽  
Thyroid Hormone Action

scholarly journals Comparison of Thyroidectomized Calf Serum and Stripped Serum for the Study of Thyroid Hormone Action in Human Skin Fibroblasts In Vitro

Thyroid ◽  
2009 ◽  
Vol 19 (6) ◽  
pp. 639-644 ◽  
Author(s):  
Lars C. Moeller ◽  
Craig Wardrip ◽  
Marek Niekrasz ◽  
Samuel Refetoff ◽  
Roy E. Weiss
Keyword(s):  
Thyroid Hormone ◽  
Human Skin ◽  
Calf Serum ◽  
Skin Fibroblasts ◽  
Hormone Action ◽  
Human Skin Fibroblasts ◽  
Thyroid Hormone Action

scholarly journals Quyu Shengji Formula Facilitates Diabetic Wound Healing via Inhibiting the Expression of Prostaglandin Transporter

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Yi Lu ◽  
Xiaojie Ding ◽  
Fei Qi ◽  
Yi Ru ◽  
Le Kuai ◽  
...  
Keyword(s):  
Wound Healing ◽  
Therapeutic Potential ◽  
Quantitative Polymerase Chain Reaction ◽  
Expression Patterns ◽  
Therapeutic Effects ◽  
Diabetic Ulcer ◽  
Angiogenesis Factor ◽  
Endothelial Growth Factor

Background. Quyu Shengji Formula (QSF), a Chinese medicine formula widely used in the clinic, has proven therapeutic effects on diabetic ulcers. Nevertheless, the potential mechanism of how QSF cures diabetic ulcer remains elusive. Objective. To assess the mechanism of QSF against wound healing defects in diabetes. Methods. Db/db mice were adopted to determine the therapeutic potential of QSF. Further histology analysis was performed by hematoxylin and eosin (H&E) staining. Moreover, the expression patterns of prostaglandin transporter (PGT), prostaglandin E2 (PGE2), and angiogenesis factor vascular endothelial growth factor (VEGF) were evaluated by immunostaining (IHC) analysis, ELISA assay, real-time quantitative polymerase chain reaction (RT-qPCR), and western blot analysis in vivo. Human dermal microvascular endothelial cells (HDMECs) and the shRNA interference technique were used to explore the effects of QSF on cell migration, PGT, PGE2, and angiogenesis factor VEGF in vitro. Results. Applied QSF on the wound of db/db mice significantly accelerated wound closure. Reductions of PGT and elevations of PGE2 and increased angiogenesis factor VEGF levels were shown after QSF treatment in vivo and in vitro. Furthermore, QSF promoted HDMEC migration. Inhibition of the expression of PGT by shRNA reversed phenotypes of QSF treatment in vitro. Conclusion. Taken together, our findings reveal that QSF ameliorates diabetes-associated wound healing defects by abolishing the expression of PGT.

In Vivo and In Vitro Evaluation of the Therapeutic Potential of Some Turkish Scorzonera Species as Wound Healing Agent

2012 ◽  
Vol 18 (10) ◽  
pp. 1421-1433 ◽  
Author(s):  
Ipek Sutar ◽  
Ozlem Bahadir Acikara ◽  
Gulcin Saltan Citoglu ◽  
Hikmet Keles ◽  
Burcin Ergene ◽  
...  
Keyword(s):  
Wound Healing ◽  
Therapeutic Potential ◽  
In Vitro Evaluation ◽  
Healing Agent

scholarly journals Thyroid hormone action in the absence of thyroid hormone receptor DNA-binding in vivo

2003 ◽  
Vol 112 (4) ◽  
pp. 588-597 ◽  
Author(s):  
Nobuyuki Shibusawa ◽  
Koshi Hashimoto ◽  
Amisra A. Nikrodhanond ◽  
M. Charles Liberman ◽  
Meredithe L. Applebury ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Dna Binding ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Hormone Action ◽  
Thyroid Hormone Action
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