The Role of Vitamin D Deficiency in the Incidence, Progression, and Complications of Type 1 Diabetes Mellitus

The “nonclassic” role of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) has been recently widely recognized. In type 1 diabetes mellitus (T1D), it plays an immunomodulatory role through the vitamin D receptor (VDR) present on pancreatic and immune cells. Specific VDR allelic variants have been associated with T1D in many countries. Furthermore, vitamin D deficiency has been prevalent in T1D, and the seasonal and latitude variability in the incidence of T1D can be partly explained by the related variability in vitamin D level. In fact, retrospective studies of vitamin D supplementation during pregnancy or infancy showed a lower incidence of T1D. We will review the different mechanisms of the vitamin D protective effect against insulitis and present the available data on the role of vitamin D deficiency in the control, progression, and complications of T1D.

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Glycemic changes after vitamin D supplementation in patients with type 1 diabetes mellitus and vitamin D deficiency

Annals of Saudi Medicine ◽

10.4103/0256-4947.72265 ◽

2010 ◽

Vol 30 (6) ◽

pp. 454-458 ◽

Cited By ~ 44

Author(s):

Khalid S. Aljabri ◽

Somoa A. Bokhari ◽

Murtadha J. Khan

Keyword(s):

Diabetes Mellitus ◽

Vitamin D ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Vitamin D Deficiency ◽

Vitamin D Supplementation

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Potential role of vitamin D in the prevention and treatment of type 1 diabetes mellitus

Journal of obstetrics and women s diseases ◽

10.17816/jowd70955 ◽

2021 ◽

Vol 70 (2) ◽

pp. 91-105

Author(s):

Elena V. Misharina ◽

Mariya I. Yarmolinskaya ◽

Elena I. Abashova

Keyword(s):

Diabetes Mellitus ◽

Vitamin D ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Vitamin D Deficiency ◽

Current Data ◽

Vitamin D Metabolism ◽

Immunomodulating Therapy

The incidence of type 1 diabetes mellitus is increasing worldwide, and the number of people with vitamin D deficiency in all age groups, including children and adolescents, is simultaneously growing in the world. Over the past decades, it has been found that vitamin D, in addition to participating in the regulation of calcium homeostasis and bone metabolism, has an anti-inflammatory and immunomodulatory effect. Epidemiological evidence suggests the involvement of vitamin D deficiency in the pathogenesis of type 1 diabetes mellitus. Polymorphisms in genes important for vitamin D metabolism also modulate the risk of type 1 diabetes mellitus. Several studies have evaluated the role of vitamin D as adjuvant immunomodulating therapy in patients with newly diagnosed type 1 diabetes mellitus. The purpose of this review is to present current data on the involvement of vitamin D in the pathogenesis of type 1 diabetes mellitus and to evaluate its role as a drug for the prevention of the disease and its use in treatment in addition to insulin therapy.

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Serum vitamin D deficiency in children and adolescents is associated with type 1 diabetes mellitus

Endocrine Connections ◽

10.1530/ec-18-0191 ◽

2018 ◽

Vol 7 (12) ◽

pp. 1275-1279 ◽

Cited By ~ 5

Author(s):

Changwei Liu ◽

Jingwen Wang ◽

Yuanyuan Wan ◽

Xiaona Xia ◽

Jian Pan ◽

...

Keyword(s):

Diabetes Mellitus ◽

Vitamin D ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Vitamin D Deficiency ◽

Newly Diagnosed ◽

25Ohd Level ◽

Serum 25Ohd ◽

The Mean

Background To investigate the relationship 25-hydroxy vitamin D (25OHD) level among children and in children with type 1 diabetes mellitus (T1DM). Methods A case–control study was conducted to compare the serum 25OHD levels between cases and controls. This study recruited 296 T1DM children (106 newly diagnosed T1DM patients and 190 established T1DM patients), and 295 age- and gender-matched healthy subjects as controls. Results The mean serum 25OHD in T1DM children was 48.69 ± 15.26 nmol/L and in the controls was 57.93 ± 19.03 nmol/L. The mean serum 25OHD in T1DM children was lower than that of controls (P < 0.01). The mean serum 25OHD level (50.42 ± 14.74 nmol/L) in the newly diagnosed T1DM children was higher than that (47.70 ± 15.50 nmol/L) in the established T1DM children but the difference was not statistically significant (P = 0.16). HbA1c values were associated with 25OHD levels in established T1DM children (r = 0.264, P < 0.01), and there was no association between 25OHD and HbA1c in newly diagnosed T1DM children (r = 0.164; P > 0.05). Conclusion Vitamin D deficiency is common in T1DM children, and it should be worthy of attention on the lack of vitamin D in established T1DM children.

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